Personal information

tendon, regenerative medicine, cell biology, extracellular matrix, secretome
United States

Biography

Jason Chang Marvin, Ph.D. (Pronouns: he/they) is a Harvard Medical School (HMS) Dean's Postdoctoral Fellow in the Center for Regenerative Medicine at the Massachusetts General Hospital (MGH) under the mentorship of Prof. Jenna Galloway. As a postdoctoral fellow, Jason aims to complement their engineering skillset with genetic and developmental biology approaches to investigate the biological mechanisms underlying effective musculoskeletal tissue repair and remodeling. Specifically, he will leverage the zebrafish, a robust vertebrate model of tendon regeneration, to generate novel ECM transgenic reporter lines that will be coupled with integrative multi-omics analyses. Their research seeks to elucidate the role of key ECM constituents in regulating the activity of resident cell populations in the tendon to ultimately orchestrate an improved healing response. This work will provide important mechanistic insight into designing new clinical interventions for tendinopathy. After completing his postdoctoral training, Jason is interested in pursuing a tenure-track faculty position in biomedical engineering/bioengineering and/or orthopaedic surgery.

Jason received his B.S. in biomedical engineering from the University of Texas at Dallas (UT-Dallas) in May 2017. Their undergraduate senior thesis under the mentorship of Prof. Danieli Rodrigues focused on characterizing the biocompatibility of commercial dental cement formulations used in clinical implant restorations. More recently, Jason received his Ph.D. in biomedical engineering from Cornell University in April 2022. Their dissertation research under the mentorship of Prof. Nelly Andarawis-Puri leveraged the super-healer Murphy Roth's Large (MRL/MpJ) mouse strain to identify candidate protein regulators of mammalian tendon regeneration. This work culminated in the development of a patented protein-based biologic therapy that can promote regenerative behavior in otherwise non-healer rodent tendon cells. Their dissertation research was supported by a National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) Fellow and Cornell Provost Diversity Fellowship.

Jason is currently a member of the Biomedical Engineering Society (BMES) Diversity Committee, Orthopaedic Research Society (ORS) Public Outreach Committee, and ORS Tendon Section Membership Committee. Previously, Jason served as the Director of Mentorship for Out in STEM (oSTEM), Inc. to help launch a global mentorship program for LGBTQ+ students and professionals. At Cornell, Jason served as a Center for Teaching Innovation (CTI) Graduate Fellow and Graduate Resident Fellow (GRF) in the West Campus House System, facilitating workshops and resources to enhance the personal and professional development of his fellow Cornellians. Jason has also served as the Outreach Co-Chair for the Cornell Graduate Biomedical Engineering Society chapter and as a GRASSHOPR Fellow to improve STEM literacy and expose local youth to careers in science. He has also organized a series of Communication Science (ComSciCon) workshops (Cornell’18/NY’19/ScienceWriters’19) that offered STEM researchers hands-on science communication training.

Activities

Employment (1)

Massachusetts General Hospital: Boston, Massachusetts, US

2022-07-11 to present | HMS Dean's Postdoctoral Fellow (Center for Regenerative Medicine)
Employment
Source: Self-asserted source
Jason Chang Marvin

Education and qualifications (3)

Cornell University: Ithaca, New York, US

2017-08-01 to 2022-04-25 | Doctor of Philosophy (PhD) (Biomedical Engineering)
Qualification
Source: Self-asserted source
Jason Chang Marvin

Cornell University: Ithaca, New York, US

2017-08-01 to 2019-06-30 | Master's of Science (MS) (Biomedical Engineering)
Qualification
Source: Self-asserted source
Jason Chang Marvin

University of Texas at Dallas: Richardson, Texas, US

2013-08-01 to 2017-05-31 | Bachelor's Degree (BS) (Biomedical Engineering)
Education
Source: Self-asserted source
Jason Chang Marvin

Professional activities (10)

Orthopaedic Research Society: Rosemont, Illinois, US

2022-10-31 to present | Member and Organizer (Education, Diversity, Equity, and Inclusion Research Interest Group (RIG))
Service
Source: Self-asserted source
Jason Chang Marvin

