Nompumelelo Prudence Mkhwanazi (0000-0002-0808-9201)

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Biography

Dr Nompumelelo Mkhwanazi holds a PhD in Virology as well as a master’s degree in medical science, which is followed by a BSc (Hons) degree in Biochemistry and a Bachelor of Science degree in Biochemistry and Microbiology. She is currently a Lecturer in Human Physiology and Medical Microbiology in the School of Laboratory Medicine and Medical Science at the University of KwaZulu-Natal and a faculty member and research supervisor at the HIV Pathogenesis Programme. Dr Mkhwanazi is interested in understanding the host-pathogen interactions, particularly those involving antiviral immune responses linked to preventing or managing HIV infection. Additionally, she is interested in the antiviral screening of bioactive substances derived from natural products and secondary metabolites from endophytic fungi. Her work aims to produce an HIV cure by utilising the antiviral properties of natural chemicals. Her areas of interest include microbiology, virology, immunology, medication development and screening, and interactions between viruses and hosts. Six honours and five master’s degree students have graduated with her. At present, she supervises four master’s and four doctoral students. She has co-authored a total of twenty peer-reviewed articles. Through peer review, she has reviewed five manuscripts for Wiley, Frontiers, Dove Press, and MDPI Journal. She is a supervisor and researcher at the Sub-Saharan African Network for TB/HIV Research Excellence consortium. Her research is funded by the South African Medical Research Council, the National Research Foundation and the Poliomyelitis Research Foundation.

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University of KwaZulu-Natal: Durban, KwaZulu-Natal, South Africa, ZA

2013-02-01 to present | HPP Faculty member; Lecturer; Research supervisor (HIV Pathogenesis Programme; School of Laboratory medicine and Medical Science)

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Nompumelelo Prudence Mkhwanazi

https://orcid.org/0000-0002-0808-9201

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Biography

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Employment (1)

University of KwaZulu-Natal: Durban, KwaZulu-Natal, South Africa, ZA

Education and qualifications (4)

University of KwaZulu-Natal: Durban, KZN, ZA

University of KwaZulu-Natal Press: Durban, KwaZulu-Natal, South Africa, ZA

University of KwaZulu-Natal - Pietermaritzburg Campus: Pietermaritzburg, KwaZulu-Natal, ZA

University of KwaZulu-Natal - Pietermaritzburg Campus: Pietermaritzburg, KwaZulu-Natal, ZA

Professional activities (1)

IAVI Leadership Development Programme: Nairobi, Kenya, KE

Funding (3)

Antiviral and immunomodulatory activities of the endophytic fungi secondary metabolites

Evolution of anti-Tat antibodies in early treated individuals

Antiviral testing from endophytic secondary metabolites

Works (25)

Alternaria alternata (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication

Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis

Analysis of antioxidant nutrients, anti-HIV and anticancer metabolic fingerprints of Pelargonium quercifolium (L.f) L'Hér

Camptothecin and Its Derivatives from Traditional Chinese Medicine in Combination with Anticancer Therapy Regimens: A Systematic Review and Meta-Analysis

Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and E-Selectin rs1805193 Polymorphisms in African Women Living with HIV and Preeclampsia

Anti-HIV Activity and Immunomodulatory Properties of Fractionated Crude Extracts of Alternaria alternata

In vitro anti-HIV, cytotoxicity and nutritional analysis of Trianthema portulacastrum L. (Aizoaceae)

Synthesis, characterization, in vitro antimycobacterial and cytotoxicity evaluation, DFT calculations, molecular docking and ADME studies of new isomeric benzimidazole-1,2,3-triazole-quinoline hybrid mixtures

Cationic Chitosan Derivatives for the Inactivation of HIV‑1 and SARS-CoV‑2 Enveloped Viruses

Epigenetic Induction of Secondary Metabolites Production in Endophytic Fungi Penicillium chrysogenum and GC-MS Analysis of Crude Metabolites with Anti-HIV-1 Activity

Developments in Exploring Fungal Secondary Metabolites as Antiviral Compounds and Advances in HIV-1 Inhibitor Screening Assays

Secondary metabolites produced by endophytic fungi, <i>Alternaria alternata</i>, as potential inhibitors of the human immunodeficiency virus.

Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.

HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703.

Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.

Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.

Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality

Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.

Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.

Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons.

Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.

Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.

High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.

Peer review (2 reviews for 1 publication/grant)

HLA-A7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B5703.