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Employment (5)

Columbia University: New York, NY, US

2015-01-18 to present | Assistant Professor (Medicine)
Employment
Source: Self-asserted source
Lale Ozcan

Columbia University: New York, NY, US

2011-01-01 to 2015-01-17 | Associate Research Scientist (Medicine)
Employment
Source: Self-asserted source
Lale Ozcan

Columbia University: New York, NY, US

2008-06-01 to 2010-12-31 | Post-doctoral Scientist (Medicine)
Employment
Source: Self-asserted source
Lale Ozcan

Children's Hospital Boston: Boston, MA, US

2007-02-01 to 2008-05-10 | Post-doctoral Fellow (Endocrinology)
Employment
Source: Self-asserted source
Lale Ozcan

Harvard School of Public Health: Boston, MA, US

2005-01-01 to 2007-01-31 | Post-doctoral Fellow (Genetics and Complex Diseases)
Employment
Source: Self-asserted source
Lale Ozcan

Education and qualifications (1)

Istanbul University: Fatih, Istanbul, TR

1998-10-02 to 2004-09-30 | M.D.
Education
Source: Self-asserted source
Lale Ozcan

Funding (10)

Role of Geranylgeranylation and Hepatic Rap1a on Cholesterol Metabolism

2022-07-01 to 2025-06-30 | Grant
American Heart Association (Dallas, US)
GRANT_NUMBER:

971273
Source: check_circle
American Heart Association

Hepatic Rap1 in Glucose Homeostasis

2020 to 2022 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Md., Md., US)
GRANT_NUMBER:

DK124457
Source: Self-asserted source
Lale Ozcan

Role of Glucagon Receptor Signaling in PCSK9 Regulation

2017-01 to 2018-12 | Grant
Pfizer (NY, NY, US)
GRANT_NUMBER:

WI218501
Source: Self-asserted source
Lale Ozcan

Role of DACH1 in Obesity-Induced Hepatic Insulin Resistance

2016-07 to 2021-06 | Grant
National Institutes of Health (Md., Md., US)
GRANT_NUMBER:

DK106045
Source: Self-asserted source
Lale Ozcan

Sex Differences and the Role of a Novel Calcium Kinase Signaling Pathway in Metabolism

2016-07 to 2017-06 | Grant
Columbia University (NY, NY, US)
GRANT_NUMBER:

Provost’s Junior Faculty Grant
Source: Self-asserted source
Lale Ozcan

Hepatic DACH1 Regulates Lipid Metabolism

2016-02 to 2018-01 | Grant
National Institutes of Health (Md., Md., US)
GRANT_NUMBER:

DK063608 Pilot / Feasibility
Source: Self-asserted source
Lale Ozcan

Role of DACH1 in Obesity-Induced Hepatic Insulin Resistance

2016-01 to 2016-07 | Award
American Diabetes Association (VA, VA, US)
GRANT_NUMBER:

1-16-JDF-068

Source: Self-asserted source
Lale Ozcan

Role of CaMKII-TRB3 pathway in insulin signaling and hepatosteatosis in obesity

2013-03 to 2014-02 | Grant
New York Obesity and Nutrition Research Center (New York, US)
GRANT_NUMBER:

DK26687
Source: Self-asserted source
Lale Ozcan

Role of CaMKII in hepatic insulin signaling in obesity

2012-03 to 2013-02 | Grant
New York Obesity and Nutrition Research Center (New York, US)
GRANT_NUMBER:

DK26687

Source: Self-asserted source
Lale Ozcan

Role of CaMKII in atherosclerosis and proatherogenic effects related to insulin resistance

2011-01 to 2014-12 | Grant
American Heart Association (TX-Affiliate, US)
GRANT_NUMBER:

11SDG5300022
Source: Self-asserted source
Lale Ozcan

Works (31)

RAP1A Suppresses Hepatic Steatosis via Regulating the Amino Acid Mediated mTORC1 Activation

JHEP Reports
2024-12 | Journal article
DOI: 10.1016/j.jhepr.2024.101303
Contributors: Heena Agarwal; Yating Wang; Brea Tinsley; Xiaobo Wang; Lale Ozcan
Source: check_circle
Crossref

Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9

Journal of Lipid Research
2024-03 | Journal article
DOI: 10.1016/j.jlr.2024.100515
Contributors: Yating Wang; Brea Tinsley; Stefano Spolitu; John A. Zadroga; Heena Agarwal; Amesh K. Sarecha; Lale Ozcan
Source: check_circle
Crossref

Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

Cell Reports
2022-08 | Journal article
DOI: 10.1016/j.celrep.2022.111259
Contributors: Yating Wang; Stefano Spolitu; John A. Zadroga; Amesh K. Sarecha; Lale Ozcan
Source: check_circle
Crossref

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.

Molecular metabolism
2021-07-22 | Journal article
DOI: 10.1016/j.molmet.2021.101300
PMID: 34303021
PMC: PMC8365526
Source: Self-asserted source
Lale Ozcan

Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis.

PloS one
2021-05-13 | Journal article
DOI: 10.1371/journal.pone.0246600
PMID: 33983975
PMC: PMC8118275
Source: Self-asserted source
Lale Ozcan
grade
Preferred source (of 2)‎

Targeting Soluble DPP-4 for Insulin Resistance: Origin Matters.

The Journal of clinical endocrinology and metabolism
2021-03-01 | Journal article
DOI: 10.1210/clinem/dgaa902
PMID: 33274386
Source: Self-asserted source
Lale Ozcan

Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity.

