Personal information

Bioinformatics and Molecular modeling, Medicinal Chemistry, Protein Catalysis and Allostery, Natural Products and Drug Discovery, Peptide Science
Brazil

Biography

Biomedical scientist and Lecture at the Federal University of Western Pará (Amazon region, Brazil), where teaches the disciplines of Structural Biology, Omics Sciences, Drug Design, and Bioinformatics. Currently, works with bioinformatics, chemometrics, and molecular modeling tools applied to (1) design and discovery of bioactive compounds, (2) prediction of pharmacokinetic and self-assembling properties of peptides, (3) analysis of allostery and catalysis of enzymes. E-mail: kaue.costa@ufopa.edu.br

Activities

Employment (3)

Federal University of Western Pará: Santarém, Pará, BR

Employment
Source: Self-asserted source
Kauê Santana da Costa

Instituto Nacional de Pesquisas da Amazônia: Manaus, Amazonas, BR

2022-03 to present | Professor (Programa de Pós-gradução em Genética e Biologia Evolutiva)
Employment
Source: Self-asserted source
Kauê Santana da Costa

Instituto Evandro Chagas: Ananindeua, Pará, BR

2013-04-04 to 2014-10-10
Employment
Source: Self-asserted source
Kauê Santana da Costa

Education and qualifications (1)

Federal University of Pará: Belém, Pará, BR

Qualification
Source: Self-asserted source
Kauê Santana da Costa

Professional activities (1)

Associação Brasileira de Bioinformática e Biologia Computacional: São Paulo, São Paulo, BR

AB3C
Service
Source: Self-asserted source
Kauê Santana da Costa

Works (36)

Rational Approach to New Chemical Entities with Antiproliferative Activity on Ab1 Tyrosine Kinase Encoded by the BCR-ABL Gene: An Hierarchical Biochemoinformatics Analysis

Pharmaceuticals
2024-11-06 | Journal article
Contributors: Vitor H. da S. Sanches; Cleison C. Lobato; Luciane B. Silva; Igor V. F. dos Santos; Elcimar de S. Barros; Alexandre de A. Maciel; Elenilze F. B. Ferreira; Kauê S. da Costa; José M. Espejo-Román; Joaquín M. C. Rosa et al.
Source: check_circle
Crossref
grade
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Investigating molecular descriptors in cell-penetrating peptides prediction with deep learning: Employing N, O, and hydrophobicity according to the Eisenberg scale

PLOS ONE
2024-06-13 | Journal article
Contributors: Juliana Auzier Seixas Feio; Hilal Tayara; Ewerton Cristhian Lima de Oliveira; Claudomiro de Souza de Sales; Kauê Santana da Costa; Anderson Henrique Lima e Lima
Source: check_circle
Crossref

BrainPepPass: A Framework Based on Supervised Dimensionality Reduction for Predicting Blood-Brain Barrier-Penetrating Peptides

Journal of Chemical Information and Modeling
2024-04-08 | Journal article
Contributors: Ewerton Cristhian Lima de Oliveira; Hannah Hirmz; Evelien Wynendaele; Juliana Auzier Seixas Feio; Igor Matheus Souza Moreira; Kauê Santana da Costa; Anderson H. Lima; Bart De Spiegeleer; Claudomiro de Souza de Sales Júnior
Source: check_circle
Crossref

Comparative analysis of the reactivity of anthocyanidins, leucoanthocyanidins, and flavonols using a quantum chemistry approach

Journal of Molecular Modeling
2023-04 | Journal article
Contributors: Sergio Antônio de Souza Farias; Kauê Santana da Costa; João B. L. Martins
Source: check_circle
Crossref

<i>In Vitro</i> Antibacterial Activity and <i>in Silico</i> Analysis of the Bioactivity of Major Compounds Obtained from the Essential Oil of <i>Virola surinamensis</i> Warb (<i>Myristicaceae</i>)

Journal of Food Quality
2022 | Journal article
Contributors: Almeida, Lorena Queiroz; do Nascimento, Lidiane Diniz; Miranda da Costa, Fernando Augusto; da Costa, Kaue Santana; de Aguiar Andrade, Eloisa Helena
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Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Advances in UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Covalent Inhibition

