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drug delivery, nanomedicine, biomaterials, nanotechnology
United States

Biography

Dr. Xiaoyang Xu is a tenured full professor in the Department of Chemical and Materials Engineering at the New Jersey Institute of Technology (NJIT) and heads the Nanomedicine and Biomedical Materials Laboratory. He is also affiliated to the Department of Biomedical Engineering at NJIT. He earned his Ph.D. in Chemistry from Northwestern University under the mentorship of Professor Chad Mirkin, a world-renowned scientist in chemistry and nanomaterials. Dr. Xu later pursued postdoctoral research in nanomedicine and drug delivery with Professor Robert S. Langer at the Massachusetts Institute of Technology, a pioneer in tissue engineering and drug delivery. Dr. Xu’s research focuses on the development of novel functional biomaterials, nucleic acid drug nanocarriers, targeted nanomedicines, and nano-diagnostic agents, with applications in drug delivery, tissue engineering, gene therapy, and precision medicine. He has published over 60 SCI papers in journals such as Nature Communications, Science Advances, Bioactive Materials, JACS, PNAS, Angewandte Chemie, and ACS Nano, with more than 11,000 citations and has applied for several patents related to drug delivery systems. Dr. Xu's research team is committed to translating lab discoveries into clinical applications to enhance the prevention and treatment of cancer, cardiovascular diseases, and diabetes.

Activities

Employment (3)

New Jersey Institute of Technology: Newark, US

2024 to present | Professor (Chemical and Materials Engineering)
Employment
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xiaoyang xu

New Jersey Institute of Technology: Newark, NJ, US

2020 to 2024 | Associate Professor (Chemical and Materials Engineering)
Employment
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xiaoyang xu

New Jersey Institute of Technology: Newark, US

2014 to 2020 | Assistant Professor (Chemical and Materials Engineering)
Employment
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xiaoyang xu

Education and qualifications (2)

Massachusetts Institute of Technology: Cambridge, MA, US

2009-12 to 2014 | Postdoctoral Fellow (Chemical Engineering)
Education
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xiaoyang xu

Northwestern University: Evanston, IL, US

2004-03 to 2009-09 | Ph.D (Chemistry)
Education
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xiaoyang xu

Works (50 of 74)

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Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes

Aging and Disease
2025 | Journal article
Contributors: El-Araby, Rady E.; Tu, Qisheng; Xie, Ying; Aboushousha, Tarek; Li, Zhongyu; Xu, Xiaoyang; Zhu, Zoe X.; Dong, Lily Q.; Chen, Jake
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Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion

ACS Nano
2024 | Journal article
Contributors: Wang, Bin; Tang, Maoping; Chen, Qijing; Ho, William; Teng, Yilong; Xiong, Xiaojian; Jia, Zhitong; Li, Xiuling; Xu, Xiaoyang; Zhang, Xue-Qing
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grade
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Retrosynthesis prediction with an iterative string editing model

Nature Communications
2024 | Journal article
Contributors: Han, Yuqiang; Xu, Xiaoyang; Hsieh, Chang-Yu; Ding, Keyan; Xu, Hongxia; Xu, Renjun; Hou, Tingjun; Zhang, Qiang; Chen, Huajun
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Targeted mRNA Nanoparticles Ameliorate Blood-Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization

ACS Nano
2024 | Journal article
Contributors: Gao, Mingzhu; Li, Yan; Ho, William; Chen, Chen; Chen, Qijing; Li, Fengshi; Tang, Maoping; Fan, Qiuyue; Wan, Jieqing; Yu, Weifeng et al.
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Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy

ACS Nano
2024-12-17 | Journal article
Contributors: Chenshuang Zhang; Yilong Teng; Xin Bai; Maoping Tang; William Stewart; Jake Jinkun Chen; Xiaoyang Xu; Xue-Qing Zhang
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Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy

Nature Communications
2024-08-10 | Journal article
Contributors: Xin Bai; Qijing Chen; Fengqiao Li; Yilong Teng; Maoping Tang; Jia Huang; Xiaoyang Xu; Xue-Qing Zhang
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Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of <i>KRAS</i>-Mutant Non-Small-Cell Lung Cancer

ACS Applied Materials & Interfaces
2023 | Journal article
Contributors: Zhao, Guolin; Ho, William; Chu, Jinxian; Xiong, Xiaojian; Hu, Bin; Boakye-Yiadom, Kofi Oti; Xu, Xiaoyang; Zhang, Xue-Qing
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Modulating Plaque Inflammation <i>via</i> Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis

ACS Nano
2023 | Journal article
Contributors: Gao, Mingzhu; Tang, Maoping; Ho, William; Teng, Yilong; Chen, Qijing; Bu, Lei; Xu, Xiaoyang; Zhang, Xue-Qing
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mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy

