Personal information

United Kingdom

Biography

Summary of research career
After the completion of my BSc and MSc degrees in Biochemistry and Translational oncology respectively I joined Tim Skerry’s group in Sheffield as a Staff candidate PhD student to work on the Wellcome Early Stage Seeding Drug Discovery project aiming the Development of Adrenomedullin 2 receptor antagonists for pancreatic cancer. During that time we have successfully develop novel Adrenomedullin 2 receptor antagonists with great potential to be used as cancer therapeutic agents. As a result the group was further awarded with the Wellcome late Stage Seeding Drug Discovery Award to further develop these antagonists.

Expertise/Techniques
During that time, I have developed a high throughput cell based cAMP screening assay for the identification of novel small molecule antagonists against Adrenomedullin 2 receptor using a liquid handling platform on which I have become the main administrator after I have attended a four day training course. Moreover, I have successfully obtained a Home Office Licence and I have become competent on performing several in-vivo techniques including: Schedule 1, Subcutaneous, Intraperitoneal (IP) and Intracardiac injections. Using these techniques we were able to establish compound efficacy in both subcutaneous and orthotopic in-vivo models. Also I have successfully completed a hands-on SPR (Surface plasmon resonance) training course that further help me to develop my drug discovery and pharmacology skills. Furthermore, my role involved the use of several basic biology, biochemistry and histology techniques.

Interests
I am particularly interested in the deeper understanding of the role of receptor associate modifying proteins (RAMPs) in the pharmacology of G protein coupled receptors (including the calcitonin family of receptors and PTH receptors).

Activities

Employment (2)

University of Sheffield: Sheffield, South Yorkshire, GB

2018-04-01 to present | Post-doctoral Research associate (Oncology and Metabolism)
Employment
Source: Self-asserted source
PARIS AVGOUSTOU

University of Sheffield: Sheffield, South Yorkshire, GB

2015-03-01 to 2018-03-31 | Research technician (Oncology and Metabolism)
Employment
Source: Self-asserted source
PARIS AVGOUSTOU

Education and qualifications (3)

University of Sheffield: Sheffield, South Yorkshire, GB

2015-03-01 to 2018-10-01 | PhD (Oncology and Metabolism)
Education
Source: Self-asserted source
PARIS AVGOUSTOU

University of Sheffield: Sheffield, South Yorkshire, GB

2013-09-01 to 2014-09-01 | MSc (Res) Translational Oncology
Education
Source: Self-asserted source
PARIS AVGOUSTOU

University of Surrey: Guildford, Surrey, GB

2010-10-01 to 2013-07-17 | BSc Biochemistry
Education
Source: Self-asserted source
PARIS AVGOUSTOU

Works (5)

Receptor activity modifying protein modulation of parathyroid hormone-1 receptor function and signalling

2024-04-19 | Preprint
Contributors: Paris Avgoustou; Ameera B. A. Jailani; Aditya J. Desai; Dave J. Roberts; Ewan R. Lilley; Grant W. Stothard; Timothy M. Skerry; Gareth O. Richards
Source: check_circle
Crossref

Targeting the adrenomedullin-2 receptor for the discovery and development of novel anti-cancer agents

Expert Opinion on Drug Discovery
2022-08-03 | Journal article
Contributors: Ameera B. A. Jailani; Kamilla J. A. Bigos; Paris Avgoustou; Joseph L. Egan; Robert A. Hathway; Timothy M. Skerry; Gareth O. Richards
Source: check_circle
Crossref

Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

Journal of Medicinal Chemistry
2021-03-25 | Journal article
Contributors: Jean-Olivier Zirimwabagabo; Ameera B. A. Jailani; Paris Avgoustou; Matthew J. Tozer; Karl R. Gibson; Paul A. Glossop; James E. J. Mills; Roderick A. Porter; Paul Blaney; Ning Wang et al.
Source: check_circle
Crossref

Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor

ACS Pharmacology & Translational Science
2020-08-14 | Journal article
Contributors: Paris Avgoustou; Ameera B. A. Jailani; Jean-Olivier Zirimwabagabo; Matthew J. Tozer; Karl R. Gibson; Paul A. Glossop; James E. J. Mills; Roderick A. Porter; Paul Blaney; Peter J. Bungay et al.
Source: check_circle
Crossref

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions.

Clinical & experimental metastasis
2015-08-01 | Journal article
Source: Self-asserted source
PARIS AVGOUSTOU

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)