Personal information

Websites & social links

Lab website

Other IDs

ResearcherID: R-3803-2016

Keywords

neuroimmunology, pain, itch, neurodegeneration, host defense, innate immunity

Countries

United States

Activities

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Employment (3)

Harvard Medical School: Boston, MA, US

2021-05-01 to present | Associate Professor (Immunology)
Employment
Source: Self-asserted source
Isaac Chiu

Harvard Medical School: Boston, MA, US

2014-09-02 to 2021-04-30 | Assistant Professor (Immunology)
Employment
Source: Self-asserted source
Isaac Chiu

Boston Children's Hospital: Boston, MA, US

2010 to 2014 | Postdoctoral fellow (Kirby Neurobiology Center)
Employment
Source: Self-asserted source
Isaac Chiu

Education and qualifications (2)

Harvard medical school: Boston, MA, US

2002 to 2009 | PhD (Immunology)
Education
Source: Self-asserted source
Isaac Chiu

Harvard University: Cambridge, MA, US

1998-09-01 to 2002-06-02 | A.B. (Biochemistry)
Education
Source: Self-asserted source
Isaac Chiu

Funding (4)

Pain and Neuro-immune Signaling in S. pyogenes pathogenesis

2017-09-25 to 2022-08-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.7072453
GRANT_NUMBER: R01AI130019
Source: Self-asserted source
Isaac Chiu via DimensionsWizard

Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota

2016-09-30 to 2021-06-30 | Grant
National Center for Complementary and Integrative Health (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.6443333
GRANT_NUMBER: DP2AT009499
Source: Self-asserted source
Isaac Chiu via DimensionsWizard

The role of nociceptor neurons in bacterial host defense and inflammation

2015-04-15 to 2017-03-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.3935779
GRANT_NUMBER: K22AI114810
Source: Self-asserted source
Isaac Chiu via DimensionsWizard

The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial I

2011-08-01 to 2013-07-31 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2390710
GRANT_NUMBER: F32NS076297
Source: Self-asserted source
Isaac Chiu via DimensionsWizard

Works (50 of 51)

Items per page:
Page 1 of 2

Sensory neurons on guard: roles in pathogen defense and host immunity

Current Opinion in Immunology
2025-04 | Journal article
DOI: 10.1016/j.coi.2025.102541
Contributors: Ozge Erdogan; Xiao-Qian Hu; Isaac M Chiu
Source: check_circle
Crossref

The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract

Nature Reviews Gastroenterology & Hepatology
2025-03 | Journal article
DOI: 10.1038/s41575-024-01017-9
Contributors: Kimberly A. Meerschaert; Isaac M. Chiu
Source: check_circle
Crossref

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis

Science Immunology
2025-01-28 | Journal article | Author
DOI: 10.1126/sciimmunol.adu2910
Contributors: beth stevens; Alec J Walker; Quentin Richardson; Ruaidhri Jackson; Christophe Benoist; JLTrejo; ELISA CINTADO; Isaac Chiu; Diane Mathis; Miguel Marin-Rodero et al.
Source: check_circle
AAAS - Science
grade
Preferred source (of 2)‎

Gasdermin D is activated but does not drive neurodegeneration in SOD1G93Amodel of ALS: Implications for targeting pyroptosis

2024-10-12 | Preprint
DOI: 10.1101/2024.10.10.617609
Contributors: Georgia Gunner; Himanish Basu; Yueting Lu; Matthew Bergstresser; Dylan Neel; So Yoen Choi; Isaac M. Chiu
Source: check_circle
Crossref

Sensory neurons: An integrated component of innate immunity

Immunity
2024-04 | Journal article
DOI: 10.1016/j.immuni.2024.03.008
Contributors: Liwen Deng; Jacob E. Gillis; Isaac M. Chiu; Daniel H. Kaplan
Source: check_circle
Crossref

