Personal information

Emails & domains

Verified email addresses

Websites & social links

Github

Other IDs

Scopus Author ID: 7202846387
Scopus Author ID: 57200376872

Keywords

bioinformatics, epilepsy

Countries

Luxembourg

Biography

Research Scientist in Bioinformatics at the Luxembourg Centre for Systems Biomedicine, an interdisciplinary centre of the University of Luxembourg. I'm the training coordinator for the Luxembourgish node of ELIXIR.

Activities

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Employment (1)

University of Luxembourg: Esch-sur-Alzette, LU

2012-04-01 to present | Research Scientist (Luxembourg Centre for Systems Biomedicine)
Employment
Source: Self-asserted source
Roland Krause

Education and qualifications (3)

University of Luxembourg: Luxembourg, LU

2018-10-06 to present | Autorisation a dirige des recherches
Qualification
Source: Self-asserted source
Roland Krause

Ruprecht Karls Universität Heidelberg : Heidelberg, Baden-Württemberg, DE

2001 to 2004 | Dr. sc. hum. (Medizinische Fakultät Heidelberg)
Education
Source: Self-asserted source
Roland Krause

Hochschule Mannheim: Mannheim, Baden-Württemberg, DE

1994 to 1999 | Dipl. Ing. (FH)
Education
Source: Self-asserted source
Roland Krause

Funding (5)

EMBO Practical Course: Integrated multi-omic analyses of microbial communities

2020-03 to present | Grant
EMBO (Heidelberg, DE)
URL: https://meetings.embo.org/event/20-microbial-communities
Source: Self-asserted source
Roland Krause

TREAT-ION: Subproject 2: Data integration and in silico Precision Medicine

2019-03 to 2022-10 | Contract
University of Tübingen (Tübingen, DE)
URL: https://treat-ion.de
Source: Self-asserted source
Roland Krause

Centralized data management and analysis facilities

2017-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://grants.uberresearch.com/501100001659/394775100/Centralized-data-management-and-analysis-facilities
GRANT_NUMBER: 394775100
Source: Self-asserted source
Roland Krause via DimensionsWizard

Rare genetic factors in epileptogenesis

2017-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://grants.uberresearch.com/501100001659/394774029/Rare-genetic-factors-in-epileptogenesis
GRANT_NUMBER: 394774029
Source: Self-asserted source
Roland Krause via DimensionsWizard

EMBO Practical Course Phenotyping Neurological Syndromes

Grant
European Molecular Biology Organization (Heidelberg, DE)
GRANT_NUMBER:

PC18/11
Source: Self-asserted source
Roland Krause

Works (50 of 80)

Items per page:
Page 1 of 2

Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

Nature Neuroscience
2024-10 | Journal article
DOI: 10.1038/s41593-024-01747-8
Part of ISSN: 1097-6256
Part of ISSN: 1546-1726
Contributors: Epi25 Collaborative; Siwei Chen; Bassel W. Abou-Khalil; Zaid Afawi; Quratulain Zulfiqar Ali; Elisabetta Amadori; Alison Anderson; Joe Anderson; Danielle M. Andrade; Grazia Annesi et al.
Source: Self-asserted source
Roland Krause

Training Certification Criteria v1.1.1

Zenodo
2024-03-15 | Other
DOI: 10.5281/zenodo.10823267
Contributors: Eva Alloza; Mihail Anton; Roland Krause; Loredana Le Pera; Patricia M. Palagi; Fotis E. Psomopoulos; Allegra Via; Daniel Wibberg
Source: check_circle
DataCite

Training Certification Criteria v1.1.1

Zenodo
2024-03-15 | Other
DOI: 10.5281/zenodo.10823266
Contributors: Eva Alloza; Mihail Anton; Roland Krause; Loredana Le Pera; Patricia M. Palagi; Fotis E. Psomopoulos; Allegra Via; Daniel Wibberg
Source: check_circle
DataCite

