Personal information

Hypoxia, HIF, Ubiquitin, Metabolism, Iron, Oxygen
United Kingdom

Activities

Employment (1)

University of Cambridge: Cambridge, Cambridgeshire, GB

Wellcome Senior Clinical Research Fellow, Professor of Respiratory Medicine, Honorary Consultant Physician (Medicine)
Employment
Source: Self-asserted source
James Alexander Nathan

Education and qualifications (3)

University of Cambridge Medicine: Cambridge, Cambridgeshire, GB

2008 to present | PhD (Medicine)
Qualification
Source: Self-asserted source
James Alexander Nathan

Royal College of Physicians: London, London, GB

2001 to present | MRCP
Qualification
Source: Self-asserted source
James Alexander Nathan

University of Bristol: Bristol, Bristol, GB

1998 to present | MBChB
Qualification
Source: Self-asserted source
James Alexander Nathan

Professional activities (8)

Royal College of Physicians: London, London, GB

Membership
Source: Self-asserted source
James Alexander Nathan

Lister Institute of Preventive Medicine: London, GB

Lister Fellowship Prize
Distinction
Source: Self-asserted source
James Alexander Nathan

Lister Institute of Preventive Medicine: London, GB

Source: Self-asserted source
James Alexander Nathan

British Thoracic Society: London, GB

Source: Self-asserted source
James Alexander Nathan

Association of Physicians of Great Britain & Ireland: London, GB

2021-04 to present
Invited position
Source: Self-asserted source
James Alexander Nathan

Association of Physicians of Great Britain & Ireland: London, GB

2021-04 to present | Fellow
Membership
Source: Self-asserted source
James Alexander Nathan

Association of Physicians of Great Britian & Ireland: London, GB

2021-03-15 to present | Fellow
Invited position
Source: Self-asserted source
James Alexander Nathan

Royal College of Physicians: London, London, GB

2013 to present | FRCP
Invited position
Source: Self-asserted source
James Alexander Nathan

Works (50 of 58)

Items per page:
Page 1 of 2

A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway

Biochemical Society Transactions
2024-12-19 | Journal article
Contributors: Tekle Pauzaite; James A. Nathan
Source: check_circle
Crossref

ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism

2024-09-12 | Preprint
Contributors: Guinevere L Grice; Eleanor Minogue; Hudson W Coates; Mekdes Debela; Nicole Kaneider-Kaser; P Robin Antrobus; Randall S Johnson; James A Nathan
Source: check_circle
Crossref

Hypoxia promotes airway differentiation in the human lung epithelium

2024-08-09 | Preprint
Contributors: Ziqi Dong; Niek Wit; Aastha Agarwal; Dnyanesh Dubal; Jelle van den Ameele; Adam James Reid; James A. Nathan; Emma L. Rawlins
Source: check_circle
Crossref

Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response

The EMBO Journal
2024-07-15 | Journal article
Contributors: Tekle Pauzaite; Niek Wit; Rachel V Seear; James A Nathan
Source: check_circle
Crossref

Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response

2024-01-11 | Preprint
Contributors: Tekle Pauzaite; Niek Wit; Rachel V Seear; James A Nathan
Source: check_circle
Crossref

Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction

2023-12 | Preprint
Contributors: Meng B; Zhao N; Mlcochova P; Ferreira IA; Ortmann BM; Davis T; Wit N; Rehwinkel J; Cook S; Maxwell PH et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis.

Nature communications
2023-08 | Journal article
Contributors: Dickson AS; Pauzaite T; Arnaiz E; Ortmann BM; West JA; Volkmar N; Martinelli AW; Li Z; Wit N; Vitkup D et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

Glutarate regulates T cell metabolism and anti-tumour immunity.

Nature metabolism
2023-08 | Journal article
Contributors: Minogue E; Cunha PP; Wadsworth BJ; Grice GL; Sah-Teli SK; Hughes R; Bargiela D; Quaranta A; Zurita J; Antrobus R et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.

