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Plasmodium, Malaria, Natural products, Biodiversity, Fluorophores, Molecular tools, Imaging, Drug targets
France, United States, Belgium, Germany, Brazil

Activities

Employment (5)

Institut de Recherche pour le Dévelopement: Paris, Paris, FR

2013-01-01 to present | Primary Investigator, CRCN IRD (UMR 261 MERIT)
Employment
Source: Self-asserted source
Romain Duval

Institut de Recherche pour le Développement: Toulouse, Midi-Pyrénées, FR

2008-01-01 to 2011-01-01 | Primary Investigator, CR1 IRD (UMR 152 Pharma-DEV)
Employment
Source: Self-asserted source
Romain Duval

Université de Paris Faculté de Santé: Paris, Île-de-France, FR

2007 to 2008 | Post-Doctoral Fellow (Laboratoire de Pharmacologie et Pharmacochimie Antitumorale - U648 INSERM)
Employment
Source: Self-asserted source
Romain Duval

Institut de Chimie des Substances Naturelles, UPR 2301 CNRS: Gif-sur-Yvette, Île-de-France, FR

2006 to 2007 | Post-Doctoral Fellow (Laboratoire de Synthèse Biomimétique)
Employment
Source: Self-asserted source
Romain Duval

University of Missouri Columbia: Columbia, MO, US

2004 to 2006 | Post-Doctorate Fellow (Radiopharmaceutical Sciences Institute (RSI))
Employment
Source: Self-asserted source
Romain Duval

Education and qualifications (3)

Université Paris-Sud: Orsay, Île-de-France, FR

1999 to 2003 | Pharmacochemistry PhD ( Laboratoire de Chimie des Substances Naturelles, UMR 8076 CNRS BioCIS)
Education
Source: Self-asserted source
Romain Duval

Museum National d'Histoire Naturelle: Paris, Île-de-France, FR

1997 to 1998 | Research Master (Molecular Biology)
Education
Source: Self-asserted source
Romain Duval

Université Catholique de Louvain: Louvain-la-Neuve, BE

1992 to 1997 | Master (Chemistry)
Education
Source: Self-asserted source
Romain Duval

Professional activities (2)

CAPES: Botucatu, Sao Paulo, BR

2012-01-01 to 2013-01-01 | Visiting Professor (Chemistry)
Invited position
Source: Self-asserted source
Romain Duval

CNPQ: Florianopolis, Santa Catarina, BR

2011-01-01 to 2012-01-01 | Visiting Professor (Chemistry)
Invited position
Source: Self-asserted source
Romain Duval

Funding (11)

OXO-Tags: Novel Fluorogenic Photoactivatable Tags for Interactomic and Bio-imaging Applications

2022-01 to 2025-01 | Grant
ANR (Paris, Paris, FR)
Source: Self-asserted source
Romain Duval

Design of photoactivatable fluorogenic tags for the covalent capture of biological interactomes.

2020-01 to 2021-01 | Grant
IdEX (Paris, Paris, FR)
Source: Self-asserted source
Romain Duval

Artemisinin resistance and Plasmodium falciparum cell cycle

2019-01 to 2022-01 | Grant
ANR (Paris, paris, FR)
Source: Self-asserted source
Romain Duval

Dextromethorphan analogues as specific inhibitors of P. falciparum hepatic stages

2018-01 to 2021-01 | Salary award
ED MTCI (Paris, Paris, FR)
Source: Self-asserted source
Romain Duval

Deciphering the mechanisms of action of two antimalarial redox-active drugs with gametocytocidal and transmission-blocking properties - from yeast to malarial parasites

2017-01 to 2020-01 | Grant
ANR (Paris, Paris, FR)
Source: Self-asserted source
Romain Duval

Synthesis and validation of fluorescent probes mimicking artemisinin derivatives in P. falciparum

2015-01 to 2018-01 | Salary award
ED MTCI (Paris, Paris, FR)
Source: Self-asserted source
Romain Duval

Dextromethorphan evaluation as prophylaxis antimalarial by bioluminescent imaging in mice

