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Scopus Author ID: 7004381068

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Employment (1)

Sheffield Hallam University: Sheffield, Sheffield, GB

2007-07-01 to present | Professor of Mass Spectrometry (Biosciences and Chemistry)
Employment
Source: Self-asserted source
Malcolm Clench

Education and qualifications (2)

Manchester Polytechnic/UMIST: Manchester, GB

1982-02-28 to 1985-03-01 | PhD "Strategies for Peptide and Protein Sequencing by Fast Atom Bombardment Mass Spectrometry" (Biosciences/Chemistry)
Education
Source: Self-asserted source
Malcolm Clench

Sheffield City Polytechnic: Sheffield , GB

1977-09-30 to 1981-06-30 | BSc(Hons) Applied Chemistry (Chemistry)
Education
Source: Self-asserted source
Malcolm Clench

Works (50 of 100)

Items per page:
Page 1 of 2

Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA–ICP–TOFMS Imaging

Analytical Chemistry
2022-02-08 | Journal article
DOI: 10.1021/acs.analchem.1c04857
Contributors: Oana M. Voloaca; Malcolm R. Clench; Gunda Koellensperger; Laura M. Cole; Sarah L. Haywood-Small; Sarah Theiner
Source: check_circle
Crossref

Monitoring the three‐dimensional distribution of endogenous species in the lungs by matrix‐assisted laser desorption/ionization mass spectrometry imaging

Rapid Communications in Mass Spectrometry
2021-01-15 | Journal article
DOI: 10.1002/rcm.8957
Contributors: Bryn Flinders; Josie Morrell; Peter S. Marshall; Lisa E. Ranshaw; Ron M.A. Heeren; Malcolm R. Clench
Source: check_circle
Crossref

Laser ablation inductively coupled plasma mass spectrometry as a novel clinical imaging tool to detect asbestos fibres in malignant mesothelioma

Rapid Communications in Mass Spectrometry
2020-11-15 | Journal article
DOI: 10.1002/rcm.8906
Contributors: Oana M. Voloaca; Calum J. Greenhalgh; Laura M. Cole; Malcolm R. Clench; Amy J. Managh; Sarah L. Haywood‐Small
Source: check_circle
Crossref

Emerging applications in mass spectrometry imaging; enablers and roadblocks

Journal of Spectral Imaging
2020-10-26 | Journal article
DOI: 10.1255/jsi.2020.a13
Contributors: Cristina Russo; Cameron Heaton; Lucy Flint; Oana Voloaca; Sarah Haywood-Small; Malcolm Clench; Simona Francese; Laura Cole
Source: check_circle
Crossref

Characterization of an Aggregated Three-Dimensional Cell Culture Model by Multimodal Mass Spectrometry Imaging

Analytical Chemistry
2020-09-15 | Journal article
DOI: 10.1021/acs.analchem.0c02389
Contributors: Lucy E. Flint; Gregory Hamm; Joseph D. Ready; Stephanie Ling; Catherine J. Duckett; Neil A. Cross; Laura M. Cole; David P. Smith; Richard J. A. Goodwin; Malcolm R. Clench
Source: check_circle
Crossref

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

Proceedings of the National Academy of Sciences
2020-03-17 | Journal article
DOI: 10.1073/pnas.1917421117
Contributors: Eylan Yutuc; Roberto Angelini; Mark Baumert; Natalia Mast; Irina Pikuleva; Jillian Newton; Malcolm R. Clench; David O. F. Skibinski; Owain W. Howell; Yuqin Wang et al.
Source: check_circle
Crossref

Matrix-assisted ionisation in vacuum mass spectrometry and imaging on a modified quadrupole-quadrupole-time-of-flight mass spectrometer

Journal of Spectral Imaging
2019-07-15 | Journal article
DOI: 10.1255/jsi.2019.a12
Contributors: Alex Harding; James Hough; Charlotte Curtis; Daniel Kinsman; Malcolm Clench
Source: check_circle
Crossref

