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ETH Zurich: Zurich, CH

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Source: Self-asserted source
Volodymyr Korkhov

Works (43)

Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics

EMBO Reports
2024-02-13 | Journal article | Author
DOI: 10.1038/s44319-024-00076-y
Part of ISSN: 1469-3178
Contributors: Basavraj Khanppnavar; Dina Schuster; Pia Lavriha; Federico Uliana; Merve Özel; Ved Mehta; Alexander Leitner; Paola Picotti; Volodymyr Korkhov
Source: Self-asserted source
Volodymyr Korkhov

Structural basis of activation and inhibition of the Ca<sup>2+</sup>/calmodulin-sensitive adenylyl cyclase 8

2023-03-04 | Preprint | Author
DOI: 10.1101/2023.03.03.531047
Contributors: Basavraj Khanppnavar; Dina Schuster; Merve Özel; Ved Mehta; Alexander Leitner; Paola Picotti; Volodymyr Korkhov
Source: Self-asserted source
Volodymyr Korkhov

Structural basis of organic cation transporter-3 inhibition

Nature Communications
2022-11-07 | Journal article | Author
DOI: 10.1038/s41467-022-34284-8
Part of ISSN: 2041-1723
Contributors: Basavraj Khanppnavar; Julian Maier; Freja Herborg; Ralph Gradisch; Erika Lazzarin; Dino Luethi; Jae-Won Yang; chao qi; Marion Holy; Kathrin Jäntsch et al.
Source: Self-asserted source
Volodymyr Korkhov

Structural basis of organic cation transporter-3 inhibition

2022-07 | Preprint
DOI: 10.1101/2022.07.14.499921
PPR: PPR518346
Contributors: Khanppnavar B; Maier J; Herborg F; Gradisch R; Lazzarin E; Luethi D; Yang J; Qi C; Holy M; Jäntsch K et al.
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structure of the connexin-43 gap junction channel reveals a closed sieve-like molecular gate

2022-03 | Preprint
DOI: 10.1101/2022.03.26.485947
PPR: PPR472722
Contributors: Qi C; Acosta-Gutierrez S; Lavriha P; Othman A; Lopez-Pigozzi D; Bayraktar E; Schuster D; Picotti P; Zamboni N; Bortolozzi M et al.
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structural basis of adenylyl cyclase 9 activation.

Nature communications
2022-02 | Journal article
DOI: 10.1038/s41467-022-28685-y
PMID: 35210418
PMC: PMC8873477
Contributors: Qi C; Lavriha P; Mehta V; Khanppnavar B; Mohammed I; Li Y; Lazaratos M; Schaefer JV; Dreier B; Plückthun A et al.
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structure of <i>Mycobacterium tuberculosis</i> Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

2021-12 | Preprint
DOI: 10.1101/2021.12.01.470738
PPR: PPR427705
Contributors: Mehta V; Khanppnavar B; Schuster D; Kantarci I; Vercellino I; Kosturanova A; Iype T; Stefanic S; Picotti P; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structural basis of adenylyl cyclase 9 activation

2021-08 | Preprint
DOI: 10.1101/2021.08.11.455989
PPR: PPR382041
Contributors: Qi C; Lavriha P; Mehta V; Khanppnavar B; Mohammed I; Li Y; Lazaratos M; Schaefer JV; Dreier B; Plückthun A et al.
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

CAP1 binds and activates adenylyl cyclase in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America
2021-06 | Journal article
DOI: 10.1073/pnas.2024576118
PMID: 34099549
PMC: PMC8214675
Contributors: Zhang X; Pizzoni A; Hong K; Naim N; Qi C; Korkhov V; Altschuler DL
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion.

Nature communications
2021-06 | Journal article
DOI: 10.1038/s41467-021-24083-y
PMID: 34145271
PMC: PMC8213820
Contributors: Lentini G; Ben Chaabene R; Vadas O; Ramakrishnan C; Mukherjee B; Mehta V; Lunghi M; Grossmann J; Maco B; Visentin R et al.
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Cryo-EM structure of the Hedgehog release protein Dispatched.

Science advances
2020-04 | Journal article
DOI: 10.1126/sciadv.aay7928
PMID: 32494603
PMC: PMC7159904
Contributors: Cannac F; Qi C; Falschlunger J; Hausmann G; Basler K; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structure and function of adenylyl cyclases, key enzymes in cellular signaling.

