Personal information

translesion replication, Y-family DNA polymerases, DNA repair, mutagenesis

Activities

Employment (2)

University of North Carolina: Chapel Hill, North Carolina, US

Employment
Source: Self-asserted source
Alexandra Vaisman

National Institute of Child Health and Human Development: Bethesda, MD, US

Employment
Source: Self-asserted source
Alexandra Vaisman

Works (43)

A short adaptive path from DNA to RNA polymerases

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
DOI:

10.1073/pnas.1120964109

Contributors: Cozens, C.; Holliger, P.; Pinheiro, V.B.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Critical amino acids in Escherichia coli UmuC responsible for sugar discrimination and base-substitution fidelity

Nucleic Acids Research
2012 | Journal article
DOI:

10.1093/nar/gks233

Contributors: Goodman, M.F.; Karata, K.; Kuban, W.; McDonald, J.P.; Vaisman, A.; Woodgate, R.; Yang, W.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Escherichia coli UmuC active site mutants: Effects on translesion DNA synthesis, mutagenesis and cell survival

DNA Repair
2012 | Journal article
DOI:

10.1016/j.dnarep.2012.06.005

Contributors: Goodman, M.F.; Karata, K.; Kuban, W.; McDonald, J.P.; Vaisman, A.; Woodgate, R.; Yang, W.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Mechanisms Employed by Escherichia coli to Prevent Ribonucleotide Incorporation into Genomic DNA by Pol V

PLoS Genetics
2012 | Journal article
DOI:

10.1371/journal.pgen.1003030

Contributors: Goodman, M.F.; Kuban, W.; McDonald, J.P.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Simple and efficient purification of Escherichia coli DNA polymerase V: Cofactor requirements for optimal activity and processivity in vitro

DNA Repair
2012 | Journal article
DOI:

10.1016/j.dnarep.2012.01.012

Contributors: Goodman, M.F.; Karata, K.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Translesion DNA Synthesis

2012 | Interactive resource | Author
DOI:

10.1128/ecosal.7.2.2

Contributors: Alexandra Vaisman
Source: Self-asserted source
Alexandra Vaisman

Molecular breeding of polymerases for resistance to environmental inhibitors

Nucleic Acids Research
2011 | Journal article
DOI:

10.1093/nar/gkq1360

Contributors: Arana, M.E.; Baar, C.; D'Abbadie, M.; Hofreiter, M.; Holliger, P.; Kunkel, T.A.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

Nature Immunology
2011 | Journal article
DOI:

10.1038/ni.1970

Contributors: Gearhart, P.J.; Gramlich, H.S.; Martomo, S.A.; Maul, R.W.; McClure, R.L.; Saribasak, H.; Schatz, D.G.; Vaisman, A.; Wilson, D.M.; Woodgate, R. et al.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Characterization of polVR391: A Y-family polymerase encoded by rumA′B from the IncJ conjugative transposon, R391

Molecular Microbiology
2007 | Journal article
DOI:

10.1111/j.1365-2958.2006.05561.x

Contributors: Karata, K.; Mead, S.; Vaisman, A.; Valjavec-Gratian, M.; Vandewiele, D.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Molecular breeding of polymerases for amplification of ancient DNA

Nature Biotechnology
2007 | Journal article
DOI:

10.1038/nbt1321

Contributors: Cadet, J.; D'Abbadie, M.; Gasparutto, D.; Hofreiter, M.; Holliger, P.; Loakes, D.; Pääbo, S.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

DNA polymerase ι-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers

DNA Repair
2006 | Journal article
DOI:

10.1016/j.dnarep.2005.09.011

Contributors: Iwai, S.; Takasawa, K.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Erratum: Human DNA polymerase η promotes DNA synthesis from strand invasion intermediates of homologous recombination (Molecular Cell (December 9, 2005) 20 (783-792)

Molecular Cell
2006 | Journal article
DOI:

10.1016/j.molcel.2006.01.027

Contributors: Fanning, E.; Liu, Y.; McIlwraith, M.J.; Vaisman, A.; West, S.C.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase ι

DNA Repair
2006 | Journal article
DOI:

10.1016/j.dnarep.2005.12.006

Contributors: Gearhart, P.J.; Hanaoka, F.; Hoeijmakers, J.H.; Maas, A.; Martomo, S.A.; Vaisman, A.; Woodgate, R.; Yang, W.W.; Yokoi, M.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Fidelity of Dpo4: Effect of metal ions, nucleotide selection and pyrophosphorolysis

EMBO Journal
2005 | Journal article
DOI:

10.1038/sj.emboj.7600786

Contributors: Ling, H.; Vaisman, A.; Woodgate, R.; Yang, W.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Human DNA polymerase η promotes DNA synthesis from strand invasion intermediates of homologous recombination

Molecular Cell
2005 | Journal article
DOI:

10.1016/j.molcel.2005.10.001

Contributors: Fanning, E.; Liu, Y.; Mcllwraith, M.J.; Vaisman, A.; West, S.C.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

MSH2-MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes

Journal of Experimental Medicine
2005 | Journal article
DOI:

10.1084/jem.20042066

Contributors: Gearhart, P.J.; Hanaoka, F.; Lan, L.; Martomo, S.A.; Sullivan, P.; Vaisman, A.; Wilson, T.M.; Woodgate, R.; Yasui, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution

Nature Biotechnology
2004 | Journal article
DOI:

10.1038/nbt974

Contributors: Boudsocq, F.; Brown, A.; Ghadessy, F.J.; Holliger, P.; Iwai, S.; Loakes, D.; Ramsay, N.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication

Journal of Biological Chemistry
2004 | Journal article
DOI:

10.1074/jbc.M405249200

Contributors: Boudsocq, F.; Kokoska, R.J.; Kunkel, T.A.; Ling, H.; Plosky, B.B.; Vaisman, A.; Woodgate, R.; Yang, W.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Efficiency of Extension of Mismatched Primer Termini across from Cisplatin and Oxaliplatin Adducts by Human DNA Polymerases β and η in Vitro

Biochemistry
2003 | Journal article
DOI:

10.1021/bi035359p

Contributors: Bassett, E.; Chaney, S.G.; Hanaoka, F.; Havener, J.M.; Masutani, C.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase ι

DNA Repair
2003 | Journal article
DOI:

10.1016/S1568-7864(03)00094-6

Contributors: Frank, E.G.; Hanaoka, F.; Iwai, S.; Ohashi, E.; Ohmori, H.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases β and η

DNA Repair
2002 | Journal article
DOI:

10.1016/S1568-7864(02)00150-7

Contributors: Bassett, E.; Chaney, S.G.; Hanaoka, F.; Masutani, C.; McCall, C.M.; Tropea, K.A.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

polι-dependent lesion bypass in vitro

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
2002 | Journal article
Contributors: Frank, E.G.; McDonald, J.P.; Tissier, A.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Biochemical characterization of human DNA polymerase ι provides clues to its biological function

Biochemical Society Transactions
2001 | Journal article
DOI:

10.1042/0300-5127:0290183

Contributors: Boudsocq, F.; Fernàndez De Henestrosa, A.R.; Frank, E.G.; McDonald, J.P.; McLenigan, M.P.; Tissier, A.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Human DNA Polymerase ι Promiscuous Mismatch Extension

Journal of Biological Chemistry
2001 | Journal article
DOI:

10.1074/jbc.M102694200

Contributors: Frank, E.G.; Goodman, M.F.; Tissier, A.; Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

The Effect of DNA Structure on the Catalytic Efficiency and Fidelity of Human DNA Polymerase β on Templates with Platinum-DNA Adducts

Journal of Biological Chemistry
2001 | Journal article
DOI:

10.1074/jbc.M007805200

Contributors: Chaney, S.G.; Vaisman, A.; Warren, M.W.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Unique misinsertion specificity of poι may decrease the mutagenic potential of deaminated cytosines

EMBO Journal
2001 | Journal article
DOI:

10.1093/emboj/20.22.6520

Contributors: Vaisman, A.; Woodgate, R.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

DNA adduct tolerance and bypass.