Gordon Research Conferences: Kingston, Rhode Island, US

2022-08-12 to present | Co-Chair (Gordon Research Seminar (GRS) on Musculoskeletal Biology and Bioengineering)
Invited position
Source: Self-asserted source
Jason Chang Marvin

Biomedical Engineering Society: Landover, Maryland, US

2022-07-01 to present | Member (BME Organizations leading Diversity (BOLD))
Service
Source: Self-asserted source
Jason Chang Marvin

Orthopaedic Research Society: Rosemont, Illinois, US

2021-02-01 to present | Member (Tendon Section Membership Committee)
Service
Source: Self-asserted source
Jason Chang Marvin

Orthopaedic Research Society: Rosemont, Illinois, US

2021-01-01 to present | Member (Public Outreach Committee)
Service
Source: Self-asserted source
Jason Chang Marvin

Biomedical Engineering Society: Landover, Maryland, US

2020-01-01 to 2023-01-01 | Member (Diversity Committee)
Service
Source: Self-asserted source
Jason Chang Marvin

ComSciCon: N/A, US

2019-10-01 to 2020-10-01 | Conference Chair (ComSciCon-Science Writers (SciWri) 2020 Workshop)
Invited position
Source: Self-asserted source
Jason Chang Marvin

ComSciCon: N/A, US

2018-11-01 to 2019-10-01 | Conference Chair (ComSciCon-Science Writers (SciWri) 2019 Workshop)
Invited position
Source: Self-asserted source
Jason Chang Marvin

Out in Science, Technology, Engineering, and Mathematics (oSTEM), Inc.: N/A, US

2018-12-01 to 2019-06-01 | Director of Mentorship (Diversity, Equity, and Inclusion Committee)
Service
Source: Self-asserted source
Jason Chang Marvin

ComSciCon: N/A, US

2017-10-01 to 2018-10-01 | Co-Organizer (ComSciCon-Cornell 2018 Workshop)
Invited position
Source: Self-asserted source
Jason Chang Marvin

Works (6)

Proteins Derived From MRL/MpJ Tendon Provisional Extracellular Matrix and Secretome Promote Pro-Regenerative Tenocyte Behavior

2024-07-11 | Preprint
Contributors: Jason C. Marvin; Ethan J. Liu; Hsin Huei Chen; David A. Shiovitz; Nelly Andarawis-Puri
Source: check_circle
Crossref

Regenerative MRL/MpJ tendon cells exhibit sex differences in morphology, proliferation, mechanosensitivity, and cell–ECM organization

Journal of Orthopaedic Research
2023-10 | Journal article
Contributors: Jason C. Marvin; Molly E. Brakewood; Mong L. S. Poon; Nelly Andarawis‐Puri
Source: check_circle
Crossref

Detergent-Free Decellularization Preserves the Mechanical and Biological Integrity of Murine Tendon

Tissue Engineering Part C: Methods
2022-11-03 | Journal article
Part of ISSN: 1937-3384
Part of ISSN: 1937-3392
Contributors: Jason Chang Marvin; Ai Mochida; Juan Paredes; Brenna Renee Vaughn; Nelly Andarawis-Puri
Source: Self-asserted source
Jason Chang Marvin
grade
Preferred source (of 2)‎

Innate tissue properties drive improved tendon healing in MRL/MpJ and harness cues that enhance behavior of canonical healing cells

The FASEB Journal
2020-06 | Journal article
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Jason Chang Marvin

In Vitro Evaluation of Cell Compatibility of Dental Cements Used with Titanium Implant Components

Journal of prosthodontics : official journal of the American College of Prosthodontists
2019 | Journal article
Source: Self-asserted source
Jason Chang Marvin

High-performance coils and yarns of polymeric piezoelectric nanofibers

ACS applied materials & interfaces
2015 | Journal article
Source: Self-asserted source
Jason Chang Marvin

Peer review (5 reviews for 1 publication/grant)

Review activity for Connective tissue research. (5)