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Activities

Employment (1)

Brown University: Providence, RI, US

Employment
Source: check_circle
Brown University

Education and qualifications (3)

Philipps-Universität Marburg: Marburg, Hessen, DE

2006-09-01 to 2009-12-21 | Ph.D
Education
Source: Self-asserted source
Xiaodi F. Chen

Philipps-Universität Marburg: Marburg, Hessen, DE

2001-09-01 to 2006-07-31 | M.Sc.
Education
Source: Self-asserted source
Xiaodi F. Chen

Shanghai Medical College of Fudan University: Shanghai, CN

1991-09-01 to 1996-06-30 | B.M. (US M.D. equivalent)
Education
Source: Self-asserted source
Xiaodi F. Chen

Professional activities (4)

Charles H. Hood Foundation: Boston, US

2024-11-22 to 2024-11-22 | Grant reviewer
Service
Source: Self-asserted source
Xiaodi F. Chen

NIH Developmental Brain Disorders Study Section: Washington, DC, US

2024-10-23 to 2024-10-25 | Grant Reviewer
Service
Source: Self-asserted source
Xiaodi F. Chen

NIH Developmental Brain Disorders Study Section: Washington DC, US

2024-02-26 to 2024-02-27 | Grant Reviewer
Service
Source: Self-asserted source
Xiaodi F. Chen

NIH Developmental Brain Disorders Study Section: Bethesda, MD, US

2022-11-02 to 2022-11-03 | Grant Reviewer
Service
Source: Self-asserted source
Xiaodi F. Chen

Funding (12)

Syn3 Effects on Chronic Inflammation and Neurodevelopment in Neonatal HIE

2025-02 to 2027-01 | Grant
Brain Injury Association of America (Vienna, US)
Source: Self-asserted source
Xiaodi F. Chen

R21NS133544: A novel BDNF potentiator for the treatment of neonatal brain injury

Source: Self-asserted source
Xiaodi F. Chen

Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury

2023-09 to 2026-08 | Grant
NIH/NINDS (Bethesda, MD, US)
GRANT_NUMBER:

R44 NS084575

Source: Self-asserted source
Xiaodi F. Chen

Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemia

2021-05-01 to 2026-01-31 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
GRANT_NUMBER: R01NS117428
Source: Self-asserted source
Xiaodi F. Chen via DimensionsWizard

5R01NS117428-02

2021-04 to 2026-01 | Grant
National Institute of Neurological Disorders and Stroke (Md., Md., US)
Source: Self-asserted source
Xiaodi F. Chen

Oh-Zopfi Pilot Project Grant

2019-07 to 2020-06 | Grant
Department of Pediatrics, Women & Infants’ Hospital of RI, The Alpert Medical School of Brown University (Providence, US)
Source: Self-asserted source
Xiaodi F. Chen

Oh-Zopfi Pilot Project Grant

2018-06 to 2019-05 | Grant
Women & Infants Hospital of RI, Alpert Medical School of Brown University (Providence, US)
Source: Self-asserted source
Xiaodi F. Chen

5R01HD057100-07

2017-08 to 2021-07 | Grant
National Institutes of Health (MD, MD, US)
Source: Self-asserted source
Xiaodi F. Chen

2 R44 NS084575-02

2017-06 to 2019-05 | Grant
National Institutes of Health (MD, MD, US)
Source: Self-asserted source
Xiaodi F. Chen

1R21NS095130-01A1

2016-08 to 2018-07 | Grant
National Institutes of Health (MD, MD, US)
Source: Self-asserted source
Xiaodi F. Chen

1R21NS096525-01

2016-08 to 2018-07 | Grant
National Institutes of Health (MD, MD, US)
Source: Self-asserted source
Xiaodi F. Chen

Oh-Zopfi Pilot Project Grant

2015-05 to 2017-04 | Grant
Women & Infants Hospital of RI, Alpert Medical School of Brown University (Providence, US)
Source: Self-asserted source
Xiaodi F. Chen

Works (42)

Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats.

