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University of Reading: Reading, Berkshire, GB

(Biomedical Sciences)
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University of Reading

Works (26)

TRIPLE Score: GPVI and CD36 Expression Predict a Prothrombotic Platelet Function Phenotype

Circulation Research
2025-02-14 | Journal article
Contributors: Alexander P. Bye; Neline Kriek; Carly Kempster; Joanne L. Dunster; Joanne L. Mitchell; Tanya Sage; Suzannah Rawlings; Maria V. Diaz Alonso; Valentina Shpakova; Abigail Whyte et al.
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Crossref

Cucurbitacins elicit anti-platelet activity via perturbation of the actin cytoskeleton and integrin function.

Thrombosis and haemostasis
2022-03 | Journal article
Contributors: Kriek N; Nock S; Sage T; Khalifa B; Bye A; Mitchell JL; Thomson S; McLaughlin MG; Jones S; Gibbins JM et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis.

Cells
2021-10 | Journal article
Contributors: Alatawi KA; Ravishankar D; Patra PH; Bye AP; Stainer AR; Patel K; Widera D; Vaiyapuri S
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets.

Blood
2021-10 | Journal article
Contributors: Bye AP; Hoepel W; Mitchell JL; Jégouic S; Loureiro S; Sage T; Vidarsson G; Nouta J; Wuhrer M; de Taeye S et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Multiparameter phenotyping of platelet reactivity for stratification of human cohorts.

Blood advances
2021-10 | Journal article
Contributors: Dunster JL; Bye AP; Kriek N; Sage T; Mitchell JL; Kempster C; Batista J; McKinney H; Thomas P; Jones CI et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling.

Haematologica
2021-07 | Journal article
Contributors: Unsworth AJ; Bye AP; Sage T; Gaspar RS; Eaton N; Drew C; Stainer A; Kriek N; Volberding PJ; Hutchinson JL et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets

2021-03 | Preprint
Contributors: Bye AP; Hoepel W; Mitchell JL; Jégouic S; Loureiro S; Sage T; de Taeye S; van Gils M; Kriek N; Cooper N et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets.

Blood
2021-02 | Journal article
Contributors: Sahli KA; Flora GD; Sasikumar P; Maghrabi AH; Holbrook LM; AlOuda SK; Elgheznawy A; Sage T; Stainer AR; Adiyaman R et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring.

Scientific reports
2021-01 | Journal article
Contributors: Gaspar RS; Unsworth AJ; Al-Dibouni A; Bye AP; Sage T; Stewart M; Wells S; Cox RD; Gibbins JM; Sellayah D et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Maternal High-fat Diet During Pregnancy Programs Platelet Hyperactivation in Male Mouse Offspring

2020-07 | Preprint
Contributors: Gaspar RS; Unsworth AJ; Bye A; Sage T; Stewart M; Wells S; Cox RD; Gibbins JM; Sellayah D; Hughes C
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Ca 2+ waves coordinate purinergic receptor–evoked integrin activation and polarization

Science Signaling
2020-01-21 | Journal article
Contributors: Alexander P. Bye; Jonathan M. Gibbins; Martyn P. Mahaut-Smith
Source: check_circle
Crossref

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation.

Journal of thrombosis and haemostasis : JTH
2019-12 | Journal article
Contributors: Dunster JL; Unsworth AJ; Bye AP; Haining EJ; Sowa MA; Di Y; Sage T; Pallini C; Pike JA; Hardy AT et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction.

Platelets
2018-09 | Journal article
Contributors: Unsworth AJ; Bye AP; Kriek N; Sage T; Osborne AA; Donaghy D; Gibbins JM
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Move along, nothing to see here: Btk inhibitors stop platelets sticking to plaques.

Journal of thrombosis and haemostasis : JTH
2018-07 | Journal article
Contributors: Bye AP; Gibbins JM
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis.

Journal of thrombosis and haemostasis : JTH
2018-04 | Journal article
Contributors: Sasikumar P; AlOuda KS; Kaiser WJ; Holbrook LM; Kriek N; Unsworth AJ; Bye AP; Sage T; Ushioda R; Nagata K et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Immobilization of Nonactivated Unfixed Platelets for Real-Time Single-Cell Analysis.

Methods in molecular biology (Clifton, N.J.)
2018-01 | Journal article
Contributors: Bye AP; Ilkan Z; Unsworth AJ; Jones CI
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Screening and High-Throughput Platelet Assays.

Methods in molecular biology (Clifton, N.J.)
2018-01 | Journal article
Contributors: Bye AP; Unsworth AJ; Gibbins JM
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib.

Blood advances
2017-12 | Journal article
Contributors: Bye AP; Unsworth AJ; Desborough MJ; Hildyard CAT; Appleby N; Bruce D; Kriek N; Nock SH; Sage T; Hughes CE et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.

Arteriosclerosis, thrombosis, and vascular biology
2017-06 | Journal article
Contributors: Unsworth AJ; Bye AP; Tannetta DS; Desborough MJR; Kriek N; Sage T; Allan HE; Crescente M; Yaqoob P; Warner TD et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

RXR Ligands Negatively Regulate Thrombosis and Hemostasis.

Arteriosclerosis, thrombosis, and vascular biology
2017-03 | Journal article
Contributors: Unsworth AJ; Flora GD; Sasikumar P; Bye AP; Sage T; Kriek N; Crescente M; Gibbins JM
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Platelet-Derived Inhibitors of Platelet Activation

Platelets in Thrombotic and Non-Thrombotic DisordersPathophysiology, Pharmacology and Therapeutics: an Update
2017-02 | Journal article
Contributors: Unsworth A; Bye A; Gibbins J
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity.

Journal of thrombosis and haemostasis : JTH
2017-02 | Journal article
Contributors: Unsworth AJ; Kriek N; Bye AP; Naran K; Sage T; Flora GD; Gibbins JM
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

Arteriosclerosis, thrombosis, and vascular biology
2016-10 | Journal article
Contributors: Moraes LA; Unsworth AJ; Vaiyapuri S; Ali MS; Sasikumar P; Sage T; Flora GD; Bye AP; Kriek N; Dorchies E et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Platelet signaling: a complex interplay between inhibitory and activatory networks.

Journal of thrombosis and haemostasis : JTH
2016-04 | Journal article
Contributors: Bye AP; Unsworth AJ; Gibbins JM
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen.

Arteriosclerosis, thrombosis, and vascular biology
2015-09 | Journal article
Contributors: Bye AP; Unsworth AJ; Vaiyapuri S; Stainer AR; Fry MJ; Gibbins JM
Source: Self-asserted source
Alexander Bye via Europe PubMed Central

Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.

Circulation
2012-04 | Journal article
Contributors: Vaiyapuri S; Jones CI; Sasikumar P; Moraes LA; Munger SJ; Wright JR; Ali MS; Sage T; Kaiser WJ; Tucker KL et al.
Source: Self-asserted source
Alexander Bye via Europe PubMed Central