2000 | Book | Author
ISBN:

ISBN-13: 9781617370915

Contributors: Alexandra Vaisman
Source: Self-asserted source
Alexandra Vaisman

Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase η

Biochemistry
2000 | Journal article
DOI:

10.1021/bi000130k

Contributors: Chaney, S.G.; Hanaoka, F.; Masutani, C.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Oxaliplatin-induced damage of cellular DNA

Molecular Pharmacology
2000 | Journal article
Contributors: Arnett, B.; Chaney, S.G.; Chapman, W.G.; Faivre, S.; Herzig, M.C.S.; Juniewicz, P.E.; Raymond, E.; Trevino, A.V.; Vaisman, A.; Varchenko, M. et al.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

The efficiency and fidelity of translesion synthesis past cisplatin and oxaliplatin GpG adducts by human DNA polymerase β

Journal of Biological Chemistry
2000 | Journal article
DOI:

10.1074/jbc.275.17.13017

Contributors: Chaney, S.G.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Effect of DNA polymerases and high mobility group protein 1 on the carrier ligand specificity for translesion synthesis past Platinum - DNA adducts

Biochemistry
1999 | Journal article
DOI:

10.1021/bi9909187

Contributors: Chaney, S.G.; Copeland, W.C.; Hinkle, D.C.; Lim, S.E.; Patrick, S.M.; Turchi, J.J.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Efficient nucleotide excision repair of cisplatin, oxaliplatin, and bis- acetoammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts

Cancer Research
1999 | Journal article
Contributors: Chaney, S.G.; Reardon, J.T.; Sancar, A.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: Correlation with replicative bypass of platinum-DNA adducts

Cancer Research
1998 | Journal article
Contributors: Barrett, J.C.; Chaney, S.G.; Hamilton, T.C.; Kunkel, T.A.; Risinger, J.I.; Umar, A.; Vaisman, A.; Varchenko, M.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Cell cycle changes associated with formation of Pt-DNA adducts in human ovarian carcinoma cells with different cisplatin sensitivity

Cytometry
1997 | Journal article
DOI:

10.1002/(SICI)1097-0320(19970101)27:1<54::AID-CYTO7>3.0.CO;2-L

Contributors: Chaney, S.G.; Said, I.; Vaisman, A.; Varchenko, M.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Decreased inhibition of DNA replication by platinum adducts in mismatch repair defective cell lines

FASEB Journal
1997 | Journal article
Contributors: Chanev, S.G.; Vaisman, A.; Varchenko, M.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines

Cancer Chemotherapy and Pharmacology
1997 | Journal article
DOI:

10.1007/s002800050568

Contributors: Chaney, S.G.; Delmastro, D.A.; Li, J.; Solle, M.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Cisplatin-induced alterations in the expression of the mRNAs for UV- damage recognition protein

Oncology Research
1996 | Journal article
Contributors: Chaney, S.G.; Keeney, S.; Linn, S.; Nichols, A.F.; Vaisman, A.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

A clinical and pharmacokinetic study of high-dose carboplatin, paclitaxel, granulocyte colony-stimulating factor, and peripheral blood stem cells in patients with unresectable or metastatic cancer

Seminars in Oncology
1995 | Journal article
Contributors: Bentley, S.; Bernard, S.; Brecher, M.; Brouwer, K.; Chaney, S.; Graham, M.; Johnston, C.; Letrent, S.; Serody, J.; Shea, T. et al.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

Organ-specific biotransformation of ormaplatin in the Fischer 344 rat

Cancer Chemotherapy and Pharmacology
1995 | Journal article
DOI:

10.1007/s002800050347

Contributors: Chaney, S.G.; Holbrook, D.J.; Sakata, M.K.; Thompson, D.C.; Vaisman, A.; Wyrick, S.D.
Source: Self-asserted source
Alexandra Vaisman via Scopus - Elsevier

DNA Polymerases η and ι

Book chapter
DOI:

http://dx.doi.org/10.1016/s0065-3233(04)69007-3

Source: Self-asserted source
Alexandra Vaisman

Induction of UV-Damage Recognition Protein by Cisplatin Treatment

Journal article
DOI:

http://dx.doi.org/10.1021/bi00001a013

Source: Self-asserted source
Alexandra Vaisman

Specificity of platinum–DNA adduct repair

Journal article
DOI:

http://dx.doi.org/10.1016/s0162-0134(99)00149-x

Source: Self-asserted source
Alexandra Vaisman
grade
Preferred source (of 2)‎

Translesion DNA Polymerases, Eukaryotic

Book chapter
DOI:

http://dx.doi.org/10.1016/b0-12-443710-9/00210-6

Source: Self-asserted source
Alexandra Vaisman