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dendritic cell, innate immunity, TLR, endosomes, autophagy, membrane traffic, MARCH, ubiquitin ligas

Biography

Date of birth: June 24th, 1965.
Nationality: Italian.

EDUCATION:
1984 - Liceo Classico G. Leopardi, Milan, Italy - Baccalaureate
1989 - MSc Biological sciences, summa cum laude, University of Milan, Italy.
1993 - PhD in Biotechnology, summa cum laude, University of Milan, Italy.
2011 - Habilitation for Research Direction (HDR), 2011, University Aix-Marseille -France.
2019 - Habilitation Full Professor MIUR: Molecular Biology (sc 05/E2, 05/E3, 05/F1) and Gen. Clinical

POSITIONS:
2014-today: CNRS Research Director, Laboratory for Dendritic Cell Biology, CIML, Marseille, France.
2003-2009 : CNRS Senior Research Scientist, Laboratory for Dendritic Cell Biology, CIML, Marseille, France.
2000- 2003 : Marie Skłodowska -Curie Fellow, Centre d'Immunologie de Marseille-Luminy (CIML), Marseille, France.
1996-1999: Associate research scientist, Ira Mellman's Laboratory, Cell Biology Dept and Immunobiology Dept, Yale University School of Medicine, New Haven CT, USA.
1994-1996: Postdoctoral fellow, Pietro De Camilli's Laboratory, HHMI Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven CT, USA.
1993-1994: Postdoctoral fellow, Paolo Dellabona's Laboratory, Immunology Dept, DIBIT San Raffaele Hospital, Milan, Italy.

Activities

Employment (3)

CNRS - Centre d'Immunologie de Marseille-Luminy: Marseille, FR

2000 to present | Research Director (Dendritic Cell Biology Laboratory)
Employment
Source: Self-asserted source
Gatti E.

CNRS: Aveiro, PT

2013-01 to 2018-12 | Coordinator of CNRS-LIA with University of Aveiro (IBIMED - Institute for BioMedicine)
Employment
Source: Self-asserted source
Gatti E.

Yale University School of Medicine: New Haven, CT, US

1996 to 1999 | Research Associate (Cell Biology Department)
Employment
Source: Self-asserted source
Gatti E.

Education and qualifications (1)

Marie Skłodowska-Curie Actions: Marseille, FR

2000 to 2004 | Marie Curie Research Fellow
Qualification
Source: Self-asserted source
Gatti E.

Professional activities (2)

Milano-Bicocca University : Milan, Lombardia, IT

2017-02-01 to present | Adjunct Professor Molecular Immunology (Biotecnologies and Biosciences Dept)
Invited position
Source: Self-asserted source
Gatti E.

University of Aveiro: Aveiro, PT

2013 to present | Professor in Molecular Immunology (IBiMed)
Invited position
Source: Self-asserted source
Gatti E.

Works (50 of 73)

Items per page:
Page 1 of 2

Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation

bioRxiv
2024 | Other
EID:

2-s2.0-85210901617

Part of ISSN: 26928205
Contributors: Barros, D.; Ferreira, B.H.; Garcia-Gonzalez, P.; Carbone, F.; Luka, M.; Leite-Pinheiro, F.; Antas, P.; Mendes, A.; Machado, M.D.; Zhang, L. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

VPS34-IN1 inhibits cap-mediated translation and synergizes with STING to drive type-I IFN expression in human plasmacytoid DCs

bioRxiv
2024 | Other
EID:

2-s2.0-85199630717

Part of ISSN: 26928205
Contributors: Antas, P.; Machado, M.D.; Leite-Pinheiro, F.; Barros, D.; Ramalhinho, C.; Mendes, A.; Ferreira, B.H.; Carvoeiro, D.; Reverendo, M.; Duarte, I.F. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

“Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma”

bioRxiv
2024 | Other
EID:

2-s2.0-85211346166

Part of ISSN: 26928205
Contributors: Argüello, R.J.; Pierre, P.; Gigan, J.P.; Garcia-Gonzalez, P.; Galliot, L.; Ghaffar, Y.; Santibanez, F.F.; Seillier, E.; Heguy, R.L.; Fischaux, S. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

Nature Communications
2023 | Journal article
EID:

2-s2.0-85165258586

Part of ISSN: 20411723
Contributors: Char, R.; Liu, Z.; Jacqueline, C.; Davieau, M.; Delgado, M.-G.; Soufflet, C.; Fallet, M.; Chasson, L.; Chapuy, R.; Camosseto, V. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Rufy3 regulates anti-bacterial responses by controlling endolysosomes perinuclear positioning in activated phagocytes.

