Martin-Perez J. (0000-0002-2292-0057)

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Biography

Professional address: Instituto de Investigaciones Biomédicas A. Sols, CSIC-UAM
Arturo Duperier 4, 28029 Madrid, Spain
Telephone: 34-91 585 4416; Fax: 34-91 585 4401
E. Mail: jmartin@iib.uam.es
Professional position: Investigador Científico (CSIC, Spanish National Research Council).
Instituto de Investigaciones Biomédicas A. Sols, CSIC-UAM.

Education
1970 - 75. Bachelor in Science Degree (Biochemistry). University Complutense, Madrid, Spain.
1978. Master in Science Degree. University Complutense, Madrid, Spain.
1981. Ph. D. Degree. University Complutense, Madrid, Spain.

Professional Appointments
1975. Student Assistant. Department of Endocrinology, University Clinic “Puerta de Hierro” University Autonoma, Madrid, Spain.
1976 - 1977. Cheurcher. Research for the Master in Science Degree. Human Reproductive Research Unit, Medical School, Free University of Brussels, Belgium.
1978 - 1980. Research Fellow (Ph. D. Student). Department of Experimental Therapy. Sandoz Pharmaceuticals, Basel, Switzerland.
1980 - 1984. Postdoctoral Fellow. Cell Biology Section, Friedrich Miescher Institute, Basel, Switzerland.
1984 - 1987. Postdoctoral Fellow and Research Associate. Department of Cellular and Developmental Biology, The Biological Laboratories and Diabetes Research Unit, Massachusetts General Hospital, Harvard University.
1986. Assistant Professor. Department of Biochemistry, Medical School, University of Montreal Quebec, Canada. Position declined.
1987. Científico Titular. Instituto de Investigaciones Biomédicas A. Sols, CSIC-UAM, Madrid, Spain.
1999-2002-2003-2004-2006-2011. Honorary Professor, Department of Biochemistry, UAM.
2007. Investigador Científico. Instituto de Investigaciones Biomédicas A. Sols, CSIC-UAM, Madrid, Spain.

Fellowships and Awards
1. 1976. Ford Foundation Fellowship.
2. 1981. Ph.D. with Magna Cum Laude
3. 1982. Postdoctoral Fellowship, Leukemia Society of America. Declined.
4. 1984. Long Term EMBO Postdoctoral Fellowship for USA.
5. 1985. Postdoctoral Fellowship, Leukemia Society of America.
6. 1988. Juan March Fellowship in Molecular Biology
7. 1989. FEBS Short Term Fellowship

Scientific Societies Membership
1. American Society of Cell Biology.
2. Spanish Society of Biochemistry and Molecular Biology.
3. Spanish Group for Breast Cancer Research (GEICAM).

Additional Information
Fluency in English, French and Spanish.

Activities

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The Relevance of the SH2 Domain for c-Src Functionality in Triple-Negative Breast Cancer Cells

Cancers

2021-01-26 | Journal article

DOI: 10.3390/cancers13030462

Contributors: Víctor Mayoral-Varo; María Pilar Sánchez-Bailón; Annarica Calcabrini; Marta García-Hernández; Valerio Frezza; María Elena Martín; Víctor M. González; Jorge Martín-Pérez

Martin-Perez J.

https://orcid.org/0000-0002-2292-0057

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Works (44)

The Relevance of the SH2 Domain for c-Src Functionality in Triple-Negative Breast Cancer Cells

Correction: Alcalá, S., et al. Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells. Int. J. Mol. Sci. 2020, 21, 7437

Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells

c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells

miR205 inhibits stem cell renewal in SUM159PT breast cancer cells

An Update on Src Family of Nonreceptor Tyrosine Kinases Biology.

Role of SRC family kinases in prolactin signaling.

Cyr61 as mediator of Src signaling in triple negative breast cancer cells.

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.

Protein tyrosine phosphatases as novel targets in breast cancer therapy.

MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.).

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.

Studying the regulation of MAP Kinase by MAP Kinase phosphatases in vitro and in cell systems.

A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling.

Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.

Activation of the unliganded estrogen receptor by prolactin in breast cancer cells.

HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.

Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate.

Role of c-Src in human MCF7 breast cancer cell tumorigenesis.

Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.

Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells.

Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions.

Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways.

Effect of metamizol on promyelocytic and terminally differentiated granulocytic cells. Comparative analysis with acetylsalicylic acid and diclofenac.

Src family kinases are required for prolactin induction of cell proliferation.

Stimulation of c-Src by prolactin is independent of Jak2.

Influence of prolactin on the differentiation of mouse B-lymphoid precursors.

Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.

Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.

Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1).

Prolactin receptor is associated with c-src kinase in rat liver.

Down-regulation of c-Myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells.

Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin.

Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus.

Transformation by Rous sarcoma virus induces clathrin heavy chain phosphorylation.

Phosphopeptide analysis of 40 S ribosomal protein S6.

Activation of ribosomal protein S6 phosphorylation during meiotic maturation of Xenopus laevis oocytes: in vitro ordered appearance of S6 phosphopeptides.

Effect of dopamine receptor stimulation on the inhibition of LH pulsatility by a met-enkephaline (FK 33-824).

EGF, PGF2 alpha and insulin induce the phosphorylation of identical S6 peptides in swiss mouse 3T3 cells: effect of cAMP on early sites of phosphorylation.

Ordered phosphorylation of 40S ribosomal protein S6 after serum stimulation of quiescent 3T3 cells.

The effect of serum, EGF, PGF2 alpha and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis.

Inhibitory action of a met-enkephalin on ACTH release in man.

Failure of oxytocin and lysine-vasopressin to stimulate prolactin release in humans.