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Scopus Author ID: 57200720157

Biography

Saira currently leads the influenza antivirals team at the WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Laboratory at the Peter Doherty Institute for Infection and Immunity. Saira has previously worked as a consultant to the WHO Global Influenza programme and as a post doc at the Crick Worldwide Influenza Centre (WHO) at the Francis Crick Institute and the Roslin Institute, University of Edinburgh. Saira worked on understanding replication and characterising fitness determinants of influenza and SARS CoV-2 viruses and the development of novel vaccines and antivirals.

Activities

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Employment (6)

World Health Organization: Geneva, GE, CH

2022-11-01 to 2023-03-01 | Consultant (Global Influenza Programme)
Employment
Source: Self-asserted source
Saira Hussain

The Francis Crick Institute: London, GB

2020-11-01 to 2021-09-17 | Senior Laboratory Research Scientist (The Francis Crick Institute )
Employment
Source: Self-asserted source
Saira Hussain

The Francis Crick Institute: London, GB

2016-10-01 to 2020-10-31 | Post-doctoral research fellow (Crick Worldwide Influenza Centre)
Employment
Source: Self-asserted source
Saira Hussain

University of Edinburgh: Edinburgh, GB

2013-10-01 to 2016-09-30 | Post-doctoral research fellow (Paul Digard Group, Infection and Immunity)
Employment
Source: Self-asserted source
Saira Hussain

MRC National Institute for Medical Research: London, GB

2012-10-01 to 2013-03-31 | Post-doctoral research assistant (John McCauley Group, Virology)
Employment
Source: Self-asserted source
Saira Hussain

Imperial College London: London, Westminster, GB

2007-05-01 to 2007-08-31 | Undergraduate summer research placement student (Biochemistry )
Employment
Source: Self-asserted source
Saira Hussain

Education and qualifications (3)

Birkbeck, University of London: London, GB

2020-09 | Msc Bioinfo0rmatics with Systems Biology
Education
Source: Self-asserted source
Saira Hussain

University College London: London, GB

2008-10 to 2013-01 | PhD Infection and Immunity
Education
Source: Self-asserted source
Saira Hussain

Imperial College London: London, Westminster, GB

2004-10 to 2008-07 | BSc(Hons) 2:1 Biology with Microbiology
Education
Source: Self-asserted source
Saira Hussain

Works (25)

Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion

PLOS Biology
2025-01-21 | Journal article
DOI: 10.1371/journal.pbio.3002982
Part of ISSN: 1545-7885
Contributors: Harriet Mears; George Young; Theo Sanderson; Ruth Harvey; Jamie Barrett-Rodger; Rebecca Penn; Vanessa Cowton; Wilhelm Furnon; Giuditta De Lorenzo; Margaret Crawford et al.
Source: Self-asserted source
Saira Hussain

Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly.

Communications biology
2022-11 | Journal article
DOI: 10.1038/s42003-022-04183-1
PMID: 36357779
PMC: PMC9648435
Contributors: Calder LJ; Calcraft T; Hussain S; Harvey R; Rosenthal PB
Source: Self-asserted source
Saira Hussain via Europe PubMed Central

SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies

Science Translational Medicine
2022-07-27 | Journal article
DOI: 10.1101/2021.11.30.470568
DOI: 10.1126/scitranslmed.abn3715
Part of ISSN: 1946-6234
Part of ISSN: 1946-6242
Contributors: Saira Hussain
Source: Self-asserted source
Saira Hussain
grade
Preferred source (of 2)‎

Emergence of new subgenomic mRNAs in SARS-CoV-2

[]
2022-04-20 | Preprint
DOI: 10.1101/2022.04.20.488895
Source: Self-asserted source
Saira Hussain

Evolution of the SARS-CoV-2 spike protein in the human host

Nature Communications
2022-03-04 | Journal article
DOI: 10.1038/s41467-022-28768-w
Source: Self-asserted source
Saira Hussain

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

Med:Cell Press
2021 | Journal article
DOI: 10.1101/2021.02.15.431291
DOI: 10.1016/j.medj.2021.08.001
Source: Self-asserted source
Saira Hussain
grade
Preferred source (of 2)‎

Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions

Journal of General virology
2021-10 | Journal article
DOI: 10.1099/jgv.0.001648
Source: Self-asserted source
Saira Hussain

AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC

The Lancet
2021-06 | Journal article
DOI: 10.1016/s0140-6736(21)01462-8
Part of ISSN: 0140-6736
Source: Self-asserted source
Saira Hussain

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination

The Lancet
2021-06 | Journal article
DOI: 10.1016/s0140-6736(21)01290-3
Part of ISSN: 0140-6736
Source: Self-asserted source
Saira Hussain

PA-X is an avian virulence factor in H9N2 avian influenza virus

Journal of General Virology
2021-03-01 | Journal article
DOI: 10.1099/jgv.0.001531
Part of ISSN: 0022-1317
Part of ISSN: 1465-2099
Source: Self-asserted source
Saira Hussain

Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

PLOS Pathogens
2021-02 | Journal article
DOI: 10.1371/journal.ppat.1009352
DOI: 10.1101/2020.08.28.267526
Source: Self-asserted source
Saira Hussain
grade
Preferred source (of 2)‎

Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Nature Communications
2020 | Journal article
DOI: 10.1038/s41467-020-19146-5
Part of ISSN: 2041-1723
Source: Self-asserted source
Saira Hussain
grade
Preferred source (of 2)‎

Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses

Journal of Virology
2020 | Journal article
DOI: 10.1128/jvi.01173-20
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Source: Self-asserted source
Saira Hussain
grade
Preferred source (of 2)‎

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Science
2020-12-11 | Journal article
DOI: 10.1126/science.abe1107
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Source: Self-asserted source
Saira Hussain

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Nature Communications
2020-08-31 | Journal article
DOI: 10.1101/2020.08.31.275701
DOI: 10.1038/s41467-020-20654-7
Part of ISSN: 2041-1723
Source: Self-asserted source
Saira Hussain
grade
Preferred source (of 2)‎

Staphylococcus aureus Lipase 1 Enhances Influenza A Virus Replication

mBio
2020-08-25 | Journal article
DOI: 10.1128/mbio.00975-20
Part of ISSN: 2161-2129
Part of ISSN: 2150-7511
Source: Self-asserted source
Saira Hussain

Molecular characterisation of Influenza C viruses from outbreaks in Hong Kong SAR, China

Journal of Virology
2020-08-19 | Journal article
DOI: 10.1128/jvi.01051-20
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Source: Self-asserted source
Saira Hussain

Segment 2 from influenza A(H1N1) 2009 pandemic viruses confers temperature-sensitive haemagglutinin yield on candidate vaccine virus growth in eggs that can be epistatically complemented by PB2 701D

Journal of General Virology
2019-07-01 | Journal article
DOI: 10.1099/jgv.0.001279
Part of ISSN: 0022-1317
Part of ISSN: 1465-2099
Source: Self-asserted source
Saira Hussain

Mutation of Influenza A Virus PA-X Decreases Pathogenicity in Chicken Embryos and Can Increase the Yield of Reassortant Candidate Vaccine Viruses

Journal of Virology
2019-01-15 | Journal article
DOI: 10.1128/jvi.01551-18
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Source: Self-asserted source
Saira Hussain

An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection

Mucosal Immunology
2018-01 | Journal article
DOI: 10.1038/mi.2017.45
Part of ISSN: 1933-0219
Part of ISSN: 1935-3456
Source: Self-asserted source
Saira Hussain

Strain-specific antiviral activity of iminosugars against human influenza A viruses

Journal of Antimicrobial Chemotherapy
2015-01-01 | Journal article
DOI: 10.1093/jac/dku349
Part of ISSN: 0305-7453
Part of ISSN: 1460-2091
Source: Self-asserted source
Saira Hussain

Iminosugars as antivirals against human influenza A viruses

2013 | Dissertation or Thesis
Source: Self-asserted source
Saira Hussain

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

Biochemical Journal
Journal article
DOI: 10.1042/bcj20210201
DOI: 10.1101/2021.04.07.438808
Part of ISSN: 0264-6021
Part of ISSN: 1470-8728
Source: Self-asserted source
Saira Hussain
grade
Preferred source (of 2)‎

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Lancet
Journal article
DOI: 10.1016/S0140-6736(21)01854-7
Source: Self-asserted source
Saira Hussain

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

eLife
Journal article
DOI: 10.7554/eLife.69317
Source: Self-asserted source
Saira Hussain
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