Research Square
2022 | Other
EID:

2-s2.0-85167489821

Contributors: Char, R.; Liu, Z.; Davieau, M.; Jacqueline, C.; Delgado, M.-G.; Chapuy, R.; Fallet, M.; Chasson, L.; Camosseto, V.; Strock, E. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.

Royal Society open science
2021-07-14 | Journal article
Source: Self-asserted source
Gatti E.
grade
Preferred source (of 2)‎

LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia.

Haematologica
2021-04-29 | Journal article
Source: Self-asserted source
Gatti E.
grade
Preferred source (of 2)‎

Developmentally regulated PERK activity renders dendritic cells insensitive to subtilase cytotoxin-induced integrated stress response

bioRxiv
2020 | Other
EID:

2-s2.0-85098838075

Part of ISSN: 26928205
Contributors: Mendes, A.; Gigan, J.P.; Rodrigues, C.R.; Choteau, S.A.; Sanseau, D.; Barros, D.; Almeida, C.; Camosseto, V.; Argüello, R.J.; Chasson, L. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

Cell Metabolism
2020 | Journal article
EID:

2-s2.0-85096689445

Part of ISSN: 19327420 15504131
Contributors: Argüello, R.J.; Combes, A.J.; Char, R.; Gigan, J.-P.; Baaziz, A.I.; Bousiquot, E.; Camosseto, V.; Samad, B.; Tsui, J.; Yan, P. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

ZENITH: A Flow Cytometry Based Method for Functional Profiling Energy Metabolism with Single Cell Resolution

SSRN
2020 | Other
EID:

2-s2.0-85110274573

Part of ISSN: 15565068
Contributors: Argüello, R.J.; Combes, A.J.; Char, R.; Bousiquot, E.; Gigan, J.-P.; Camosseto, V.; Samad, B.; Tsui, J.; Yan, P.; Boissoneau, S. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier
grade
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Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4.

Life science alliance
2020-12-21 | Journal article
Source: Self-asserted source
Gatti E.
grade
Preferred source (of 2)‎

At the crossway of ER-stress and proinflammatory responses

FEBS Journal
2019 | Journal article
EID:

2-s2.0-85041633677

Part of ISSN: 17424658 1742464X
Contributors: Reverendo, M.; Mendes, A.; Argüello, R.J.; Gatti, E.; Pierre, P.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Polymerase III transcription is necessary for T cell priming by dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America
2019-10-21 | Journal article
Source: Self-asserted source
Gatti E.
grade
Preferred source (of 2)‎

Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases.

Methods in molecular biology (Clifton, N.J.)
2019-01-01 | Journal article
Source: Self-asserted source
Gatti E.
grade
Preferred source (of 2)‎

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2a dephosphorylation by the GADD34/PP1c complex

Science Signaling
2018 | Journal article
EID:

2-s2.0-85041034889

Contributors: Perego, J.; Mendes, A.; Bourbon, C.; Camosseto, V.; Combes, A.; Liu, H.; Manh, T.-P.V.; Dalet, A.; Chasson, L.; Spinelli, L. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Autophagy and MHC-restricted antigen presentation.

Molecular immunology
2018-05-19 | Journal article
Source: Self-asserted source
Gatti E.
grade
Preferred source (of 2)‎

BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

Nature Communications
2017 | Journal article
EID:

2-s2.0-85031693380

Part of ISSN: 20411723
Contributors: Combes, A.; Camosseto, V.; N'Guessan, P.; Argüello, R.J.; Mussard, J.; Caux, C.; Bendriss-Vermare, N.; Pierre, P.; Gatti, E.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier
grade
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Detection of a Subset of Posttranscriptional Transfer RNA Modifications in Vivo with a Restriction Fragment Length Polymorphism-Based Method

Biochemistry
2017 | Journal article
EID:

2-s2.0-85027270330

Part of ISSN: 15204995 00062960
Contributors: Wulff, T.F.; Argüello, R.J.; Jordàn, M.M.; Frigolé, H.R.; Hauquier, G.; Filonava, L.; Camacho, N.; Gatti, E.; Pierre, P.; De Pouplana, L.R. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier
grade
Preferred source (of 2)‎

Guanabenz prevents d-galactosamine/lipopolysaccharide-induced liver damage and mortality

Frontiers in Immunology
2017 | Journal article
EID:

2-s2.0-85020482028

Contributors: Perego, J.; Bourbon, C.; Chasson, L.; Laprie, C.; Spinelli, L.; Camosseto, V.; Gatti, E.; Pierre, P.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