Frontiers in Molecular Biosciences
2022 | Journal article
Contributors: De Oliveira, Maycon Vinicius Damasceno; Furtado, Renan Machado; Da Costa, Kaue S.; Vakal, Serhii; Lima, Anderson H.
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Web of Science Researcher Profile Sync

Biological Membrane-Penetrating Peptides: Computational Prediction and Applications

Frontiers in Cellular and Infection Microbiology
2022 | Journal article
Contributors: de Oliveira, Ewerton Cristhian Lima; da Costa, Kaue Santana; Taube, Paulo Sergio; Lima, Anderson H.; de Sales Junior, Claudomiro de Souza
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First report on the <i>Annona exsucca</i> DC. Essential oil and <i>in silico</i> identification of potential biological targets of its major compounds

Natural Product Research
2022 | Journal article
Contributors: Cascaes, Marcia Moraes; Silva, Sebastiao Gomes; Cruz, Jorddy Neves; Santana de Oliveira, Mozaniel; Oliveira, Jorge; Moraes, Angelo Antonio Barbosa de; Costa, Fernando Augusto Miranda da; da Costa, Kaue Santana; Diniz do Nascimento, Lidiane; Helena de Aguiar Andrade, Eloisa
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Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Physicochemical characterization and antioxidant activity of honey samples of <i>Apis mellifera</i> and different species of Meliponinae subfamily from the Brazilian eastern Amazon region

Food Science and Technology
2022 | Journal article
Contributors: Gomes, Victor Valentim; Portela Bandeira, Adelene Menezes; Saraiva Cordovil, Kelly Prissila; Bandeira Filho, Jose dos Reis; Braghini, Francieli; Biluca, Fabiola Carina; Gonzaga, Luciano Valdemiro; Fett, Roseane; da Costa, Kaue Santana; Ramos de Azevedo, Marcia Mourao et al.
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Structural changes and adaptative evolutionary constraints in FLOWERING LOCUS T and TERMINAL FLOWER1-like genes of flowering plants

Frontiers in Genetics
2022 | Journal article
Contributors: de Jesus, Deivid Almeida; Batista, Darlisson Mesquista; Monteiro, Elton Figueira; Salzman, Shayla; Carvalho, Lucas Miguel; Santana, Kaue; Andre, Thiago
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Synthesis, Characterization, Applications, and Toxicity of Green Synthesized Nanoparticles

Current Pharmaceutical Biotechnology
2022 | Journal article
Contributors: Galucio, Joao Marcos Pereira; de Souza, Sorrel Godinho Barbosa; Vasconcelos, Arthur Abinader; Lima, Alan Kelbis Oliveira; da Costa, Kaue Santana; Braga, Hugo de Campos; Taube, Paulo Sergio
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Virtual screening of natural products against 5-enolpyruvylshikimate-3-phosphate synthase using the Anagreen herbicide-like natural compound library

RSC Advances
2022 | Journal article
Contributors: Damasceno de Oliveira, Maycon Vinicius; Bittencourt Fernandes, Gilson Mateus; da Costa, Kaue S.; Vakal, Serhii; Lima, Anderson H.
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Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Host-Guest Inclusion Complexes of Natural Products and Nanosystems: Applications in the Development of Repellents

Molecules
2022-04-14 | Journal article
Part of ISSN: 1420-3049
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 3)‎

Analysis of Conformational, Structural, Magnetic, and Electronic Properties Related to Antioxidant Activity: Revisiting Flavan, Anthocyanidin, Flavanone, Flavonol, Isoflavone, Flavone, and Flavan-3-ol

ACS Omega
2021 | Journal article
Contributors: de Souza Farias, Sergio Antonio; da Costa, Kaue Santana; Martins, Joao B. L.
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Web of Science Researcher Profile Sync
grade
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Analysis of Kojic Acid Derivatives as Competitive Inhibitors of Tyrosinase: A Molecular Modeling Approach

