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Works (47)

A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury

Bone & Joint Research
2024-09-19 | Journal article
DOI: 10.1302/2046-3758.139.BJR-2024-0109
Contributors: Raneem Kalsoum; Catherine J. Minns Lowe; Sophie Gilbert; Andrew W. McCaskie; Martyn Snow; Karina Wright; Geoff Bruce; Deborah J. Mason; Fiona E. Watt
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Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms

Biochemistry and Biophysics Reports
2022-12 | Journal article
DOI: 10.1016/j.bbrep.2022.101323
Contributors: S.J. Gilbert; E.J. Blain; D.J. Mason
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REPURPOSING AN ANTI-EPILEPSY GLUTAMATE RECEPTOR ANTAGONIST FOR THE PREVENTION OF POST-TRAUMATIC OSTEOARTHRITIS

Osteoarthritis and Cartilage
2020 | Journal article
DOI: 10.1016/J.JOCA.2020.02.767
WOSUID: WOS:000527813600751
Contributors: Bonnet, C. S.; Gilbert, S. J.; Mason, D. J.
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THE USE OF A 3-DIMENSIONAL MECHANICAL LOADING MODEL OF HUMAN STEM CELL DERIVED OSTEOCYTES TO STUDY THE 'MECHANOSOME'

Osteoarthritis and Cartilage
2020 | Journal article
WOSUID: WOS:000527813600281
Contributors: Gilbert, S.; Bonnet, C.; Mason, D.
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REPURPOSING GLUTAMATE RECEPTOR ANTAGONISTS TO PREVENT POST-TRAUMATIC OSTEOARTHRITIS

Osteoarthritis and Cartilage
2019 | Journal article
DOI: 10.1016/J.JOCA.2019.02.255
WOSUID: WOS:000466779301039
Contributors: Bonnet, C.; Gilbert, S.; Mason, D.
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ROLE FOR PROTEIN KINASE R IN BONE CELL SIGNALLING

Osteoarthritis and Cartilage
2019 | Journal article
DOI: 10.1016/J.JOCA.2019.02.310
WOSUID: WOS:000466779301092
Contributors: Gilbert, S.; Russel, T.; Elford, C.; Evans, B.; Blain, E.; Mason, D.
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Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis

Journal of Orthopaedic Research
2018 | Journal article
DOI: 10.1002/JOR.23872
WOSUID: WOS:000442216700007
Contributors: Gilbert, Sophie J.; Bonnet, Cleo S.; Stadnik, Paulina; Duance, Victor C.; Mason, Deborah J.; Blain, Emma J.
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Mechano-regulation of miRNA-221,-222,-21 and-27: implications for articular cartilage homeostasis

International Journal of Experimental Pathology
2018 | Journal article
WOSUID: WOS:000459467900129
Contributors: Stadnik, P. S.; Charlton, S.; Gilbert, S. J.; Tarn, J.; Skelton, A. J.; Barter, M. J.; Duance, V. C.; Young, D. A.; Blain, E. J.
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Importance of reference gene selection for articular cartilage mechanobiology studies

International Journal of Experimental Pathology
2016 | Journal article
WOSUID: WOS:000392018800022
Contributors: Al-Sabah, A.; Stadnik, P.; Gilbert, S.; Duance, V.; Blain, E.
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Importance of reference gene selection for articular cartilage mechanobiology studies

Osteoarthritis and Cartilage
2016 | Journal article
DOI: 10.1016/J.JOCA.2015.11.007
WOSUID: WOS:000372552200019
Contributors: Al-Sabah, A.; Stadnik, P.; Gilbert, S. J.; Duance, V. C.; Blain, E. J.
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Investigation of the early inflammatory process that occurs during the development of post-traumatic osteoarthritis

International Journal of Experimental Pathology
2016 | Journal article
WOSUID: WOS:000397965700049
Contributors: Gilbert, S. J.; Bonnet, C. S.; Duance, V. C.; Mason, D. J.; Blain, E. J.
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NBQX, an AMPA-kainate glutamate receptor antagonist, alleviates inflammation and pain related behaviour in two models of osteoarthritis