Quantitative Investigation of Terbinafine Hydrochloride Absorption into a Living Skin Equivalent Model by MALDI-MSI

Analytical Chemistry
2018-08-21 | Journal article
DOI: 10.1021/acs.analchem.8b02648
Contributors: Cristina Russo; Neil Brickelbank; Catherine Duckett; Steve Mellor; Stephen Rumbelow; Malcolm R. Clench
Source: check_circle
Crossref

Examination of the skin barrier repair/wound healing process using a living skin equivalent model and matrix‐assisted laser desorption‐ionization‐mass spectrometry imaging

International Journal of Cosmetic Science
2018-04 | Journal article
DOI: 10.1111/ics.12446
Contributors: E. E. L. Lewis; M. R. T. Barrett; L. Freeman‐Parry; R. A. Bojar; M. R. Clench
Source: check_circle
Crossref

Antigen retrieval prior to on-tissue digestion of formalin-fixed paraffin-embedded tumour tissue sections yields oxidation of proline residues

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
2017-07 | Journal article
DOI: 10.1016/j.bbapap.2016.11.019
Contributors: Marie-Claude Djidja; Emmanuelle Claude; Peter Scriven; David W. Allen; Vikki A. Carolan; Malcolm R. Clench
Source: check_circle
Crossref

Alternative surfactants for improved efficiency of in situ tryptic proteolysis of fingermarks

Journal of the American Society for Mass Spectrometry
2015 | Journal article
DOI: 10.1007/s13361-015-1140-z
EID:

2-s2.0-84929008772
Contributors: Patel, E.; Clench, M.R.; West, A.; Marshall, P.S.; Marshall, N.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics

Bioanalysis
2015 | Journal article
DOI: 10.4155/bio.14.280
EID:

2-s2.0-84920736329
Contributors: Patel, E.; Cole, L.M.; Bradshaw, R.; Batubara, A.; Mitchell, C.A.; Francese, S.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Mass spectrometry imaging for the proteomic study of clinical tissue

Proteomics - Clinical Applications
2015 | Journal article
DOI: 10.1002/prca.201400103
EID:

2-s2.0-84928054071
Contributors: Cole, L.M.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

"afterlife experiment": Use of MALDI-MS and SIMS imaging for the study of the nitrogen cycle within plants

Analytical Chemistry
2014 | Journal article
DOI: 10.1021/ac501191w
EID:

2-s2.0-84910675758
Contributors: Seaman, C.; Flinders, B.; Eijkel, G.; Heeren, R.M.A.; Bricklebank, N.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Direct detection of blood in fingermarks by MALDI MS profiling and Imaging

Science and Justice
2014 | Journal article
DOI: 10.1016/j.scijus.2013.12.004
EID:

2-s2.0-84895873032
Contributors: Bradshaw, R.; Bleay, S.; Clench, M.R.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Identification of the reactive metabolites of fenclozic acid in bile duct cannulated rats

Analytical Chemistry
2014 | Journal article
DOI: 10.1021/ac502943d
EID:

2-s2.0-84922569861
Contributors: Martin, S.; Lenz, E.M.; Keene, W.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

MALDI-MSI and label-free LC-ESI-MS/MS shotgun proteomics to investigate protein induction in a murine fibrosarcoma model following treatment with a vascular disrupting agent

Proteomics
2014 | Journal article
DOI: 10.1002/pmic.201300429
EID:

2-s2.0-84897413741
Contributors: Cole, L.M.; Bluff, J.E.; Carolan, V.A.; Paley, M.N.; Tozer, G.M.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis

Analytical Chemistry
2014 | Journal article
DOI: 10.1021/ac502217r
EID:

2-s2.0-84906260278
Contributors: Swales, J.G.; Tucker, J.W.; Strittmatter, N.; Nilsson, A.; Cobice, D.; Clench, M.R.; Mackay, C.L.; Andren, P.E.; Takáts, Z.; Webborn, P.J.H. et al.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Radiation-induced changes in serum lipidome of head and neck cancer patients