The role of cellular and molecular neuroimmune crosstalk in gut immunity

Cellular & Molecular Immunology
2023-06-19 | Journal article
DOI: 10.1038/s41423-023-01054-5
Contributors: Daping Yang; Nicole Almanzar; Isaac M. Chiu
Source: check_circle
Crossref

An airway-to-brain sensory pathway mediates influenza-induced sickness

Nature
2023-03-23 | Journal article
DOI: 10.1038/s41586-023-05796-0
Contributors: Na-Ryum Bin; Sara L. Prescott; Nao Horio; Yandan Wang; Isaac M. Chiu; Stephen D. Liberles
Source: check_circle
Crossref

Interactions between nociceptor sensory neurons and microbial pathogens in pain

Pain
2022-11 | Journal article
DOI: 10.1097/j.pain.0000000000002721
Contributors: Larissa Staurengo-Ferrari; Liwen Deng; Isaac M. Chiu
Source: check_circle
Crossref

Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis

Immunological Reviews
2022-10 | Journal article
DOI: 10.1111/imr.13083
Contributors: Dylan V. Neel; Himanish Basu; Georgia Gunner; Isaac M. Chiu
Source: check_circle
Crossref

Enteric glial cells mediate gut immunity and repair

Trends in Neurosciences
2022-04 | Journal article
DOI: 10.1016/j.tins.2021.12.001
Contributors: Antonia Wallrapp; Daping Yang; Isaac M. Chiu
Source: check_circle
Crossref

Somatosensory and autonomic neuronal regulation of the immune response

Nature Reviews Neuroscience
2022-03 | Journal article
DOI: 10.1038/s41583-021-00555-4
Contributors: Swalpa Udit; Kimbria Blake; Isaac M. Chiu
Source: check_circle
Crossref

Bacteria hijack a neuro-immune axis in the meninges to facilitate brain invasion

2022-03-25 | Preprint
DOI: 10.21203/rs.3.rs-1479118/v1
Contributors: Isaac Chiu; Felipe Pinho-Ribeiro; Liwen Deng; Dylan Neel; Ozge Erdogan; Alec Walker; Simone Carneiro-Nascimento; Kathleen He; Glendon Wu; Beth Stevens et al.
Source: check_circle
Crossref

The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes

Mucosal Immunology
2021-05 | Journal article
DOI: 10.1038/s41385-020-00368-1
Contributors: Amanda Jacobson; Daping Yang; Madeleine Vella; Isaac M. Chiu
Source: check_circle
Crossref

Microbes and pain

PLOS Pathogens
2021-04-01 | Journal article
DOI: 10.1371/journal.ppat.1009398
Contributors: Liwen Deng; Jorn Coers; Isaac M. Chiu
Source: check_circle
Crossref

Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle

Proceedings of the National Academy of Sciences
2020-03-10 | Journal article
DOI: 10.1073/pnas.1922559117
Contributors: Kathy Wang; Omar K. Yaghi; Raul German Spallanzani; Xin Chen; David Zemmour; Nicole Lai; Isaac M. Chiu; Christophe Benoist; Diane Mathis
Source: check_circle
Crossref

Nociceptor nerves set the stage for skin immunity

Cell Research
2019-11-16 | Journal article
DOI: 10.1038/s41422-019-0240-x
Contributors: Felipe A. Pinho-Ribeiro; Isaac M. Chiu
Source: check_circle
Crossref

Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.

Immunity
2019-04-10 | Journal article
DOI: 10.1016/j.immuni.2019.03.023
PMID: 31027995
Source: Self-asserted source
Isaac Chiu

Pain and immunity: implications for host defence.

Nature reviews. Immunology
2019-03-15 | Journal article
DOI: 10.1038/s41577-019-0147-2
PMID: 30874629
Source: Self-asserted source
Isaac Chiu
grade
Preferred source (of 2)‎

Molecular link between itch and atopic dermatitis.