International Journal of Experimental Pathology
2016 | Journal article
WOSUID: WOS:000392018800026
Contributors: Bonnet, C. S.; Gilbert, S. J.; Williams, A. S.; Walsh, D. A.; Mason, D. J.
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AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis

Annals of the Rheumatic Diseases
2015 | Journal article
DOI: 10.1136/ANNRHEUMDIS-2013-203670
WOSUID: WOS:000345945700046
Contributors: Bonnet, Cleo S.; Williams, Anwen S.; Gilbert, Sophie J.; Harvey, Ann K.; Evans, Bronwen A.; Mason, Deborah J.
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Deletion of P58(IPK), the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice

Frontiers in Endocrinology
2014 | Journal article
DOI: 10.3389/FENDO.2014.00174
WOSUID: WOS:000209749800172
Contributors: Gilbert, Sophie J.; Meakin, Lee B.; Bonnet, Cleo S.; Nowell, Mari A.; Ladiges, Warren C.; Morton, John; Duance, Victor C.; Mason, Deborah J.
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NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis

International Journal of Experimental Pathology
2014 | Journal article
WOSUID: WOS:000336267400009
Contributors: Bonnet, C. S.; Williams, A. S.; Gilbert, S. J.; Harvey, A. K.; Evans, B. A.; Mason, D. J.
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The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo

International Journal of Experimental Pathology
2014 | Journal article
WOSUID: WOS:000336267400022
Contributors: Gilbert, S. J.; Meakin, L. B.; Mason, D. J.; Duance, V. C.; Blain, E. J.
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The use of pulsed low-intensity ultrasound (PLIUS) as a therapy for cartilage repair

International Journal of Experimental Pathology
2014 | Journal article
WOSUID: WOS:000336267400023
Contributors: Gilbert, S. J.; Stevens, J.; Vishwakarma, A. R.; Archer, C. W.; Duance, V. C.
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A deletion mutation of the gene P58(IPK), the cellular inhibitor of PKR and PERK, results in a bone phenotype in mice

International Journal of Experimental Pathology
2013 | Journal article
WOSUID: WOS:000324105200034
Contributors: Gilbert, S. J.; Meakin, L. B.; Nowell, M. A.; Ladiges, W. C.; Morton, J.; Price, J. S.; Duance, V. C.; Mason, D. J.
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INTRA-ARTICULAR AMPA/KAINATE GLUTAMATE RECEPTOR ANTAGONISTS ALLEVIATE INFLAMMATION, PAIN AND PATHOLOGY IN RAT ANTIGEN INDUCED ARTHRITIS

Osteoporosis International
2012 | Journal article
WOSUID: WOS:000309261000017
Contributors: Bonnet, Cleo; Williams, Anwen; Harvey, Ann; Gilbert, Sophie; Moideen, Abdul; Nowell, Mari; Mason, Deborah
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PROTEIN KINASE R PLAYS A PIVOTAL ROLE IN ONCOSTATIN M AND INTERLEUKIN-1 SIGNALLING IN BOVINE ARTICULAR CARTILAGE CHONDROCYTES

eCM Journal
2012 | Journal article
DOI: 10.22203/ECM.V023A04
WOSUID: WOS:000307554200004
Contributors: Gilbert, S. J.; Blain, E. J.; Al-Sabah, A.; Zhang, Y.; Duance, V. C.; Mason, D. J.
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Type IX Collagen Interacts with Fibronectin Providing an Important Molecular Bridge in Articular Cartilage

Journal of Biological Chemistry
2011 | Journal article
DOI: 10.1074/JBC.M111.238188
WOSUID: WOS:000295406300052
Contributors: Parsons, Philippa; Gilbert, Sophie J.; Vaughan-Thomas, Anne; Sorrell, David A.; Notman, Rebecca; Bishop, Mark; Hayes, Anthony J.; Mason, Deborah J.; Duance, Victor C.
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Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint

International Journal of Experimental Pathology
2010 | Journal article
WOSUID: WOS:000275205700036
Contributors: Gilbert, S. J.; Patel, M.; Toumi, H.; Duance, V. C.; Mason, D. J.
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TGFbeta1-mediated collagen biosynthesis in articular chondrocytes is dependent on an intact microtubular network