International Journal of Molecular Sciences
2014 | Journal article
DOI: 10.3390/ijms15046609
EID:

2-s2.0-84899148563
Contributors: Jelonek, K.; Pietrowska, M.; Ros, M.; Zagdanski, A.; Suchwalko, A.; Polanska, J.; Marczyk, M.; Rutkowski, T.; Skladowski, K.; Clench, M.R. et al.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

The use of hydrazine-based derivatization reagents for improved sensitivity and detection of carbonyl containing compounds using MALDI-MSI

Analytical and Bioanalytical Chemistry
2014 | Journal article
DOI: 10.1007/s00216-014-8223-8
EID:

2-s2.0-84908426218
Contributors: Flinders, B.; Morrell, J.; Marshall, P.S.; Ranshaw, L.E.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Beyond the ridge pattern: Multi-informative analysis of latent fingermarks by MALDI mass spectrometry

Analyst
2013 | Journal article
DOI: 10.1039/c3an36896c
EID:

2-s2.0-84879771448
Contributors: Francese, S.; Bradshaw, R.; Ferguson, L.S.; Wolstenholme, R.; Clench, M.R.; Bleay, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Curcumin: A multipurpose matrix for MALDI mass spectrometry imaging applications

Analytical Chemistry
2013 | Journal article
DOI: 10.1021/ac4007396
EID:

2-s2.0-84878272582
Contributors: Francese, S.; Bradshaw, R.; Flinders, B.; Mitchell, C.; Bleay, S.; Cicero, L.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging

European Journal of Mass Spectrometry
2013 | Journal article
DOI: 10.1255/ejms.1212
EID:

2-s2.0-84878842043
Contributors: Mahmoud, K.; Cole, L.M.; Newton, J.; Mohamed, S.; Al-Enazi, M.; Quirke, P.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Efficiency of the dry-wet method for the MALDI-MSI analysis of latent fingermarks

Journal of Mass Spectrometry
2013 | Journal article
DOI: 10.1002/jms.3216
EID:

2-s2.0-84878504103
Contributors: Ferguson, L.S.; Creasey, S.; Wolstenholme, R.; Clench, M.R.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Matrix assisted laser desorption ionisation ion mobility separation mass spectrometry imaging of ex-vivo human skin

International Journal for Ion Mobility Spectrometry
2013 | Journal article
DOI: 10.1007/s12127-013-0124-6
EID:

2-s2.0-84876926998
Contributors: Hart, P.J.; Francese, S.; Woodroofe, M.N.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Recombinant « IMS TAG» proteins - A new method for validating bottom-up matrix-assisted laser desorption/ionisation ion mobility separation mass spectrometry imaging

Rapid Communications in Mass Spectrometry
2013 | Journal article
DOI: 10.1002/rcm.6693
EID:

2-s2.0-84885213661
Contributors: Cole, L.M.; Mahmoud, K.; Haywood-Small, S.; Tozer, G.M.; Smith, D.P.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Spectroscopic imaging based approach for condom identification in condom contaminated fingermarks

Analyst
2013 | Journal article
DOI: 10.1039/c3an00195d
EID:

2-s2.0-84875834297
Contributors: Bradshaw, R.; Wolstenholme, R.; Ferguson, L.S.; Sammon, C.; Mader, K.; Claude, E.; Blackledge, R.D.; Clench, M.R.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

T4 Report* Metabolomics in toxicology and preclinical research

Altex
2013 | Journal article
EID:

2-s2.0-84877593138
Contributors: Ramirez, T.; Daneshian, M.; Kamp, H.; Bois, F.Y.; Clench, M.R.; Coen, M.; Donley, B.; Fischer, S.M.; Ekman, D.R.; Fabian, E. et al.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Targeting of Hypoxia in AQ4N-Treated Tumour xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging

Current Analytical Chemistry
2013 | Journal article
EID:

2-s2.0-84875340078
Contributors: Djidja, M.-C.; Francese, S.; Claude, E.; Loadman, P.; Sutton, C.; Shynder, S.; Cooper, P.; Patterson, L.H.; Carolan, V.A.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

The relationship of HLA-class I derived leader peptide mismatch and renal function within the first 12months post-renal transplant

Tissue Antigens
2013 | Journal article
DOI: 10.1111/tan.12191
EID:

2-s2.0-84890856618
Contributors: Battle, R.; Woodroofe, N.; Clench, M.; Clark, B.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Towards the integration of matrix assisted laser desorption ionisation mass spectrometry imaging into the current fingermark examination workflow

Forensic Science International
2013 | Journal article
DOI: 10.1016/j.forsciint.2013.07.013
EID:

2-s2.0-84882792069
Contributors: Bradshaw, R.; Bleay, S.; Wolstenholme, R.; Clench, M.R.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Bioactive actions of pomegranate fruit extracts on leukemia cell lines in vitro hold promise for new therapeutic agents for leukemia

Nutrition and Cancer
2012 | Journal article
DOI: 10.1080/01635581.2012.630155
EID:

2-s2.0-84856928858
Contributors: Dahlawi, H.; Jordan-Mahy, N.; Clench, M.R.; Le Maitre, C.L.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Direct detection of peptides and small proteins in fingermarks and determination of sex by MALDI mass spectrometry profiling

Analyst
2012 | Journal article
DOI: 10.1039/c2an36074h
EID:

2-s2.0-84866517851
Contributors: Ferguson, L.S.; Wulfert, F.; Wolstenholme, R.; Fonville, J.M.; Clench, M.R.; Carolan, V.A.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells

Anti-Cancer Agents in Medicinal Chemistry
2012 | Journal article
EID:

2-s2.0-84861662981
Contributors: Zaini, R.G.; Brandt, K.; Clench, M.R.; Le Maitre, C.L.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

In situ imaging of honeybee (Apis mellifera) venom components from aqueous and aluminum hydroxide-adsorbed venom immunotherapy preparations

Journal of Allergy and Clinical Immunology
2012 | Journal article
DOI: 10.1016/j.jaci.2011.10.014
EID:

2-s2.0-84860455187
Contributors: Seppälä, U.; Francese, S.; Turillazzi, S.; Moneti, G.; Clench, M.; Barber, D.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Instrumentation and software for mass spectrometry imaging-Making the most of what you've got

Journal of Proteomics
2012 | Journal article
DOI: 10.1016/j.jprot.2012.07.016
EID:

2-s2.0-84865188601
Contributors: Trim, P.J.; Djidja, M.-C.; Muharib, T.; Cole, L.M.; Flinders, B.; Carolan, V.A.; Francese, S.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Reaction of homopiperazine with endogenous formaldehyde: A carbon hydrogen addition metabolite/product identified in rat urine and blood

Drug Metabolism and Disposition
2012 | Journal article
DOI: 10.1124/dmd.112.044917
EID:

2-s2.0-84863930272
Contributors: Martin, S.; Lenz, E.M.; Temesi, D.; Wild, M.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Separation of overlapping fingermarks by Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging

Forensic Science International
2012 | Journal article
DOI: 10.1016/j.forsciint.2012.07.009
EID:

2-s2.0-84865614186
Contributors: Bradshaw, R.; Rao, W.; Wolstenholme, R.; Clench, M.R.; Bleay, S.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

A novel matrix-assisted laser desorption/ionisation mass spectrometry imaging based methodology for the identification of sexual assault suspects

Rapid Communications in Mass Spectrometry
2011 | Journal article
DOI: 10.1002/rcm.4858
EID:

2-s2.0-78651334050
Contributors: Bradshaw, R.; Wolstenholme, R.; Blackledge, R.D.; Clench, M.R.; Ferguson, L.S.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Bioactive chemicals from carrot (daucus carota) juice extracts for the treatment of leukemia

Journal of Medicinal Food
2011 | Journal article
DOI: 10.1089/jmf.2010.0284
EID:

2-s2.0-80755175241
Contributors: Zaini, R.; Clench, M.R.; Le Maitre, C.L.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI

Methods
2011 | Journal article
DOI: 10.1016/j.ymeth.2011.03.007
EID:

2-s2.0-79961177469
Contributors: Cole, L.M.; Djidja, M.-C.; Bluff, J.; Claude, E.; Carolan, V.A.; Paley, M.; Tozer, G.M.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

MALDI-MS imaging of lipids in ex vivo human skin

Analytical and Bioanalytical Chemistry
2011 | Journal article
DOI: 10.1007/s00216-011-5090-4
EID:

2-s2.0-79960564434
Contributors: Hart, P.J.; Francese, S.; Claude, E.; Woodroofe, M.N.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Matrix-assisted laser desorption mass spectrometry imaging for the examination of imipramine absorption by Straticell-RHE-EPI/001 an artificial model of the human epidermis

Xenobiotica
2011 | Journal article
DOI: 10.3109/00498254.2011.573015
EID:

2-s2.0-79960115291
Contributors: Avery, J.L.; McEwen, A.; Flinders, B.; Francese, S.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Two-step matrix application for the enhancement and imaging of latent fingermarks

Analytical Chemistry
2011 | Journal article
DOI: 10.1021/ac200619f
EID:

2-s2.0-79960345187
Contributors: Ferguson, L.; Bradshaw, R.; Wolstenholme, R.; Clench, M.; Francese, S.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Direct analysis of pharmaceutical tablet formulations using matrix-assisted laser desorption/ionisation mass spectrometry imaging

Rapid Communications in Mass Spectrometry
2010 | Journal article
DOI: 10.1002/rcm.4525
EID:

2-s2.0-77952913101
Contributors: Earnshaw, C.J.; Carolan, V.A.; Richards, D.S.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Examination of the translocation of sulfonylurea herbicides in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging

Rapid Communications in Mass Spectrometry
2010 | Journal article
DOI: 10.1002/rcm.4767
EID:

2-s2.0-78651231750
Contributors: Anderson, D.M.G.; Carolan, V.A.; Crosland, S.; Sharples, K.R.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Introduction of a 20 kHz Nd:YVO4 laser into a hybrid quadrupole time-of-flight mass spectrometer for MALDI-MS imaging

Analytical and Bioanalytical Chemistry
2010 | Journal article
DOI: 10.1007/s00216-010-3874-6
EID:

2-s2.0-77956057273
Contributors: Trim, P.J.; Djidja, M.-C.; Atkinson, S.J.; Oakes, K.; Cole, L.M.; Anderson, D.M.G.; Hart, P.J.; Francese, S.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

MALDI Mass Spectrometry Imaging, a New Frontier in Biostructural Techniques: Applications in Biomedicine

Mass Spectrometry for Microbial Proteomics
2010 | Book
DOI: 10.1002/9780470665497.ch5
EID:

2-s2.0-84860466291
Contributors: Francese, S.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Novel molecular tumour classification using MALDI-mass spectrometry imaging of tissue micro-array

Analytical and Bioanalytical Chemistry
2010 | Journal article
DOI: 10.1007/s00216-010-3554-6
EID:

2-s2.0-77951256401
Contributors: Djidja, M.-C.; Claude, E.; Snel, M.F.; Francese, S.; Scriven, P.; Carolan, V.; Clench, M.R.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier

Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and -9: Implications for chemotaxis

Biochemical and Biophysical Research Communications
2009 | Journal article
DOI: 10.1016/j.bbrc.2009.02.164
EID:

2-s2.0-63349107684
Contributors: Denney, H.; Clench, M.R.; Woodroofe, M.N.
Source: Self-asserted source
Malcolm Clench via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (12 reviews for 3 publications/grants)

Review activity for Analytical chemistry. (10)
Review activity for Journal of the American Society for Mass Spectrometry. (1)
Review activity for Molecular pharmaceutics. (1)
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