Molecules
2021 | Journal article
Contributors: Cardoso, Richelly; Valente, Renan; Souza da Costa, Clauber Henrique; Vianez Jr, Joao Lidio da S. Gonsalves; da Costa, Kaue Santana; de Molfetta, Fabio Alberto; Alves, Claudio Nahum
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Web of Science Researcher Profile Sync
grade
Preferred source (of 3)‎

Applications of Virtual Screening in Bioprospecting: Facts, Shifts, and Perspectives to Explore the Chemo-Structural Diversity of Natural Products

Frontiers in Chemistry
2021 | Journal article
Contributors: Santana, Kaue; do Nascimento, Lidiane Diniz; Lima, Anderson Lima E.; Damasceno, Vinicius; Nahum, Claudio; Braga, Rodolpho C.; Lameira, Jeronimo
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Assessment of the PETase conformational changes induced by poly(ethylene terephthalate) binding

Proteins: Structure, Function, and Bioinformatics
2021 | Journal article
Contributors: da Costa, Clauber Henrique Souza; dos Santos, Alberto M.; Alves, Claudio Nahum; Marti, Sergio; Moliner, Vicent; Santana, Kaue; Lameira, Jeronimo
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grade
Preferred source (of 2)‎

Assessment of the PETase Conformational Changes Induced by Poly(ethylene terephthalate) Binding

Authorea
2021 | Journal article
Contributors: Clauber Henrique Costa; Alberto dos Santos; Cláudio Nahum Alves; Sérgio Martí; Vicente Moliner; Kaue Santana; Jeronimo Lameira Silva
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Drying Effects on Chemical Composition and Antioxidant Activity of <i>Lippia thymoides</i> Essential Oil, a Natural Source of Thymol

Molecules
2021 | Journal article
Contributors: Nascimento, Lidiane Diniz do; Silva, Sebastiao Gomes; Cascaes, Marcia Moraes; Costa, Kaue Santana da; Figueiredo, Pablo Luis Baia; Costa, Cristiane Maria Leal; Andrade, Eloisa Helena de Aguiar; de Faria, Lenio Jose Guerreiro
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grade
Preferred source (of 3)‎

In silico analyses of toxicity of the major constituents of essential oils from two Ipomoea L. species

Toxicon
2021 | Journal article
Contributors: da Silva Junior, Oseias Souza; Pereira Franco, Celeste de Jesus; Barbosa de Moraes, Angelo Antonio; Cruz, Jorddy Neves; da Costa, Kaue Santana; do Nascimento, Lidiane Diniz; de Aguiar Andrade, Eloisa Helena
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Web of Science Researcher Profile Sync
grade
Preferred source (of 3)‎

Predicting cell-penetrating peptides using machine learning algorithms and navigating in their chemical space

Scientific Reports
2021 | Journal article
Contributors: Lima de Oliveira, Ewerton Cristhian; Santana, Kaue; Josino, Luiz; Lima e Lima, Anderson Henrique; de Sales Junior, Claudomiro de Souza
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grade
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Structural Changes and Adaptative Evolutionary Constraints In FLOWERING LOCUS T and TERMINAL FLOWER1-Like Genes of Flowering Plants

2021-03-11 | Preprint
Contributors: Deivid Almeida de Jesus; Darlisson Mesquista Batista; Shayla Salzman; Lucas Miguel Carvalho; Kaue Santana; Thiago André
Source: check_circle
Crossref

Investigation of the target-site resistance of EPSP synthase mutants P106T and T102I/P106S against glyphosate

RSC Advances
2020 | Journal article
Part of ISSN: 2046-2069
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 3)‎

Targeting shikimate pathway: in silico analysis of phosphoenolpyruvate derivatives as inhibitors of EPSP synthase and DAHP synthase

Journal of Molecular Graphics and Modelling
2020-09 | Journal article
Part of ISSN: 1093-3263
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 3)‎

Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications

Biomolecules
2020-07-01 | Journal article
Part of ISSN: 2218-273X
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 5)‎