Current opinion in structural biology
2020-04 | Journal article
DOI: 10.1016/j.sbi.2020.03.003
PMID: 32334344
Contributors: Khannpnavar B; Mehta V; Qi C; Korkhov V
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Affinity Purification of Membrane Proteins.

Methods in molecular biology (Clifton, N.J.)
2020-01 | Journal article
DOI: 10.1007/978-1-0716-0373-4_9
PMID: 32112319
Contributors: Graeber E; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structural basis of sterol recognition by human hedgehog receptor PTCH1.

Science advances
2019-09 | Journal article
DOI: 10.1126/sciadv.aaw6490
PMID: 31555730
PMC: PMC6750913
Contributors: Qi C; Di Minin G; Vercellino I; Wutz A; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Characterisation of the ligand binding sites in the translocator protein TSPO using the chimeric bacterial-mammalian constructs.

Protein expression and purification
2019-07 | Journal article
DOI: 10.1016/j.pep.2019.105456
PMID: 31326501
Contributors: Graeber E; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Cryo-EM structure of the Hedgehog release protein Dispatched

2019-07 | Preprint
DOI: 10.1101/707513
PPR: PPR86049
Contributors: Cannac F; Qi C; Falschlunger J; Hausmann G; Basler K; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein.

Science (New York, N.Y.)
2019-04 | Journal article
DOI: 10.1126/science.aav0778
PMID: 31023924
Contributors: Qi C; Sorrentino S; Medalia O; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structural basis of sterol recognition by human hedgehog receptor PTCH1

2018-12 | Preprint
DOI: 10.1101/508325
PPR: PPR66125
Contributors: Qi C; Minin GD; Vercellino I; Wutz A; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Expression and purification of the mammalian translocator protein for structural studies.

PloS one
2018-06 | Journal article
DOI: 10.1371/journal.pone.0198832
PMID: 29897975
PMC: PMC5999236
Contributors: Graeber E; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation.

Proceedings of the National Academy of Sciences of the United States of America
2017-10 | Journal article
DOI: 10.1073/pnas.1712621114
PMID: 29087332
PMC: PMC5699072
Contributors: Vercellino I; Rezabkova L; Olieric V; Polyhach Y; Weinert T; Kammerer RA; Jeschke G; Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F.

Scientific reports
2017-01 | Journal article
DOI: 10.1038/srep41575
PMID: 28128319
PMC: PMC5269720
Contributors: Mireku SA; Ruetz M; Zhou T; Korkhov VM; Kräutler B; Locher KP
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

On the efficiency of NHS ester cross-linkers for stabilizing integral membrane protein complexes.

Journal of the American Society for Mass Spectrometry
2014-11 | Journal article
DOI: 10.1007/s13361-014-1035-4
PMID: 25404159
Contributors: Chen F; Gerber S; Korkhov VM; Mireku S; Bucher M; Locher KP; Zenobi R
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F.

Nature structural & molecular biology
2014-11 | Journal article
DOI: 10.1038/nsmb.2918
PMID: 25402482
Contributors: Korkhov VM; Mireku SA; Veprintsev DB; Locher KP
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Conformational cycle of the vitamin B12 ABC importer in liposomes detected by double electron-electron resonance (DEER).

The Journal of biological chemistry
2013-12 | Journal article
DOI: 10.1074/jbc.m113.512178
PMID: 24362024
PMC: PMC3916522
Contributors: Joseph B; Korkhov VM; Yulikov M; Jeschke G; Bordignon E
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

High-mass matrix-assisted laser desorption ionization-mass spectrometry of integral membrane proteins and their complexes.

Analytical chemistry
2013-03 | Journal article
DOI: 10.1021/ac4000943
PMID: 23463947
Contributors: Chen F; Gerber S; Heuser K; Korkhov VM; Lizak C; Mireku S; Locher KP; Zenobi R
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F.

Nature
2012-09 | Journal article
DOI: 10.1038/nature11442
PMID: 23000901
Contributors: Korkhov VM; Mireku SA; Locher KP
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Asymmetric states of vitamin B₁₂ transporter BtuCD are not discriminated by its cognate substrate binding protein BtuF.

FEBS letters
2012-03 | Journal article
DOI: 10.1016/j.febslet.2012.02.042
PMID: 22569249
Contributors: Korkhov VM; Mireku SA; Hvorup RN; Locher KP
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals.

Structure (London, England : 1993)
2010-06 | Journal article
DOI: 10.1016/j.str.2010.03.001
PMID: 20541505
PMC: PMC2911597
Contributors: Korkhov VM; Sachse C; Short JM; Tate CG
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Direct observation of molecular arrays in the organized smooth endoplasmic reticulum.

