Personal information

Other IDs

Scopus Author ID: 7103073803
Loop profile: 902102

Keywords

G-quadruplex, telomere, topoisomerase, docetaxel, cabazitaxel, irinotecan, pyridostatin, 360A, PDC

Biography

Jean-François RIOU, PharmD, PhD
Born 1958

Research expertise and interests
Thematic at the interface of chemistry and biology, expertise in molecular and cellular pharmacology, contribution to pioneering work on G-quadruplex ligands:
-G-quadruplex ligands : effects on genome and telomere stability
-Molecular and cellular pharmacology of taxoids and DNA topoisomerase inhibitors: on the market docetaxel, cabazitaxel, irinotecan.
-Aging: telomere biology and epigenetic in Microcebus murinus

1983 Diplôme d’Etat de Docteur en Pharmacie, Univ. Paris V.
1986 Thèse en Pharmacologie Moléculaire et Cellulaire, Univ. Paris VI (Dir. JB Le Pecq).
1999 Habilitation à Diriger des Recherches, Univ. Paris V.
2001/2007 Professeur des Universités (PR1) Univ. Reims,
2007/2023 Professeur du Muséum National d’Histoire Naturelle (PR1), Paris.
since 2024 Retired

Activities

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Employment (8)

Muséum national d'Histoire naturelle: Paris, FR

2023-10-01 to present | Retraité
Employment
Source: Self-asserted source
jean-francois riou

Muséum National d'Histoire Naturelle: Paris, Île-de-France, FR

2007-09-01 to 2023-09-30 | Team Leader (Structure des Acides Nucléiques, Télomères et Evolution)
Employment
Source: Self-asserted source
jean-francois riou

Muséum National d'Histoire Naturelle: Paris, Île-de-France, FR

2014-01-01 to 2018-06-30 | Directeur (Structure et Instabilité des Génomes, CNRS UMR 7196, Inserm U1154)
Employment
Source: Self-asserted source
jean-francois riou

Muséum National d'Histoire Naturelle: Paris, Île-de-France, FR

2009-09-01 to 2013-12-31 | Directeur adjoint (Inserm U565 CNRS UMR 7196)
Employment
Source: Self-asserted source
jean-francois riou

Université de Reims Champagne-Ardenne: Reims, Champagne-Ardenne, FR

2002-10-01 to 2007-08-31 | Directeur d'unité (JE2428 Onco-Pharmacologie)
Employment
Source: Self-asserted source
jean-francois riou

Université de Reims Champagne-Ardenne: Reims, Champagne-Ardenne, FR

2001-02-01 to 2007-08-31 | Professeur de Physiologie Humaine (UFR de Pharmacie)
Employment
Source: Self-asserted source
jean-francois riou

Aventis Pharma SA: Vitry sur Seine, FR

1998-01-01 to 2000-01-31 | Chef du Service de Pharmacologie Moléculaire (Departement d'Oncologie)
Employment
Source: Self-asserted source
jean-francois riou

Rhone-Poulenc Santé puis RP-Rorer: Vitry sur Seine, FR

1989-09-01 to 1997-12-31 | Responsable des études de Pharmacologie Moléculaire et Cellulaire (Département d'Oncologie)
Employment
Source: Self-asserted source
jean-francois riou

Education and qualifications (3)

Université Paris Descartes: Paris, Île-de-France, FR

1999 to present | HDR
Education
Source: Self-asserted source
jean-francois riou

Université Pierre et Marie Curie: Paris, Île-de-France, FR

1983 to 1986 | Ph D
Education
Source: Self-asserted source
jean-francois riou

Université Paris Descartes: Paris, Île-de-France, FR

1983 to 1983 | Pharm D
Education
Source: Self-asserted source
jean-francois riou

Works (50 of 174)

Items per page:
Page 1 of 4

Multiple hPOT1–TPP1 cooperatively unfold contiguous telomeric G-quadruplexes proceeding from 3′ toward 5′, a feature due to a 3′-end binding preference and to structuring of telomeric DNA

Nucleic Acids Research
2021-10-11 | Journal article
DOI: 10.1093/nar/gkab768
Contributors: Jean Chatain; Georges Hatem; Emmanuelle Delagoutte; Jean-François Riou; Patrizia Alberti; Carole Saintomé
Source: check_circle
Crossref