2015-01 to 2016-01 | Grant
IRD (Marseille, Bouches-du-Rhône, FR)
Source: Self-asserted source
Romain Duval

Conjunction of fluo-giroxin with stem cells to monitor cellular reparation in preclinical imaging

2013-01 to 2015-01 | Grant
FAPESP (Sao Paulo, Sao Paulo, BR)
Source: Self-asserted source
Romain Duval

Synthesis of a fluorescent snake venom toxin for preclinical imaging

2012-01 to 2013-01 | Salary award
CAPES (Brasilia, Brasilia, BR)
Source: Self-asserted source
Romain Duval

Design of a universal fluorogenic chalcone probe to image M. tuberculosis and L. amazonensis

2011-01 to 2012-01 | Salary award
CNPq (Brasilia, Brasilia, BR)
Source: Self-asserted source
Romain Duval

Mechanisms of action and targets of new antimalarial redox molecules

2009-01 to 2012-01 | Grant
ANR (Paris, Paris, FR)
Source: Self-asserted source
Romain Duval

Works (29)

Artemisia : vers de futurs antipaludiques ? Une prospection rationnelle de produits naturels contre les stades chimio-réfractaires de Plasmodium.

Ethnopharmacologia
2023 | Journal article
Contributors: Alexandre Maciuk; Dominique Mazier; Romain Duval
Source: Self-asserted source
Romain Duval

Future antimalarials from Artemisia? A rationale for natural product mining against drug-refractory Plasmodium stages

Natural Product Reports
2023 | Journal article
Contributors: Alexandre Maciuk; Dominique Mazier; Romain Duval
Source: check_circle
Crossref

Targeting chalcone binding sites in living Leishmania using a reversible fluorogenic benzochalcone probe.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2022-03 | Journal article
Contributors: Batista AS; Oliveira SDS; Pomel S; Commere PH; Mazan V; Lee M; Loiseau PM; Rossi-Bergmann B; Prina E; Duval R
Source: Self-asserted source
Romain Duval via Europe PubMed Central

Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids.

Pharmaceutics
2022-02 | Journal article
Contributors: Keita A; Franetich JF; Carraz M; Valentin L; Bordessoules M; Baron L; Bigeard P; Dupuy F; Geay V; Tefit M et al.
Source: Self-asserted source
Romain Duval via Europe PubMed Central

Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites.

Life science alliance
2021-12 | Journal article
Contributors: Ashraf K; Tajeri S; Arnold CS; Amanzougaghene N; Franetich JF; Vantaux A; Soulard V; Bordessoulles M; Cazals G; Bousema T et al.
Source: Self-asserted source
Romain Duval via Europe PubMed Central

A Photoalkylative Fluorogenic Probe of Guttiferone A for Live Cell Imaging and Proteome Labeling in Plasmodium falciparum

Molecules
2020-11-04 | Journal article
Part of ISSN: 1420-3049
Contributors: Romain Duval; Romain Duval; Kevin Cottet; Magali Blaud; Anaïs Merckx; Sandrine Houzé; Philippe Grellier; Marie-Christine Lallemand; Sylvie Michel
Source: Self-asserted source
Romain Duval
grade
Preferred source (of 2)‎

Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability

2020-05 | Other
OTHER-ID:

PPR164401

Contributors: Bouyer G; Barbieri D; Dupuy F; Marteau A; Sissoko A; N’Dri M; Neveu G; Bedault L; Khodabux N; Roman D et al.
Source: Self-asserted source
Romain Duval via Europe PubMed Central

A Chemically Stable Fluorescent Mimic of Dihydroartemisinin, Artemether, and Arteether with Conserved Bioactivity and Specificity Shows High Pharmacological Relevance to the Antimalarial Drugs.

ACS infectious diseases
2020-04 | Journal article
Contributors: Sissoko A; Vásquez-Ocmín P; Maciuk A; Barbieri D; Neveu G; Rondepierre L; Grougnet R; Leproux P; Blaud M; Hammad K et al.
Source: Self-asserted source
Romain Duval via Europe PubMed Central
grade
Preferred source (of 2)‎

Artemisinin and its derivatives target mitochondrial c-type cytochromes in yeast and human cells.

