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CaMKK2, AMPK, signalling pathways, energy metabolism, mood disorders, metabolic sensing
Australia

Biography

Dr Scott’s primary research interest is on understanding the molecular mechanisms that regulate cellular energy metabolism. His research is specifically focused on role of the CaM kinase family of enzymes (CaMKs) in the regulation of cellular and whole-body energy homeostasis. Dr Scott has established a number of national and international collaborations with academic and industrial partners to develop drugs that target the CaMKs as potential new therapies for metabolic diseases, lipid-driven cancers, and neurodevelopmental disorders.

Dr Scott graduated with a Bachelor of Science (Hons) from the University of Glasgow and a PhD in Biochemistry from the University of Dundee funded by a Wellcome Trust Prize scholarship, after which he moved to Melbourne to undertake postdoctoral studies with Prof Bruce Kemp AO at St Vincent’s Institute of Medical Research (SVIMR). Dr Scott is a Monash Research Talent Accelerator Fellow and Lab Head at Monash Institute of Pharmaceutical Sciences (MIPS), and an Honorary Senior Research Fellow at the Florey Institute of Neuroscience and Mental Health. He also holds a Senior Research Associate appointment at SVIMR. His research team uses a wide range of techniques including biochemistry, cell biology, protein crystallography, mass spectrometry, and genetically modified mouse models to decipher the role of the CaMK family in the regulation of energy metabolism in health and disease.

Activities

Employment (4)

Monash Institute of Pharmaceutical Sciences: Parkville, VIC, AU

2022-05-02 to present | Lab Head, Neurometabolism (Drug Discovery Biology)
Employment
Source: Self-asserted source
John W Scott

St Vincent's Institute of Medical Research: Fitzroy, VIC, AU

2018-01-01 to 2022-04-29 | Lab Head, Neurometabolism
Employment
Source: Self-asserted source
John W Scott

Saint Vincent's Institute of Medical Research: Fitzroy, VIC, AU

2006-05-15 to 2017-12-31 | Senior Research Officer (Protein Chemistry and Metabolism)
Employment
Source: Self-asserted source
John W Scott

University of Dundee: Dundee, Dundee, GB

2002-07-15 to 2006-04-30 | Research Fellow (Cell Signalling)
Employment
Source: Self-asserted source
John W Scott

Education and qualifications (2)

University of Dundee: Dundee, Dundee, GB

1997-10-10 to 2002-07-02 | Doctor of Philosophy (PhD) (School of Life Sciences)
Education
Source: Self-asserted source
John W Scott

University Of Glasgow: Glasgow, Scotland, GB

1993-10-01 to 1997-07-04 | Bachelor of Science (Honours) (School of Life Sciences)
Education
Source: Self-asserted source
John W Scott

Professional activities (8)

Biochemical Society: London, GB

Full membership
Membership
Source: Self-asserted source
John W Scott

SYNthesis Research: Melbourne, Victoria, AU

2022-05-02 to present | Scientific Consultant
Invited position
Source: Self-asserted source
John W Scott

Australian Society for Biochemistry and Molecular Biology: Kent Town, SA, AU

2018-01-09 to present
Membership
Source: Self-asserted source
John W Scott

Nature Publishing Group: London, GB

2018 to present | Editorial Board Member (Scientific Reports)
Membership
Source: Self-asserted source
John W Scott

Florey Institute of Neuroscience and Mental Health: Melbourne, Victoria, AU

2018 to present | Senior Honorary Research Fellow
Invited position
Source: Self-asserted source
John W Scott

St Vincent's Institute of Medical Research: Fitzroy, VIC, AU

2022-05-01 to 2025-04-30 | Honorary Research Associate
Invited position
Source: Self-asserted source
John W Scott

Australian Catholic University: Melbourne, VIC, AU

2018-08-01 to 2022-04-29 | Senior Honorary Research Fellow (Mary MacKillop Institute of Health Research)
Invited position
Source: Self-asserted source
John W Scott

Siragen Pharmaceuticals: San Diego, California, US

2018 to 2022 | Scientific Advisory Board Member
Invited position
Source: Self-asserted source
John W Scott

Funding (6)

Uncovering New Mechanisms of Metabolite-Sensing and Signaling

2021-01 to 2023-12 | Grant
Australian Research Council (Canberra, ACT, AU)
GRANT_NUMBER:

DP210102840

Source: Self-asserted source
John W Scott

Validating CaMKK2 as a Rational Treatment Target for Bipolar Disorder

2021-01 to 2023-12 | Grant
National Health and Medical Research Council (Canberra, ACT, AU)
GRANT_NUMBER:

2001817

Source: Self-asserted source
John W Scott

Regulation of energy metabolism by CaMKK2

2018-01-01 to 2020-12-31 | Grant
National Health and Medical Research Council (Canberra, AU)
GRANT_NUMBER: 1138102
Source: Self-asserted source
John W Scott via DimensionsWizard

Signaling pathways to enhance potency of AMPK-targeting drugs

2016-01-01 to 2018-01-01 | Grant
National Health and Medical Research Council (Canberra, AU)
GRANT_NUMBER: 1098459
Source: Self-asserted source
John W Scott via DimensionsWizard

Metabolic stress sensing by AMPK: implications for energy balance and isoform-targetting therapeutics

2013-01-01 to 2015-01-01 | Grant
National Health and Medical Research Council (Canberra, AU)
GRANT_NUMBER: 1049197
Source: Self-asserted source
John W Scott via DimensionsWizard

Regulation of Ca2+/calmodulin dependent protein kinase kinase-2 by phosphorylation

2012-01-01 to 2014-01-01 | Grant
National Health and Medical Research Council (Canberra, AU)
GRANT_NUMBER: 1028256
Source: Self-asserted source
John W Scott via DimensionsWizard

Peer review (1 review for 1 publication/grant)

Review activity for Molecular brain (1)