Carl Jenkinson (0000-0002-1838-5282)

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Biography

I am a group leader at the MRC London Institute of Medical Sciences. My program of research aims to establish novel bioanalytical methods using mass spectrometry for translational applications within clinical endocrinology. Current research activity has focused on the analysis of vitamin D metabolism and novel approaches to define optimum and sufficient levels across population groups, and the impact of vitamin D and its supplementation on health outcomes. Additionally, Other research interests include investigating the role of steroid metabolomics in health, including as diagnostic tools for screening adrenal incidentaloma, as well as mass spectrometry applications for anabolic steroid detection in sports doping tests.

Alongside these research interests I have been involved in professional bodies and working groups across subject fields. I received Chartered Chemist (CChem) status and membership to the Royal Society of Chemistry, and recently accepted onto the Society and Endocrinology Leadership & Development Award Program, providing funding and unique opportunities across endocrinology to develop my professional profile and career development.

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MRC London Institute of Medical Sciences: London, GB

2023-04-15 to present | Group Leader (Program Leader Track)

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Carl Jenkinson

https://orcid.org/0000-0002-1838-5282

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Biography

Activities

Employment (4)

MRC London Institute of Medical Sciences: London, GB

University of Birmingham: Birmingham, GB

University of Birmingham: Birmingham, GB

Anzac Research Institute: Concord, Sydney, New South Wales, AU

Education and qualifications (2)

Kingston University: Kingston-Upon-Thames, London, GB

Kingston University: Kingston-Upon-Thames, London, GB

Professional activities (12)

Imperial College London: London, Westminster, GB

University of Sydney: Sydney, AU

Endocrine Society of Australia: Sydney, New South Wales, AU

Royal Society of Chemistry: London, GB

Society for Endocrinology: Bristol, GB

Society for Endocrinology: Bristol, GB

University of Western Australia: Perth, AU

British Mass Spectrometry Society: Northwich, GB

Royal Society of Chemistry: London, GB

Vitamin D Workshop: Boston, US

Anzac Research Institute: Concord, New South Wales, AU

Wythenshawe Hospital: Manchester, GB

Funding (9)

Leadership & Development Awards Programme

Investigating vitamin D and steroid hormone metabolism in postmenopausal osteoporosis

Assessing the role of vitamin D metabolism in ageing

Development and Application of Mass Spectrometry Methods for Analysis of Optimal Vitamin D

Research Visit

Research Visit

Royal Society of Chemistry Summer Studentships

Role of deconjugation on the measurement of circulating vitamin D metabolites

Nitrogen evaporator manifold equipment

Works (50 of 58)

Severe Hypercalcemia in Pregnancy Presenting a Diagnostic Conundrum

Cardiometabolic disease burden and steroid excretion in benign adrenal tumors: a cross-sectional multicenter study

Circulating conjugated and unconjugated vitamin D metabolite measurements by liquid chromatography mass spectrometry

Measurements of circulating conjugated and unconjugated vitamin D metabolites by enzyme hydrolysis combined with liquid chromatography mass spectrometry

Placental uptake and metabolism of 25 (OH) vitamin D determine its activity within the fetoplacental unit

Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

Urinary steroid metabolomics for adrenocortical cancer diagnosis. Comparison of gas chromatography mass spectrometry to liquid chromatography mass spectrometry

Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis

Development of a LC-MS/MS method to measure serum 3-sulfate and 3-glucuronide 25-hydroxyvitamin D3 metabolites; comparisons to unconjugated 25OHD in pregnancy and polycystic ovary syndrome

Diet-induced vitamin D deficiency reduces skeletal muscle mitochondrial respiration

Low serum 1, 25 (OH) 2D3 in end-stage renal disease: is reduced 1$α$-hydroxylase the only problem?

Placental uptake and metabolism as determinants of pregnancy vitamin D status

Simultaneous measurement of 13 circulating vitamin D3 and D2 mono and dihydroxy metabolites using liquid chromatography mass spectrometry

Trophoblast uptake of DBP regulates intracellular actin and promotes matrix invasion

Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit

11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial

Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective

Free versus total serum 25-hydroxyvitamin D in a murine model of colitis

Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis

The vitamin D metabolome: An update on analysis and function

The vitamin D metabolome: An update on analysis and function

Analysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)

Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization

Nicotinamide nucleotide transhydrogenase as a novel treatment target in adrenocortical carcinoma

Serum and urine vitamin D metabolite analysis in early preeclampsia

The utility of ultra-high performance supercritical fluid chromatography--tandem mass spectrometry (UHPSFC-MS/MS) for clinically relevant steroid analysis

VITAMIN D STATUS AND INFLUENCE ON OUTCOMES FOLLOWING MAJOR BURN INJURY: AN OBSERVATIONAL COHORT STUDY

Analysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)

1, 25-dihydroxyvitamin D deficiency in haemodialysis patients is corrected by vitamin D supplementation

11-Oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome

25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression

Androgen excess is highly prevalent in women with idiopathic intracranial hypertension and is biochemically distinct from polycystic ovary syndromes

Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma

Automated development of an LC-MS/MS method for measuring multiple vitamin D metabolites using MUSCLE software

Dissecting the androgen excess phenotype of women with idiopathic intracranial hypertension

DISSECTING THE ANDROGEN EXCESS PHENOTYPE OF WOMEN WITH IDIOPATHIC INTRACRANIAL HYPERTENSION

Dysregulation of maternal and placental vitamin D metabolism in preeclampsia

Influence of vitamin D on outcomes following burn injury: An observational cohort study