Science advances
2023-05 | Journal article
Contributors: Wit N; Gogola E; West JA; Vornbäumen T; Seear RV; Bailey PSJ; Burgos-Barragan G; Wang M; Krawczyk P; Huberts DHEW et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

Cigarette smoke preferentially induces full length ACE2 expression in differentiated primary human airway cultures but does not alter the efficiency of cellular SARS-CoV-2 infection.

Heliyon
2023-03 | Journal article
Contributors: Porter LM; Guo W; Crozier TW; Greenwood EJ; Ortmann B; Kottmann D; Nathan JA; Mahadeva R; Lehner PJ; McCaughan F
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

Nitrosylation rewires metabolism

Nature Chemical Biology
2023-03 | Journal article
Contributors: James A. Nathan
Source: check_circle
Crossref

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.

PLoS biology
2023-02 | Journal article
Contributors: Shilts J; Crozier TWM; Teixeira-Silva A; Gabaev I; Gerber PP; Greenwood EJD; Watson SJ; Ortmann BM; Gawden-Bone CM; Pauzaite T et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

A Case of Thrombotic Microangiopathy and Acute Sarcoidosis.

Chest
2022-11 | Journal article
Contributors: Martinelli AW; Dunn W; McClure ME; Walker I; Stewart A; Karia S; Preston SD; Thiru S; Torpey N; Ojha S et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

Chromatin oxygen sensing by histone H3 prolyl hydroxylation

Nature Genetics
2022-11 | Journal article
Contributors: James A. Nathan
Source: check_circle
Crossref

Metabolite-driven antitumor immunity.

Science (New York, N.Y.)
2022-09 | Journal article
Contributors: Nathan JA
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion [version 1; peer review: 2 approved]

2022-09-07 | Journal article
Part of ISSN: 2398-502X
Funded by GRANT_NUMBER: 15/20A
Funded by GRANT_NUMBER: 2015/10/McCaughan
Funded by GRANT_NUMBER:

210688

Funded by GRANT_NUMBER:

215477

Funded by GRANT_NUMBER: BRC-1215-20014
Funded by GRANT_NUMBER: MR/P001601/1, MR/V000489/1
Funded by GRANT_NUMBER: MR/T032413/1
Funded by GRANT_NUMBER: MR/V011561/1
Funded by GRANT_NUMBER: MR/V028448/1
Funded by GRANT_NUMBER: NC/S001204/1
Funded by GRANT_NUMBER: WPA15-02
Contributors: Thomas W.M. Crozier; Edward J.D. Greenwood; James C. Williamson; Wenrui Guo; Linsey M. Porter; Ildar Gabaev; Ana Teixeira-Silva; Guinevere L. Grice; Arthur Wickenhagen; Richard J. Stanton et al.
Source: check_circle
Wellcome Open Research

Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures

Life Science Alliance
2022-04 | Journal article
Contributors: Wenrui Guo; Linsey M Porter; Thomas WM Crozier; Matthew Coates; Akhilesh Jha; Mikel McKie; James A Nathan; Paul J Lehner; Edward JD Greenwood; Frank McCaughan
Source: check_circle
Crossref

Cigarette smoke preferentially induces full length ACE2 exposure in primary human airway cells but does not alter susceptibility to SARS-CoV-2 infection

2021-09 | Preprint
Contributors: Porter LM; Guo W; Crozier TW; Greenwood EJ; Ortmann B; Kottmann D; Nathan JA; Mahadeva R; Lehner PJ; McCaughan F
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

Genetic approaches to understand cellular responses to oxygen availability.

The FEBS journal
2021-06 | Journal article
Contributors: Ortmann BM; Nathan JA
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes.

