Personal information

Lymphatic System Physiology, Lymph Node, Fluid and Mass Transport, Lymphatic Endothelial Cell Biology, Vaccine Delivery, Adaptive Immunity, Microfluidics
United States

Biography

My PhD research is focused on fluid and molecule transport in lymph nodes. I am interested in lymph, antigen, chemokine, cytokine and cell transport in LNs to better understand how the immune system works. My goal is to utilize this knowledge in improving vaccine design and delivery technologies as well as better understanding tumor microenvironment for novel therapeutic strategies.

Activities

Employment (6)

Genentech: San Francisco, US

2024-02 to present (translational PKPD)
Employment
Source: Self-asserted source
Mohammad Jafarnejad

Denali Therapeutics: South San Francisco, CA, US

2021-04 to 2023-11 (Quantitative Pharmacology)
Employment
Source: Self-asserted source
Mohammad Jafarnejad

Genentech Inc: South San Francisco, CA, US

2019-10 to 2021-04 (Preclinical Translational Pharmacokinetic)
Employment
Source: Self-asserted source
Mohammad Jafarnejad

Johns Hopkins University: Baltimore, MD, US

2016-11-07 to 2019-10-27 | Postdoctoral Fellow (Biomedical Engineering)
Employment
Source: Self-asserted source
Mohammad Jafarnejad

Imperial College London: London, London, GB

2013-01-28 to 2016-10-31 | Graduate Research Assistant (Department of Bioengineering)
Employment
Source: Self-asserted source
Mohammad Jafarnejad

Texas A&M University: College Station, TX, US

2011-01-25 to 2012-12-14 | Graduate Research Assistant (Department of Biomedical Engineering)
Employment
Source: Self-asserted source
Mohammad Jafarnejad

Education and qualifications (3)

Imperial College London: London, London, GB

2013-01-28 to 2016-08-01 | PhD (Department of Bioengineering )
Education
Source: Self-asserted source
Mohammad Jafarnejad

Texas A&M University: College Station, TX, US

2011-01-25 to 2012-12-14 | MS (Department of Biomedical Engineering)
Education
Source: Self-asserted source
Mohammad Jafarnejad

Sharif University of Technology: Tehran, IR

2005-09-20 to 2011-06-20 | BS (Department of Mechanical Engineering)
Education
Source: Self-asserted source
Mohammad Jafarnejad

Works (17)

Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunity

Journal of The Royal Society Interface
2021-12 | Journal article
Contributors: Sarah C. Johnson; Jennifer Frattolin; Lowell T. Edgar; Mohammad Jafarnejad; James E. Moore Jr
Source: check_circle
Crossref

Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunity

2020-06-19 | Preprint
Contributors: Sarah C Johnson; Jennifer Frattolin; Lowell T. Edgar; Mohammad Jafarnejad; James E. Moore, Jr.
Source: check_circle
Crossref

A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer

The AAPS Journal
2019-09 | Journal article
Contributors: Mohammad Jafarnejad; Chang Gong; Edward Gabrielson; Imke H. Bartelink; Paolo Vicini; Bing Wang; Rajesh Narwal; Lorin Roskos; Aleksander S. Popel
Source: check_circle
Crossref

Quantification of the Whole Lymph Node Vasculature Based on Tomography of the Vessel Corrosion Casts

Scientific Reports
2019-09-16 | Journal article
Contributors: M. Jafarnejad; A. Z. Ismail; D. Duarte; C. Vyas; A. Ghahramani; D. C. Zawieja; C. Lo Celso; G. Poologasundarampillai; J. E. Moore, Jr.
Source: check_circle
Crossref

Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma

npj Systems Biology and Applications
2019-08-16 | Journal article
Contributors: Mohammad Jafarnejad; Richard J. Sové; Ludmila Danilova; Adam C. Mirando; Yu Zhang; Mark Yarchoan; Phuoc T. Tran; Niranjan B. Pandey; Elana J. Fertig; Aleksander S. Popel
Source: check_circle
Crossref

A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade

Scientific Reports
2019-08-02 | Journal article
Contributors: Oleg Milberg; Chang Gong; Mohammad Jafarnejad; Imke H. Bartelink; Bing Wang; Paolo Vicini; Rajesh Narwal; Lorin Roskos; Aleksander S. Popel
Source: check_circle
Crossref

Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides.