Nature Communications
2023 | Journal article
Contributors: Li, Fengqiao; Zhang, Xue-Qing; Ho, William; Tang, Maoping; Li, Zhongyu; Bu, Lei; Xu, Xiaoyang
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Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells

ACS Nano
2023 | Journal article
Contributors: Zhang, Chenshuang; Teng, Yilong; Li, Fengqiao; Ho, William; Bai, Xin; Xu, Xiaoyang; Zhang, Xue-Qing
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Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines

ACS Nano
2022 | Journal article
Contributors: Li, Zhongyu; Zhang, Xue-Qing; Ho, William; Li, Fengqiao; Gao, Mingzhu; Bai, Xin; Xu, Xiaoyang
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Identification and Characterization of a Novel Long Noncoding RNA that Regulates Osteogenesis in Diet-Induced Obesity Mice

Frontiers in Cell and Developmental Biology
2022 | Journal article
Contributors: Hu, Zhekai; Qiu, Wei; Yu, Yuedi; Wu, Xingwen; Fang, Fuchun; Zhu, Xiaofang; Xu, Xiaoyang; Tu, Qisheng; Van Dyke, Thomas E.; Morgan, Elise F. et al.
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Inhaled siRNA nanoparticles targeting <i>IL11</i> inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge

Science Advances
2022 | Journal article
Contributors: Bai, Xin; Zhao, Guolin; Chen, Qijing; Li, Zhongyu; Gao, Mingzhu; Ho, William; Xu, Xiaoyang; Zhang, Xue-Qing
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Injectable Hydrogels for Vascular Tissue Engineering

Methods in Molecular Biology
2022 | Journal article
Contributors: Li, Fengqiao; Ho, William; Xu, Xiaoyang
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Rational design of engineered H-ferritin nanoparticles with improved siRNA delivery efficacy across an <i>in vitro</i> model of the mouse BBB

Nanoscale
2022 | Journal article
Contributors: Yuan, Ziwei; Wang, Bin; Teng, Yilong; Ho, William; Hu, Bin; Boakye-Yiadom, Kofi Oti; Xu, Xiaoyang; Zhang, Xue-Qing
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Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy

Bioactive Materials
2022 | Journal article
Contributors: Wang, Bin; Tang, Maoping; Yuan, Ziwei; Li, Zhongyu; Hu, Bin; Bai, Xin; Chu, Jinxian; Xu, Xiaoyang; Zhang, Xue-Qing
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Lipid‐Polymer Hybrid “Particle‐in‐Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID‐19 Vaccines

Advanced Functional Materials
2022-10 | Journal article | Author
Part of ISSN: 1616-301X
Part of ISSN: 1616-3028
Contributors: Zhongyu Li; Xue‐Qing Zhang; William Ho; Xin Bai; Dabbu Kumar Jaijyan; Fengqiao Li; Ranjeet Kumar; Afsal Kolloli; Selvakumar Subbian; Hua Zhu et al.
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xiaoyang xu
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An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing

Bioactive Materials
2021 | Journal article
Contributors: Hu, Bin; Gao, Mingzhu; Boakye-Yiadom, Kofi Oti; Ho, William; Yu, Wei; Xu, Xiaoyang; Zhang, Xue-Qing
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Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment

Biomaterials Science
2021 | Journal article
Contributors: Yu, Wei; Hu, Bin; Boakye-Yiadom, Kofi Oti; Ho, William; Chen, Qijing; Xu, Xiaoyang; Zhang, Xue-Qing
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Injectable PLGA-Coated Ropivacaine Produces A Long-Lasting Analgesic Effect on Incisional Pain and Neuropathic Pain

The Journal of Pain
2021 | Journal article
Contributors: Tian, Xue; Zhu, He; Du, Shibin; Zhang, Xue-Qing; Lin, Fuqing; Ji, Fengtao; Tsou, Yung-Hao; Li, Zhongyu; Feng, Yi; Ticehurst, Kathryn et al.
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Next-Generation Vaccines: Nanoparticle-Mediated DNA and mRNA Delivery

Advanced Healthcare Materials
2021 | Journal article
Contributors: Ho, William; Gao, Mingzhu; Li, Fengqiao; Li, Zhongyu; Zhang, Xue-Qing; Xu, Xiaoyang
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Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis

Frontiers in Cell and Developmental Biology
2021 | Journal article
Contributors: Li, Xiangfen; Zhu, Xiaofang; Wu, Hongle; Van Dyke, Thomas E.; Xu, Xiaoyang; Morgan, Elise F.; Fu, Wenyu; Liu, Chuanju; Tu, Qisheng; Huang, Dingming et al.
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Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage -targeted gene therapy