Proceedings of the National Academy of Sciences of the United States of America
2018-12-11 | Journal article
DOI: 10.1073/pnas.1818879115
PMID: 30538205
Source: Self-asserted source
Isaac Chiu

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection.

Cell
2018-05-10 | Journal article
DOI: 10.1016/j.cell.2018.04.006
PMID: 29754819
Source: Self-asserted source
Isaac Chiu

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.

Nature medicine
2018-03-05 | Journal article
DOI: 10.1038/nm.4501
PMID: 29505031
PMC: PMC6263165
Source: Self-asserted source
Isaac Chiu

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.

Nature communications
2018-01-02 | Journal article
DOI: 10.1038/s41467-017-02448-6
PMID: 29295977
PMC: PMC5750211
Source: Self-asserted source
Isaac Chiu

Neuro-immune interactions in inflammation and host defense: Implications for transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2017-10-27 | Journal article
DOI: 10.1111/ajt.14515
PMID: 28941325
PMC: PMC5820210
Source: Self-asserted source
Isaac Chiu

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Nature
2017-09-13 | Journal article
DOI: 10.1038/nature24029
PMID: 28902842
PMC: PMC5746044
Source: Self-asserted source
Isaac Chiu

Neuro-immune interactions in allergic diseases: novel targets for therapeutics.

International immunology
2017-06-01 | Journal article
DOI: 10.1093/intimm/dxx040
PMID: 28814067
PMC: PMC5890890
Source: Self-asserted source
Isaac Chiu

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

Cell
2017-03-02 | Journal article
DOI: 10.1016/j.cell.2017.02.009
PMID: 28262351
PMC: PMC5396461
Source: Self-asserted source
Isaac Chiu

Infection, Pain, and Itch.

Neuroscience bulletin
2017-01-31 | Journal article
DOI: 10.1007/s12264-017-0098-1
PMID: 28144843
PMC: PMC5799131
Source: Self-asserted source
Isaac Chiu

Bacterial Signaling to the Nervous System through Toxins and Metabolites.

Journal of molecular biology
2017-01-06 | Journal article
DOI: 10.1016/j.jmb.2016.12.023
PMID: 28065740
PMC: PMC5325782
Source: Self-asserted source
Isaac Chiu
grade
Preferred source (of 2)‎

Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.

Trends in immunology
2016-10-25 | Journal article
DOI: 10.1016/j.it.2016.10.001
PMID: 27793571
PMC: PMC5205568
Source: Self-asserted source
Isaac Chiu

Pain and infection: pathogen detection by nociceptors.

Pain
2016-06-01 | Journal article
DOI: 10.1097/j.pain.0000000000000559
PMID: 27183444
PMC: PMC4874496
Source: Self-asserted source
Isaac Chiu

Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?

Cell host & microbe
2016-06-01 | Journal article
DOI: 10.1016/j.chom.2016.05.010
PMID: 27281567
Source: Self-asserted source
Isaac Chiu

CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.

Proceedings of the National Academy of Sciences of the United States of America
2015-11-23 | Journal article
DOI: 10.1073/pnas.1501372112
PMID: 26598697
PMC: PMC4679057
Source: Self-asserted source
Isaac Chiu

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

Neuron
2015-06-25 | Journal article
DOI: 10.1016/j.neuron.2015.06.007
PMID: 26119026
PMC: PMC4506220
Source: Self-asserted source
Isaac Chiu

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

eLife
2014-12-19 | Journal article
DOI: 10.7554/eLife.04660
PMID: 25525749
PMC: PMC4383053
Source: Self-asserted source
Isaac Chiu

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

Nature neuroscience
2014-11-24 | Journal article
DOI: 10.1038/nn.3886
PMID: 25420066
PMC: PMC4429606
Source: Self-asserted source
Isaac Chiu

L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials.