Experimental neurology
2025-01-19 | Journal article
Contributors: Chen XF; Kroke B; Ni J; Munoz C; Appleman M; Jacobs B; Tran T; Nguyen KV; Qiu C; Stonestreet BS et al.
Source: Self-asserted source
Xiaodi F. Chen

Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia-Ischemia in Neonatal Rats.

Molecular neurobiology
2024-11-07 | Journal article
Contributors: Koehn LM; Nguyen KV; Tucker R; Lim YP; Chen X; Stonestreet BS
Source: Self-asserted source
Xiaodi F. Chen

Editorial: Autophagy: unveiling the mechanisms and implications in health and disease.

Frontiers in physiology
2024-09-30 | Journal article
Contributors: Cheng S; Chen X; Liao A
Source: Self-asserted source
Xiaodi F. Chen

Association between decreased cord blood inter-alpha inhibitor levels and neonatal encephalopathy at birth.

Early human development
2024-05-07 | Journal article
Contributors: Lynn Bitar; Stonestreet BS; Lim YP; Qiu J; Chen X; Mir IN; Chalak LF
Source: Self-asserted source
Xiaodi F. Chen

Neuroprotective efficacy of hypothermia and Inter-alpha Inhibitor Proteins after hypoxic ischemic brain injury in neonatal rats.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2024-03-06 | Journal article
Contributors: Chen XF; Wu Y; Kim B; Nguyen KV; Chen A; Qiu J; Santoso AR; Disdier C; Lim YP; Stonestreet BS
Source: Self-asserted source
Xiaodi F. Chen

Inter-Alpha Inhibitor Proteins Modify the Microvasculature after Exposure to Hypoxia-Ischemia and Hypoxia in Neonatal Rats.

International journal of molecular sciences
2023-04-04 | Journal article
Contributors: FRANCESCO GIROLAMO; Yow-Pin Lim; Virgintino D; Barbara Stonestreet; Chen XF
Source: Self-asserted source
Xiaodi F. Chen

Editorial: Perinatal Hypoxic-Ischemic Brain Injury: Mechanisms, Pathogenesis, and Potential Therapeutic Strategies

Frontiers in Cellular Neuroscience
2022-11-16 | Journal article
Contributors: Xiaodi F. Chen
Source: Self-asserted source
Xiaodi F. Chen

Effects of Three Different Doses of Inter-Alpha Inhibitor Proteins on Severe Hypoxia-Ischemia-Related Brain Injury in Neonatal Rats.

International journal of molecular sciences
2022-11-03 | Journal article | Author
Contributors: Liam Matthew Koehn; Nguyen K; Xiaodi F. Chen; Santoso A; Tucker R; Yow-Pin Lim; Barbara Stonestreet
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 3)‎

Time Course of Changes in the Neurovascular Unit after Hypoxic-Ischemic Injury in Neonatal Rats.

International journal of molecular sciences
2022-04-10 | Journal article
Contributors: Xiaodi F. Chen
Source: Self-asserted source
Xiaodi F. Chen

Inter-alpha Inhibitor Proteins Ameliorate Brain Injury and Improve Behavioral Outcomes in a Sex-Dependent Manner After Exposure to Neonatal Hypoxia Ischemia in Newborn and Young Adult Rats.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2022-03-15 | Journal article
Contributors: Xiaodi F. Chen
Source: Self-asserted source
Xiaodi F. Chen

Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate.

Journal of neonatal-perinatal medicine
2022-01-01 | Journal article
Contributors: Xiaodi F. Chen
Source: Self-asserted source
Xiaodi F. Chen

Changes in Cellular Localization of Inter-Alpha Inhibitor Proteins after Cerebral Ischemia in the Near-Term Ovine Fetus.

