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Loop profile: 2264913
ResearcherID: I-7052-2013
Scopus Author ID: 55848680100

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Switzerland, Chile

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Employment (1)

F Hoffmann-La Roche AG Research and Development Division: Basel, Basel-Stadt, CH

2016-06-01 to present | Clinical Pharmacologist and DMPK Leader
Employment
Source: Self-asserted source
Andrés Olivares-Morales

Education and qualifications (2)

Universidad Austral de Chile: Valdivia, CL

Pharm.D
Education
Source: Self-asserted source
Andrés Olivares-Morales

The University of Manchester: Manchester, Manchester, GB

PhD in Pharmacometrics
Education
Source: Self-asserted source
Andrés Olivares-Morales

Works (20)

A Machine Learning Framework to Improve Rat Clearance Predictions and Inform Physiologically Based Pharmacokinetic Modeling

Molecular Pharmaceutics
2023-10-02 | Journal article
DOI: 10.1021/acs.molpharmaceut.3c00374
Contributors: Andrea Andrews-Morger; Michael Reutlinger; Neil Parrott; Andrés Olivares-Morales
Source: check_circle
Crossref

A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

CPT: Pharmacometrics & Systems Pharmacology
2023-03 | Journal article
DOI: 10.1002/psp4.12915
Contributors: Estelle Yau; Michael Gertz; Kayode Ogungbenro; Leon Aarons; Andrés Olivares‐Morales
Source: check_circle
Crossref

Investigation of simplified physiologically‐based pharmacokinetic models in rat and human

CPT: Pharmacometrics & Systems Pharmacology
2023-03 | Journal article
DOI: 10.1002/psp4.12911
Contributors: Estelle Yau; Andrés Olivares‐Morales; Kayode Ogungbenro; Leon Aarons; Michael Gertz
Source: check_circle
Crossref

Can We Predict Clinical Pharmacokinetics of Highly Lipophilic Compounds by Integration of Machine Learning or In Vitro Data into Physiologically Based Models? A Feasibility Study Based on 12 Development Compounds

Molecular Pharmaceutics
2022-11-07 | Journal article
DOI: 10.1021/acs.molpharmaceut.2c00350
Contributors: Neil Parrott; Nenad Manevski; Andrés Olivares-Morales
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Crossref

LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen Prediction of Oral Drugs

ACS Medicinal Chemistry Letters
2022-09-08 | Journal article
DOI: 10.1021/acsmedchemlett.2c00183
Contributors: Giuseppe Cecere; Laura Guasch; Andres M. Olivares-Morales; Kenichi Umehara; Antonia F. Stepan
Source: check_circle
Crossref

Evaluation of the Success of High-Throughput Physiologically Based Pharmacokinetic (HT-PBPK) Modeling Predictions to Inform Early Drug Discovery

Molecular Pharmaceutics
2022-07-04 | Journal article
DOI: 10.1021/acs.molpharmaceut.2c00040
Contributors: Doha Naga; Neil Parrott; Gerhard F. Ecker; Andrés Olivares-Morales
Source: check_circle
Crossref

Translating pharmacology models effectively to predict therapeutic benefit.

Drug discovery today
2022-03 | Journal article
DOI: 10.1016/j.drudis.2022.03.009
PMID: 35304340
Contributors: Dudal S; Bissantz C; Caruso A; David-Pierson P; Driessen W; Koller E; Krippendorff BF; Lechmann M; Olivares-Morales A; Paehler A et al.
Source: Self-asserted source
Andrés Olivares-Morales via Europe PubMed Central

Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium

Clinical and Translational Science
2020 | Journal article
DOI: 10.1111/cts.12843
EID:

2-s2.0-85088855858

Part of ISBN:

17528062 17528054
Contributors: van Groen, B.D.; Pilla Reddy, V.; Badée, J.; Olivares-Morales, A.; Johnson, T.N.; Nicolaï, J.; Annaert, P.; Smits, A.; de Wildt, S.N.; Knibbe, C.A.J. et al.
Source: Self-asserted source
Andrés Olivares-Morales via Scopus - Elsevier

Correction to: Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.

The AAPS journal
2020-11 | Journal article
DOI: 10.1208/s12248-020-00535-z
PMID: 33244667
PMC: PMC7852959
Contributors: Riedmaier AE; DeMent K; Huckle J; Bransford P; Stillhart C; Lloyd R; Alluri R; Basu S; Chen Y; Dhamankar V et al.
Source: Self-asserted source
Andrés Olivares-Morales via Europe PubMed Central

Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective.