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins

Scientific Reports
2021-06-29 | Journal article
DOI: 10.1038/s41598-021-92806-8
Contributors: A. Pipier; A. Devaux; T. Lavergne; A. Adrait; Y. Couté; S. Britton; P. Calsou; J. F. Riou; E. Defrancq; D. Gomez
Source: check_circle
Crossref

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

eLife
2021-06-28 | Journal article
DOI: 10.7554/eLife.65184
Contributors: Madeleine Bossaert; Angélique Pipier; Jean-Francois Riou; Céline Noirot; Linh-Trang Nguyên; Remy-Felix Serre; Olivier Bouchez; Eric Defrancq; Patrick Calsou; Sébastien Britton et al.
Source: check_circle
Crossref

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins

2021-04-06 | Preprint
DOI: 10.1101/2021.04.06.438633
Contributors: A. Pipier; A. Devaux; T. Lavergne; A. Adrait; Y. Couté; S. Britton; P. Calsou; J.F. Riou; E. Defrancq; D. Gomez
Source: check_circle
Crossref

Sex-Specific Response to Caloric Restriction After Reproductive Investment in Microcebus murinus: An Integrative Approach.

Frontiers in physiology
2020-06-16 | Journal article
DOI: 10.3389/fphys.2020.00506
PMID: 32612534
PMC: PMC7308708
Source: Self-asserted source
jean-francois riou

AP-TSS: A New Method for the Analysis of RNA Expression from Particular and Challenging Transcription Start Sites

Biomolecules
2020-05-28 | Journal article
DOI: 10.3390/biom10060827
Part of ISSN: 2218-273X
Source: Self-asserted source
jean-francois riou

Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands

BioRxiv
2020-02-19 | Preprint
DOI: 10.1101/2020.02.18.953851
Source: Self-asserted source
jean-francois riou

Investigating the effect of mono- And dimeric 360A G-quadruplex ligands on telomere stability by single telomere length analysis (STELA)

Molecules
2019 | Journal article
DOI: 10.3390/molecules24030577
EID:

2-s2.0-85061060422
Contributors: Hwang, I.P.; Mailliet, P.; Hossard, V.; Riou, J.-F.; Bugaut, A.; Roger, L.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Repression of TERRA Expression by Subtelomeric DNA Methylation Is Dependent on NRF1 Binding.

International journal of molecular sciences
2019-06-07 | Journal article
DOI: 10.3390/ijms20112791
PMID: 31181625
PMC: PMC6600276
Source: Self-asserted source
jean-francois riou

Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

Chemical Communications
2018 | Journal article
DOI: 10.1039/C7CC07048A
Contributors: C. Saintomé; P. Alberti; N. Guinot; P. Lejault; J. Chatain; P. Mailliet; J.-F. Riou; A. Bugaut
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Metabolic and genomic adaptations to winter fattening in a primate species, the grey mouse lemur (Microcebus murinus)

International Journal of Obesity
2018 | Journal article
DOI: 10.1038/ijo.2017.195
EID:

2-s2.0-85041690429
Contributors: Terrien, J.; Gaudubois, M.; Champeval, D.; Zaninotto, V.; Roger, L.; Riou, J.F.; Aujard, F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

The binding efficiency of RPA to telomeric G-strands folded into contiguous G-quadruplexes is independent of the number of G4 units

Biochimie
2018 | Journal article
DOI: 10.1016/j.biochi.2017.11.017
EID:

2-s2.0-85037175374
Contributors: Lancrey, A.; Safa, L.; Chatain, J.; Delagoutte, E.; Riou, J.-F.; Alberti, P.; Saintomé, C.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex

Scientific Report
2017 | Journal article
DOI: 10.1038/s41598-017-11177-1
Source: Self-asserted source
jean-francois riou
grade
Preferred source (of 2)‎

5′ to 3′ unfolding directionality of DNA secondary structures by replication protein A: G-quadruplexes and duplexes

Journal of Biological Chemistry
2016 | Journal article
DOI: 10.1074/jbc.M115.709667
EID:

2-s2.0-84988970110
Contributors: Safa, L.; Gueddouda, N.M.; Thiébaut, F.; Delagoutte, E.; Petruseva, I.; Lavrik, O.; Mendoza, O.; Bourdoncle, A.; Alberti, P.; Riou, J.-F. et al.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Telomere regulation during ageing and tumorigenesis of the grey mouse lemur

Biochimie
2015 | Journal article
DOI: 10.1016/j.biochi.2015.04.002
EID:

2-s2.0-84928471472
Contributors: Trochet, D.; Mergui, X.; Ivkovic, I.; Porreca, R.M.; Gerbault-Seureau, M.; Sidibe, A.; Richard, F.; Londono-Vallejo, A.; Perret, M.; Aujard, F. et al.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability

Biochimie
2014 | Journal article
DOI: 10.1016/j.biochi.2014.04.006
EID:

2-s2.0-84903703440
Contributors: Safa, L.; Delagoutte, E.; Petruseva, I.; Alberti, P.; Lavrik, O.; Riou, J.-F.; Saintomé, C.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

G4 motifs affect origin positioning and efficiency in two vertebrate replicators

EMBO Journal
2014 | Journal article
DOI: 10.1002/embj.201387506
EID:

2-s2.0-84898649803
Contributors: Valton, A.-L.; Hassan-Zadeh, V.; Lema, I.; Boggetto, N.; Alberti, P.; Saintomé, C.; Riou, J.-F.; Prioleau, M.-N.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

Nucleic Acids Research
2013 | Journal article
DOI: 10.1093/nar/gkt073
EID:

2-s2.0-84876047695
Contributors: Douarre, C.; Mergui, X.; Sidibe, A.; Gomez, D.; Alberti, P.; Mailliet, P.; Trentesaux, C.; Riou, J.-F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Preclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors

Clinical Cancer Research
2013 | Journal article
DOI: 10.1158/1078-0432.CCR-12-3146
EID:

2-s2.0-84878973180
Contributors: Vrignaud, P.; Sémiond, D.; Lejeune, P.; Bouchard, H.; Calvet, L.; Combeau, C.; Riou, J.-F.; Commerçon, A.; Lavelle, F.; Bissery, M.-C.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Le ciblage de la télomérase et des télomères

Les cibles nucléaires en Oncologie
2013-05 | Book chapter
ISBN: 978-2-7420-0766-0
Source: Self-asserted source
jean-francois riou

Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines

BMC Research Notes
2012 | Journal article
DOI: 10.1186/1756-0500-5-138
EID:

2-s2.0-84857961888
Contributors: Halder, R.; Riou, J.-F.; Teulade-Fichou, M.-P.; Frickey, T.; Hartig, J.S.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells

Biochimie
2012 | Journal article
DOI: 10.1016/j.biochi.2012.07.003
EID:

2-s2.0-84868205791
Contributors: Sidibe, A.; Hamon, F.; Largy, E.; Gomez, D.; Teulade-Fichou, M.-P.; Trentesaux, C.; Riou, J.-F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

Organic and Biomolecular Chemistry
2012 | Journal article
DOI: 10.1039/c2ob25830g
EID:

2-s2.0-84864447477
Contributors: Müller, S.; Sanders, D.A.; Di Antonio, M.; Matsis, S.; Riou, J.-F.; Rodriguez, R.; Balasubramanian, S.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Topoisomerases and carcinogenesis: Topoisomerase IIIα and BLM

DNA Topoisomerases and Cancer
2012 | Book chapter
Part of DOI: 10.1007/978-1-4614-0323-4_8
EID:

2-s2.0-85028597542
Contributors: Amor-Guéret, M.; Riou, J.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

An acyclic oligoheteroaryle that discriminates strongly between diverse G-Quadruplex topologies

Angewandte Chemie - International Edition
2011 | Journal article
DOI: 10.1002/anie.201103422
EID:

2-s2.0-80052478355
Contributors: Hamon, F.; Largy, E.; Guédin-Beaurepaire, A.; Rouchon-Dagois, M.; Sidibe, A.; Monchaud, D.; Mergny, J.-L.; Riou, J.-F.; Nguyen, C.-H.; Teulade-Fichou, M.-P.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells

Nucleic Acids Research
2010 | Journal article
DOI: 10.1093/nar/gkq563
EID:

2-s2.0-77957082956
Contributors: Gomez, D.; Guédin, A.; Mergny, J.-L.; Salles, B.; Riou, J.-F.; Teulade-Fichou, M.-P.; Calsou, P.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Senescence and cellular immortality,Sénescence et immortalité cellulaire

Bulletin du Cancer
2010 | Journal article
DOI: 10.1684/bdc.2010.1205
EID:

2-s2.0-78650119275
Contributors: Trentesaux, C.; Riou, J.-F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd<sup>0</sup> catalysed reductive N-heteroannulation

Organic and Biomolecular Chemistry
2010 | Journal article
DOI: 10.1039/c0ob00149j
EID:

2-s2.0-84962425602
Contributors: Laronze-Cochard, M.; Cochard, F.; Daras, E.; Lansiaux, A.; Brassart, B.; Vanquelef, E.; Prost, E.; Nuzillard, J.-M.; Baldeyrou, B.; Goosens, J.-F. et al.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

Bioorganic and Medicinal Chemistry Letters
2010 | Journal article
DOI: 10.1016/j.bmcl.2010.09.066
EID:

2-s2.0-77958057953
Contributors: Hampel, S.M.; Sidibe, A.; Gunaratnam, M.; Riou, J.-F.; Neidle, S.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers

Bioorganic and Medicinal Chemistry Letters
2009 | Journal article
DOI: 10.1016/j.bmcl.2009.05.025
EID:

2-s2.0-66749124825
Contributors: El Bakali, J.; Klupsch, F.; Guédin, A.; Brassart, B.; Fontaine, G.; Farce, A.; Roussel, P.; Houssin, R.; Bernier, J.-L.; Chavatte, P. et al.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN

Genes and Development
2009 | Journal article
DOI: 10.1101/gad.544009
EID:

2-s2.0-72849126603
Contributors: Arnoult, N.; Saintome, C.; Ourliac-Garnier, I.; Riou, J.-F.; Londoño-Vallejo, A.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Human telomeres that contain (CTAGGG)<inf>n</inf> repeats show replication dependent instability in somatic cells and the male germline

Nucleic Acids Research
2009 | Journal article
DOI: 10.1093/nar/gkp629
EID:

2-s2.0-70350692143
Contributors: Mendez-bermudez, A.; Hills, M.; Pickett, H.A.; Phan, A.T.; Mergny, J.-L.; Riou, J.-F.; Royle, N.J.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Sequence variant (CTAGGG)<inf>n</inf> in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad

Nucleic Acids Research
2009 | Journal article
DOI: 10.1093/nar/gkp630
EID:

2-s2.0-70350692142
Contributors: Lim, K.W.; Alberti, P.; Guédin, A.; Lacroix, L.; Riou, J.-F.; Royle, N.J.; Mergny, J.-L.; Phan, A.T.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands

European Journal of Medicinal Chemistry
2009 | Journal article
DOI: 10.1016/j.ejmech.2009.04.021
EID:

2-s2.0-67749103504
Contributors: Laronze-Cochard, M.; Kim, Y.-M.; Brassart, B.; Riou, J.-F.; Laronze, J.-Y.; Sapi, J.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIα to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells

PLoS ONE
2009 | Journal article
DOI: 10.1371/journal.pone.0006919
EID:

2-s2.0-70349084987
Contributors: Temime-Smaali, N.; Guittat, L.; Sidibe, A.; Shin-Ya, K.; Trentesaux, C.; Riou, J.-F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Three science pioneers awarded for the discovery of the ends of chromosomes,Trois pionniers de la science récompensés pour le début de la fin des chromosomes

Bulletin du Cancer
2009 | Journal article
DOI: 10.1684/bdc.2009.0977
EID:

2-s2.0-74549210089
Contributors: Riou, J.-F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Poly-heteroaryl derivatives for the treatment of cancer

2009-11-02 | Patent
PAT:

US Patent App. 13/124,136, 2009
Source: Self-asserted source
jean-francois riou

Chemical derivatives and their application as antitelomerase agents

2009-01-27 | Patent
PAT:

US Patent 7,482,352, 2009
Source: Self-asserted source
jean-francois riou
grade
Preferred source (of 5)‎

A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres

Journal of the American Chemical Society
2008 | Journal article
DOI: 10.1021/ja805615w
EID:

2-s2.0-56749151077
Contributors: Rodriguez, R.; Müller, S.; Yeoman, J.A.; Trentesaux, C.; Riou, J.-F.; Balasubramanian, S.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

DNA and RNA quadruplex ligands.

