Personal information
Biography
I lead an independent research group of nine people: a PostDoc fellow, four PhD students, one reseaerch assistant and three MSc intern students.
Our group is involved in the investigation of mechanisms controlling genome stability in human cells during the S-phase of the cell cycle. These pathways are essential to prevent neoplastic transformation. We seek to elucidate the cellular pathways elicited by replication fork arrest and their inherent regulation to identify potential targets for cancer therapy.
Currently, our research projects focus on:
1) The identification of regulatory mechanisms controlling the recovery of perturbed replication forks in normal or pathological conditions;
2) The identification of the role of replication stress in the onset of Werner syndrome and other human genetic diseases How the WRN protein is regulated and the functional implications of the identified PTM on the molecular pathology of Werner syndrome;
3) The identification of cancer-specific replication fork recovery pathways, their implications for cancer genetic instability, and of novel therapeutic approaches that exploit replication stress in tumours.
Activities
Employment (8)
Education and qualifications (3)
Professional activities (8)
Funding (19)
28972
RF-2016-02362022
GEP15050
GGP12144
GGP04094
Works (50 of 67)
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