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China

Biography

Protein structures, dynamics and interactions by solution NMR spectroscopy

Activities

Employment (3)

Chinese Academy of Sciences Innovation Academy for Precision Measurement Science and Technology: Wuhan, Hubei, CN

2019-06-28 to present
Employment
Source: Self-asserted source
Yunfei Hu

Soochow University : Suzhou, Jiangsu, CN

2018-07-01 to 2019-06-25 | Professor (Medical College)
Employment
Source: Self-asserted source
Yunfei Hu

Peking University: Beijing, Beijing, CN

2012-07-05 to 2018-06-28 (Beijing NMR Center)
Employment
Source: Self-asserted source
Yunfei Hu

Education and qualifications (1)

Peking University: Beijing, Beijing, CN

2005-09-01 to 2010-07-04 | Doctor (College of Life Sciences)
Education
Source: Self-asserted source
Yunfei Hu

Funding (1)

Functional mechanism of acid resistant HdeA and HdeB chaperones

Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER:

31370718

Source: Self-asserted source
Yunfei Hu

Works (50)

Structural basis for the regulation of plant transcription factor WRKY33 by the VQ protein SIB1

Communications Biology
2024 | Journal article
EID:

2-s2.0-85192914332

Part of ISSN: 23993642
Contributors: Dong, X.; Yu, L.; Zhang, Q.; Yang, J.; Gong, Z.; Niu, X.; Li, H.; Zhang, X.; Liu, M.; Jin, C. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Visualizing the M2 muscarinic acetylcholine receptor activation regulated by aromatic ring dynamics

bioRxiv
2024 | Other
EID:

2-s2.0-85189363349

Part of ISSN: 26928205
Contributors: Gong, Z.; Zhang, X.; Liu, M.; Jin, C.; Hu, Y.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Distinct activation mechanisms of β-arrestin 1 revealed by <sup>19</sup>F NMR spectroscopy

bioRxiv
2023 | Other
EID:

2-s2.0-85160666157

Part of ISSN: 26928205
Contributors: Zhai, R.; Wang, Z.; Chai, Z.; Li, C.; Jin, C.; Hu, Y.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Distinct activation mechanisms of β-arrestin-1 revealed by <sup>19</sup>F NMR spectroscopy

Nature Communications
2023 | Journal article
EID:

2-s2.0-85178250453

Part of ISSN: 20411723
Contributors: Zhai, R.; Wang, Z.; Chai, Z.; Niu, X.; Li, C.; Jin, C.; Hu, Y.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor

Nature Communications
2023 | Journal article
EID:

2-s2.0-85152107714

Part of ISSN: 20411723
Contributors: Heng, J.; Hu, Y.; Pérez-Hernández, G.; Inoue, A.; Zhao, J.; Ma, X.; Sun, X.; Kawakami, K.; Ikuta, T.; Ding, J. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structure of the DNA binding domain of Arabidopsis transcription factor WRKY11

Biochemical and Biophysical Research Communications
2023 | Journal article
EID:

2-s2.0-85149735346

Part of ISSN: 10902104 0006291X
Contributors: Wang, J.; Lin, Y.; Yang, J.; Zhang, Q.; Liu, M.; Hu, Y.; Dong, X.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor

Nature Communications
2023 | Journal article
EID:

2-s2.0-85146774432

Part of ISSN: 20411723
Contributors: Xu, J.; Wang, Q.; Hübner, H.; Hu, Y.; Niu, X.; Wang, H.; Maeda, S.; Inoue, A.; Tao, Y.; Gmeiner, P. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Conformational dynamics in GPCR signaling by NMR

Magnetic Resonance Letters
2022 | Journal article
EID:

2-s2.0-85152090605

Part of ISSN: 27725162 20970048
Contributors: Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptor

bioRxiv
2021 | Other
EID:

2-s2.0-85102225739

Part of ISSN: 26928205
Contributors: Xu, J.; Hübner, H.; Hu, Y.; Niu, X.; Gmeiner, P.; Jin, C.; Kobilka, B.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

NMR assignments and characterization of the DNA-binding domain of Arabidopsis transcription factor WRKY11

Magnetic Resonance Letters
2021 | Journal article
EID:

2-s2.0-85135719162

Part of ISSN: 27725162 20970048
Contributors: Wang, J.; Lin, Y.; Zhu, Q.; Zhang, J.; Liu, M.; Hu, Y.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