Nucleic acids symposium series (2004)
2008 | Journal article
DOI: 10.1093/nass/nrn004
PMID: 18776226
Source: Self-asserted source
jean-francois riou via Europe PubMed Central

Proteome alteration induced by hTERT transfection of human fibroblast cells

Proteome Science
2008 | Journal article
DOI: 10.1186/1477-5956-6-12
Source: Self-asserted source
jean-francois riou
grade
Preferred source (of 2)‎

Targeting telomeres and telomerase

Biochimie
2008 | Journal article
DOI: 10.1016/j.biochi.2007.07.011
EID:

2-s2.0-37049004147
Contributors: De Cian, A.; Lacroix, L.; Douarre, C.; Temime-Smaali, N.; Trentesaux, C.; Riou, J.-F.; Mergny, J.-L.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Topoisomerase IIIα is required for normal proliferation and telomere stability in alternative lengthening of telomeres

EMBO Journal
2008 | Journal article
DOI: 10.1038/emboj.2008.74
EID:

2-s2.0-44349180746
Contributors: Temime-Smaali, N.; Guittat, L.; Wenner, T.; Bayart, E.; Douarre, C.; Gomez, D.; Giraud-Panis, M.-J.; Londono-Vallejo, A.; Gilson, E.; Amor-Guéret, M. et al.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

A new steroid derivative stabilizes G-quadruplexes and induces telomere uncapping in human tumor cells

Molecular Pharmacology
2007 | Journal article
DOI: 10.1124/mol.107.036574
EID:

2-s2.0-34548304323
Contributors: Brassart, B.; Gomez, D.; De Cian, A.; Paterski, R.; Montagnac, A.; Qui, K.-H.; Temime-Smaali, N.; Trentesaux, C.; Mergny, J.-L.; Gueritte, F. et al.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Mechanism of acridine-based telomerase inhibition and telomere shortening

Biochemical Pharmacology
2007 | Journal article
DOI: 10.1016/j.bcp.2007.06.011
EID:

2-s2.0-34547112050
Contributors: Gunaratnam, M.; Greciano, O.; Martins, C.; Reszka, A.P.; Schultes, C.M.; Morjani, H.; Riou, J.-F.; Neidle, S.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Telomerase and Telomere interacting agents

Targeted Therapies in Oncology
2007 | Book chapter
ISBN: 9781420020588 1420020587
Source: Self-asserted source
jean-francois riou

Telomerase: A dimeric ménage à trois

ChemBioChem
2007 | Journal article
DOI: 10.1002/cbic.200700272
EID:

2-s2.0-34548757171
Contributors: Mergny, J.-L.; Lacroix, L.; Riou, J.-F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Erratum: Delineation of the domains required for physical and functional interaction of p14<sup>ARF</sup> with human topoisomerase I (Oncogene (2003) 22 (1945-1954) DOI: 10.1038/sj.onc.1206214)

Oncogene
2006 | Journal article
DOI: 10.1038/sj.onc.1209539
EID:

2-s2.0-33646570881
Contributors: Ayrault, O.; Karayan, L.; Riou, J.-F.; Larsen, C.-J.; Séité, P.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier

Quadruplex Ligand Recognition: Biological Aspects

Quadrupex Nucleic Acids
2006 | Book chapter
DOI: 10.1039/9781847555298
Source: Self-asserted source
jean-francois riou

Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells

Journal of Biological Chemistry
2006 | Journal article
DOI: 10.1074/jbc.M605828200
EID:

2-s2.0-33845994055
Contributors: Gomez, D.; Wenner, T.; Brassart, B.; Douarre, C.; O'Donohue, M.-F.; El Khoury, V.; Shin-Ya, K.; Morjani, H.; Trentesaux, C.; Riou, J.-F.
Source: Self-asserted source
jean-francois riou via Scopus - Elsevier
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