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Employment (4)

University of Pittsburgh: Pittsburgh, PA, US

Employment
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University of Pittsburgh

Applied BioMath (United States): Concord, Massachusetts, US

2022-05-16 to present | Principal Scientist (Modeling)
Employment
Source: Self-asserted source
Timothy Lezon

University of Pittsburgh: Pittsburgh, Pennsylvania, US

2010-10-01 to 2022-05-13 | Assistant Professor (Computational and Systems Biology)
Employment
Source: Self-asserted source
Timothy Lezon

University of Pittsburgh: Pittsburgh, Pennsylvania, US

2007-06-01 to 2010-10-01 | Postdoctoral Associate (Computational and Systems Biology)
Employment
Source: Self-asserted source
Timothy Lezon

Education and qualifications (2)

The Pennsylvania State University: State College, Pennsylvania, US

2007-05 | Ph.D. (Physics)
Education
Source: Self-asserted source
Timothy Lezon

University of Illinois: Urbana-Champaign, IL, US

1997 | B.S. (Physics)
Education
Source: Self-asserted source
Timothy Lezon

Funding (1)

Phenotypic screening and computational modeling for development of combination therapies for Alzheimer's disease

2018-09-30 to 2020-08-31 | Grant
National Institute on Aging (Baltimore, US)
GRANT_NUMBER: R56AG059612
Source: Self-asserted source
Timothy Lezon via DimensionsWizard

Works (25)

Harnessing human microphysiology systems as key experimental models for quantitative systems pharmacology

Handbook of Experimental Pharmacology
2019 | Book chapter
EID:

2-s2.0-85077222700

Part of ISSN: 18650325 01712004
Contributors: Taylor, D.L.; Gough, A.; Schurdak, M.E.; Vernetti, L.; Chennubhotla, C.S.; Lefever, D.; Pei, F.; Faeder, J.R.; Lezon, T.R.; Stern, A.M. et al.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

A quantitative systems pharmacology approach to infer pathways involved in complex disease phenotypes

Methods in Molecular Biology
2018 | Book chapter
EID:

2-s2.0-85046722442

Part of ISSN: 10643745
Contributors: Schurdak, M.E.; Pei, F.; Lezon, T.R.; Carlisle, D.; Friedlander, R.; Taylor, D.L.; Stern, A.M.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Biologically relevant heterogeneity: Metrics and practical insights

SLAS Discovery
2017 | Journal article
EID:

2-s2.0-85021689350

Part of ISSN: 24725560 24725552
Contributors: Gough, A.; Stern, A.M.; Maier, J.; Lezon, T.; Shun, T.-Y.; Chennubhotla, C.; Schurdak, M.E.; Haney, S.A.; Lansing Taylor, D.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology

Scientific Reports
2017 | Journal article
EID:

2-s2.0-85038610518

Part of ISSN: 20452322
Contributors: Pei, F.; Li, H.; Henderson, M.J.; Titus, S.A.; Jadhav, A.; Simeonov, A.; Cobanoglu, M.C.; Mousavi, S.H.; Shun, T.; McDermott, L. et al.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
EID:

2-s2.0-85029555523

Part of ISSN: 10916490 00278424
Contributors: Suofu, Y.; Li, W.; Jean-Alphonse, F.G.; Jia, J.; Khattar, N.K.; Li, J.; Baranov, S.V.; Leronni, D.; Mihalik, A.C.; He, Y. et al.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Modeling global changes induced by local perturbations to the HIV-1 capsid

Journal of Molecular Graphics and Modelling
2017 | Journal article
EID:

2-s2.0-85003004883

Contributors: Bergman, S.; Lezon, T.R.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Platform for quantitative evaluation of spatial intratumoral heterogeneity in multiplexed fluorescence images

Cancer Research
2017 | Journal article
EID:

2-s2.0-85034976750

Part of ISSN: 15387445 00085472
Contributors: Spagnolo, D.M.; Al-Kofahi, Y.; Zhu, P.; Lezon, T.R.; Gough, A.; Stern, A.M.; Lee, A.V.; Ginty, F.; Sarachan, B.; Taylor, D.L. et al.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

Journal of Pathology Informatics
2016 | Journal article
EID:

2-s2.0-85009238173

Contributors: Spagnolo, D.M.; Gyanchandani, R.; Al-Kofahi, Y.; Stern, A.M.; Lezon, T.R.; Gough, A.; Meyer, D.E.; Ginty, F.; Sarachan, B.; Fine, J. et al.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Proteomic screening and lasso regression reveal differential signaling in insulin and insulin-like growth factor I (IGF1) pathways

Molecular and Cellular Proteomics
2016 | Journal article
EID:

2-s2.0-84989206827

Contributors: Erdem, C.; Nagle, A.M.; Casa, A.J.; Litzenburger, B.C.; Wang, Y.-F.; Taylor, D.L.; Lee, A.V.; Lezon, T.R.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

High-Content Analysis with Cellular and Tissue Systems Biology: A Bridge between Cancer Cell Biology and Tissue-Based Diagnostics

The Molecular Basis of Cancer: Fourth Edition
2015 | Book
EID:

2-s2.0-84903025541

Contributors: Gough, A.; Lezon, T.; Faeder, J.R.; Chennubhotla, C.; Murphy, R.F.; Critchley-Thorne, R.; Taylor, D.L.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Evol and ProDy for bridging protein sequence evolution and structural dynamics

Bioinformatics
2014 | Journal article
EID:

2-s2.0-84907486031

Contributors: Bakan, A.; Dutta, A.; Mao, W.; Liu, Y.; Chennubhotla, C.; Lezon, T.R.; Bahar, I.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Identifying and quantifying heterogeneity in high content analysis: Application of heterogeneity indices to drug discovery

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84904497596

Contributors: Gough, A.H.; Chen, N.; Shun, T.Y.; Lezon, T.R.; Boltz, R.C.; Reese, C.E.; Wagner, J.; Vernetti, L.A.; Grandis, J.R.; Lee, A.V. et al.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter Glt <inf>Ph</inf>

Biophysical Journal
2012 | Journal article
EID:

2-s2.0-84858763413

Contributors: Lezon, T.R.; Bahar, I.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

The effects of rigid motions on elastic network model force constants

Proteins: Structure, Function and Bioinformatics
2012 | Journal article
EID:

2-s2.0-84857733978

Contributors: Lezon, T.R.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Sodium-coupled secondary transporters: Insights from structure-based computations

Molecular Machines
2011 | Book
EID:

2-s2.0-84881405804

Contributors: Zomot, E.; Bakan, A.; Shrivastava, I.H.; De Chancie, J.; Lezon, T.R.; Bahar, I.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Global dynamics of proteins: Bridging between structure and function

Annual Review of Biophysics
2010 | Book
EID:

2-s2.0-77952938726

Contributors: Bahar, I.; Lezon, T.R.; Yang, L.-W.; Eyal, E.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Normal mode analysis of biomolecular structures: Functional mechanisms of membrane proteins

Chemical Reviews
2010 | Journal article
EID:

2-s2.0-77949634796

Contributors: Bahar, I.; Lezon, T.R.; Bakan, A.; Shrivastava, I.H.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Using entropy maximization to understand the determinants of structural dynamics beyond native contact topology

PLoS Computational Biology
2010 | Journal article
EID:

2-s2.0-77955496805

Contributors: Lezon, T.R.; Bahar, I.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Global motions of the nuclear pore complex: Insights from elastic network models

PLoS Computational Biology
2009 | Journal article
EID:

2-s2.0-70349661903

Contributors: Lezon, T.R.; Sali, A.; Bahar, I.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

The Most Probable Genetic Interaction Networks Inferred from Gene Expression Patterns

Analysis of Microarray Data: A Network-Based Approach
2008 | Book
EID:

2-s2.0-84889614605

Contributors: Lezon, T.R.; Banavar, J.R.; Cieplak, M.; Fedoroff, N.V.; Maritan, A.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Geometry of proteins: Hydrogen bonding, sterics, and marginally compact tubes

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
2006 | Journal article
EID:

2-s2.0-33645159311

Contributors: Banavar, J.R.; Cieplak, M.; Flammini, A.; Hoang, T.X.; Kamien, R.D.; Lezon, T.; Marenduzzo, D.; Maritan, A.; Seno, F.; Snir, Y. et al.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

The origami of life

Journal of Physics Condensed Matter
2006 | Journal article
EID:

2-s2.0-32644435785

Contributors: Lezon, T.R.; Banavar, J.R.; Maritan, A.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns

Proceedings of the National Academy of Sciences of the United States of America
2006 | Journal article
EID:

2-s2.0-35548985891

Contributors: Lezon, T.R.; Banavar, J.R.; Cieplak, M.; Maritan, A.; Fedoroff, N.V.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

What determines the spectrum of protein native state structures?

Proteins: Structure, Function and Genetics
2006 | Journal article
EID:

2-s2.0-33645299543

Contributors: Lezon, T.R.; Banavar, J.E.; Lesk, A.M.; Maritan, A.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Recognition of Coarse-Grained Protein Tertiary Structure

Proteins: Structure, Function and Genetics
2004 | Journal article
EID:

2-s2.0-2442426488

Contributors: Lezon, T.; Banavar, J.R.; Maritan, A.
Source: Self-asserted source
Timothy Lezon via Scopus - Elsevier

Peer review (1 review for 1 publication/grant)

Review activity for PloS one. (1)