NMR-Based Methods for Protein Analysis

Analytical Chemistry
2021 | Journal article
EID:

2-s2.0-85099963852

Part of ISSN: 15206882 00032700
Contributors: Hu, Y.; Cheng, K.; He, L.; Zhang, X.; Jiang, B.; Jiang, L.; Li, C.; Wang, G.; Yang, Y.; Liu, M.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Analysis of β<sub>2</sub>AR-G<sub>s</sub> and β<sub>2</sub>AR-G<sub>i</sub> complex formation by NMR spectroscopy

Proceedings of the National Academy of Sciences of the United States of America
2020 | Journal article
EID:

2-s2.0-85091263671

Part of ISSN: 10916490 00278424
Contributors: Ma, X.; Hu, Y.; Batebi, H.; Heng, J.; Xu, J.; Liu, X.; Niu, X.; Li, H.; Hildebrand, P.W.; Jin, C. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Backbone <sup>1</sup>H, <sup>13</sup>C and <sup>15</sup>N resonance assignments of the proteasome lid subunit Rpn12 from Saccharomyces cerevisiae

Biomolecular NMR Assignments
2020 | Journal article
EID:

2-s2.0-85079628766

Part of ISSN: 1874270X 18742718
Contributors: Niu, X.; Ma, S.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Conformational Dynamics of the Periplasmic Chaperone SurA

Biochemistry
2020 | Journal article
EID:

2-s2.0-85090511001

Part of ISSN: 15204995 00062960
Contributors: Jia, M.; Wu, B.; Yang, Z.; Chen, C.; Zhao, M.; Hou, X.; Niu, X.; Jin, C.; Hu, Y.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Mechanisms of Chaperones as Active Assistant/Protector for Proteins: Insights from NMR Studies

Chinese Journal of Chemistry
2020 | Journal article
EID:

2-s2.0-85082297750

Part of ISSN: 16147065 1001604X
Contributors: Hu, Y.; Li, C.; He, L.; Jin, C.; Liu, M.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

<sup>1</sup> H, <sup>13</sup> C and <sup>15</sup> N resonance assignments of the second peptidyl-prolyl isomerase domain of chaperone SurA from Escherichia coli

Biomolecular NMR Assignments
2019 | Journal article
EID:

2-s2.0-85060604243

Part of ISSN: 1874270X 18742718
Contributors: Jia, M.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Conformational Complexity and Dynamics in a GPCR Revealed by NMR Spectroscopy

SSRN
2019 | Other
EID:

2-s2.0-85113996514

Part of ISSN: 15565068
Contributors: Xu, J.; Hu, Y.; Kaindl, J.; Risel, P.; Hübner, H.; Meada, S.; Niu, X.; Li, H.; Gmeiner, P.; Jin, C. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy

Molecular Cell
2019 | Journal article
EID:

2-s2.0-85068407294

Part of ISSN: 10974164 10972765
Contributors: Xu, J.; Hu, Y.; Kaindl, J.; Risel, P.; Hübner, H.; Maeda, S.; Niu, X.; Li, H.; Gmeiner, P.; Jin, C. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

NMR <sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5

Biomolecular NMR Assignments
2019 | Journal article
EID:

2-s2.0-85053555406

Part of ISSN: 1874270X 18742718
Contributors: Zhang, W.; Zhao, C.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone

Journal of Biological Chemistry
2019 | Journal article
EID:

2-s2.0-85063464697

Part of ISSN: 1083351X 00219258
Contributors: Yu, X.-C.; Hu, Y.; Ding, J.; Li, H.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade

Scientific Reports
2018 | Journal article
EID:

2-s2.0-85055079891

Part of ISSN: 20452322
Contributors: Zhang, W.; Niu, X.; Ding, J.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Residue selective <sup>15</sup>N CEST and CPMG experiments for studies of millisecond timescale protein dynamics

Journal of Magnetic Resonance
2018 | Journal article
EID:

2-s2.0-85048125205

Part of ISSN: 10960856 10907807
Contributors: Niu, X.; Ding, J.; Zhang, W.; Li, Q.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structure of the N-terminal domain of proteasome lid subunit Rpn5

Biochemical and Biophysical Research Communications
2018 | Journal article
EID:

2-s2.0-85052723449

Part of ISSN: 10902104 0006291X
Contributors: Zhang, W.; Zhao, C.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Structural basis and mechanism of the unfolding-induced activation of an acid response chaperone HdeA

bioRxiv
2018 | Other
EID:

2-s2.0-85095494482

Part of ISSN: 26928205
Contributors: Yu, X.-C.; Hu, Y.; Ding, J.; Li, H.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Characterizations of the Interactions between Escherichia coli Periplasmic Chaperone HdeA and Its Native Substrates during Acid Stress

Biochemistry
2017 | Journal article
EID:

2-s2.0-85032615216

Part of ISSN: 15204995 00062960
Contributors: Yu, X.-C.; Yang, C.; Ding, J.; Niu, X.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe

Journal of Biological Chemistry
2017 | Journal article
EID:

2-s2.0-85018516326

Part of ISSN: 1083351X 00219258
Contributors: Guan, L.; He, P.; Yang, F.; Zhang, Y.; Hu, Y.; Ding, J.; Hua, Y.; Zhang, Y.; Ye, Q.; Hu, J. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

A hybrid mechanism for the synechocystis arsenate reductase revealed by structural snapshots during arsenate reduction

Journal of Biological Chemistry
2015 | Journal article
EID:

2-s2.0-84941365336

Part of ISSN: 1083351X 00219258
Contributors: Hu, C.; Yu, C.; Liu, Y.; Hou, X.; Liu, X.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

HdeB chaperone activity is coupled to its intrinsic dynamic properties

Scientific Reports
2015 | Journal article
EID:

2-s2.0-84947935528

Part of ISSN: 20452322
Contributors: Ding, J.; Yang, C.; Niu, X.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structure of yeast Rpn9: Insights into proteasome lid assembly

Journal of Biological Chemistry
2015 | Journal article
EID:

2-s2.0-84924891318

Part of ISSN: 1083351X 00219258
Contributors: Hu, Y.; Wu, Y.; Li, Q.; Zhang, W.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

<sup>1</sup>H, <sup>13</sup>C and <sup>15</sup>N resonance assignments of Rpn9, a regulatory subunit of 26S proteasome from Saccharomyces cerevisiae

Biomolecular NMR Assignments
2014 | Journal article
EID:

2-s2.0-84879627193

Part of ISSN: 1874270X 18742718
Contributors: Wu, Y.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

<sup>1</sup>H, <sup>13</sup>C and <sup>15</sup>N resonance assignments of the apo and holo states of flavodoxin YqcA from Escherichia coli

Biomolecular NMR Assignments
2014 | Journal article
EID:

2-s2.0-84878502555

Part of ISSN: 1874270X 18742718
Contributors: Ye, Q.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

<sup>1</sup>H, <sup>13</sup>C and <sup>15</sup>N resonance assignments of the VWA domain of Saccharomyces cerevisiae Rpn10, a regulatory subunit of 26S proteasome

Biomolecular NMR Assignments
2014 | Journal article
EID:

2-s2.0-84883710495

Part of ISSN: 1874270X 18742718
Contributors: Wu, Y.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Conformational dynamics of Escherichia coli flavodoxins in apo- and holo-states by solution NMR spectroscopy

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84905455198

Part of ISSN: 19326203
Contributors: Ye, Q.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Long-chain flavodoxin FldB from Escherichia coli

Journal of Biomolecular NMR
2014 | Journal article
EID:

2-s2.0-84922073510

Part of ISSN: 15735001 09252738
Contributors: Ye, Q.; Fu, W.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structure of the TatB component of the twin-arginine translocation system

Biochimica et Biophysica Acta - Biomembranes
2014 | Journal article
EID:

2-s2.0-84899038051

Part of ISSN: 18792642 00052736
Contributors: Zhang, Y.; Wang, L.; Hu, Y.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Structural basis for TatA oligomerization: An NMR study of Escherichia coli TatA dimeric structure

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84905454613

Part of ISSN: 19326203
Contributors: Zhang, Y.; Hu, Y.; Li, H.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Chitin-induced dimerization activates a plant immune receptor

Science
2012 | Journal article
EID:

2-s2.0-84861665941

Part of ISSN: 10959203 00368075
Contributors: Liu, T.; Liu, Z.; Song, C.; Hu, Y.; Han, Z.; She, J.; Fan, G.; Wang, J.; Jin, C.; Chang, J. et al.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Structures of anabaena calcium-binding protein CcbP: Insights into CA <sup>2+</sup> signaling during heterocyst differentiation

Journal of Biological Chemistry
2011 | Journal article
EID:

2-s2.0-79953320845

Part of ISSN: 1083351X 00219258
Contributors: Hu, Y.; Zhang, X.; Shi, Y.; Zhou, Y.; Zhang, W.; Su, X.-D.; Xia, B.; Zhao, J.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

NMR characterizations of the ice binding surface of an antifreeze protein

PLoS ONE
2010 | Journal article
EID:

2-s2.0-78650826724

Part of ISSN: 19326203
Contributors: Hong, J.; Hu, Y.; Li, C.; Jia, Z.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution NMR structure of the TatA component of the twin-arginine protein transport system from gram-positive bacterium bacillus subtilis

Journal of the American Chemical Society
2010 | Journal article
EID:

2-s2.0-78449239236

Part of ISSN: 00027863 15205126
Contributors: Hu, Y.; Zhao, E.; Li, H.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structure of a Plasmodium falciparum AMA-1/MSP 1 chimeric protein vaccine candidate (PfCP-2.9) for malaria

Malaria Journal
2010 | Journal article
EID:

2-s2.0-77950659057

Part of ISSN: 14752875
Contributors: Peng, H.; Hu, Y.; Zhou, A.; Jin, C.; Pan, W.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structure of the Escherichia coli HybE reveals a novel fold

Proteins: Structure, Function and Bioinformatics
2009 | Journal article
EID:

2-s2.0-66149164338

Part of ISSN: 08873585 10970134
Contributors: Shao, X.; Lu, J.; Hu, Y.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis

Journal of Biological Chemistry
2007 | Journal article
EID:

2-s2.0-34249668288

Part of ISSN: 00219258 1083351X
Contributors: Li, Y.; Hu, Y.; Zhang, X.; Xu, H.; Lescop, E.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Lipid interaction converts prion protein to a PrP<sup>Sc</sup>-like proteinase k-resistant conformation under physiological conditions

Biochemistry
2007 | Journal article
EID:

2-s2.0-34250158426

Part of ISSN: 00062960
Contributors: Wang, F.; Yang, F.; Hu, Y.; Wang, X.; Wang, X.; Jin, C.; Ma, J.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structure of the bacterial chemotaxis adaptor protein CheW from Escherichia coli

Biochemical and Biophysical Research Communications
2007 | Journal article
EID:

2-s2.0-34447567138

Part of ISSN: 0006291X 10902104
Contributors: Li, Y.; Hu, Y.; Fu, W.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structures and backbone dynamics of a flavodoxin mioC from Escherichia coli in both apo- and holo-forms: Implications for cofactor binding and electron transfer

Journal of Biological Chemistry
2006 | Journal article
EID:

2-s2.0-33845921565

Part of ISSN: 00219258 1083351X
Contributors: Hu, Y.; Li, Y.; Zhang, X.; Guo, X.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases

Journal of Biological Chemistry
2006 | Journal article
EID:

2-s2.0-33745839780

Part of ISSN: 00219258 1083351X
Contributors: Kang, X.; Hu, Y.; Li, Y.; Guo, X.; Jiang, X.; Lai, L.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

The Bacillus subtilis YkuV is a thiol:disulfide oxidoreductase revealed by its redox structures and activity

Journal of Biological Chemistry
2006 | Journal article
EID:

2-s2.0-33646350771

Part of ISSN: 00219258 1083351X
Contributors: Zhang, X.; Hu, Y.; Guo, X.; Lescop, E.; Li, Y.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

The solution structure of Escherichia coli Wzb reveals a novel substrate recognition mechanism of prokaryotic low molecular weight protein-tyrosine phosphatases

Journal of Biological Chemistry
2006 | Journal article
EID:

2-s2.0-33745842893

Part of ISSN: 00219258 1083351X
Contributors: Lescop, E.; Hu, Y.; Xu, H.; Hu, W.; Chen, J.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Solution structures and backbone dynamics of arsenate reductase from Bacillus subtilis: Reversible conformational switch associated with arsenate reduction

Journal of Biological Chemistry
2005 | Journal article
EID:

2-s2.0-28244499943

Part of ISSN: 00219258
Contributors: Guo, X.; Li, Y.; Peng, K.; Hu, Y.; Li, C.; Xia, B.; Jin, C.
Source: Self-asserted source
Yunfei Hu via Scopus - Elsevier

Peer review (3 reviews for 3 publications/grants)

Review activity for ChemBioChem. (1)
Review activity for Communications biology. (1)
Review activity for The journal of physical chemistry. (1)