International Journal of Experimental Pathology
2010 | Journal article
WOSUID: WOS:000275205700049
Contributors: Blain, E. J.; Gilbert, S. J.; Duance, V. C.
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A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes

International Journal of Experimental Pathology
2009 | Journal article
WOSUID: WOS:000264345300041
Contributors: Gilbert, S. J.; Duance, V. C.; Mason, D. J.
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An immunofluorescence method for post-embedded tissue in acrylic resin Technovit 9100 New (R) using fluorescein isothiocyanate secondary detection marker

International Journal of Experimental Pathology
2009 | Journal article
WOSUID: WOS:000264345300074
Contributors: Singhrao, S. K.; Mueller, C. T.; Gilbert, S. J.; Duance, V. C.; Archer, C. W.
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An Immunofluorescence Method for Postembedded Tissue in the Acrylic Resin Technovit 9100 New (R) Using Fluorescein Isothiocyanate Secondary Detection

Microscopy Research and Technique
2009 | Journal article
DOI: 10.1002/JEMT.20705
WOSUID: WOS:000268475300005
Contributors: Singhrao, Sim K.; Mueller, Carsten T.; Gilbert, Sophie J.; Duance, Victor C.; Archer, Charles W.
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Biological responses of chondrocytes to poly(ethylene terephthalate)/polycaprolactone, (PET/PCL) co-polymer flat scaffolds as a potential biomaterial for matrix-induced autologous chondrocyte implantation (MACI)

International Journal of Experimental Pathology
2009 | Journal article
WOSUID: WOS:000262516200049
Contributors: Singhrao, Sim. K.; Gilbert, Sophie. J.; Khan, Ilyas; Duance, Victor C.; Archer, Charles W.
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Clonal chondroprogenitors maintain telomerase activity and Sox9 expression during extended monolayer culture and retain chondrogenic potential

Osteoarthritis and Cartilage
2009 | Journal article
DOI: 10.1016/J.JOCA.2008.08.002
WOSUID: WOS:000264975000015
Contributors: Khan, I. M.; Bishop, J. C.; Gilbert, S.; Archer, C. W.
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Enhanced Tissue Integration During Cartilage Repair In Vitro Can Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge

Tissue Engineering Part A
2009 | Journal article
DOI: 10.1089/TEN.TEA.2008.0361
WOSUID: WOS:000267843700029
Contributors: Gilbert, Sophie J.; Singhrao, Sim K.; Khan, Ilyas M.; Gonzalez, Lee G.; Thomson, Brian M.; Burdon, Drew; Duance, Victor C.; Archer, Charles W.
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CARTILAGE INTEGRATION: EVALUATION OF THE REASONS FOR FAILURE OF INTEGRATION DURING CARTILAGE REPAIR. A REVIEW

eCM Journal
2008 | Journal article
DOI: 10.22203/ECM.V016A04
WOSUID: WOS:000265867200006
Contributors: Khan, I. M.; Gilbert, S. J.; Singhrao, S. K.; Duance, V. C.; Archer, C. W.
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Inhibition of chondrocyte death at the wound edge enhances integrative cartilage repair

International Journal of Experimental Pathology
2008 | Journal article
WOSUID: WOS:000255603000020
Contributors: Gilbert, Sophie J.; Singhrao, Sim K.; Khan, Ilyas; Duance, Victor C.; Archer, Charles W.
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Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage

Osteoarthritis and Cartilage
2008 | Journal article
DOI: 10.1016/J.JOCA.2007.10.004
WOSUID: WOS:000257241700010
Contributors: Khan, I. M.; Gilbert, S. J.; Caterson, B.; Sandell, L. J.; Archer, C. W.
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Sphingomyelin'ase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway

Arthritis & Rheumatism-arthritis Care & Research
2008 | Journal article
DOI: 10.1002/ART.23172
WOSUID: WOS:000252733100024
Contributors: Gilbert, S. J.; Blain, E. J.; Duance, V. C.; Mason, D. J.
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The potential of IGF-1 and TGF beta 1 for promoting "Adult'' articular cartilage repair: An in vitro study