Journal of theoretical biology
2018-07-20 | Journal article
Source: Self-asserted source
Mohammad Jafarnejad

Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat.

Frontiers in physiology
2018-05-30 | Journal article
Source: Self-asserted source
Mohammad Jafarnejad

A novel computational model predicts key regulators of chemokine gradient formation in lymph nodes and site-specific roles for CCL19 and ACKR4

Journal of Immunology
2017 | Journal article
EID:

2-s2.0-85029683848

Contributors: Jafarnejad, M.; Zawieja, D.C.; Brook, B.S.; Nibbs, R.J.B.; Moore, J.E.
Source: Self-asserted source
Mohammad Jafarnejad via Scopus - Elsevier
grade
Preferred source (of 2)‎

Demonstration and Analysis of the Suction Effect for Pumping Lymph from Tissue Beds at Subatmospheric Pressure

Scientific Reports
2017 | Journal article
EID:

2-s2.0-85029879333

Contributors: Jamalian, S.; Jafarnejad, M.; Zawieja, S.D.; Bertram, C.D.; Gashev, A.A.; Zawieja, D.C.; Davis, M.J.; Moore, J.E.
Source: Self-asserted source
Mohammad Jafarnejad via Scopus - Elsevier

The passive biomechanics of human pelvic collecting lymphatic vessels

PLoS ONE
2017 | Journal article
EID:

2-s2.0-85027868260

Contributors: Athanasiou, D.; Edgar, L.T.; Jafarnejad, M.; Nixon, K.; Duarte, D.; Hawkins, E.D.; Jamalian, S.; Cunnea, P.; Lo Celso, C.; Kobayashi, S. et al.
Source: Self-asserted source
Mohammad Jafarnejad via Scopus - Elsevier

Microfluidics and Future of Cancer Diagnostics

Ex Vivo Engineering of the Tumor Microenvironment
2016 | Other
Contributors: Samira Jamalian; Mohammad Jafarnejad; Amir R. Aref
Source: Self-asserted source
Mohammad Jafarnejad via Crossref Metadata Search

Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes

Lymphatic Research and Biology
2015 | Journal article
Contributors: Mohammad Jafarnejad; Matthew C. Woodruff; David C. Zawieja; Michael C. Carroll; J.E. Moore
Source: Self-asserted source
Mohammad Jafarnejad via Crossref Metadata Search

Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells

Am J Physiol Heart Circ Physiol
2015-01 | Journal article
DOI:

10.1152/ajpheart.00744.2014

Contributors: M. Jafarnejad; W. E. Cromer; R. R. Kaunas; S. L. Zhang; D. C. Zawieja; J. E. Moore
Source: Self-asserted source
Mohammad Jafarnejad via Crossref Metadata Search

Calcium regulation in lymphatic endothelial cells under flow

2013 | Conference paper
DOI:

10.1115/SBC2013-14828

EID:

2-s2.0-84894641210

Contributors: Jafarnejad, M.; Cromer, W.E.; Kaunas, R.R.; Zawieja, D.C.; Moore Jr., J.E.
Source: Self-asserted source
Mohammad Jafarnejad via Scopus - Elsevier

Developing a model for mass transport of nitric oxide in the lymphatic system

ASME 2012 Summer Bioengineering Conference, SBC 2012
2012 | Journal article
DOI:

10.1115/SBC2012-80795

Contributors: Wilson, J.T.; Jafarnejad, M.; Walsh, P.; Zawieja, D.C.; Kaunas, R.; Moore Jr., J.E.
Source: Self-asserted source
Mohammad Jafarnejad via Scopus - Elsevier
grade
Preferred source (of 2)‎

Investigation of wall shear stress related factors in realistic carotid bifurcation geometries and different flow conditions

2010 | Journal article
EID:

2-s2.0-78649493956

Contributors: Jamalian Ardakani, S.S.; Jafarnejad, M.; Firoozabadi, B.; Saidi, M.S.
Source: Self-asserted source
Mohammad Jafarnejad via Scopus - Elsevier