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Biography

Dr. Paulus has been the Scientific Director and President of the Laureate Institute for Brain Research (LIBR) in Tulsa, OK since May 2014. Prior he had been a Professor in the Department of Psychiatry at the University of California San Diego and the Director of Telemental Health at the Veterans Affairs San Diego Health Care System. Dr. Paulus has a Google Scholar h-index of 101 and has published over 400 peer-reviewed manuscripts. Dr. Paulus is the Deputy Editor of JAMA Psychiatry, a Series Editor for Current Topics in Behavioral Neuroscience, and is on several editorial boards of top-tier psychiatric journals. He has served on numerous NIH and International Study Sections and is currently on the National Institute of Mental Health Board of Scientific Councilors. The goal for LIBR is to identify disease-modifying processes (DMP) based on circuits, behavior, or other levels of analysis, which – when modulated – change (1) the risk for, (2) the severity of, or (3) the recurrence of a disease such as mood, anxiety, or substance use disorder. Dr. Paulus’ program of research is to delineate DMPs and provide pathways towards the development of process-specific transdiagnostic interventions that have pragmatic utility, i.e. improve a patient’s condition faster with fewer side effects and fewer recurrences, and explanatory value, i.e. refine our understanding of the causal relationships between specific processes and a mental health condition.

Activities

Employment (1)

Laureate Institute for Brain Research: Tulsa, OK, US

2014-05-14 to present
Employment
Source: Self-asserted source
Martin Paulus

Professional activities (3)

Society for Neuroscience: Washington, DC, US

Membership
Source: Self-asserted source
Martin Paulus

Anxiety and Depression Association of America: Silver Spring, MD, US

Membership
Source: Self-asserted source
Martin Paulus

American College of Neuropsychopharmacology: Brentwood, TN, US

Membership
Source: Self-asserted source
Martin Paulus

Funding (13)

The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)

Source: Self-asserted source
Martin Paulus via DimensionsWizard

ABCD-USA Consortium: Research Project

2015-09-30 to 2020-05-31 | Grant
National Institute on Drug Abuse (n/a, US)
GRANT_NUMBER: grant.U01DA041089
Source: Self-asserted source
Martin Paulus via DimensionsWizard

Latent Constructs: Negative-Positive Valence Domains in Anxiety and Depression

Source: Self-asserted source
Martin Paulus via DimensionsWizard

Center on Interoceptive Dysregulation in Addiction (CIDIA)

Source: Self-asserted source
Martin Paulus via DimensionsWizard

Negative reinforcement and interoceptive dysfunction in stimulant dependence.

Source: Self-asserted source
Martin Paulus via DimensionsWizard

Collaborative Research: DRU: Behavioral and Neural Effects of Sleep Deprivation on Specific Components of Decision Making

Source: Self-asserted source
Martin Paulus via DimensionsWizard

Time processing in stimulant users: Impulsivity and temporal discounting

Source: Self-asserted source
Martin Paulus via DimensionsWizard

STIMULANT DEPENDENCE: NEURAL MECHANISMS OF RELAPSE

2004-09-30 to 2010-06-30 | Grant
National Institute on Drug Abuse (n/a, US)
GRANT_NUMBER: grant.R01DA018307
Source: Self-asserted source
Martin Paulus via DimensionsWizard

Neurobiology Of Transition To Stimulant Dependence

2003-07-01 to 2012-07-31 | Grant
National Institute on Drug Abuse (n/a, US)
GRANT_NUMBER: grant.R01DA016663
Source: Self-asserted source
Martin Paulus via DimensionsWizard

NEUROIMAGING OF DECISION MAKING IN STIMULANT ADDICTION

Source: Self-asserted source
Martin Paulus via DimensionsWizard

MDMA &Amphetamine--Behavioral Organization in Mice

2001-04-01 to 2005-03-31 | Grant
National Institute on Drug Abuse (n/a, US)
GRANT_NUMBER: grant.R21DA014200
Source: Self-asserted source
Martin Paulus via DimensionsWizard

NON LINEAR DYSREGULATION IN SCHIZOPHRENIA

1998-05-01 to 2001-04-30 | Grant
National Institute of Mental Health (n/a, US)
GRANT_NUMBER: grant.R03MH058358
Source: Self-asserted source
Martin Paulus via DimensionsWizard

DRUGS OF ABUSE EFFECTS ON BEHAVIORAL ORGANIZATION

1997-09-30 to 2001-07-31 | Grant
National Institute on Drug Abuse (n/a, US)
GRANT_NUMBER: grant.R01DA011277
Source: Self-asserted source
Martin Paulus via DimensionsWizard