The AAPS journal
2020-09 | Journal article
DOI: 10.1208/s12248-020-00508-2
PMID: 32981010
PMC: PMC7520419
Contributors: Riedmaier AE; DeMent K; Huckle J; Bransford P; Stillhart C; Lloyd R; Alluri R; Basu S; Chen Y; Dhamankar V et al.
Source: Self-asserted source
Andrés Olivares-Morales via Europe PubMed Central

Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution

The AAPS Journal
2020-03 | Journal article
DOI: 10.1208/s12248-020-0418-7
Contributors: Estelle Yau; Andrés Olivares-Morales; Michael Gertz; Neil Parrott; Adam S. Darwich; Leon Aarons; Kayode Ogungbenro
Source: check_circle
Crossref
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Real-World Data and Physiologically-Based Mechanistic Models for Precision Medicine.

Clinical pharmacology and therapeutics
2020-02-23 | Journal article
DOI: 10.1002/cpt.1780
PMID: 32090313
Source: Self-asserted source
Andrés Olivares-Morales
grade
Preferred source (of 2)‎

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report

AAPS Journal
2019 | Journal article
DOI: 10.1208/s12248-019-0298-x
EID:

2-s2.0-85061365178
Contributors: Heimbach, T.; Suarez-Sharp, S.; Kakhi, M.; Holmstock, N.; Olivares-Morales, A.; Pepin, X.; Sjögren, E.; Tsakalozou, E.; Seo, P.; Li, M. et al.
Source: Self-asserted source
Andrés Olivares-Morales via Scopus - Elsevier

Impact of target interactions on small-molecule drug disposition: An overlooked area

Nature Reviews Drug Discovery
2018 | Journal article
DOI: 10.1038/nrd.2018.26
EID:

2-s2.0-85044627516
Contributors: Van Waterschoot, R.A.B.; Parrott, N.J.; Olivares-Morales, A.; Lavé, T.; Rowland, M.; Smith, D.A.
Source: Self-asserted source
Andrés Olivares-Morales via Scopus - Elsevier

Importance of target-mediated drug disposition for small molecules

Drug Discovery Today
2018-12 | Journal article
DOI: 10.1016/j.drudis.2018.06.010
Contributors: Dennis A. Smith; Robert A.B. van Waterschoot; Neil J. Parrott; Andrés Olivares-Morales; Thierry Lavé; Malcolm Rowland
Source: check_circle
Crossref
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Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin

The AAPS Journal
2016-11-08 | Journal article
DOI: 10.1208/s12248-016-9965-3
Contributors: Andrés Olivares-Morales; Avijit Ghosh; Leon Aarons; Amin Rostami-Hodjegan
Source: check_circle
Crossref
grade
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Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

The AAPS Journal
2015-09 | Journal article
DOI: 10.1208/s12248-015-9758-0
Source: check_circle
Crossref
grade
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Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model

European Journal of Pharmaceutical Sciences
2015-01 | Journal article
DOI:

10.1016/j.ejps.2014.10.018
Contributors: Andrés Olivares-Morales; Yoshiteru Kamiyama; Adam S. Darwich; Leon Aarons; Amin Rostami-Hodjegan
Source: Self-asserted source
Andrés Olivares-Morales via Crossref Metadata Search
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Animal versus human oral drug bioavailability: Do they correlate?

European Journal of Pharmaceutical Sciences
2014 | Journal article
DOI:

10.1016/j.ejps.2013.08.018

Part of ISSN:

0928-0987;1879-0720
Contributors: Musther, Helen; Olivares-Morales, Andres; Hatley, Oliver J. D.; Liu, Bo; Hodjegan, Amin Rostami
Source: Self-asserted source
Andrés Olivares-Morales via ResearcherID
grade
Preferred source (of 2)‎

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

Pharmaceutical Research
2014 | Journal article
DOI:

10.1007/s11095-013-1193-2

Part of ISSN:

0724-8741;1573-904X
Contributors: Olivares-Morales, Andres; Hatley, Oliver J. D.; Turner, David; Galetin, Aleksandra; Aarons, Leon; Rostami-Hodjegan, Amin
Source: Self-asserted source
Andrés Olivares-Morales via ResearcherID
grade
Preferred source (of 2)‎

Peer review (5 reviews for 4 publications/grants)

Review activity for Clinical pharmacokinetics (2)
Review activity for Journal of chemical information and modeling. (1)
Review activity for Molecular pharmaceutics. (1)
Review activity for Pharmaceutical research. (1)
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