International journal of molecular sciences
2021-10-04 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

High‐mobility group box‐1 and inter‐alpha inhibitor proteins: In vitro binding and co‐localization in cerebral cortex after hypoxic‐ischemic injury

The FASEB Journal
2021-03 | Journal article
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Novel Neuroprotective Agents to Treat Neonatal Hypoxic-Ischemic Encephalopathy: Inter-Alpha Inhibitor Proteins.

International journal of molecular sciences
2020-12-02 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Potential neuroinvasive and neurotrophic properties of SARS-CoV-2 in pediatric patients: comparison of SARS-CoV-2 with non-segmented RNA viruses.

Journal of neurovirology
2020-10-14 | Journal article
Contributors: Xiaodi F. Chen
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Effects of inter-alpha inhibitor proteins on brain injury after exposure of neonatal rats to severe hypoxia-ischemia.

Experimental neurology
2020-09-05 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Potential neuroinvasive and neurotrophic properties of SARS-CoV-2 in pediatric patients: Comparison of SARS-CoV-2 with non-segmented RNA viruses

2020-06-15 | Preprint
Contributors: Xiaodi Chen
Source: check_circle
Crossref

Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain.

Journal of neuroinflammation
2020-05-28 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Critical Shifts in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by the Positive Ion Mode MALDI-Mass Spectrometry.

Cell medicine
2020-02-07 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis After Hypoxic-Ischemic Brain Injury in Neonatal Rats.

Current pharmaceutical design
2020-01-01 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Ontogeny of inter-alpha inhibitor protein (IAIP) expression in human brain.

Journal of neuroscience research
2019-12-04 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Inter-alpha inhibitor proteins attenuate lipopolysaccharide-induced blood-brain barrier disruption and downregulate circulating interleukin 6 in mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
2019-06-24 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 3)‎

Inter-alpha Inhibitor Proteins Modulate Neuroinflammatory Biomarkers After Hypoxia-Ischemia in Neonatal Rats.

Journal of neuropathology and experimental neurology
2019-05-29 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats.

Experimental neurology
2019-03-23 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Rapid Alterations in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by MALDI-Mass Spectrometry.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
2019-01-25 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats.

Experimental neurology
2018-09-12 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain.

Developmental neuroscience
2018-07-26 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period.

Brain sciences
2018-06-07 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus.

Brain, behavior, and immunity
2017-08-02 | Journal article
Source: Self-asserted source
Xiaodi F. Chen
grade
Preferred source (of 2)‎

Neutralizing anti-interleukin-1β antibodies reduce ischemia-related interleukin-1β transport across the blood-brain barrier in fetal sheep.

Neuroscience
2017-01-09 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Ischemia reduces inter-alpha inhibitor proteins in the brain of the ovine fetus.

Developmental neurobiology
2016-11-17 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Expression and localization of Inter-alpha Inhibitors in rodent brain.

Neuroscience
2016-03-08 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin.

Scientific reports
2016-01-19 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Ontogeny of tight junction protein expression in the ovine cerebral cortex during development.

Neuroscience
2015-09-28 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Interleukin-1β transfer across the blood-brain barrier in the ovine fetus.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
2015-06-17 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2015-01-21 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia.

Neurobiology of disease
2014-09-26 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep.

Neuroimmunomodulation
2013-07-18 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Ischemia-reperfusion impairs blood-brain barrier function and alters tight junction protein expression in the ovine fetus.

Neuroscience
2012-09-15 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

In-vitro validation of cytokine neutralizing antibodies by testing with ovine mononuclear splenocytes.

Journal of comparative pathology
2012-07-20 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

TRPM3 is a nociceptor channel involved in the detection of noxious heat.

Neuron
2011-05-01 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Drosophila TRPM channel is essential for the control of extracellular magnesium levels.

PloS one
2010-05-06 | Journal article
Source: Self-asserted source
Xiaodi F. Chen

Peer review (2 reviews for 1 publication/grant)

Review activity for Heliyon. (2)