Works (50 of 239)

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Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder

Molecular Psychiatry
2025-02 | Journal article
Contributors: Soumyabrata Munshi; Ahlam M. Alarbi; Haixia Zheng; Rayus Kuplicki; Kaiping Burrows; Leandra K. Figueroa-Hall; Teresa A. Victor; Robin L. Aupperle; Sahib S. Khalsa; Martin P. Paulus et al.
Source: check_circle
Crossref

Reduced Neural Activation During Positive Social Approach is Associated with Better Response to Approach Avoidance Training for Social Anxiety Disorder

Journal of Mood & Anxiety Disorders
2025-02 | Journal article
Contributors: Christopher Hunt; Morgan M. Caudle; Martin P. Paulus; Murray B. Stein; Charles T. Taylor; Jessica Bomyea
Source: check_circle
Crossref

Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders

2025-02-13 | Preprint
Contributors: Marishka M. Mehta; Navid Hakimi; Orestes Pena; Taylor Torres; Carter M. Goldman; Claire A. Lavalley; Jennifer L. Stewart; Hannah Berg; Maria Ironside; Martin P. Paulus et al.
Source: check_circle
Crossref

Leveraging Large Language Models and Agent-Based Systems for Scientific Data Analysis: Validation Study

JMIR Mental Health
2025-02-13 | Journal article
Contributors: Dale Peasley; Rayus Kuplicki; Sandip Sen; Martin Paulus
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Structural, Behavioral, and Symptomatic Predictors of Risk Allele Frequency at rs10866912

2024-12-06 | Preprint
Contributors: Katherine L. Forthman; Sathish Periyasamy; Rayus Kuplicki; Martin P. Paulus; Bryan J. Mowry
Source: check_circle
Crossref

Neuroimaging biomarkers of addiction

Nature Mental Health
2024-11-18 | Journal article
Contributors: Hamed Ekhtiari; Arshiya Sangchooli; Owen Carmichael; F. Gerard Moeller; Patricio O’Donnell; Maria A. Oquendo; Martin P. Paulus; Diego A. Pizzagalli; Tatiana Ramey; Joseph P. Schacht et al.
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Crossref

Multimorbidity in neurodegenerative diseases: a network analysis

Informatics for Health and Social Care
2024-10 | Journal article
Contributors: Mostafa Amini; Ali Bagheri; Martin P. Paulus; Dursun Delen
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Crossref

Computational Mechanisms of Learning and Forgetting Differentiate Affective and Substance Use Disorders

2024-10-31 | Preprint
Contributors: Navid Hakimi; Ko-Ping Chou; Jennifer Stewart; Martin Paulus; Ryan Smith
Source: check_circle
Crossref

Aging increases the distinctiveness of emotional brain states across rumination, worry, and positive thinking

2024-10-29 | Preprint
Contributors: Masaya Misaki; Aki Tsuchiyagaito; Salvador Guinjoan; Martin Paulus
Source: check_circle
Crossref

Increased Insular Functional Connectivity During Repetitive Negative Thinking in Major Depression and Healthy Volunteers

2024-10-16 | Preprint
Contributors: Landon S Edwards; Saampras Ganesan; Jolene Tay; Eli S Elliott; Masaya Misaki; Evan J White; Martin P Paulus; Salvador M Guinjoan; Aki Tsuchiyagaito
Source: check_circle
Crossref

Reversible and Noninvasive Modulation of a Historical Surgical Target for Depression with Low Intensity Focused Ultrasound

2024-10-01 | Preprint
Contributors: Aki Tsuchiyagaito; Rayus Kuplicki; Masaya Misaki; Landon S. Edwards; Joan A. Camprodon; Kate D. Fitzgerald; Sahib S. Khalsa; Noah S. Philip; Martin P. Paulus; Salvador M. Guinjoan
Source: check_circle
Crossref

Whole-brain mechanism of neurofeedback therapy: predictive modeling of neurofeedback outcomes on repetitive negative thinking in depression

Translational Psychiatry
2024-09-04 | Journal article
Contributors: Masaya Misaki; Aki Tsuchiyagaito; Salvador M. Guinjoan; Michael L. Rohan; Martin P. Paulus
Source: check_circle
Crossref

Neuroimaging Biomarkers in Addiction

2024-09-03 | Preprint
Contributors: Hamed Ekhtiari; Arshiya Sangchooli; Owen Carmichael; Gerard Moeller; Patricio ODonnell; Maria Oquendo; Martin P. Paulus; Diego A. Pizzagalli; Tatiana Ramey; Joseph Schacht et al.
Source: check_circle
Crossref

Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation

Neuropsychopharmacology
2024-07 | Journal article
Contributors: Charles Verdonk; Adam R. Teed; Evan J. White; Xi Ren; Jennifer L. Stewart; Martin P. Paulus; Sahib S. Khalsa
Source: check_circle
Crossref

Genetic Correlates of Treatment-Resistant Depression: Insights from Polygenic Scores Across Cognitive, Temperamental, and Sleep Traits in the All of US cohort

2024-07-05 | Preprint
Contributors: Bohan Xu; Katherine L. Forthman; Rayus Kuplicki; Jonathan Ahern; Robert Loughnan; Firas Naber; Wesley K. Thompson; Charles B. Nemeroff; Martin P. Paulus; Chun Chieh Fan
Source: check_circle
Crossref

Computational Mechanisms Underlying Multi-Step Planning Deficits in Methamphetamine Use Disorder

2024-06-28 | Preprint
Contributors: Claire A. Lavalley; Marishka M. Mehta; Samuel Taylor; Anne E. Chuning; Jennifer L. Stewart; Quentin J. M. Huys; Sahib S. Khalsa; Martin P. Paulus; Ryan Smith
Source: check_circle
Crossref

Screen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study

Journal of Behavioral Addictions
2024-06-26 | Journal article
Contributors: Yihong Zhao; Martin P. Paulus; Susan F. Tapert; Kara S. Bagot; R. Todd Constable; H. Klar Yaggi; Nancy S. Redeker; Marc N. Potenza
Source: check_circle
Crossref

Opportunities and risks of large language models in psychiatry

NPP—Digital Psychiatry and Neuroscience
2024-05-24 | Journal article
Contributors: Nick Obradovich; Sahib S. Khalsa; Waqas U. Khan; Jina Suh; Roy H. Perlis; Olusola Ajilore; Martin P. Paulus
Source: check_circle
Crossref

Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder

2024-01-12 | Preprint
Contributors: Soumyabrata Munshi; Ahlam M. Alarbi; Haixia Zheng; Rayus Kuplicki; Kaiping Burrows; Leandra K. Figueroa-Hall; Teresa A. Victor; Robin L. Aupperle; Sahib S. Khalsa; Martin P. Paulus et al.
Source: check_circle
Crossref

Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples

Molecular Psychiatry
2023-12 | Journal article
Contributors: Haixia Zheng; Maree J. Webster; Cynthia Shannon Weickert; Clare L. Beasley; Martin P. Paulus; Robert H. Yolken; Jonathan Savitz
Source: check_circle
Crossref

Impaired eating behaviors but intact metabolic hormone levels in individuals with major depressive disorder and generalized anxiety disorder

Journal of Psychiatric Research
2023-12 | Journal article
Contributors: Breanna A. McNaughton; Kaiping Burrows; Emily Choquette; Tate Poplin; Rayus Kuplicki; Martin P. Paulus; Maria Ironside; Jennifer L. Stewart
Source: check_circle
Crossref

Thalamo-cortical circuits associated with trait- and state-repetitive negative thinking in major depressive disorder

Journal of Psychiatric Research
2023-12 | Journal article
Contributors: Aki Tsuchiyagaito; Masaya Misaki; Gabe Cochran; Noah S. Philip; Martin P. Paulus; Salvador M. Guinjoan
Source: check_circle
Crossref

Whole-brain Mechanism of Neurofeedback Therapy: Predictive Modeling of Neurofeedback Outcomes on Repetitive Negative Thinking in Depression

2023-11-17 | Preprint
Contributors: Masaya Misaki; Aki Tsuchiyagaito; Salvador M. Guinjoan; Michael L. Rohan; Martin P. Paulus
Source: check_circle
Crossref

Dose-response in modulating brain function with transcranial direct current stimulation: From local to network levels

PLOS Computational Biology
2023-10-26 | Journal article
Contributors: Ghazaleh Soleimani; Marcus Kaiser; Rayus Kupliki; Martin Paulus; Hamed Ekhtiari
Source: check_circle
Crossref

The unique face of anxious depression: Increased sustained threat circuitry response during fear acquisition

2023-10-17 | Preprint
Contributors: Tate Poplin; Maria Ironside; Rayus Kuplicki; Robin L. Aupperle; Salvador M. Guinjoan; Sahib S. Khalsa; Jennifer L. Stewart; Teresa A. Victor; Martin P. Paulus; Namik Kirlic
Source: check_circle
Crossref

Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication study

2023-10-12 | Preprint
Contributors: Claire A. Lavalley; Navid Hakimi; Samuel Taylor; Rayus Kuplicki; Katherine L. Forthman; Jennifer L. Stewart; Martin P. Paulus; Sahib S. Khalsa; Ryan Smith
Source: check_circle
Crossref

Intensity of repetitive negative thinking in depression is associated with greater functional connectivity between semantic processing and emotion regulation areas

Psychological Medicine
2023-09 | Journal article
Contributors: Aki Tsuchiyagaito; Stella M. Sánchez; Masaya Misaki; Rayus Kuplicki; Heekyong Park; Martin P. Paulus; Salvador M. Guinjoan
Source: check_circle
Crossref

State-specific alterations in the neural computations underlying inhibitory control in women remitted from bulimia nervosa

Molecular Psychiatry
2023-07 | Journal article
Contributors: Laura A. Berner; Katia M. Harlé; Alan N. Simmons; Angela Yu; Martin P. Paulus; Amanda Bischoff-Grethe; Christina E. Wierenga; Ursula F. Bailer; Walter H. Kaye
Source: check_circle
Crossref

Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation

2023-06-12 | Preprint
Contributors: Charles Verdonk; Adam R. Teed; Evan J. White; Xi Ren; Jennifer L. Stewart; Martin P. Paulus; Sahib S. Khalsa
Source: check_circle
Crossref

A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals

2023-06-01 | Preprint
Contributors: McKenna M. Garland; Raminta Wilson; Wesley K. Thompson; Murray B. Stein; Martin P. Paulus; Justin S. Feinstein; Sahib S. Khalsa
Source: check_circle
Crossref

Optimizing Individual Targeting of Fronto-Amygdala Network with Transcranial Magnetic Stimulation (TMS): Biophysical, Physiological and Behavioral Variations in People with Methamphetamine Use Disorder

2023-04-03 | Preprint
Contributors: Ghazaleh Soleimani; Christine A. Conelea; Rayus Kuplicki; Alexander Opitz; Kelvin O Lim; Martin P. Paulus; Hamed Ekhtiari
Source: check_circle
Crossref

Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort

Journal of Behavioral Addictions
2023-03-30 | Journal article
Contributors: Yihong Zhao; Martin P. Paulus; Marc N. Potenza
Source: check_circle
Crossref

Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state

2023-03-25 | Preprint
Contributors: Masaya Misaki; Aki Tsuchiyagaito; Salvador M. Guinjoan; Michael L. Rohan; Martin P. Paulus
Source: check_circle
Crossref

Five recommendations for using large-scale publicly available data to advance health among American Indian peoples: the Adolescent Brain and Cognitive Development (ABCD) StudySM as an illustrative case

Neuropsychopharmacology
2023-01 | Journal article
Contributors: Evan J. White; Mara J. Demuth; Andrea Wiglesworth; Ashleigh D. Coser; Brady A. Garrett; Terrence K. Kominsky; Valarie Jernigan; Wesley K. Thompson; Martin Paulus; Robin Aupperle
Source: check_circle
Crossref

Neural substrates of continuous and discrete inhibitory control

Translational Psychiatry
2023-01-24 | Journal article
Contributors: Jonathon R. Howlett; Heekyeong Park; Martin P. Paulus
Source: check_circle
Crossref

Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples

2023-01-05 | Preprint
Contributors: Haixia Zheng; Maree Webster; Cynthia Weickert; Clare Beasley; Martin Paulus; Robert Yolken; Jonathan Savitz
Source: check_circle
Crossref

Attenuated interoceptive processing in individuals with major depressive disorder and high repetitive negative thinking

Journal of Psychiatric Research
2022-12 | Journal article
Contributors: Heekyeong Park; Stella M. Sanchez; Rayus Kuplicki; Aki Tsuchiyagaito; Sahib S. Khalsa; Martin P. Paulus; Salvador M. Guinjoan
Source: check_circle
Crossref

Are we really targeting and stimulating DLPFC by placing tES electrodes over F3/F4?

2022-12-06 | Preprint
Contributors: Hamed Ekhtiari; Ghazaleh Soleimani; Rayus Kuplicki; Jazmin Camchong; Alexander Opitz; Martin Paulus; Kelvin Lim
Source: check_circle
Crossref

Are we really targeting and stimulating DLPFC by placing transcranial electrical stimulation (tES) electrodes over F3/F4?