Biochimica et biophysica acta. Molecular cell research
2020-01 | Journal article
Contributors: Laleve A; Panozzo C; Kühl I; Bourand-Plantefol A; Ostojic J; Sissoko A; Tribouillard-Tanvier D; Cornu D; Burg A; Meunier B et al.
Source: Self-asserted source
Romain Duval via Europe PubMed Central
grade
Preferred source (of 2)‎

Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe

Chemical Science
2019 | Journal article
Contributors: Emma Colucci-Guyon; Ariane S. Batista; Suellen D. S. Oliveira; Magali Blaud; Ismael C. Bellettini; Benoit S. Marteyn; Karine Leblanc; Philippe Herbomel; Romain Duval
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Artemisinin Bioactivity and Resistance in Malaria Parasites.

Trends in parasitology
2019-11 | Journal article
Contributors: Talman AM; Clain J; Duval R; Ménard R; Ariey F
Source: Self-asserted source
Romain Duval via Europe PubMed Central
grade
Preferred source (of 2)‎

Fluorescent natural products as probes and tracers in biology

Natural Product Reports
2017 | Journal article
Contributors: Romain Duval; Christophe Duplais
Source: check_circle
Crossref

Biomimetic Synthesis of Manzamine Alkaloids

Biomimetic Organic Synthesis
2011 | Book chapter
EID:

2-s2.0-84857156390

Contributors: Duval, R.; Poupon, E.
Source: Self-asserted source
Romain Duval via Scopus - Elsevier

Fischer indole synthesis in water: simple, efficient preparation of naltrindole, naltriben and analogs

Green Chemistry
2010 | Journal article
WOSUID:

WOS:000274396800019

Contributors: Duval, Romain A.; Lever, John R.
Source: Self-asserted source
Romain Duval via ResearcherID

Synthesis of 6-Amino-5-cyano-1,4-disubstituted-2(1H)-Pyrimidinones via Copper-(I)-catalyzed Alkyne-azide 'Click Chemistry' and Their Reactivity

Molecules
2010 | Journal article
WOSUID:

WOS:000285709000022

Contributors: Najahi, Ennaji; Sudor, Jan; Chabchoub, Fakher; Nepveu, Francoise; Zribi, Fethi; Duval, Romain
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Rapid Discovery of Triazolobenzylidene-Thiazolopyrimidines (TBTP) as CDC25 Phosphatase Inhibitors by Parallel Click Chemistry and in Situ Screening

Journal of Combinatorial Chemistry
2009 | Journal article
WOSUID:

WOS:000271428500002

Contributors: Duval, Romain; Kolb, Stephanie; Braud, Emmanuelle; Genest, David; Garbay, Christiane
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Indium-labeled macrocyclic conjugates of naltrindole: High-affinity radioligands for in vivo studies of peripheral delta opioid receptors

Journal of Medicinal Chemistry
2007 | Journal article
WOSUID:

WOS:000245954600017

Contributors: Duval, Romain A.; Allmon, Rachel L.; Lever, John R.
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Localization of cocaine analog [I-125]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter

Journal of Biological Chemistry
2007 | Journal article
WOSUID:

WOS:000245780300038

Contributors: Vaughan, Roxanne A.; Sakrikar, Dhananjay S.; Parnas, M. Laura; Adkins, Steven; Foster, James D.; Duval, Romain A.; Lever, John R.; Kulkarni, Santosh S.; Hauck-Newman, Amy
Source: Self-asserted source
Romain Duval via ResearcherID

Analogues of cytotoxic squamocin using reliable reactions: new insights into the reactivity and role of the alpha,beta-unsaturated lactone of the annonaceous acetogenins

Tetrahedron
2006 | Journal article
WOSUID:

WOS:000238280100013

Contributors: Duval, Romain A.; Poupon, Erwan; Romero, Vanessa; Peris, Eva; Lewin, Guy; Cortes, Diego; Brandt, Ulrich; Hocquemiller, Reynald
Source: Self-asserted source
Romain Duval via ResearcherID

Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins

Biochemistry
2006 | Journal article
WOSUID:

WOS:000235792300028

Contributors: Duval, RA; Lewin, G; Peris, E; Chahboune, N; Garofano, A; Drose, S; Cortes, D; Brandt, U; Hocquemiller, R
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Semisynthesis and screening of a small library of pro-apoptotic squamocin analogues: Selection and study of a benzoquinone hybrid with an improved biological profile.

