Personal information
Biography
Summary of research career
After the completion of my BSc and MSc degrees in Biochemistry and Translational oncology respectively I joined Tim Skerry’s group in Sheffield as a Staff candidate PhD student to work on the Wellcome Early Stage Seeding Drug Discovery project aiming the Development of Adrenomedullin 2 receptor antagonists for pancreatic cancer. During that time we have successfully develop novel Adrenomedullin 2 receptor antagonists with great potential to be used as cancer therapeutic agents. As a result the group was further awarded with the Wellcome late Stage Seeding Drug Discovery Award to further develop these antagonists.
Expertise/Techniques
During that time, I have developed a high throughput cell based cAMP screening assay for the identification of novel small molecule antagonists against Adrenomedullin 2 receptor using a liquid handling platform on which I have become the main administrator after I have attended a four day training course. Moreover, I have successfully obtained a Home Office Licence and I have become competent on performing several in-vivo techniques including: Schedule 1, Subcutaneous, Intraperitoneal (IP) and Intracardiac injections. Using these techniques we were able to establish compound efficacy in both subcutaneous and orthotopic in-vivo models. Also I have successfully completed a hands-on SPR (Surface plasmon resonance) training course that further help me to develop my drug discovery and pharmacology skills. Furthermore, my role involved the use of several basic biology, biochemistry and histology techniques.
Interests
I am particularly interested in the deeper understanding of the role of receptor associate modifying proteins (RAMPs) in the pharmacology of G protein coupled receptors (including the calcitonin family of receptors and PTH receptors).