The Journal of clinical investigation
2020-08-01 | Journal article
DOI: 10.1172/jci135919
PMID: 32657780
PMC: PMC7410057
Source: Self-asserted source
Lale Ozcan

Proprotein convertase subtilisin/kexin type 9 and lipid metabolism.

Current opinion in lipidology
2019-06-01 | Journal article
DOI: 10.1097/mol.0000000000000601
PMID: 30925519
Source: Self-asserted source
Lale Ozcan

Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol.

Circulation research
2019-01-01 | Journal article
DOI: 10.1161/circresaha.118.313648
PMID: 30582457
Source: Self-asserted source
Lale Ozcan

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1.

Blood
2018-12-01 | Journal article
DOI: 10.1182/blood-2018-07-864843
PMID: 30504459
Source: Self-asserted source
Lale Ozcan
grade
Preferred source (of 2)‎

A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes.

Diabetes
2018-09-01 | Journal article
DOI: 10.2337/dbi18-0026
PMID: 30135135
Source: Self-asserted source
Lale Ozcan

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.

Cell reports
2018-07-01 | Journal article
DOI: 10.1016/j.celrep.2018.06.039
PMID: 29996093
PMC: PMC6086569
Source: Self-asserted source
Lale Ozcan

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.

Nature
2018-03-21 | Journal article
DOI: 10.1038/nature26138
PMID: 29562231
PMC: PMC6021131
Source: Self-asserted source
Lale Ozcan

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.

The Journal of clinical investigation
2017-10-03 | Journal article
DOI: 10.1172/JCI94735
PMID: 28972541
PMC: PMC5663361
Source: Self-asserted source
Lale Ozcan

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Gastroenterology
2017-08-30 | Journal article
DOI: 10.1053/j.gastro.2017.08.039
PMID: 28859855
PMC: PMC5705280
Source: Self-asserted source
Lale Ozcan

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.

Cell reports
2016-05-26 | Journal article
DOI: 10.1016/j.celrep.2016.05.006
PMID: 27239042
PMC: PMC5068925
Source: Self-asserted source
Lale Ozcan

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

Diabetes
2015-10 | Journal article
DOI: 10.2337/db14-1945
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Lale Ozcan

Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity.

PloS one
2015-08-28 | Journal article
DOI: 10.1371/journal.pone.0135842
PMID: 26317499
PMC: PMC4552860
Source: Self-asserted source
Lale Ozcan

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway.

Proceedings of the National Academy of Sciences of the United States of America
2014-09-22 | Journal article
DOI: 10.1073/pnas.1410851111
PMID: 25246560
PMC: PMC4210018
Source: Self-asserted source
Lale Ozcan

CaMKII in cardiometabolic disease.

Aging
2014-06-01 | Journal article
DOI: 10.18632/aging.100675
PMID: 25011473
PMC: PMC4100805
Source: Self-asserted source
Lale Ozcan

Common therapeutic targets in cardiometabolic disease.

Science translational medicine
2014-06-01 | Journal article
DOI: 10.1126/scitranslmed.3008908
PMID: 24898746
PMC: PMC4176709
Source: Self-asserted source
Lale Ozcan

Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

Cell metabolism
2013-11-21 | Journal article
DOI: 10.1016/j.cmet.2013.10.011
PMID: 24268736
PMC: PMC3863383
Source: Self-asserted source
Lale Ozcan

Endoplasmic reticulum stress in cardiometabolic disorders.

Current atherosclerosis reports
2012-10-01 | Journal article
DOI: 10.1007/s11883-012-0270-z
PMID: 22847769
Source: Self-asserted source
Lale Ozcan

Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

Cell metabolism
2012-04-12 | Journal article
DOI: 10.1016/j.cmet.2012.03.002
PMID: 22503562
PMC: PMC3348356
Source: Self-asserted source
Lale Ozcan

Role of endoplasmic reticulum stress in metabolic disease and other disorders.

Annual review of medicine
2012-01-01 | Journal article
DOI: 10.1146/annurev-med-043010-144749
PMID: 22248326
PMC: PMC3290993
Source: Self-asserted source
Lale Ozcan

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis.

The Journal of cell biology
2010-12-06 | Journal article
DOI: 10.1083/jcb.201006121
PMID: 21135141
PMC: PMC3002036
Source: Self-asserted source
Lale Ozcan

Pivotal role of calcium/calmodulin-dependent protein kinase II in ER stress-induced apoptosis.

Cell cycle (Georgetown, Tex.)
2010-01-10 | Journal article
DOI: 10.4161/cc.9.2.10596
PMID: 20023415
PMC: PMC2846633
Source: Self-asserted source
Lale Ozcan

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

The Journal of clinical investigation
2009-09-08 | Journal article
DOI: 10.1172/JCI38857
PMID: 19741297
PMC: PMC2752072
Source: Self-asserted source
Lale Ozcan

Endoplasmic reticulum stress plays a central role in development of leptin resistance.

Cell metabolism
2009-01-01 | Journal article
DOI: 10.1016/j.cmet.2008.12.004
PMID: 19117545
Source: Self-asserted source
Lale Ozcan

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Molecular cell
2008-03-01 | Journal article
DOI: 10.1016/j.molcel.2007.12.023
PMID: 18342602
PMC: PMC2361721
Source: Self-asserted source
Lale Ozcan

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

Science (New York, N.Y.)
2006-08-01 | Journal article
DOI: 10.1126/science.1128294
PMID: 16931765
PMC: PMC4741373
Source: Self-asserted source
Lale Ozcan

Peer review (5 reviews for 1 publication/grant)

Review activity for American Heart Association (5)
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