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Nature Genetics
2023-09 | Journal article
DOI: 10.1038/s41588-023-01485-w
Part of ISSN: 1061-4036
Part of ISSN: 1546-1718
Contributors: International League Against Epilepsy Consortium on Complex Epilepsies; Remi Stevelink; Ciarán Campbell; Siwei Chen; Bassel Abou-Khalil; Oluyomi M. Adesoji; Zaid Afawi; Elisabetta Amadori; Alison Anderson; Joseph Anderson et al.
Source: Self-asserted source
Roland Krause

Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis

OpenAlex
2022-11-01 | Other
DOI: 10.60692/d3d0h-ce751
Contributors: Remi Stevelink; Dania Al-Toma; Floor Jansen; Herm Lamberink; A. A. Asadi-Pooya; Mohsen Farazdaghi; Gonçalo Cação; Sita Jayalakshmi; ANUJA PATIL; ÇIGDEM OZKARA et al.
Source: check_circle
DataCite

Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis

OpenAlex
2022-11-01 | Other
DOI: 10.60692/6bzfy-nx959
Contributors: Remi Stevelink; Dania Al-Toma; Floor Jansen; Herm Lamberink; A. A. Asadi-Pooya; Mohsen Farazdaghi; Gonçalo Cação; Sita Jayalakshmi; ANUJA PATIL; ÇIGDEM OZKARA et al.
Source: check_circle
DataCite

Benchmarking of univariate pleiotropy detection methods applied to epilepsy

Human Mutation
2022-09 | Journal article
DOI: 10.1002/humu.24417
Contributors: Oluyomi M. Adesoji; Herbert Schulz; Patrick May; Roland Krause; Holger Lerche; Michael Nothnagel
Source: check_circle
Crossref

Community-driven ELIXIR activities in single-cell omics [version 1; peer review: 2 approved with reservations]

2022-07-29 | Journal article
DOI: 10.12688/f1000research.122312.1
Part of ISSN: 2046-1402
Funded by GRANT_NUMBER: http://dx.doi.org/10.13039/501100004063
Contributors: Paulo Czarnewski; Ahmed Mahfouz; Raffaele A. Calogero; Patricia M. Palagi; Laura Portell-Silva; Asier Gonzalez-Uriarte; Charlotte Soneson; Tony Burdett; Barbara Szomolay; Pavankumar Videm et al.
Source: check_circle
F1000

A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam

Epilepsia
2022-06 | Journal article
DOI: 10.1111/epi.17228
Contributors: Ciarán Campbell; Mark McCormack; Sonn Patel; Caragh Stapleton; Dheeraj Bobbili; Roland Krause; Chantal Depondt; Graeme J. Sills; Bobby P. Koeleman; Pasquale Striano et al.
Source: check_circle
Crossref

Association of ultra‐rare coding variants with genetic generalized epilepsy: A case–control whole exome sequencing study

Epilepsia
2022-03 | Journal article
DOI: 10.1111/epi.17166
Part of ISSN: 0013-9580
Part of ISSN: 1528-1167
Source: Self-asserted source
Roland Krause

Phenotypic homogeneity in childhood epilepsies evolves in gene-specific patterns across 3251 patient-years of clinical data

European Journal of Human Genetics
2021-11 | Journal article
DOI: 10.1038/s41431-021-00908-8
Part of ISSN: 1018-4813
Part of ISSN: 1476-5438
Source: Self-asserted source
Roland Krause

Distinct gene-set burden patterns underlie common generalized and focal epilepsies

eBioMedicine
2021-10 | Journal article
DOI: 10.1016/j.ebiom.2021.103588
Part of ISSN: 2352-3964
Source: Self-asserted source
Roland Krause
grade
Preferred source (of 2)‎

Assessing the role of rare genetic variants in drug‐resistant, non‐lesional focal epilepsy

Annals of Clinical and Translational Neurology
2021-07 | Journal article
DOI: 10.1002/acn3.51374
Contributors: Stefan Wolking; Claudia Moreau; Mark McCormack; Roland Krause; Martin Krenn; Samuel Berkovic; Gianpiero L. Cavalleri; Norman Delanty; Chantal Depondt; Michael R. Johnson et al.
Source: check_circle
Crossref

Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations

Epilepsia
2021-07 | Journal article
DOI: 10.1111/epi.16922
Part of ISSN: 0013-9580
Part of ISSN: 1528-1167
Source: Self-asserted source
Roland Krause

Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable

Epilepsia
2021-06 | Journal article
DOI: 10.1111/epi.16908
Contributors: David Lewis‐Smith; Peter D. Galer; Ganna Balagura; Hugh Kearney; Shiva Ganesan; Mahgenn Cosico; Margaret O'Brien; Priya Vaidiswaran; Roland Krause; Colin A. Ellis et al.
Source: check_circle
Crossref

Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals

The American Journal of Human Genetics
2021-06 | Journal article
DOI: 10.1016/j.ajhg.2021.04.009
Part of ISSN: 0002-9297
Source: Self-asserted source
Roland Krause

Role of Common Genetic Variants for Drug-Resistance to Specific Anti-Seizure Medications

Frontiers in Pharmacology
2021-06-09 | Journal article
DOI: 10.3389/fphar.2021.688386
Part of ISSN: 1663-9812
Source: Self-asserted source
Roland Krause

Loss-of-function variants in the KCNQ5 gene are associated with genetic generalized epilepsies

[]
2021-04-20 | Preprint
DOI: 10.1101/2021.04.20.21255696
Source: Self-asserted source
Roland Krause

Ultra-rare constrained missense variants in the epilepsies: Shared and specific enrichment patterns in neuronal gene-sets

2021-04-19 | Preprint
DOI: 10.1101/2021.04.18.440264
Contributors: Mahmoud Koko; Roland Krause; Thomas Sander; Dheeraj Reddy Bobbili; Michael Nothnagel; Patrick May; Holger Lerche
Source: check_circle
Crossref

Climate change and epilepsy: Insights from clinical and basic science studies.

Epilepsy & behavior : E&B
2021-02-09 | Journal article
DOI: 10.1016/j.yebeh.2021.107791
PMID: 33578223
Source: Self-asserted source
Roland Krause

The Human Phenotype Ontology in 2021.

Nucleic acids research
2021-01-01 | Journal article
DOI: 10.1093/nar/gkaa1043
PMID: 33264411
PMC: PMC7778952
Source: Self-asserted source
Roland Krause

Gene family information facilitates variant interpretation and identification of disease-associated genes in neurodevelopmental disorders

Genome Medicine
2020-12 | Journal article
DOI: 10.1186/s13073-020-00725-6
Part of ISSN: 1756-994X
Source: Self-asserted source
Roland Krause

Reproducible analysis

Zenodo
2020-10-07 | Other
DOI: 10.5281/zenodo.4071506
Contributors: Roland Krause
Source: check_circle
DataCite
grade
Preferred source (of 3)‎

Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data.

Life science alliance
2020-09-24 | Journal article
DOI: 10.26508/lsa.202000867
PMID: 32972997
PMC: PMC7536825
Source: Self-asserted source
Roland Krause

Semantic Similarity Analysis Reveals Robust Gene-Disease Relationships in Developmental and Epileptic Encephalopathies.

American journal of human genetics
2020-08-26 | Journal article
DOI: 10.1016/j.ajhg.2020.08.003
PMID: 32853554
Source: Self-asserted source
Roland Krause
grade
Preferred source (of 2)‎

A framework to assess the quality and impact of bioinformatics training across ELIXIR.

PLoS computational biology
2020-07-23 | Journal article
DOI: 10.1371/journal.pcbi.1007976
PMID: 32702016
PMC: PMC7377377
Source: Self-asserted source
Roland Krause

Ten simple rules for making training materials FAIR

Apollo - University of Cambridge Repository
2020-05-22 | Other
DOI: 10.17863/cam.52755
Contributors: Leyla Jael Castro; Bérénice Batut; Melissa Burke; Mateusz Kuzak; Fotis E. Psomopoulos; Ricardo Arcila; Teresa Attwood; Niall Beard; Dr D Carvalho-Silva; Alexandros Dimopoulos et al.
Source: check_circle
DataCite

Genomic and clinical predictors of lacosamide response in refractory epilepsies

Epilepsia Open
2019-09 | Journal article
DOI: 10.1002/epi4.12360
Source: Self-asserted source
Roland Krause

Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy

Epilepsia Open
2019-07 | Journal article
DOI: 10.1002/epi4.12349
PMID: 31440723
Source: Self-asserted source
Roland Krause

