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Activities

Employment (7)

Tokyo Metropolitan University: Tokyo, JP

2023-10-01 to present | Associate Professor (Graduate School of Science)
Employment
Source: Self-asserted source
Tetsuhisa Otani

National Institute for Physiological Sciences: Okazaki, JP

2016-04-01 to 2023-09-30 | Assistant Professor (Laboratory for Cell Structure)
Employment
Source: Self-asserted source
Tetsuhisa Otani

National Institute for Physiological Sciences: Okazaki, JP

2015-10-01 to 2016-03-31 | Assistant Professor (Laboratory for Cerebral Structure)
Employment
Source: Self-asserted source
Tetsuhisa Otani

RIKEN Center for Developmental Biology: Kobe, JP

2015-04-01 to 2015-09-30 | Technical Staff (Laboratory for Morphogenetic Signaling)
Employment
Source: Self-asserted source
Tetsuhisa Otani

RIKEN Center for Developmental Biology: Kobe, JP

2007-04-01 to 2015-03-31 | Research Scientist (Laboratory for Morphogenetic Signaling)
Employment
Source: Self-asserted source
Tetsuhisa Otani

RIKEN Center for Developmental Biology: Kobe, JP

2006-11-01 to 2007-03-31 | Research Scientist (Laboratory for Cell Adhesion and Tissue Patterning)
Employment
Source: Self-asserted source
Tetsuhisa Otani

RIKEN Center for Developmental Biology: Kobe, JP

2005-04-01 to 2006-10-31 | Research Associate (Laboratory for Cell Adhesion and Tissue Patterning)
Employment
Source: Self-asserted source
Tetsuhisa Otani

Education and qualifications (1)

Kyoto University: Kyoto, JP

2000-04-01 to 2005-03-31 | PhD (Graduate School of Biostudies)
Education
Source: Self-asserted source
Tetsuhisa Otani

Funding (2)

Mechanisms of tension homeostasis and its role in epithelial morphogenesis

2016-04 to 2018-03 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER:

16K18544

Source: Self-asserted source
Tetsuhisa Otani

Dynamic interactions between cytoplasmic dynein and cargo molecules

2012-04 to 2015-03 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER:

24770197

Source: Self-asserted source
Tetsuhisa Otani

Works (26)

Competitive elimination of ZO-1/ZO-2-deficient cells regulates epithelial barrier homeostasis

2025-01-13 | Preprint
Contributors: Tetsuhisa Otani; Thanh Phuong Nguyen; Noriyuki Kinoshita; Toshihiko Fujimori; Mikio Furuse
Source: check_circle
Crossref

Cell position-based evaluation of mechanical features of cells in multicellular systems

2024-11-11 | Preprint
Contributors: Hiroshi Koyama; Atsushi M. Ito; Hisashi Okumura; Tetsuhisa Otani; Kazuyuki Nakamura; Toshihiko Fujimori
Source: check_circle
Crossref

Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells

2024-09-26 | Preprint
Contributors: Eriko Deguchi; Shuhao Lin; Daiki Hirayama; Kimiya Matsuda; Akira Tanave; Kenta Sumiyama; Shinya Tsukiji; Tetsuhisa Otani; Mikio Furuse; Alexander Sorkin et al.
Source: check_circle
Crossref

ZO-1 shuttles between tight junctions and podosomes by riding ERK activation waves during collective cell migration

2024-08-09 | Preprint
Contributors: Sayuki Hirano; Yohei Kondo; Noriyuki Kinoshita; Tetsuhisa Otani; Mikio Furuse; Naoto Ueno; Kazuhiro Aoki
Source: check_circle
Crossref

Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex

Journal of Cell Biology
2024-05-06 | Journal article
Contributors: Thanh Phuong Nguyen; Tetsuhisa Otani; Motosuke Tsutsumi; Noriyuki Kinoshita; Sachiko Fujiwara; Tomomi Nemoto; Toshihiko Fujimori; Mikio Furuse
Source: check_circle
Crossref

Effective mechanical potential of cell–cell interaction explains three-dimensional morphologies during early embryogenesis

PLOS Computational Biology
2023-08-07 | Journal article
Contributors: Hiroshi Koyama; Philip K. Maini; Hisashi Okumura; Atsushi M. Ito; Kazuyuki Nakamura; Tetsuhisa Otani; Kagayaki Kato; Toshihiko Fujimori
Source: check_circle
Crossref

Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex

2023-08-04 | Preprint
Contributors: Thanh Phuong Nguyen; Tetsuhisa Otani; Motosuke Tsutsumi; Sachiko Fujiwara; Tomomi Nemoto; Toshihiko Fujimori; Mikio Furuse
Source: check_circle
Crossref

ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions

Cells
2022-11-25 | Journal article
Contributors: Alexis J. Haas; Ceniz Zihni; Susanne M. Krug; Riccardo Maraspini; Tetsuhisa Otani; Mikio Furuse; Alf Honigmann; Maria S. Balda; Karl Matter
Source: check_circle
Crossref

Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes

PLOS Biology
2022-04-25 | Journal article
Part of ISSN: 1545-7885
Source: Self-asserted source
Tetsuhisa Otani

JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells

Cellular and Molecular Life Sciences
2022-02 | Journal article
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Source: Self-asserted source
Tetsuhisa Otani

Angulin-1 seals tricellular contacts independently of tricellulin and claudins

Journal of Cell Biology
2021-09-06 | Journal article
Contributors: Taichi Sugawara; Kyoko Furuse; Tetsuhisa Otani; Tomohiko Wakayama; Mikio Furuse
Source: check_circle
Crossref

Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.

Molecular biology of the cell
2021-02-10 | Journal article
Source: Self-asserted source
Tetsuhisa Otani

Tight Junction Structure and Function Revisited

Trends in Cell Biology
2020-10 | Journal article
Contributors: Tetsuhisa Otani; Mikio Furuse
Source: check_circle
Crossref

Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.

Biochimica et biophysica acta. Biomembranes
2020-04-02 | Journal article
Source: Self-asserted source
Tetsuhisa Otani

The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts

Journal of Biological Chemistry
2020-03 | Journal article
Contributors: Yukako Oda; Taichi Sugawara; Yuko Fukata; Yasushi Izumi; Tetsuhisa Otani; Tomohito Higashi; Masaki Fukata; Mikio Furuse
Source: check_circle
Crossref

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

Journal of Cell Biology
2019-10-07 | Journal article
Contributors: Tetsuhisa Otani; Thanh Phuong Nguyen; Shinsaku Tokuda; Kei Sugihara; Taichi Sugawara; Kyoko Furuse; Takashi Miura; Klaus Ebnet; Mikio Furuse
Source: check_circle
Crossref

The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity.

The FEBS journal
2019-06-01 | Journal article
Source: Self-asserted source
Tetsuhisa Otani

IKKε inhibits PKC to promote Fascin-dependent actin bundling

Development
2016-10-15 | Journal article
Contributors: Tetsuhisa Otani; Yosuke Ogura; Kazuyo Misaki; Takuya Maeda; Akiyo Kimpara; Shigenobu Yonemura; Shigeo Hayashi
Source: check_circle
Crossref

A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.

2015-10 | Journal article
Contributors: Otani T; Oshima K; Kimpara A; Takeda M; Abdu U; Hayashi S
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.

2015-07 | Journal article
Contributors: Otani T; Oshima K; Kimpara A; Takeda M; Abdu U; Hayashi S
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42.

2014-10 | Journal article
Contributors: Oda Y; Otani T; Ikenouchi J; Furuse M
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.

2013 | Journal article
Contributors: Dong B; Kakihara K; Otani T; Wada H; Hayashi S
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.

2013-11 | Journal article
Contributors: Amsalem S; Bakrhat A; Otani T; Hayashi S; Goldstein B; Abdu U
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

Rab11-FIP3 is a cell cycle-regulated phosphoprotein.

2012 | Journal article
Contributors: Collins LL; Simon G; Matheson J; Wu C; Miller MC; Otani T; Yu X; Hayashi S; Prekeris R; Gould GW
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

IKKε regulates cell elongation through recycling endosome shuttling.

2011-02 | Journal article
Contributors: Otani T; Oshima K; Onishi S; Takeda M; Shinmyozu K; Yonemura S; Hayashi S
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.

2006-10 | Journal article
Contributors: Otani T; Ichii T; Aono S; Takeichi M
Source: Self-asserted source
Tetsuhisa Otani via Europe PubMed Central

Peer review (9 reviews for 4 publications/grants)

Review activity for Acta biomaterialia. (1)
Review activity for Cells and development. (2)
Review activity for Current opinion in cell biology. (2)
Review activity for iScience. (4)