Personal information

United States

Activities

Employment (2)

Harvard Medical School: Boston, MA, US

2017-11-01 to present | Assistant Professor (Department of Microbiology)
Employment
Source: Self-asserted source
Aleksandar David Kostic

Joslin Diabetes Center: Boston, MA, US

2016-09-01 to present | Assistant Investigator (Section in Pathophysiology & Molecular Pharmacology)
Employment
Source: Self-asserted source
Aleksandar David Kostic

Education and qualifications (2)

Harvard University: Cambridge, MA, US

2008-09-01 to 2013-05-31 | PhD (Harvard Medical School; Biological and Biomedical Sciences)
Education
Source: Self-asserted source
Aleksandar David Kostic

University of Toronto: Toronto, ON, CA

2003-09-01 to 2008-05-01 | Honours Bachelor of Science
Education
Source: Self-asserted source
Aleksandar David Kostic

Funding (2)

Generation of an in vivo System for Dissection of the Human Type 1 Diabetes-associated Microbiome

2017-01 to 2021-12 | Award
American Diabetes Association Pathway to Stop Diabetes Initiator Award (VA, US)
Source: Self-asserted source
Aleksandar David Kostic

Immunological Investigation of Human Type 1 Diabetes-Associated Microbiomes in the Gnotobiotic Autoimmune Diabetic Mouse

2017-01 to 2019-12 | Award
Smith Family Awards Program for Excellence in Biomedical Research (MA, US)
Source: Self-asserted source
Aleksandar David Kostic

Works (50 of 56)

Items per page:
Page 1 of 2

Single-cell RNA-seq reveals TCR clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in NOD mice

2024-01-16 | Preprint
Contributors: Michael Robben; Md ZOhorul Islam; Sam Zimmerman; Jon Weidanz; Jose Ordovas-Montanes; Aleksandar Kostic; Jacob Luber
Source: check_circle
Crossref

DNA characterization reveals potential operon-unit packaging of extracellular vesicle cargo from a gut bacterial symbiont

2023-12-04 | Preprint
Contributors: Byeongyeon Cho; Grace Moore; Loc-Duyen Pham; Chirag Patel; Aleksandar Kostic
Source: check_circle
Crossref

Single-cell RNA-seq reveals TCR clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in NOD mice

2023-07-25 | Preprint
Contributors: Md Zohorul Islam; Sam Zimmerman; Jon Weidanz; Jose Ordovas-Montanes; Michael Robben; Jacob M. Luber; Aleksandar D Kostic
Source: check_circle
Crossref

Quantifying shared and unique gene content across 17 microbial ecosystems

2022-07-20 | Preprint
Contributors: Samuel Zimmerman; Braden T Tierney; Chirag J Patel; Aleksandar D Kostic
Source: check_circle
Crossref

The impact of multigenerational high-fat diet feeding on the gut microbiome and host metabolism

2022-02-02 | Preprint
Contributors: Marsha C. Wibowo; Zhen Yang; Theodore A. Chavkin; Brian Nguyen; Loc-Duyen Pham; Tian Lian Huang; Matthew D. Lynes; Yu-Hua Tseng; Aleksandar D. Kostic
Source: check_circle
Crossref

Using Cartesian Doubt To Build a Sequencing-Based View of Microbiology

mSystems
2021-10-26 | Journal article
Contributors: Braden T. Tierney; Erika Szymanski; James R. Henriksen; Aleksandar D. Kostic; Chirag J. Patel; Linda Kinkel
Source: check_circle
Crossref

Leveraging vibration of effects analysis for robust discovery in observational biomedical data science

PLOS Biology
2021-09-23 | Journal article
Contributors: Braden T. Tierney; Marcus Munafò; Elizabeth Anderson; Yingxuan Tan; Kajal Claypool; Sivateja Tangirala; Aleksandar D. Kostic; Arjun K. Manrai; Chirag J. Patel
Source: check_circle
Crossref

Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators.

Nature Communications
2021-05-18 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Reconstruction of ancient microbial genomes from the human gut.

Nature
2021-05-12 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Circulating short and medium chain fatty acids are associated with normoalbuminuria in type 1 diabetes of long duration.

Scientific reports
2021-04-21 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Activation of adenosine receptor A2a by gut symbionts promotes immune tolerance

2021-04-07 | Other
Contributors: Aleksandar Kostic; Tao Xu; Lidan Zhao; Md Zohorul Islam; Loc-Duyen Pham; Martina Corsi; Gregory Phillips; Michael Wannemuehler; Christophe Benoist
Source: check_circle
Crossref

Mechanisms of microbial-neuronal interactions in pain and nociception.

Neurobiology of pain (Cambridge, Mass.)
2020-12-11 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.

Cell
2020-05-12 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

A systematic machine learning and data type comparison yields metagenomic predictors of infant age, sex, breastfeeding, antibiotic usage, country of origin, and delivery type.

