Personal information

dopamine, neural stem cells, trancsription, microRNA, development
Italy

Biography

He has directed and directs a group of 6-10 researchers first at the National Institute for Neurological Disorders and Stroke, NIH, Bethesda, MD, USA, then at IGB, CNR, Naples, and coordinates the research of several investigators and students.
Since many years he has coordinated and coordinates national (progetti finalizzati CNR, FIRB) and international (EU, FIRB) research programs with the participation from two to eight research groups.
He has organized in Italy numerous workshops and international scientific conferences, directed bachelor’s and PhD thesis, received and managed research grants from more than twenty years.
He is internationally recognized as a main expert in the field of nervous system development, specifically mesencephalic dopaminergic neurons (mDA), and their degeneration (Parkinson’s disease, PD)
He has been a pioneer in the use of transplants of embryonic mDA neurons in PD animal models and in mDA differentiation from neural stem cells
His articles have been cited at least 1960 times (ISI Citation Indexes)
Total IF about 300, H index 26
In 1993 he has received the Courtesy Program Award at NIH, Bethesda, MD, USA for his studies on the development of mDA neurons.
RESEARCH ACTIVITY comprises
A) Studies on the development of mDA neurons.
B) Regenerative medicine studies in animal models.
C) Transcriptional regulation of neurogenesis.
D) Studies on neural stem cells (NSCs).
E) Studies on ADHD and on 5HT role in brain plasticity

Activities

Employment (9)

Institute of Genetics and Biophysics, CNR: Naples, IT

1989 to present | Group leader (Neuroscience)
Employment
Source: Self-asserted source
Umberto di Porzio

Institute of Genetics and Biophysics, CNR: Naples, IT

1991-02 to 2011-09 | Research Director, Group leader (Developmental Neurobiology)
Employment
Source: Self-asserted source
Umberto di Porzio

National Institutes of Health: Bethesda, MD, US

1993-03 to 1993-11 | Courtesy Program Awardee (NINDS)
Employment
Source: Self-asserted source
Umberto di Porzio

National Institutes of Health: Bethesda, MD, US

1985-02 to 1991-09 | Fogarty Visiting Scietist (NINDS)
Employment
Source: Self-asserted source
Umberto di Porzio

International Institute of Genetics and Biophyscs, CNR: Naples, IT

1975-02-15 to 1989-05 | Staff Scientist
Employment
Source: Self-asserted source
Umberto di Porzio

Yale University School of Medicine: New Haven, CT, US

1982-10 to 1984-10 | Visiting Scietist (Neurosurgery)
Employment
Source: Self-asserted source
Umberto di Porzio

College De France Chaire de Neuropharmachology: Paris, FR

1977-02 to 1980-11 | Chargè de Recherche et Metre de Recherche
Employment
Source: Self-asserted source
Umberto di Porzio

University of Naples Medical School: Naples, IT

1974-02 to 1974-05 | Senior Postdoctoral Research Fellow (General Pathology)
Employment
Source: Self-asserted source
Umberto di Porzio

University of California San Diego: La Jolla, CA, US

1972-02 to 1973-12 | Post doc (Biology)
Employment
Source: Self-asserted source
Umberto di Porzio

Education and qualifications (1)

Medical School University of Naples: Naples, IT

1971-11 | MD-PhD
Education
Source: Self-asserted source
Umberto di Porzio

Funding (12)

Molecular basis of neurodegeneration in Parkinosn's disease

2011-06 to 2014-06 | Grant
MIUR, Medical Research Italy, Neurodegeneration (Rome, IT)
GRANT_NUMBER:

RBNE08LN4P_002

Source: Self-asserted source
Umberto di Porzio

To promote neuron subtype generation from neural stem/progenitor cells.

2010-10 to 2015-03 | Grant
MIUR- FIRB International 2006 (Rome, IT)
GRANT_NUMBER:

RBIN062YH4

Source: Self-asserted source
Umberto di Porzio

Cellular and molecular mechanisms controlling the generation of midbrain dopaminergic neurons

2010 to 2012 | Grant
MIUR-PRIN (Rome, IT)
GRANT_NUMBER:

2009TBCZJB_003

Source: Self-asserted source
Umberto di Porzio

Differentiation of neural stem cells (NSC) into mDA neurons and identification of key genes involved

2008 to 2009 | Grant
Ministrery of University and Research, PRIN (rome, IT)
GRANT_NUMBER:

2007F7AJYJ_004

Source: Self-asserted source
Umberto di Porzio

Sviluppo di Tecnologie Avanzate per lo Studio della Proteomica Differenziale del Segnale (Segnalo-Proteomica)

2004 to 2007 | Grant
MIUR, FIRB (Rome, IT)
GRANT_NUMBER:

RBNE01KJHT

Source: Self-asserted source
Umberto di Porzio

Development of reporter mice for the characterization of neural stem cell plasticity, fate, connectivity and functional recovery in animal models of Parkinson’s disease

2004 to 2005 | Grant
. National Program on Stem Cells Istituto Superiore di Sanità (Rome, IT)
Source: Self-asserted source
Umberto di Porzio

2003-05 Mechanisms regulating nervous system development and neural differentiation (PRONEURO)

2003 to 2005 | Grant
MIUR, FIRB (Rome, IT)
GRANT_NUMBER:

RBNE01WY7P

Source: Self-asserted source
Umberto di Porzio

2002-05 Trophic signaling by GDNF ligands and their receptors in neuronal development and Repair

2002 to 2005 | Contract
European Commission Fifth Framework Program, Quality of Life and Management of Living Resources. (Bruxelles, BE)
GRANT_NUMBER:

QLG3-CT-2002-01000/GDNF

Source: Self-asserted source
Umberto di Porzio

2001-03 Meccanismi molecolari e cellulari che governano il destino, la localizzazione, il numero e il differenziamento dei neuroni dopaminergici mesencefalici.

2001 to 2003 | Grant
MURST (Rome, IT)
GRANT_NUMBER:

Cluster 02

Source: Self-asserted source
Umberto di Porzio

Study of dopaminergic neuron and motoneuron development as a tool to understand neurodegeneration.

2000 to 2001 | Grant
CNR (Rome, IT)
Source: Self-asserted source
Umberto di Porzio

wobbler mouse as a model of SMA motorneuron degeneration

1992 to 1997 | Grant
Telethon-UILDM (Rome, IT)
Source: Self-asserted source
Umberto di Porzio

Immortalized cell lines from mammalian central nervous system as an experimental tool to study molecules with possible, or already defined, pharmacological properties.

1988 to 1997 | Grant
Italian Cancer Research Association AIRC (Milan, IT)
Source: Self-asserted source
Umberto di Porzio