A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy

The American Journal of Human Genetics
2019-06 | Journal article
DOI: 10.1016/j.ajhg.2019.04.001
Source: Self-asserted source
Roland Krause

Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals

bioRxiv
2019-01 | Journal article
DOI: 10.1101/525683
Source: Self-asserted source
Roland Krause

Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy

European Journal of Human Genetics
2018 | Journal article
DOI: 10.1038/s41431-017-0034-x
EID:

2-s2.0-85040771554
Contributors: Bobbili, D.R.; Lal, D.; May, P.; Reinthaler, E.M.; Jabbari, K.; Thiele, H.; Nothnagel, M.; Jurkowski, W.; Feucht, M.; Nürnberg, P. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project

European Psychiatry
2018 | Journal article
DOI: 10.1016/j.eurpsy.2017.10.004
EID:

2-s2.0-85041738085
Contributors: Winterer, G.; Androsova, G.; Bender, O.; Boraschi, D.; Borchers, F.; Dschietzig, T.B.; Feinkohl, I.; Fletcher, P.; Gallinat, J.; Hadzidiakos, D. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Rare coding variants in genes encoding GABA<inf>A</inf>receptors in genetic generalised epilepsies: an exome-based case-control study

The Lancet Neurology
2018 | Journal article
DOI: 10.1016/S1474-4422(18)30215-1
EID:

2-s2.0-85049923895
Contributors: May, P.; Girard, S.; Harrer, M.; Bobbili, D.R.; Schubert, J.; Wolking, S.; Becker, F.; Lachance-Touchette, P.; Meloche, C.; Gravel, M. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Nature Communications
2018-12-10 | Journal article
DOI: 10.1038/s41467-018-07524-z
Source: Self-asserted source
Roland Krause

The Human Phenotype Ontology in 2017.

Apollo - University of Cambridge Repository
2018-05-31 | Journal article
DOI: 10.17863/CAM.23701
Contributors: Sebastian Köhler; Nicole Vasilevsky; Mark Engelstad; Erin D. Foster; Julie A McMurry; Ségolène Aymé; Gareth Baynam; Susan M Bello; Cornelius F Boerkoel; Kym M Boycott et al.
Source: check_circle
DataCite

Alterations in the α<inf>2</inf>δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies

Epilepsia
2017 | Journal article
DOI: 10.1111/epi.13898
EID:

2-s2.0-85029422978
Contributors: Santolini, I.; Celli, R.; Cannella, M.; Imbriglio, T.; Guiducci, M.; Parisi, P.; Schubert, J.; Iacomino, M.; Zara, F.; Lerche, H. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data

European Journal of Human Genetics
2017 | Journal article
DOI: 10.1038/ejhg.2017.61
EID:

2-s2.0-85019562360
Contributors: Allen, A.S.; Berkovic, S.F.; Bridgers, J.; Cossette, P.; Dlugos, D.; Epstein, M.P.; Glauser, T.; Goldstein, D.B.; Heinzen, E.L.; Jiang, Y. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy

Epilepsia
2017 | Journal article
DOI: 10.1111/epi.13777
EID:

2-s2.0-85021814480
Contributors: Berghuis, B.; van der Palen, J.; de Haan, G.-J.; Lindhout, D.; Koeleman, B.P.C.; Sander, J.W.; Møller, R.S.; Nikanorova, M.; Ingason, A.; Depondt, C. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Epilepsia
2017 | Journal article
DOI: 10.1111/epi.13871
EID:

2-s2.0-85028663333
Contributors: Androsova, G.; Krause, R.; Borghei, M.; Wassenaar, M.; Auce, P.; Avbersek, A.; Becker, F.; Berghuis, B.; Campbell, E.; Coppola, A. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Rare GABRA3 variants are associated with epileptic seizures, encephalopathy and dysmorphic features

Brain
2017 | Journal article
DOI: 10.1093/brain/awx236
EID:

2-s2.0-85032979189
Contributors: Niturad, C.E.; Lev, D.; Kalscheuer, V.M.; Charzewska, A.; Schubert, J.; Lerman-Sagie, T.; Kroes, H.Y.; Oegema, R.; Traverso, M.; Specchio, N. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

