Personal information

Verified email domains

Activities

Employment (1)

Sapienza Università di Roma: ROMA, ROMA, IT

2008-03-01 to present | Professoressa di II fascia (Biologia e Biotecnologie, C. Darwin)
Employment
Source: Self-asserted source
LAURA CIAPPONI

Education and qualifications (2)

Sapienza Università di Roma: ROMA, ROMA, IT

1994-10-01 to 1997-10-31 | Dottorato di Ricerca in Genetica e Biologia Molecolare
Education
Source: Self-asserted source
LAURA CIAPPONI

Sapienza Università di Roma: ROMA, ROMA, IT

1988-10-01 to 1993-04-28 | Scienze Biologiche
Education
Source: Self-asserted source
LAURA CIAPPONI

Works (43)

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration

Cell Death Discovery
2023-09-27 | Journal article
Contributors: Marta Marzullo; Giulia Romano; Claudia Pellacani; Federico Riccardi; Laura Ciapponi; Fabian Feiguin
Source: check_circle
Crossref

Modeling Myotonic Dystrophy Type 2 Using Drosophila melanogaster

International Journal of Molecular Sciences
2023-09-16 | Journal article
Contributors: Marta Marzullo; Sonia Coni; Assia De Simone; Gianluca Canettieri; Laura Ciapponi
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration

2023-03-14 | Preprint
Contributors: Marta Marzullo; Giulia Romano; Claudia Pellacani; Federico Riccardi; Laura Ciapponi; Fabian Feiguin
Source: check_circle
Crossref

Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle

Cell Reports
2022-12 | Journal article
Part of ISSN: 2211-1247
EID:

2-s2.0-85144347410 (17)

Contributors: Chiara D’Ercole; Paolo D’Angelo; Veronica Ruggieri; Daisy Proietti; Laura Virtanen; Cristina Parisi; Carles Sanchez Riera; Alessandra Renzini; Alberto Macone; Marta Marzullo et al.
Source: Self-asserted source
LAURA CIAPPONI

Author Correction: Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious

Communications Biology
2022-09-29 | Journal article
Contributors: A. Porrazzo; F. Cipressa; A. De Gregorio; C. De Pittà; G. Sales; L. Ciapponi; P. Morciano; G. Esposito; M. A. Tabocchini; G. Cenci
Source: check_circle
Crossref

Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious

Communications Biology
2022-09-03 | Journal article
Contributors: A. Porrazzo; F. Cipressa; A. De Gregorio; C. De Pittà; G. Sales; L. Ciapponi; P. Morciano; G. Esposito; M. A. Tabocchini; G. Cenci
Source: check_circle
Crossref

Novel cell- and stage-specific transcriptional signatures defining Drosophila neurons, glia and hemocytes

2022-07-01 | Preprint
Contributors: Rosy Sakr; Pierre B. Cattenoz; Alexia Pavlidaki; Laura Ciapponi; Marta Marzullo; Nivedita Hariharan; Tina Mukherjee; Angela Giangrande
Source: check_circle
Crossref

Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

eLife
2021-09-14 | Journal article
Part of ISSN: 2050-084X
EID:

2-s2.0-85116196697

Source: Self-asserted source
LAURA CIAPPONI

Low dose rate γ-irradiation protects Drosophila melanogaster chromosomes from double strand breaks and telomere fusions by modulating the expression of the esi-RNA biogenesis factor Loquacious

2021-07-25 | Preprint
Contributors: A. Porrazzo; F. Cipressa; A. De Gregorio; C. De Pittà; G. Sales; L. Ciapponi; P. Morciano; G. Esposito; M.A. Tabocchini; G. Cenci
Source: check_circle
Crossref

Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

2021-04-30 | Other
Contributors: Laura Ciapponi; Sonia Coni; Federica Alice Falconio; Marta Marzullo; Marzia Munafo; Benedetta Zuliani; Federica Mosti; alessandro fatica; Zaira ianniello; Alberto Macone et al.
Source: check_circle
Crossref

Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development.

PLoS genetics
2020-05-26 | Journal article
Source: Self-asserted source
LAURA CIAPPONI

TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles.

BMC biology
2020-03-26 | Journal article
EID:

2-s2.0-85082510352

Source: Self-asserted source
LAURA CIAPPONI

NBS1 interacts with HP1 to ensure genome integrity.