Chemmedchem
2006 | Journal article
WOSUID:

WOS:000202945500016

Contributors: Derbre, Severine; Duval, Romain; Roue, Gael; Garofano, Aurelio; Poupon, Erwan; Brandt, Ulrich; Susin, Santos A.; Hocquemiller, Reynald
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

AN INDIUM-LABELED DO3A CONJUGATE OF NALTRINDOLE WITH HIGH AFFINITY AND SELECTIVITY FOR DELTA OPIOID RECEPTORS: SYNTHESIS, BINDING STUDIES AND BIODISTRIBUTION

Journal of Labelled Compounds & Radiopharmaceuticals
2005 | Journal article
WOSUID:

WOS:000267210100009

Contributors: Duval, R. A.; Allmon, R. L.; Gustafson, J. L.; Carmack, T. L.; Watkinson, L. D.; Lever, J. R.
Source: Self-asserted source
Romain Duval via ResearcherID

Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: Synthesis and covalent binding studies

Bioconjugate Chemistry
2005 | Journal article
WOSUID:

WOS:000229274800023

Contributors: Lever, JR; Zou, MF; Parnas, ML; Duval, RA; Wirtz, SE; Justice, JB; Vaughan, RA; Newman, AH
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Remarkable substituent effect: beta-aminosquamocin, a potent dual inhibitor of mitochondrial complexes I and III

Biochimica Et Biophysica Acta-Bioenergetics
2005 | Journal article
WOSUID:

WOS:000232073100001

Contributors: Duval, RA; Poupon, E; Brandt, U; Hocquemiller, R
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Semisynthesis and biological activity of aminoacyl triesters of squamocin, an annonaceous acetogenin

Bioorganic & Medicinal Chemistry
2005 | Journal article
WOSUID:

WOS:000229394300016

Contributors: Duval, RA; Duret, P; Lewin, G; Peris, E; Hocquemiller, R
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae

Journal of Natural Products
2004 | Journal article
WOSUID:

WOS:000222277100025

Contributors: Fall, D; Duval, RA; Gleye, C; Laurens, A; Hocquemiller, R
Source: Self-asserted source
Romain Duval via ResearcherID
grade
Preferred source (of 2)‎

Semisynthesis of heterocyclic analogues of squamocin, a cytotoxic annonaceous acetogenin, by an unusual oxidative decarboxylation reaction

Bioorganic & Medicinal Chemistry
2003 | Journal article
WOSUID:

WOS:000184560300008

Contributors: Duval, R; Lewin, G; Hocquemiller, R
Source: Self-asserted source
Romain Duval via ResearcherID

Cancer chemotherapy: A paclitaxel prodrug for ADEPT (Antibody-Directed Enzyme Prodrug Therapy)

European Journal of Organic Chemistry
2001 | Journal article
EID:

2-s2.0-0034988631

Part of ISBN:

1434193X

Contributors: Schmidt, F.; Ungureanu, I.; Duval, R.; Pompon, A.; Monneret, C.
Source: Self-asserted source
Romain Duval via Scopus - Elsevier

Preparation and Synthetic Utility of 2-Methylselenomethyl Allyl Methyl Selenide. A Valuable Precursor to 2-Silylmethylallyllithiums

Synlett
1998-11 | Journal article
Part of ISSN: 0936-5214
Contributors: Alain Krief
Source: Self-asserted source
Romain Duval via Crossref Metadata Search
grade
Preferred source (of 2)‎

Peer review (3 reviews for 3 publications/grants)

Review activity for ACS omega. (1)
Review activity for ChemBioChem. (1)
Review activity for Nature communications (1)