The human phenotype ontology in 2017

Nucleic Acids Research
2017 | Journal article
DOI: 10.1093/nar/gkw1039
EID:

2-s2.0-85015982066
Contributors: Köhler, S.; Vasilevsky, N.A.; Engelstad, M.; Foster, E.; McMurry, J.; Aymé, S.; Baynam, G.; Bello, S.M.; Boerkoel, C.F.; Boycott, K.M. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

A systems level analysis of epileptogenesis-associated proteome alterations

Neurobiology of Disease
2017-09 | Journal article
DOI: 10.1016/j.nbd.2017.05.017
Contributors: Michael Keck; Anna Fournier; Fabio Gualtieri; Andreas Walker; Eva-Lotta von Rüden; Vera Russmann; Cornelia A. Deeg; Stefanie M. Hauck; Roland Krause; Heidrun Potschka
Source: check_circle
Crossref

70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
DOI: 10.1073/pnas.1524554113
EID:

2-s2.0-84959498646
Contributors: Yamamoto, H.; Wittek, D.; Gupta, R.; Qin, B.; Ueda, T.; Krause, R.; Yamamoto, K.; Albrecht, R.; Pech, M.; Nierhaus, K.H.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

Alzheimer's and Dementia
2016 | Journal article
DOI: 10.1016/j.jalz.2016.02.006
EID:

2-s2.0-84966539175
Contributors: Allen, G.I.; Amoroso, N.; Anghel, C.; Balagurusamy, V.; Bare, C.J.; Beaton, D.; Bellotti, R.; Bennett, D.A.; Boehme, K.L.; Boutros, P.C. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier
grade
Preferred source (of 4)‎

Evaluation of presumably disease causing SCN1A variants in a cohort of common epilepsy syndromes

PLoS ONE
2016 | Journal article
DOI: 10.1371/journal.pone.0150426
EID:

2-s2.0-84962195598
Contributors: Lal, D.; Reinthaler, E.M.; Dejanovic, B.; May, P.; Thiele, H.; Lehesjoki, A.-E.; Schwarz, G.; Riesch, E.; Ikram, M.A.; Van Duijn, C.M. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Biomarkers of postoperative delirium and cognitive dysfunction.

2015 | Journal article
DOI: 10.3389/fnagi.2015.00112
PMID: 26106326
PMC: PMC4460425
Contributors: Androsova G; Krause R; Winterer G; Schneider R
Source: Self-asserted source
Roland Krause via Europe PubMed Central

CHD2 variants are a risk factor for photosensitivity in epilepsy

Brain
2015 | Journal article
DOI: 10.1093/brain/awv028
EID:

2-s2.0-84929658567
Contributors: Galizia, E.C.; Myers, C.T.; Leu, C.; De Kovel, C.G.F.; Afrikanova, T.; Cordero-Maldonado, M.L.; Martins, T.G.; Jacmin, M.; Drury, S.; Chinthapalli, V.K. et al.
Source: Self-asserted source
Roland Krause via Scopus - Elsevier

Investigation of GRIN2A in common epilepsy phenotypes.

2015-09 | Journal article
DOI: 10.1016/j.eplepsyres.2015.05.010
PMID: 26220384
Contributors: Lal D; Steinbrücker S; Schubert J; Sander T; Becker F; Weber Y; Lerche H; Thiele H; Krause R; Lehesjoki AE et al.
Source: Self-asserted source
Roland Krause via Europe PubMed Central

CHD2 variants are a risk factor for photosensitivity in epilepsy

Brain
2015-03 | Journal article
DOI:

10.1093/brain/awv052
Contributors: E. C. Galizia; C. T. Myers; C. Leu; C. G. F. de Kovel; T. Afrikanova; M. L. Cordero-Maldonado; T. G. Martins; M. Jacmin; S. Drury; V. Krishna Chinthapalli et al.
Source: Self-asserted source
Roland Krause via Crossref Metadata Search
Items per page:
Page 1 of 2

Peer review (2 reviews for 2 publications/grants)

Review activity for F1000Research. (1)
Review activity for Faculty Opinions (1)
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