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We are dissecting the cytokine network and determine which cells are producing or responding to a particular cytokine. One of our favourite molecule we are analysing is Interleukin-10. By inactivating the expression of Interleukin-10 in various cell types, we can determine the importance of a particular cell type in a given immunological response. By this approach, we could identify that T lymphocytes are the critical cells producing Interleukin-10 and thereby control the Immune system of the gut. Also, we now identified two crucial target cells in the gut for Interleukin-10, T cells and macrophages. For the latter, Steffen Jung and I received the first Lord Alliance price in 2015. Since August 2018 Werner Muller is now Emeritus Professor at the University of Manchester and continues his scientific career at Miltenyi Biotec in research and development,