Cell death & disease
2019-12-13 | Journal article
EID:

2-s2.0-85076269280

Source: Self-asserted source
LAURA CIAPPONI

The Drosophila telomere-capping protein verrocchio binds single-stranded DNA and protects telomeres from DNA damage response

Nucleic Acids Research
2017 | Journal article
EID:

2-s2.0-85019962618

Contributors: Cicconi, A.; Micheli, E.; Vernì, F.; Jackson, A.; Gradilla, A.C.; Cipressa, F.; Raimondo, D.; Bosso, G.; Wakefield, J.G.; Ciapponi, L. et al.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

PLoS Genetics
2015 | Journal article
EID:

2-s2.0-84937775616

Contributors: Burla, R.; Carcuro, M.; Raffa, G.D.; Galati, A.; Raimondo, D.; Rizzo, A.; La Torre, M.; Micheli, E.; Ciapponi, L.; Cenci, G. et al.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth

Developmental Cell
2015 | Journal article
EID:

2-s2.0-84945252145

Contributors: D'Amico, D.; Antonucci, L.; Di Magno, L.; Coni, S.; Sdruscia, G.; Macone, A.; Miele, E.; Infante, P.; Di Marcotullio, L.; De Smaele, E. et al.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres

PLoS Genetics
2015 | Journal article
EID:

2-s2.0-84937779983

Contributors: Cenci, G.; Ciapponi, L.; Marzullo, M.; Raffa, G.D.; Morciano, P.; Raimondo, D.; Burla, R.; Saggio, I.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc

Cell Cycle
2014 | Journal article
EID:

2-s2.0-84896873986

Contributors: Antonucci, L.; D'Amico, D.; Di Magno, L.; Coni, S.; Di Marcotullio, L.; Cardinali, B.; Gulino, A.; Ciapponi, L.; Canettieri, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Organization and evolution of Drosophila terminin: Similarities and differences between Drosophila and human telomeres

Frontiers in Oncology
2013 | Journal article
EID:

2-s2.0-84887471653

Contributors: Raffa, G.D.; Cenci, G.; Ciapponi, L.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Organization and maintenance of Drosophila telomeres: the roles of terminin and non-terminin proteins.

Tsitologiia
2013 | Journal article
EID:

2-s2.0-84880049726

Contributors: Raffa, G.D.; Cenci, G.; Ciapponi, L.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Terminin: A protein complex that mediates epigenetic maintenance of Drosophila telomeres

Nucleus
2011 | Journal article
EID:

2-s2.0-80054688743

Contributors: Raffa, G.D.; Ciapponi, L.; Cenci, G.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex

Genes and Development
2010 | Journal article
EID:

2-s2.0-77955904676

Contributors: Raffa, G.D.; Raimondo, D.; Sorino, C.; Cugusi, S.; Cenci, G.; Cacchione, S.; Gatti, M.; Ciapponi, L.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Telomere capping and cellular checkpoints: Clues from fruit flies

Cytogenetic and Genome Research
2009 | Journal article
EID:

2-s2.0-59649089118

Contributors: Ciapponi, L.; Cenci, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection

Proceedings of the National Academy of Sciences of the United States of America
2009 | Journal article
EID:

2-s2.0-60549097506

Contributors: Raffa, G.D.; Siriaco, G.; Cugusi, S.; Ciapponi, L.; Cenci, G.; Wojcik, E.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference

PLoS Genetics
2008 | Journal article
EID:

2-s2.0-48249153027

Contributors: Somma, M.P.; Ceprani, F.; Bucciarelli, E.; Naim, V.; De Arcangelis, V.; Piergentili, R.; Palena, A.; Ciapponi, L.; Giansanti, M.G.; Pellacani, C. et al.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint

Nature Genetics
2008 | Journal article
EID:

2-s2.0-39749181579

Contributors: Musarò, M.; Ciapponi, L.; Fasulo, B.; Gatti, M.; Cenci, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

The Drosophila nbs protein functions in multiple pathways for the maintenance of genome stability

Genetics
2006 | Journal article
EID:

2-s2.0-33746429164

Contributors: Ciapponi, L.; Cenci, G.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

The mechanism of telomere protection: A comparison between Drosophila and humans

Chromosoma
2005 | Journal article
EID:

2-s2.0-25144468434

Contributors: Cenci, G.; Ciapponi, L.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage

Current Biology
2004 | Journal article
EID:

2-s2.0-4143072622

Contributors: Ciapponi, L.; Cenci, G.; Ducau, J.; Flores, C.; Johnson-Schlitz, D.; Gorski, M.M.; Engels, W.R.; Gatti, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: Evidence for serum factors interfering with the binding to gp130

Clinical and Experimental Immunology
2003 | Journal article
EID:

2-s2.0-0037318484

Contributors: Pignatti, P.; Ciapponi, L.; Galle, P.; Hansen, M.B.; Massa, M.; Meazza, C.; Paonessa, G.; Novick, D.; Ciliberto, G.; Martini, A. et al.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

An essential function of AP-1 heterodimers in Drosophila development

Mechanisms of Development
2002 | Journal article
EID:

2-s2.0-0036275438

Contributors: Ciapponi, L.; Bohmann, D.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Effects of IL-6 variants in multiple myeloma: Growth inhibition and induction of apoptosis in primary cells

Leukemia and Lymphoma
2002 | Journal article
EID:

2-s2.0-0036892050

Contributors: Petrucci, M.T.; Ricciardi, M.R.; Gregorj, C.; Ciapponi, L.; Savino, R.; Ciliberto, G.; Tafuri, A.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites

Genes and Development
2001 | Journal article
EID:

2-s2.0-0035876121

Contributors: Ciapponi, L.; Jackson, D.B.; Mlodzik, M.; Bohmann, D.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Adenovirus-mediated gene transfer of a human IL-6 antagonist

Gene Therapy
1997 | Journal article
EID:

2-s2.0-0030769757

Contributors: Saggio, I.; Ciapponi, L.; Savino, R.; Ciliberto, G.; Perricaudet, M.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Induction of interleukin-6 (Il-6) autoantibodies through vaccination with an engineered il-6 receptor antagonist

Nature Biotechnology
1997 | Journal article
EID:

2-s2.0-0030823269

Contributors: Ciapponi, L.; Maione, D.; Scoumanne, A.; Costa, P.; Hansen, M.B.; Svenson, M.; Bendtzen, K.; Alonzi, T.; Paonessa, G.; Cortese, R. et al.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

The receptor super-antagonist Sant7: A potent and safe inhibitor of IL-6 on human myeloma cells (review)

Oncology Reports
1997 | Journal article
EID:

2-s2.0-0030914016

Contributors: Savino, R.; Demartis, A.; Ciapponi, L.; Sporeno, E.; Toniatti, C.; Bernassola, F.; Melino, G.; Klein, B.; Ciliberto, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Cytokine gene expression in intestine of rat during the postnatal development period: Increased IL-1 expression at weaning

Life Sciences
1996 | Journal article
EID:

2-s2.0-0030572639

Contributors: Mengheri, E.; Ciapponi, L.; Vignolini, F.; Nobili, F.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells

Blood
1996 | Journal article
EID:

2-s2.0-9344259121

Contributors: Sporeno, E.; Savino, R.; Ciapponi, L.; Paonessa, G.; Cabibbo, A.; Lahm, A.; Pulkki, K.; Sun, R.-X.; Toniatti, C.; Klein, B. et al.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Definition of a composite binding site for gp130 in human interleukin-6

Journal of Biological Chemistry
1995 | Journal article
EID:

2-s2.0-0029595393

Contributors: Ciapponi, L.; Graziani, R.; Paonessa, G.; Lahm, A.; Ciliberto, G.; Savino, R.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

The Molecular Design of Human IL‐6 Receptor Antagonists

Annals of the New York Academy of Sciences
1995 | Book
EID:

2-s2.0-0029142531

Contributors: LAHM, A.; SAVINO, R.; SALVATI, A.L.; CABIBBO, A.; CIAPPONI, L.; DEMARTIS, A.; TONIATTI, C.; PAONESSA, G.; ALTAMURA, S.; CILIBERTO, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Two distinct and independent sites on IL-6 trigger gp130 dimer formation and signalling

EMBO Journal
1995 | Journal article
EID:

2-s2.0-0029002866

Contributors: Paonessa, G.; Graziani, R.; De Serio, A.; Savino, R.; Ciapponi, L.; Lahm, A.; Salvati, A.L.; Toniatti, C.; Ciliberto, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation

EMBO Journal
1994 | Journal article
EID:

2-s2.0-0028202123

Contributors: Savino, R.; Lahm, A.; Salvati, A.L.; Ciapponi, L.; Sporeno, E.; Altamura, S.; Paonessa, G.; Toniatti, C.; Ciliberto, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Rational design of a receptor super-antagonist of human interleukin-6

EMBO Journal
1994 | Journal article
EID:

2-s2.0-0028590077

Contributors: Savino, R.; Ciapponi, L.; Lahm, A.; Demartis, A.; Cabibbo, A.; Toniatti, C.; Delmastro, P.; Altamura, S.; Ciliberto, G.
Source: Self-asserted source
LAURA CIAPPONI via Scopus - Elsevier

Peer review (1 review for 1 publication/grant)

Review activity for Communications biology. (1)