PLoS computational biology
2020-05-11 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

CoproID predicts the source of coprolites and paleofeces using microbiome composition and host DNA content.

PeerJ
2020-04-17 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Reply to "Is physical performance (in mice) increased by Veillonella atypica or decreased by Lactobacillus bulgaricus?"

Journal of sport and health science
2020-03-07 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
grade
Preferred source (of 2)‎

The predictive power of the microbiome exceeds that of genome-wide association studies in the discrimination of complex human disease

[]
2020-01-02 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
grade
Preferred source (of 2)‎

The Landscape of Genetic Content in the Gut and Oral Human Microbiome.

Cell host & microbe
2019-08-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences.

Nature communications
2019-07-17 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
grade
Preferred source (of 2)‎

Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism.

Nature medicine
2019-06-24 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.

Cell host & microbe
2019-05-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes.

Science immunology
2019-02-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
grade
Preferred source (of 2)‎

The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response.

eLife
2019-01-22 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States.

Diabetes/metabolism research and reviews
2018-12-04 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status.

Cancer immunology research
2018-09-18 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Aether: leveraging linear programming for optimal cloud computing in genomics.

Bioinformatics (Oxford, England)
2018-05-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
grade
Preferred source (of 2)‎

Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
2018-04-24 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing.

GigaScience
2018-03-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites.

Cell reports
2018-03-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Aether: Leveraging Linear Programming for Optimal Cloud Computing In Genomics

2017-07-13 | Preprint
Contributors: Jacob M. Luber; Braden T. Tierney; Evan M. Cofer; Chirag J. Patel; Aleksandar D. Kostic
Source: check_circle
Crossref

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.

Proceedings of the National Academy of Sciences of the United States of America
2017-07-10 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue.

JAMA oncology
2017-07-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Gut Microbiota: Small Molecules Modulate Host Cellular Functions.

Current biology : CB
2017-04 | Journal article
Contributors: Luber JM; Kostic AD
Source: Self-asserted source
Aleksandar David Kostic via Europe PubMed Central
grade
Preferred source (of 2)‎

A Microbiome Foundation for the Study of Crohn's Disease.

Cell host & microbe
2017-03-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Emerging Concepts and Technologies for the Discovery of Microorganisms Involved in Human Disease.

Annual review of pathology
2016-12-05 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location.

Clinical and translational gastroenterology
2016-11 | Journal article
Contributors: Mima K; Cao Y; Chan AT; Qian ZR; Nowak JA; Masugi Y; Shi Y; Song M; da Silva A; Gu M et al.
Source: Self-asserted source
Aleksandar David Kostic via Europe PubMed Central
grade
Preferred source (of 2)‎

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.

Genome medicine
2016-07 | Journal article
Contributors: Shaw KA; Bertha M; Hofmekler T; Chopra P; Vatanen T; Srivatsa A; Prince J; Kumar A; Sauer C; Zwick ME et al.
Source: Self-asserted source
Aleksandar David Kostic via Europe PubMed Central
grade
Preferred source (of 2)‎

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Cell
2016-04-28 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.

JAMA oncology
2015-08 | Journal article
Contributors: Mima K; Sukawa Y; Nishihara R; Qian ZR; Yamauchi M; Inamura K; Kim SA; Masuda A; Nowak JA; Nosho K et al.
Source: Self-asserted source
Aleksandar David Kostic via Europe PubMed Central
grade
Preferred source (of 2)‎

Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.

Gut
2015-08-26 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

An integrative view of microbiome-host interactions in inflammatory bowel diseases.

Cell host & microbe
2015-05-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Cell host & microbe
2015-02-05 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Inflammatory bowel disease as a model for translating the microbiome.

Immunity
2014-06-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

The treatment-naive microbiome in new-onset Crohn's disease.

Cell host & microbe
2014-03-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
grade
Preferred source (of 2)‎

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.

PLoS pathogens
2014-02-27 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

The microbiome in inflammatory bowel disease: current status and the future ahead.

Gastroenterology
2014-02-19 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
grade
Preferred source (of 2)‎

Microbes and inflammation in colorectal cancer.

Cancer immunology research
2013-09-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.

Cell host & microbe
2013-08-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome.

The New England journal of medicine
2013-08-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic

Exploring host-microbiota interactions in animal models and humans.

Genes & development
2013-04-01 | Journal article
Source: Self-asserted source
Aleksandar David Kostic
Items per page:
Page 1 of 2

Peer review (15 reviews for 8 publications/grants)

Review activity for Cell host & microbe. (2)
Review activity for Cell metabolism. (1)
Review activity for Microbiome (2)
Review activity for Nature (4)
Review activity for Nature medicine. (1)
Review activity for Nature metabolism. (2)
Review activity for Nature microbiology. (2)
Review activity for npj biofilms and microbiomes. (1)