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Keywords

MPN, AML, Leukemia, Myelofibrosis, CALR, NFE2, LSD1, PV, ET

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United States

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Works (17)

Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications

Current Hematologic Malignancy Reports
2025-12 | Journal article
DOI: 10.1007/s11899-024-00749-4
Contributors: Mifra Faiz; Merle Riedemann; Jonas S. Jutzi; Ann Mullally
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Crossref

The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells

Leukemia
2023-04 | Journal article
DOI: 10.1038/s41375-023-01826-y
Contributors: Anne Marie Staehle; Jan Caspar Peeken; Georg Vladimirov; Mirjam Elisabeth Hoeness; Sarolta Bojtine Kovacs; Nikolaos Karantzelis; Albert Gruender; Christoph Koellerer; Jonas Samuel Jutzi; Heike Luise Pahl et al.
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Crossref

CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response

Leukemia
2023-02 | Journal article
DOI: 10.1038/s41375-022-01781-0
Contributors: Jonas S. Jutzi; Anna E. Marneth; María José Jiménez-Santos; Jessica Hem; Angel Guerra-Moreno; Benjamin Rolles; Shruti Bhatt; Samuel A. Myers; Steven A. Carr; Yuning Hong et al.
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Crossref

Two to tango! IL-13 and TGF-β drive myelofibrosis

Blood
2022-12-29 | Journal article
DOI: 10.1182/blood.2022018859
Contributors: Jonas S. Jutzi; Ann Mullally
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Crossref

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs

Blood
2022-09-15 | Journal article
DOI: 10.1182/blood.2022015629
Contributors: Jonas S. Jutzi; Anna E. Marneth; Michele Ciboddo; Angel Guerra-Moreno; María José Jiménez-Santos; Anastasia Kosmidou; James W. Dressman; Hongyan Liang; Rebecca Hamel; Patricia Lozano et al.
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Crossref

The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies

Biomolecules
2021-12-20 | Journal article
DOI: 10.3390/biom11121911
Contributors: Hans Felix Staehle; Heike Luise Pahl; Jonas Samuel Jutzi
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Crossref
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Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2V617F-driven myeloproliferative disease initiation in mice

PLOS ONE
2020-02-04 | Journal article
DOI: 10.1371/journal.pone.0228362
Contributors: Hans F. Staehle; Kevin D Bunting; Johannes Heinemann; Albert Gruender; Anne M. Omlor; Heike Luise Pahl; Jonas Samuel Jutzi
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Crossref

BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells.

Cell death & disease
2020-01-06 | Journal article
DOI: 10.1038/s41419-019-2203-z
PMID: 31907357
PMC: PMC6944703
Source: Self-asserted source
Jonas S. Jutzi

Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice.

Leukemia
2019-10-21 | Journal article
DOI: 10.1038/s41375-019-0577-7
PMID: 31636343
Source: Self-asserted source
Jonas S. Jutzi

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

Blood
2019-04-18 | Journal article
DOI: 10.1182/blood-2018-09-875047
Contributors: Jonas Samuel Jutzi; Titiksha Basu; Maximilian Pellmann; Sandra Kaiser; Doris Steinemann; Mathijs A. Sanders; Adil S. A. Hinai; Annelieke Zeilemaker; Sarolta Bojtine Kovacs; Christoph Koellerer et al.
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Crossref

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone.

HemaSphere
2018-06-08 | Journal article
DOI: 10.1097/HS9.0000000000000054
PMID: 31723778
PMC: PMC6745991
Source: Self-asserted source
Jonas S. Jutzi

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

Blood
2018-05-03 | Journal article
DOI: 10.1182/blood-2017-10-810622
Contributors: Jan C. Peeken; Jonas S. Jutzi; Julius Wehrle; Christoph Koellerer; Hans F. Staehle; Heiko Becker; Elias Schoenwandt; Thalia S. Seeger; Daniel H. Schanne; Monika Gothwal et al.
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Crossref

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

Science translational medicine
2018-02-01 | Journal article
DOI: 10.1126/scitranslmed.aam7729
PMID: 29467301
PMC: PMC6034655
Source: Self-asserted source
Jonas S. Jutzi

Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both.

Leukemia
2016-02-08 | Journal article
DOI: 10.1038/leu.2016.12
PMID: 26854026
Source: Self-asserted source
Jonas S. Jutzi

The Hen or the Egg: Inflammatory Aspects of Murine MPN Models.

Mediators of inflammation
2015-10-12 | Journal article
DOI: 10.1155/2015/101987
PMID: 26543325
PMC: PMC4620236
Source: Self-asserted source
Jonas S. Jutzi
grade
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MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.

The Journal of experimental medicine
2013-05-01 | Journal article
DOI: 10.1084/jem.20120521
PMID: 23589569
PMC: PMC3646501
Source: Self-asserted source
Jonas S. Jutzi

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

The Journal of experimental medicine
2012-01-09 | Journal article
DOI: 10.1084/jem.20110540
PMID: 22231305
PMC: PMC3260873
Source: Self-asserted source
Jonas S. Jutzi

Peer review (3 reviews for 3 publications/grants)

Review activity for Cancer metastasis reviews. (1)
Review activity for Leukemia (1)
Review activity for Signal transduction and targeted therapy. (1)
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