Unraveling the conformational dynamics of glycerol 3-phosphate dehydrogenase, a nicotinamide adenine dinucleotide-dependent enzyme of Leishmania mexicana

Journal of Biomolecular Structure and Dynamics
2020-03-25 | Journal article
Part of ISSN: 0739-1102
Part of ISSN: 1538-0254
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 4)‎

Determination of macro and trace element levels in honey from the lower amazonian region, Brazil

Brazilian Journal of Analytical Chemistry
2019 | Journal article
EID:

2-s2.0-85072641165

Part of ISSN: 21793433 21793425
Contributors: Dourado, G.S.; Gomes, V.V.; Maia, M.T.V.; Vasconcelos, A.A.; Da Costa, K.S.; Do Carmo Faial, K.; Carneiro, B.S.; Vasconcelos, N.T.; Taube, P.S.
Source: Self-asserted source
Kauê Santana da Costa via Scopus - Elsevier
grade
Preferred source (of 2)‎

Exploring the Potentiality of Natural Products from Essential Oils as Inhibitors of Odorant-Binding Proteins: A Structure- and Ligand-Based Virtual Screening Approach To Find Novel Mosquito Repellents

ACS Omega
2019-12-17 | Journal article
Part of ISSN: 2470-1343
Part of ISSN: 2470-1343
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 4)‎

Computational study of conformational changes in human 3-hydroxy-3-methylglutaryl coenzyme reductase induced by substrate binding

Journal of Biomolecular Structure and Dynamics
2019-11-02 | Journal article
Part of ISSN: 0739-1102
Part of ISSN: 1538-0254
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 3)‎

Targeting Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1: A Structure-based Virtual Screening Approach to Find Novel Inhibitors

Current Computer-Aided Drug Design
2019-10-25 | Journal article
Part of ISSN: 1573-4099
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 4)‎

In silico Identification of Natural Products with Anticancer Activity Using a Chemo-structural Database of Brazilian Biodiversity

Computational Biology and Chemistry
2019-08 | Journal article
Part of ISSN: 1476-9271
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 3)‎

Measuring the structural impact of mutations on cytochrome P450 21A2, the major steroid 21-hydroxylase related to congenital adrenal hyperplasia

Journal of Biomolecular Structure and Dynamics
2019-04-14 | Journal article
Part of ISSN: 0739-1102
Part of ISSN: 1538-0254
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 4)‎

Structural and evolutionary analysis of Leishmania Alba proteins

Molecular and Biochemical Parasitology
2017-10 | Journal article
Part of ISSN: 0166-6851
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 3)‎

Structural Analysis of Viral Infectivity Factor of HIV Type 1 and Its Interaction with A3G, EloC and EloB (vol 9, e89116, 2014)

Plos One
2014 | Journal article
Contributors: da Costa, K. S.
Source: check_circle
Web of Science Researcher Profile Sync

Structural Analysis of Viral Infectivity Factor of HIV Type 1 and Its Interaction with A3G, EloC and EloB

PLoS ONE
2014-02-26 | Journal article
Part of ISSN: 1932-6203
Source: Self-asserted source
Kauê Santana da Costa
grade
Preferred source (of 3)‎

Investigation of the target-site resistance of EPSP synthase mutants P106T and T102I/P106S against glyphosate

RSC Advances
Journal article
Source: Self-asserted source
Kauê Santana da Costa

Peer review (26 reviews for 13 publications/grants)

Review activity for Brazilian Journal of Pharmaceutical Sciences. (1)
Review activity for Communications biology. (1)
Review activity for Computational biology and chemistry (1)
Review activity for International journal of food science & technology. (1)
Review activity for International journal of tropical insect science. (1)
Review activity for Journal of biomolecular structure and dynamics. (11)
Review activity for Journal of chemical information and modeling. (1)
Review activity for Molecular pharmaceutics. (1)
Review activity for Natural product research (3)
Review activity for Nucleic acids research. (1)
Review activity for Planta medica. (2)
Review activity for Química Nova. (1)
Review activity for SAR and QSAR in environmental research. (1)