BMC cell biology
2009-08 | Journal article
DOI: 10.1186/1471-2121-10-59
PMID: 19703297
PMC: PMC2737311
Contributors: Korkhov VM; Zuber B
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions.

Nature methods
2009-07 | Journal article
DOI: 10.1038/nmeth.1347
PMID: 19578383
PMC: PMC4066579
Contributors: Barrera NP; Isaacson SC; Zhou M; Bavro VN; Welch A; Schaedler TA; Seeger MA; Miguel RN; Korkhov VM; van Veen HW et al.
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

GFP-LC3 labels organised smooth endoplasmic reticulum membranes independently of autophagy.

Journal of cellular biochemistry
2009-05 | Journal article
DOI: 10.1002/jcb.22103
PMID: 19259979
PMC: PMC2680217
Contributors: Korkhov VM
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

An emerging consensus for the structure of EmrE.

Acta crystallographica. Section D, Biological crystallography
2009-01 | Journal article
DOI: 10.1107/s0907444908036640
PMID: 19171974
PMC: PMC2631640
Contributors: Korkhov VM; Tate CG
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies.

Journal of molecular biology
2008-03 | Journal article
DOI: 10.1016/j.jmb.2008.02.056
PMID: 18367207
PMC: PMC4493858
Contributors: Korkhov VM; Milan-Lobo L; Zuber B; Farhan H; Schmid JA; Freissmuth M; Sitte HH
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Electron crystallography reveals plasticity within the drug binding site of the small multidrug transporter EmrE.

Journal of molecular biology
2008-01 | Journal article
DOI: 10.1016/j.jmb.2008.01.056
PMID: 18295794
PMC: PMC2726284
Contributors: Korkhov VM; Tate CG
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D.

The Journal of biological chemistry
2007-01 | Journal article
DOI: 10.1074/jbc.m609720200
PMID: 17210573
Contributors: Farhan H; Reiterer V; Korkhov VM; Schmid JA; Freissmuth M; Sitte HH
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle.

The Journal of biological chemistry
2006-03 | Journal article
DOI: 10.1074/jbc.m511382200
PMID: 16527819
Contributors: Korkhov VM; Holy M; Freissmuth M; Sitte HH
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor.

Molecular pharmacology
2005-12 | Journal article
DOI: 10.1124/mol.105.015818
PMID: 16339847
Contributors: Milojevic T; Reiterer V; Stefan E; Korkhov VM; Dorostkar MM; Ducza E; Ogris E; Boehm S; Freissmuth M; Nanoff C
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2005-03 | Journal article
DOI: 10.1523/jneurosci.4956-04.2005
PMID: 15745950
PMC: PMC6726088
Contributors: Calò L; Bruno V; Spinsanti P; Molinari G; Korkhov V; Esposito Z; Patanè M; Melchiorri D; Freissmuth M; Nicoletti F
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.

The Journal of biological chemistry
2004-10 | Journal article
DOI: 10.1074/jbc.m409449200
PMID: 15496410
Contributors: Korkhov VM; Farhan H; Freissmuth M; Sitte HH
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1).

The Journal of biological chemistry
2004-04 | Journal article
DOI: 10.1074/jbc.m307325200
PMID: 15073174
Contributors: Farhan H; Korkhov VM; Paulitschke V; Dorostkar MM; Scholze P; Kudlacek O; Freissmuth M; Sitte HH
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling.

The Journal of biological chemistry
2003-05 | Journal article
DOI: 10.1074/jbc.m212918200
PMID: 12764156
Contributors: Pankevych H; Korkhov V; Freissmuth M; Nanoff C
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2003-04 | Journal article
DOI: 10.1038/sj.npp.1300181
PMID: 12784121
Contributors: Kudlacek O; Just H; Korkhov VM; Vartian N; Klinger M; Pankevych H; Yang Q; Nanoff C; Freissmuth M; Boehm S
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central

Affinities of gidazepam and its analogs for mitochondrial benzodiazepine receptors.

Journal of receptor and signal transduction research
2002-02 | Journal article
DOI: 10.1081/rrs-120014610
PMID: 12503630
Contributors: Korkhov VM; Tkachuk NA; Makan SY; Pavlovsky VI; Andronati SA
Source: Self-asserted source
Volodymyr Korkhov via Europe PubMed Central
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