Journal of Controlled Release
2020 | Journal article
Contributors: Chen, Qijing; Gao, Mingzhu; Li, Zhongyu; Xiao, Yue; Bai, Xin; Boakye-Yiadom, Kofi Oti; Xu, Xiaoyang; Zhang, Xue-Qing
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Nanomedicine Approaches for Advanced Diagnosis and Treatment of Atherosclerosis and Related Ischemic Diseases

Advanced Healthcare Materials
2020 | Journal article
Contributors: Hu, Bin; Boakye-Yiadom, Kofi Oti; Yu, Wei; Yuan, Zi-Wei; Ho, William; Xu, Xiaoyang; Zhang, Xue-Qing
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Nanoparticle depots for controlled and sustained gene delivery

Journal of Controlled Release
2020 | Journal article
Contributors: Li, Zhongyu; Ho, William; Bai, Xin; Li, Fengqiao; Chen, Yen-jui; Zhang, Xue-Qing; Xu, Xiaoyang
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Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction

ACS Applied Materials & Interfaces
2019 | Journal article
Contributors: Yuan, Zhize; Tsou, Yung-Hao; Zhang, Xue-Qing; Huang, Shixing; Yang, Yang; Gao, Mingzhu; Ho, William; Zhao, Qiang; Ye, Xiaofeng; Xu, Xiaoyang
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Lysosome-targeting NIR ratiometric luminecent upcoversion nanoprobe toward arginine

Sensors and Actuators B: Chemical
2019 | Journal article
Contributors: Li, Zhanxian; Liu, Hanxiao; Li, Haixia; Tsou, Yung-Hao; Gao, Yilin; Xu, Xiaoyang; Du, Weiwei; Wei, Liuhe; Yu, Mingming
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Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities

Advanced Healthcare Materials
2019 | Journal article
Contributors: Tsou, Yung-Hao; Wang, Bin; Ho, William; Hu, Bin; Tang, Pei; Sweet, Sydney; Zhang, Xue-Qing; Xu, Xiaoyang
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Bioactive hydrogels for bone regeneration

Bioactive Materials
2018 | Journal article
Contributors: Bai, Xin; Gao, Mingzhu; Syed, Sahla; Zhuang, Jerry; Xu, Xiaoyang; Zhang, Xue-Qing
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Boron-doped graphene nanosheet-supported Pt: a highly active and selective catalyst for low temperature H<sub>2</sub>-SCR

Nanoscale
2018 | Journal article
Contributors: Hu, Maocong; Yao, Zhenhua; Li, Lili; Tsou, Yung-Hao; Kuang, Liyuan; Xu, Xiaoyang; Zhang, Wen; Wang, Xianqin
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Dopant-Free Hydrogels with Intrinsic Photoluminescence and Biodegradable Properties

Advanced Functional Materials
2018 | Journal article
Contributors: Tsou, Yung-Hao; Zhang, Xue-Qing; Bai, Xin; Zhu, He; Li, Zhongyu; Liu, Yanlan; Shi, Jinjun; Xu, Xiaoyang
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Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials (vol 13, 1701921, 2017)

Small
2018 | Journal article
Contributors: Tsou, Yung-Hao; Zhang, Xue-Qing; Zhu, He; Syed, Sahla; Xu, Xiaoyang
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Dual-Functional Dextran-PEG Hydrogel as an Antimicrobial Biomedical Material

Macromolecular Bioscience
2018 | Journal article
Contributors: Wang, Lei; Li, Xin; Sun, Tianyu; Tsou, Yung-Hao; Chen, Hong; Xu, Xiaoyang
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Exploring cutting-edge hydrogel technologies and their biomedical applications

Bioactive Materials
2018 | Journal article
Contributors: Wu, Decheng; Xu, Xiaoyang
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Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials

Small
2017 | Journal article
Contributors: Tsou, Yung-Hao; Zhang, Xue-Qing; Zhu, He; Syed, Sahla; Xu, Xiaoyang
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Synthesis of PLGA-Lipid Hybrid Nanoparticles for siRNA Delivery Using the Emulsion Method PLGA-PEG-Lipid Nanoparticles for siRNA Delivery

Methods in Molecular Biology
2017 | Journal article
Contributors: Wang, Lei; Griffel, Benjamin; Xu, Xiaoyang
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Biomaterials in siRNA Delivery: A Comprehensive Review

Advanced Healthcare Materials
2016 | Journal article
Contributors: Ho, William; Zhang, Xue-Qing; Xu, Xiaoyang
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Green Nanomaterials Preparation: Sustainable Methods and Approaches