Tissue Engineering Part A
2008 | Journal article
DOI: 10.1089/TEN.TEA.2007.0211
WOSUID: WOS:000257759700013
Contributors: Davies, Lindsay C.; Blain, Emma J.; Gilbert, Sophie J.; Caterson, Bruce; Duance, Victor C.
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Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis

Matrix Biology
2006 | Journal article
DOI: 10.1016/J.MATBIO.2006.06.002
WOSUID: WOS:000241831400003
Contributors: Blain, Emma J.; Blain, Emma J.; Gilbert, Sophie J.; Gilbert, Sophie J.; Hayes, Anthony J.; Hayes, Anthony J.; Duance, Victor C.; Duance, Victor C.
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Enhanced expression of type IIA procollagen and sGAG release in bovine cartilage cultures is mediated by proinflammatory cytokine-induced increases in endogenous ceramide

International Journal of Experimental Pathology
2006 | Journal article
WOSUID: WOS:000234855000051
Contributors: Gilbert, SJ; Khan, IM; Sandell, LJ; Duance, VC; Mason, DJ
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Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study

Arthritis Research & Therapy
2006 | Journal article
DOI: 10.1186/AR1961
WOSUID: WOS:000240985200015
Contributors: Gilbert, Sophie J.; Blain, Emma J.; Jones, Pamela; Duance, Victor C.; Mason, Deborah J.
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Protein Kinase R: A Novel Mediator of Articular Cartilage Degradation in Arthritis

Current Rheumatology Reviews
2006 | Journal article
DOI: 10.2174/157339706775697026
WOSUID: WOS:000453360800003
Contributors: Gilbert, Sophie J.; Duance, Victor C.; Mason, Deborah J.
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Age-related changes in Achilles tendon gene expression

International Journal of Experimental Pathology
2005 | Journal article
WOSUID: WOS:000233517500033
Contributors: Blain, EJ; Gilbert, SJ; Hurst, S; Zhang, Y; Aeschlimann, DP; Caterson, B; Duance, VC
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An intact cytoskeleton is essential to maintain articular cartilage chondrocyte metabolism

International Journal of Experimental Pathology
2005 | Journal article
WOSUID: WOS:000229372100018
Contributors: Blain, EJ; Gilbert, SJ; Duance, VC
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Ceramide increases matrix synthesis in articular chondrocytes

International Journal of Experimental Pathology
2005 | Journal article
WOSUID: WOS:000233517500041
Contributors: Gilbert, SJ; Blain, EJ; Duance, VC; Mason, DJ
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Changes in tendon extracellular matrix composition with age

International Journal of Experimental Pathology
2005 | Journal article
DOI: 10.1111/J.0959-9673.2004.369AR.X
WOSUID: WOS:000233517500040
Contributors: Gilbert, S; Blain, E; Zhang, Y; Rees, E; Avery, N; Aeschlimann, D; Caterson, B; Duance, V
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Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?

Arthritis Research & Therapy
2004 | Journal article
DOI: 10.1186/AR1024
WOSUID: WOS:000187021500009
Contributors: Gilbert, SJ; Duance, VC; Mason, DJ
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A novel cytokine-inducible signalling pathway in cartilage

Bone
2002 | Journal article
WOSUID: WOS:000174345000105
Contributors: Gilbert, SJ; Duance, VC; Mason, DJ
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A novel signalling pathway in cartilage

Journal of Bone and Mineral Research
2002 | Journal article
WOSUID: WOS:000176427200123
Contributors: Gilbert, SJ; Duance, VC; Mason, DJ
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Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes

Biochemical Society Transactions
2002 | Journal article
DOI: 10.1042/BST0300886
WOSUID: WOS:000179816600013
Contributors: Gilbert, SJ; Duance, VC; Mason, DJ
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Differential gene expression in early stages of osteoarthritis in vivo

Journal of Bone and Mineral Research
1999 | Journal article
WOSUID: WOS:000080615500080
Contributors: Gilbert, SJ; Duance, VC; Mason, DJ
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Peer review (9 reviews for 4 publications/grants)

Review activity for Bone & joint research. (5)
Review activity for British journal of pharmacology. (2)
Review activity for Connective tissue research. (1)
Review activity for Nature communications (1)
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