MARCH9-mediated ubiquitination regulates MHC i export from the TGN

Immunology and Cell Biology
2017 | Journal article
EID:

2-s2.0-85032221446

Part of ISSN: 14401711 08189641
Contributors: De Angelis Rigotti, F.; De Gassart, A.; Pforr, C.; Cano, F.; N'Guessan, P.; Combes, A.; Camossetto, V.; Lehner, P.J.; Pierre, P.; Gatti, E.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier
grade
Preferred source (of 2)‎

Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA

EMBO Journal
2017 | Journal article
EID:

2-s2.0-85010611998

Part of ISSN: 14602075 02614189
Contributors: Dalet, A.; Argüello, R.J.; Combes, A.; Spinelli, L.; Jaeger, S.; Fallet, M.; Vu Manh, T.-P.; Mendes, A.; Perego, J.; Reverendo, M. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier
grade
Preferred source (of 2)‎

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Autophagy
2016 | Journal article
EID:

2-s2.0-84975859238

Contributors: Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; Adams, C.M.; Adams, P.D.; Adeli, K. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy
2016 | Journal article
EID:

2-s2.0-85013763791

Contributors: Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; Adams, C.M.; Adams, P.D.; Adeli, K. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

LAMP5 fine-tunes GABAergic synaptic transmission in defined circuits of the mouse brain

PLoS ONE
2016 | Journal article
EID:

2-s2.0-84975298204

Contributors: Tiveron, M.-C.; Beurrier, C.; C�ni, C.; Andriambao, N.; Combes, A.; Koehl, M.; Maurice, N.; Gatti, E.; Abrous, D.N.; Kerkerian-Le Goff, L. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation

Immunological Reviews
2016 | Journal article
EID:

2-s2.0-84975518865

Contributors: Arg�ello, R.J.; Reverendo, M.; Gatti, E.; Pierre, P.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

RUFY4: Immunity piggybacking on autophagy?

Autophagy
2016 | Journal article
EID:

2-s2.0-84962781067

Contributors: Terawaki, S.; Camosseto, V.; Pierre, P.; Gatti, E.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis

Science Signaling
2016 | Journal article
EID:

2-s2.0-84964746101

Contributors: Tudor, J.C.; Davis, E.J.; Peixoto, L.; Wimmer, M.E.; Van Tilborg, E.; Park, A.J.; Poplawski, S.G.; Chung, C.W.; Havekes, R.; Huang, J. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies

Autoimmunity
2016 | Journal article
EID:

2-s2.0-84958039019

Contributors: Clavarino, G.; Adriouach, S.; Quesada, J.-L.; Clay, M.; Chevreau, M.; Trocmé, C.; Grange, L.; Gaudin, P.; Gatti, E.; Pierre, P. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

In vivo imaging of the spatiotemporal activity of the eIF2α-ATF4 signaling pathway: Insights into stress and related disorders

Science Signaling
2015 | Journal article
EID:

2-s2.0-84928722699

Contributors: Chaveroux, C.; Carraro, V.; Canaple, L.; Averous, J.; Maurin, A.-C.; Jousse, C.; Muranishi, Y.; Parry, L.; Mesclon, F.; Gatti, E. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response

FEBS Letters
2015 | Journal article
EID:

2-s2.0-84930179594

Contributors: Dalet, A.; Gatti, E.; Pierre, P.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

Molecular Cell
2015 | Journal article
EID:

2-s2.0-84920448565

Contributors: McEwan, D.G.; Popovic, D.; Gubas, A.; Terawaki, S.; Suzuki, H.; Stadel, D.; Coxon, F.P.; MirandadeStegmann, D.; Bhogaraju, S.; Maddi, K. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Protein synthesis regulation, a pillar of strength for innate immunity?

Current Opinion in Immunology
2015 | Journal article
EID:

2-s2.0-84920918674

Contributors: Argüello, R.J.; Rodrigues, C.R.; Gatti, E.; Pierre, P.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4

Journal of Cell Biology
2015 | Journal article
EID:

2-s2.0-84962467120

Contributors: Terawaki, S.; Camosseto, V.; Prete, F.; Wenger, T.; Papadopoulos, A.; Rondeau, C.; Combes, A.; Rodrigues, C.R.; Manh, T.-P.V.; Fallet, M. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins.

Molecular Cell
2015-01 | Journal article
Source: Self-asserted source
Gatti E.

TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish

RNA Biology
2014 | Journal article
EID:

2-s2.0-84921709623

Contributors: Reverendo, M.; Soares, A.R.; Pereira, P.M.; Carreto, L.; Ferreira, V.; Gatti, E.; Pierre, P.; Moura, G.R.; Santos, M.A.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Loss of translation: A stealth weapon against pathogens?