SUSTAINABLE CATALYSIS: WITH NON-ENDANGERED METALS, PT 1
2016 | Journal article
Contributors: Xu, Xiaoyang; Lyu, Qian; Bader, Joshua; Accordino, Meagan
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Highly specific colorimetric detection of DNA oxidation biomarker using gold nanoparticle/triplex DNA conjugates

Nanomedicine: Nanotechnology, Biology, and Medicine
2016 | Journal article
Contributors: Gao, Xun; Tsou, Yung-Hao; Garis, Marina; Huang, Haidong; Xu, Xiaoyang
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Hydrogel as a bioactive material to regulate stem cell fate

Bioactive Materials
2016 | Journal article
Contributors: Tsou, Yung-Hao; Khoneisser, Joe; Huang, Ping-Chun; Xu, Xiaoyang
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Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles

Proceedings of the National Academy of Sciences
2016-05-17 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Yuan Xue; Xiaoyang Xu; Xue-Qing Zhang; Omid C. Farokhzad; Robert Langer
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An intestinal Trojan horse for gene delivery

Nanoscale
2015 | Journal article
Contributors: Peng, Haisheng; Wang, Chao; Xu, Xiaoyang; Yu, Chenxu; Wang, Qun
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Cancer nanomedicine: from targeted delivery to combination therapy

Trends in Molecular Medicine
2015 | Journal article
Contributors: Xu, Xiaoyang; Ho, William; Zhang, Xueqing; Bertrand, Nicolas; Farokhzad, Omid
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Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment

Proceedings of the National Academy of Sciences
2015 | Journal article
Contributors: Zhu, Xi; Xu, Yingjie; Solis, Luisa M.; Tao, Wei; Wang, Liangzhe; Behrens, Carmen; Xu, Xiaoyang; Zhao, Lili; Liu, Danny; Wu, Jun et al.
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Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis

Advanced Healthcare Materials
2015 | Journal article
Contributors: Zhang, Xue-Qing; Even-Or, Orli; Xu, Xiaoyang; van Rosmalen, Mariska; Lim, Lucas; Gadde, Suresh; Farokhzad, Omid C.; Fisher, Edward A.
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Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Advanced Drug Delivery Reviews
2014 | Journal article
Contributors: Bertrand, Nicolas; Wu, Jun; Xu, Xiaoyang; Kamaly, Nazila; Farokhzad, Omid C.
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Cisplatin-RNAi nanotherapeutics for synergistic anti-tumor activity

Cancer Research
2014 | Journal article
Contributors: Xu, Xiaoyang; Zhang, Xueqing; Xie, Kun; Walker, Graham; Farokhzad, Omid
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Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers

Angewandte Chemie International Edition
2014 | Journal article
Contributors: Wu, Jun; Kamaly, Nazila; Shi, Jinjun; Zhao, Lili; Xiao, Zeyu; Hollett, Geoffrey; John, Rohit; Ray, Shaunak; Xu, Xiaoyang; Zhang, Xueqing et al.
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Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing

Nanomedicine: Nanotechnology, Biology, and Medicine
2014 | Journal article
Contributors: Shi, Jinjun; Xu, Yingjie; Xu, Xiaoyang; Zhu, Xi; Pridgen, Eric; Wu, Jun; Votruba, Alexander R.; Swami, Archana; Zetter, Bruce R.; Farokhzad, Omid C.
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Enhancing tumor cell response to chemotherapy by simultaneous delivery of siRNA and cisplatin using polymeric nanoparticles

Cancer Research
2013 | Journal article
Contributors: Xu, Xiaoyang; Zhang, Xueqing; Xie, Kun; Pridgen, Eric; Langer, Robert; Walker, Graham; Farokhzad, Omid
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Peer review (87 reviews for 22 publications/grants)

Review activity for ACS applied bio materials. (2)
Review activity for ACS applied materials & interfaces. (13)
Review activity for ACS applied polymer materials. (1)
Review activity for ACS biomaterials science & engineering. (4)
Review activity for ACS nano. (16)
Review activity for Advanced functional materials. (2)
Review activity for Advanced healthcare materials (8)
Review activity for Advanced materials. (4)
Review activity for Advanced science. (2)
Review activity for Angewandte Chemie. (1)
Review activity for Biomaterials. (9)
Review activity for Cell biomaterials. (2)
Review activity for Cell reports medicine. (1)
Review activity for Journal of controlled release. (2)
Review activity for Journal of the American Chemical Society. (4)
Review activity for Materials today bio. (1)
Review activity for Molecular pharmaceutics. (5)
Review activity for Molecular therapy. (1)
Review activity for Nano letters. (5)
Review activity for Nano research. (1)
Review activity for Nature communications (2)
Review activity for Small. (1)