Nature genetics
2021-06 | Journal article
Contributors: Ortmann BM; Burrows N; Lobb IT; Arnaiz E; Wit N; Bailey PSJ; Jordon LH; Lombardi O; Peñalver A; McCaffrey J et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated primary human airway cells

2021-04 | Preprint
Contributors: Guo W; Porter LM; Crozier TW; Coates M; Jha A; McKie M; Nathan JA; Lehner PJ; Greenwood EJ; McCaughan F
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

A thermostable, closed SARS-CoV-2 spike protein trimer

Nature Structural and Molecular Biology
2020 | Journal article
EID:

2-s2.0-85089097143

Part of ISSN: 15459985 15459993
Contributors: Xiong, X.; Qu, K.; Ciazynska, K.A.; Hosmillo, M.; Carter, A.P.; Ebrahimi, S.; Ke, Z.; Scheres, S.H.W.; Bergamaschi, L.; Grice, G.L. et al.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant

Cell Reports Medicine
2020 | Journal article
EID:

2-s2.0-85096536486

Part of ISSN: 26663791
Contributors: Mlcochova, P.; Collier, D.; Ritchie, A.; Assennato, S.M.; Hosmillo, M.; Goel, N.; Meng, B.; Chatterjee, K.; Mendoza, V.; Temperton, N. et al.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Frontiers in Cell and Developmental Biology
2020 | Journal article
EID:

2-s2.0-85090499631

Part of ISSN: 2296634X
Contributors: Sundaramurthi, H.; Roche, S.L.; Grice, G.L.; Moran, A.; Dillion, E.T.; Campiani, G.; Nathan, J.A.; Kennedy, B.N.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity

JCI Insight
2020 | Journal article
EID:

2-s2.0-85089171540

Part of ISSN: 23793708
Contributors: Wang, S.; Raybuck, A.; Shiuan, E.; Cho, S.H.; Wang, Q.; Brantley-Sieders, D.M.; Edwards, D.; Allaman, M.M.; Nathan, J.; Wilson, K.T. et al.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Squalene and cholesterol in the balance at the ER membrane

Proceedings of the National Academy of Sciences of the United States of America
2020 | Journal article
EID:

2-s2.0-85083174350

Part of ISSN: 10916490 00278424
Contributors: Nathan, J.A.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 3)‎

Critical care workers have lower seroprevalence of SARS-CoV-2 IgG compared with non-patient facing staff in first wave of COVID19

2020-11 | Preprint
Contributors: Baxendale H; Wells D; Gronlund J; Nadesalingam A; Paloniemi M; Carnell G; Tonks P; Ceron-Gutierrez L; Ebrahimi S; Sayer A et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex.

Nature communications
2020-08-13 | Journal article
Source: Self-asserted source
James Alexander Nathan
grade
Preferred source (of 2)‎

ABHD11 regulates 2-oxoglutarate abundance by protecting mitochondrial lipoylated proteins from lipid peroxidation damage

2020-04-18 | Preprint
Contributors: Peter S J Bailey; Brian M Ortmann; Jack W Houghton; Ana S H Costa; Robin Antrobus; Christian Frezza; James A Nathan
Source: check_circle
Crossref

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS

EMBO Molecular Medicine
2019 | Journal article
EID:

2-s2.0-85058464983

Contributors: Signes, A.; Cerutti, R.; Dickson, A.S.; Benincá, C.; Hinchy, E.C.; Ghezzi, D.; Carrozzo, R.; Bertini, E.; Murphy, M.P.; Nathan, J.A. et al.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 3)‎

Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
EID:

2-s2.0-85051232771

Contributors: Bailey, P.S.J.; Kalervo Hiltunen, J.; Dieckmann, C.L.; Kastaniotis, A.J.; Nathan, J.A.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 3)‎

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins

EMBO Reports
2018 | Journal article
EID:

2-s2.0-85046438615

Contributors: Stefanovic-Barrett, S.; Dickson, A.S.; Burr, S.P.; Williamson, J.C.; Lobb, I.T.; van den Boomen, D.J.H.; Lehner, P.J.; Nathan, J.A.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 3)‎

Metabolic regulation of hypoxia-inducible transcription factors: The role of small molecule metabolites and iron

Biomedicines
2018 | Journal article
EID:

2-s2.0-85050275154

Contributors: Bailey, P.S.J.; Nathan, J.A.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 3)‎

Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria

Developmental Cell
2018 | Journal article
EID:

2-s2.0-85044234869

Contributors: Kruppa, A.J.; Kishi-Itakura, C.; Masters, T.A.; Rorbach, J.E.; Grice, G.L.; Kendrick-Jones, J.; Nathan, J.A.; Minczuk, M.; Buss, F.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 2)‎

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and hrd1

eLife
2018 | Journal article
EID:

2-s2.0-85058599544

Contributors: Menzies, S.A.; Volkmar, N.; van den Boomen, D.J.H.; Timms, R.T.; Dickson, A.S.; Nathan, J.A.; Lehner, P.J.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 3)‎

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

2018-08-14 | Preprint
Contributors: Sam A. Menzies; Norbert Volkmar; Dick J. van den Boomen; Richard T. Timms; Anna S. Dickson; James A. Nathan; Paul J. Lehner
Source: check_circle
Crossref

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

Journal of Experimental Medicine
2017 | Journal article
EID:

2-s2.0-85021879272

Contributors: Thomas, D.C.; Clare, S.; Sowerby, J.M.; Pardo, M.; Juss, J.K.; Goulding, D.A.; van der Weyden, L.; Storisteanu, D.; Prakash, A.; Espéli, M. et al.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 2)‎

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular Iron levels

eLife
2017 | Journal article
EID:

2-s2.0-85017502020

Contributors: Miles, A.L.; Burr, S.P.; Grice, G.L.; Nathan, J.A.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
grade
Preferred source (of 3)‎

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

2016-11 | Journal article
Contributors: Burr SP; Costa AS; Grice GL; Timms RT; Lobb IT; Freisinger P; Dodd RB; Dougan G; Lehner PJ; Frezza C et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

The recognition of ubiquitinated proteins by the proteasome.

2016-09 | Journal article
Contributors: Grice GL; Nathan JA
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 3)‎

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

2016-01 | Journal article
Contributors: Scholz CC; Rodriguez J; Pickel C; Burr S; Fabrizio JA; Nolan KA; Spielmann P; Cavadas MA; Crifo B; Halligan DN et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.

2015-07 | Journal article
Contributors: Grice GL; Lobb IT; Weekes MP; Gygi SP; Antrobus R; Nathan JA
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

Muscle wasting in disease: molecular mechanisms and promising therapies.

2015-01 | Journal article
Contributors: Cohen S; Nathan JA; Goldberg AL
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

2014-08 | Journal article
Contributors: van den Boomen DJ; Timms RT; Grice GL; Stagg HR; Skødt K; Dougan G; Nathan JA; Lehner PJ
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.

2014-06 | Journal article
Contributors: Boname JM; Bloor S; Wandel MP; Nathan JA; Antrobus R; Dingwell KS; Thurston TL; Smith DL; Smith JC; Randow F et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.

2013-10 | Journal article
Contributors: Peth A; Nathan JA; Goldberg AL
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins.

2013-02 | Journal article
Contributors: Nathan JA; Spinnenhirn V; Schmidtke G; Basler M; Groettrup M; Goldberg AL
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

2013-02 | Journal article
Contributors: Nathan JA; Kim HT; Ting L; Gygi SP; Goldberg AL
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.

2011-08 | Journal article
Contributors: Deriziotis P; André R; Smith DM; Goold R; Kinghorn KJ; Kristiansen M; Nathan JA; Rosenzweig R; Krutauz D; Glickman MH et al.
Source: Self-asserted source
James Alexander Nathan via Europe PubMed Central
grade
Preferred source (of 2)‎

Skeletal muscle dysfunction: A ubiquitous outcome in chronic disease?

Thorax
2010 | Journal article
EID:

2-s2.0-76549089202

Contributors: Nathan, J.; Fuld, J.
Source: Self-asserted source
James Alexander Nathan via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (8 reviews for 6 publications/grants)

Review activity for Communications biology. (1)
Review activity for EMBO reports. (1)
Review activity for Nature cell biology (1)
Review activity for Nature communications (3)
Review activity for PLOS genetics. (1)
Review activity for UK Research and Innovation (1)