Organic & biomolecular chemistry
2014-09-01 | Journal article
DOI: 10.1039/c4ob01362j
PMID: 25078446
PMC: PMC4160809
Source: Self-asserted source
Isaac Chiu

Bacteria activate sensory neurons that modulate pain and inflammation.

Nature
2013-08-21 | Journal article
DOI: 10.1038/nature12479
PMID: 23965627
PMC: PMC3773968
Source: Self-asserted source
Isaac Chiu

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.

Cell reports
2013-07-11 | Journal article
DOI: 10.1016/j.celrep.2013.06.018
PMID: 23850290
PMC: PMC4272581
Source: Self-asserted source
Isaac Chiu

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.

Nature neuroscience
2012-07-26 | Journal article
DOI: 10.1038/nn.3144
PMID: 22837035
PMC: PMC3520068
Source: Self-asserted source
Isaac Chiu

Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction.

Cardiovascular research
2010-05-11 | Journal article
DOI: 10.1093/cvr/cvq141
PMID: 20462867
PMC: PMC2920809
Source: Self-asserted source
Isaac Chiu

Targeted delivery of siRNA to macrophages for anti-inflammatory treatment.

Molecular therapy : the journal of the American Society of Gene Therapy
2010-03-09 | Journal article
DOI: 10.1038/mt.2010.27
PMID: 20216529
PMC: PMC2890121
Source: Self-asserted source
Isaac Chiu

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America
2009-11-20 | Journal article
DOI: 10.1073/pnas.0911405106
PMID: 19933335
PMC: PMC2791631
Source: Self-asserted source
Isaac Chiu

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.

Proceedings of the National Academy of Sciences of the United States of America
2008-11-07 | Journal article
DOI: 10.1073/pnas.0804610105
PMID: 18997009
PMC: PMC2581614
Source: Self-asserted source
Isaac Chiu

Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action.

Biochemical and biophysical research communications
2007-05-22 | Journal article
DOI: 10.1016/j.bbrc.2007.05.058
PMID: 17521609
Source: Self-asserted source
Isaac Chiu

Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.

The Journal of cell biology
2006-10-01 | Journal article
DOI: 10.1083/jcb.200606016
PMID: 17060494
PMC: PMC2064562
Source: Self-asserted source
Isaac Chiu

Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury.

Biochemical and biophysical research communications
2006-08-22 | Journal article
DOI: 10.1016/j.bbrc.2006.08.065
PMID: 16942749
Source: Self-asserted source
Isaac Chiu

Identification of the target self-antigens in reperfusion injury.

The Journal of experimental medicine
2006-01-03 | Journal article
DOI: 10.1084/jem.20050390
PMID: 16390934
PMC: PMC2118091
Source: Self-asserted source
Isaac Chiu

Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury.

Proceedings of the National Academy of Sciences of the United States of America
2004-03-03 | Journal article
DOI: 10.1073/pnas.0400347101
PMID: 14999103
PMC: PMC374339
Source: Self-asserted source
Isaac Chiu

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.

Proceedings of the National Academy of Sciences of the United States of America
2004-01-12 | Journal article
DOI: 10.1073/pnas.2036345100
PMID: 14718661
PMC: PMC321754
Source: Self-asserted source
Isaac Chiu

The human natural killer cell immune synapse.

Proceedings of the National Academy of Sciences of the United States of America
1999-12-01 | Journal article
DOI: 10.1073/pnas.96.26.15062
PMID: 10611338
PMC: PMC24773
Source: Self-asserted source
Isaac Chiu
Items per page:
Page 1 of 2

Peer review (21 reviews for 10 publications/grants)

Review activity for Cell reports. (1)
Review activity for Cell. (3)
Review activity for eLife (1)
Review activity for Immunity. (4)
Review activity for Mucosal immunology. (1)
Review activity for Nature (6)
Review activity for Nature cell biology (1)
Review activity for Nature immunology. (1)
Review activity for Nature neuroscience. (2)
Review activity for Nature protocols (1)
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