2022-12-05 | Preprint
Contributors: Ghazaleh Soleimani; Rayus Kuplicki; Jazmin Camchong; Alexander Opitz; Martin P Paulus; Kelvin O Lim; Hamed Ekhtiari
Source: check_circle
Crossref

Dose-Response in Modulating Brain Function with Transcranial Direct Current Stimulation: From Local to Network Levels

2022-11-14 | Preprint
Contributors: Ghazaleh Soleimani; Rayus Kupliki; Martin Paulus; Hamed Ekhtiari
Source: check_circle
Crossref

Single doses of a highly selective inhibitor of phosphodiesterase 1 (lenrispodun) in healthy volunteers: a randomized pharmaco-fMRI clinical trial

Neuropsychopharmacology
2022-09 | Journal article
Contributors: Sahib S. Khalsa; Teresa A. Victor; Rayus Kuplicki; Hung-Wen Yeh; Kimberly E. Vanover; Martin P. Paulus; Robert E. Davis
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Functional magnetic resonance imaging data for the association between polygenic risk scores for neuroticism and reward-punishment processing

Data in Brief
2022-06 | Journal article
Contributors: Heekyeong Park; Katherine L. Forthman; Rayus Kuplicki; Teresa A. Victor; Hung-Wen Yeh; Wesley K. Thompson; Martin P. Paulus
Source: check_circle
Crossref

Brain structural covariation linked to screen media activity and externalizing behaviors in children

Journal of Behavioral Addictions
2022-06-30 | Journal article
Contributors: Yihong Zhao; Martin Paulus; Kara S. Bagot; R. Todd Constable; H. Klar Yaggi; Nancy S. Redeker; Marc N. Potenza
Source: check_circle
Crossref

The propensity to sign-track is associated with externalizing behaviour and distinct patterns of reward-related brain activation in youth

2022-01-29 | Preprint
Contributors: Janna M. Colaizzi; Shelly B. Flagel; Ashley N. Gearhardt; Michelle A. Borowitz; Rayus Kuplicki; Vadim Zotev; Grace Clark; Jennifer Coronado; Talia Abbott; Martin P. Paulus
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A library for fMRI real-time processing systems in python (RTPSpy) with comprehensive online noise reduction, fast and accurate anatomical image processing, and online processing simulation

2021-12-14 | Preprint
Contributors: Masaya Misaki; Jerzy Bodurka; Martin P Paulus
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Inhibitory failures in cocaine use disorder: Not paying attention when there is a need to be cautious

Drug and Alcohol Dependence
2021-09 | Journal article
Contributors: Jonathon R. Howlett; Katia M. Harlé; Martin P. Paulus
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Crossref

The pitfalls of using Gaussian Process Regression for normative modeling

PLOS ONE
2021-09-15 | Journal article
Contributors: Bohan Xu; Chi-Hua Chen; Rayus Kuplicki; Sandip Sen; Martin P. Paulus
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Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension

Translational Psychiatry
2021-09-07 | Journal article
Contributors: Haixia Zheng; Bart N. Ford; Rayus Kuplicki; Kaiping Burrows; Peter W. Hunt; Jerzy Bodurka; T. Kent Teague; Michael R. Irwin; Robert H. Yolken; Martin P. Paulus et al.
Source: check_circle
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Impact of ibuprofen and peroxisome proliferator-activated receptor gamma on emotion-related neural activation: A randomized, placebo-controlled trial

Brain, Behavior, and Immunity
2021-08 | Journal article
Contributors: Kelly T. Cosgrove; Rayus Kuplicki; Jonathan Savitz; Kaiping Burrows; W. Kyle Simmons; Sahib S. Khalsa; T. Kent Teague; Robin L. Aupperle; Martin P. Paulus
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Characterising the Photoplethysmography Pulse Waveform for Use in Human Neuroscience: The Hybrid Excess and Decay (HED) Model

2021-08-19 | Other
Contributors: Simon Williamson; Lucie Daniel-Watanabe; Johanna Finnemann; Craig Powell; Adam Teed; Micah Allen; Martin Paulus; Sahib S. Khalsa; Paul C. Fletcher
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Peer review (46 reviews for 14 publications/grants)

Review activity for Biological psychiatry. (5)
Review activity for Biological psychiatry. (7)
Review activity for Brain imaging and behavior. (1)
Review activity for EClinicalMedicine. (4)
Review activity for Journal of affective disorders. (1)
Review activity for Molecular psychiatry. (3)
Review activity for Nature aging. (1)
Review activity for Nature communications (6)
Review activity for Nature human behaviour. (1)
Review activity for Nature neuroscience. (2)
Review activity for Neuropsychopharmacology. (9)
Review activity for NPP-Digital Psychiatry and Neuroscience. (1)
Review activity for Translational psychiatry. (3)
Review activity for Trends in cognitive sciences. (2)