Nature Immunology
2013 | Journal article
EID:

2-s2.0-84887905077

Contributors: Pierre, P.; Gatti, E.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Mapping the crossroads of immune activation and cellular stress response pathways

EMBO Journal
2013 | Journal article
EID:

2-s2.0-84877587978

Contributors: Cláudio, N.; Dalet, A.; Gatti, E.; Pierre, P.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

MHC-II ubiquitination

Methods in Molecular Biology
2013 | Book
EID:

2-s2.0-84879324235

Contributors: De Gassart, A.; De Angelis Rigotti, F.; Gatti, E.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

Nature Neuroscience
2013 | Journal article
EID:

2-s2.0-84883453343

Contributors: Ma, T.; Trinh, M.A.; Wexler, A.J.; Bourbon, C.; Gatti, E.; Pierre, P.; Cavener, D.R.; Klann, E.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation

Autophagy
2012 | Journal article
EID:

2-s2.0-84859119158

Contributors: Wenger, T.; Terawaki, S.; Camosseto, V.; Abdelrassoul, R.; Mies, A.; Catalan, N.; Claudio, N.; Clavarino, G.; De Gassart, A.; Rigotti, F.D.A. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy

Autophagy
2012 | Journal article
EID:

2-s2.0-84862295360

Contributors: Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; Agnello, M.; Agostinis, P.; Aguirre-Ghiso, J.A. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection

PLoS Pathogens
2012 | Journal article
EID:

2-s2.0-84863663085

Contributors: Clavarino, G.; Cláudio, N.; Couderc, T.; Dalet, A.; Judith, D.; Camosseto, V.; Schmidt, E.K.; Wenger, T.; Lecuit, M.; Gatti, E. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic: Polycytidylic acid-stimulated dendritic cells

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
EID:

2-s2.0-84857385877

Contributors: Clavarino, G.; Claúdio, N.; Dalet, A.; Terawaki, S.; Couderc, T.; Chasson, L.; Ceppi, M.; Schmidt, E.K.; Wenger, T.; Lecuit, M. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells

Blood
2011 | Journal article
EID:

2-s2.0-79960690554

Contributors: Defays, A.; David, A.; De Gassart, A.; Rigotti, F.D.A.; Wenger, T.; Camossetto, V.; Brousset, P.; Petrella, T.; Dalod, M.; Gatti, E. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff

Journal of Virology
2011 | Journal article
EID:

2-s2.0-78650060188

Contributors: White, L.K.; Sali, T.; Alvarado, D.; Gatti, E.; Pierre, P.; Streblow, D.; DeFilippis, V.R.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

The endosomal proteome of macrophage and dendritic cells

Proteomics
2011 | Journal article
EID:

2-s2.0-79951744514

Contributors: Duclos, S.; Clavarino, G.; Rousserie, G.; Goyette, G.; Boulais, J.; Camossetto, V.; Gatti, E.; LaBoissière, S.; Pierre, P.; Desjardins, M.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

DC-ATLAS: A systems biology resource to dissect receptor specific signal transduction in dendritic cells

Immunome Research
2010 | Journal article
EID:

2-s2.0-78349238940

Contributors: Cavalieri, D.; Rivero, D.; Beltrame, L.; Buschow, S.I.; Calura, E.; Rizzetto, L.; Gessani, S.; Gauzzi, M.C.; Reith, W.; Baur, A. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: Synthesis, structure-activity relationship, and action mechanism studies

European Journal of Medicinal Chemistry
2009 | Journal article
EID:

2-s2.0-60349114714

Contributors: Moret, V.; Laras, Y.; Cresteil, T.; Aubert, G.; Ping, D.Q.; Di, C.; Barthélémy-Requin, M.; Béclin, C.; Peyrot, V.; Allegro, D. et al.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS

Immunome Research
2009 | Journal article
EID:

2-s2.0-72849110539

Contributors: Ceppi, M.; Clavarino, G.; Gatti, E.; Schmidt, E.K.; De Gassart, A.; Blankenship, D.; Ogola, G.; Banchereau, J.; Chaussabel, D.; Pierre, P.
Source: Self-asserted source
Gatti E. via Scopus - Elsevier

Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes.

2008-05 | Journal article
Contributors: Thibodeau J; Bourgeois-Daigneault MC; Huppé G; Tremblay J; Aumont A; Houde M; Bartee E; Brunet A; Gauvreau ME; de Gassart A et al.
Source: Self-asserted source
Gatti E. via Europe PubMed Central
grade
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Items per page:
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