Personal information

United Kingdom

Activities

Employment (1)

University of Leeds: Leeds, MR

Employment
Source: Self-asserted source
James L Thorne

Funding (1)

A Multi-User Flow Cytometry Facility for the Biosciences in Leeds

2017-08-01 to 2018-07-31 | Grant
Biotechnology and Biological Sciences Research Council (Swindon, GB)
GRANT_NUMBER: BB/R000352/1
Source: Self-asserted source
James L Thorne via DimensionsWizard

Works (33)

Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane

Structure
2025-01 | Journal article
Contributors: Chrysa Soteriou; Mengfan Xu; Simon D. Connell; Arwen I.I. Tyler; Antreas C. Kalli; James L. Thorne
Source: check_circle
Crossref

Phytosterol and phytostanol-mediated epigenetic changes in cancer and other non-communicable diseases: a systematic review

British Journal of Nutrition
2024-03-28 | Journal article
Contributors: Emtenan Jefrei; Mengfan Xu; J. Bernadette Moore; James L. Thorne
Source: check_circle
Crossref

NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways

Nutrition Research Reviews
2023-06 | Journal article
Contributors: Zixuan Zhang; Rachel Moon; James L. Thorne; J. Bernadette Moore
Source: check_circle
Crossref

Non-Alcoholic Fatty Liver Disease and Vitamin D in the UK Biobank: A Two-Sample Bidirectional Mendelian Randomisation Study

Nutrients
2023-03-16 | Journal article
Contributors: Zixuan Zhang; Kimberley Burrows; Harriett Fuller; Elizabeth K. Speliotes; Kushala W. M. Abeysekera; James L. Thorne; Sarah J. Lewis; Michael A. Zulyniak; J. Bernadette Moore
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Crossref
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The Second Nutrition and Cancer Networking Meeting Nutrition and Breast Cancer: Translating Evidence into Practice

Proceedings of the Nutrition Society
2023-02 | Journal article
Contributors: James L Thorne; Ingunn Holen; Bernard M Corfe
Source: check_circle
Crossref

Mass Spectrometry Reveals that Oxysterols are Secreted from Non-Alcoholic Fatty Liver Disease Induced Organoids

2023-02-22 | Preprint
Contributors: Kristina Sæterdal Kømurcu; Ingrid Wilhelmsen; James L Thorne; Stefan Johannes Karl Krauss; Steven Ray Haakon Wilson; Aleksandra Aizenshtadt; Hanne Røberg-Larsen
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Crossref

Phytosterols and phytostanols and the hallmarks of cancer in model organisms: A systematic review and meta-analysis

Critical Reviews in Food Science and Nutrition
2022-02-10 | Journal article
Contributors: Giorgia Cioccoloni; Chrysa Soteriou; Alex Websdale; Lewis Wallis; Michael A. Zulyniak; James L. Thorne
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Crossref

MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer

Cancers
2021-11-28 | Journal article
Contributors: Diana E. Baxter; Lisa M. Allinson; Waleed S. Al Amri; James A. Poulter; Arindam Pramanik; James L. Thorne; Eldo T. Verghese; Thomas A. Hughes
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Crossref
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Comprehensive profiling of liver x receptor splicing in triple negative breast cancer reveals existence of novel splice variants that are prognostic for survival

2021-06-10 | Other
Contributors: Priscilia Lianto; J. Bernadette Moore; Thomas A. Hughes; James L. Thorne
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy

British Journal of Cancer
2021-03-16 | Journal article
Contributors: Robyn V. Broad; Stacey J. Jones; Melina C. Teske; Laura M. Wastall; Andrew M. Hanby; James L. Thorne; Thomas A. Hughes
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Crossref

WHSC1/NSD2 regulates immune infiltration in prostate cancer

Journal for ImmunoTherapy of Cancer
2021-02 | Journal article
Contributors: Muzamil Y Want; Takemasa Tsuji; Prashant K Singh; James L Thorne; Junko Matsuzaki; Ellen Karasik; Bryan Gillard; Eduardo Cortes Gomez; Richard C. Koya; Amit Lugade et al.
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Crossref

Nutrition and cancer: evidence gaps and opportunities for improving knowledge

Proceedings of the Nutrition Society
2020-08-18 | Journal article
Contributors: James L. Thorne; J. Bernadette Moore; Bernard M. Corfe
Source: check_circle
Crossref

A stable luciferase reporter system to characterize LXR regulation by oxysterols and novel ligands

Methods in Molecular Biology
2019 | Book chapter
EID:

2-s2.0-85062395102

Contributors: Hutchinson, S.A.; Thorne, J.L.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Phytosterols inhibit side-chain oxysterol mediated activation of LXR in breast cancer cells

International Journal of Molecular Sciences
2019 | Journal article
EID:

2-s2.0-85068663720

Contributors: Hutchinson, S.A.; Lianto, P.; Moore, J.B.; Hughes, T.A.; Thorne, J.L.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Predicting and reducing hepatic lipotoxicity in non-alcoholic fatty liver disease

Lab animal
2019 | Journal article
EID:

2-s2.0-85065044326

Contributors: Moore, J.B.; Thorne, J.L.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Vitamin D and nonalcoholic fatty liver disease

Current Opinion in Clinical Nutrition and Metabolic Care
2019 | Journal article
EID:

2-s2.0-85072259971

Contributors: Zhang, Z.; Thorne, J.L.; Moore, J.B.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling

Nutrients
2019-11-01 | Journal article
Contributors: Samantha A Hutchinson; Priscilia Lianto; Hanne Roberg-Larsen; Sebastiano Battaglia; Thomas A Hughes; James L Thorne
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Crossref
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Fast liquid chromatography-mass spectrometry reveals side chain oxysterol heterogeneity in breast cancer tumour samples

The Journal of Steroid Biochemistry and Molecular Biology
2019-09 | Journal article
Contributors: Stian Solheim; Samantha A. Hutchinson; Elsa Lundanes; Steven R. Wilson; James L. Thorne; Hanne Roberg-Larsen
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Crossref
grade
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MiR-19b non-canonical binding is directed by HuR and confers chemosensitivity through regulation of P-glycoprotein in breast cancer

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
2018 | Journal article
EID:

2-s2.0-85054170906

Contributors: Thorne, J.L.; Battaglia, S.; Baxter, D.E.; Hayes, J.L.; Hutchinson, S.A.; Jana, S.; Millican-Slater, R.A.; Smith, L.; Teske, M.C.; Wastall, L.M. et al.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Exploring the biophysical properties of phytosterols in the plasma membrane for novel cancer prevention strategies

Biochimie
2018-10 | Journal article
Contributors: Omar Fakih; Didem Sanver; David Kane; James L. Thorne
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Crossref
grade
Preferred source (of 2)‎

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy

BMC Cancer
2015 | Journal article
EID:

2-s2.0-84941284340

Contributors: Kim, B.; Stephen, S.L.; Hanby, A.M.; Horgan, K.; Perry, S.L.; Richardson, J.; Roundhill, E.A.; Valleley, E.M.A.; Verghese, E.T.; Williams, B.J. et al.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Nuclear receptors and the Warburg effect in cancer

International Journal of Cancer
2015 | Journal article
EID:

2-s2.0-84902229709

Contributors: Thorne, J.L.; Campbell, M.J.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Cooperative behavior of the nuclear receptor superfamily and its deregulation in prostate cancer

Carcinogenesis
2014 | Journal article
EID:

2-s2.0-84893359797

Contributors: Long, M.D.; Thorne, J.L.; Russell, J.; Battaglia, S.; Singh, P.K.; Sucheston-Campbell, L.E.; Campbell, M.J.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion

Journal of Pathology
2013 | Journal article
EID:

2-s2.0-84885406105

Contributors: Verghese, E.T.; Drury, R.; Green, C.A.; Holliday, D.L.; Lu, X.; Nash, C.; Speirs, V.; Thorne, J.L.; Thygesen, H.H.; Zougman, A. et al.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Neoadjuvant Chemotherapy Induces Expression Levels of Breast Cancer Resistance Protein That Predict Disease-Free Survival in Breast Cancer

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84877043382

Contributors: Kim, B.; Fatayer, H.; Hanby, A.M.; Horgan, K.; Perry, S.L.; Valleley, E.M.A.; Verghese, E.T.; Williams, B.J.; Thorne, J.L.; Hughes, T.A.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns

Carcinogenesis
2013 | Journal article
EID:

2-s2.0-84873564427

Contributors: Doig, C.L.; Singh, P.K.; Dhiman, V.K.; Thorne, J.L.; Battaglia, S.; Sobolewski, M.; Maguire, O.; O'Neill, L.P.; Turner, B.M.; McCabe, C.J. et al.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Heterochromatin protein 1 gamma and IκB kinase alpha interdependence during tumour necrosis factor gene transcription elongation in activated macrophages

Nucleic Acids Research
2012 | Journal article
EID:

2-s2.0-84870486222

Contributors: Thorne, J.L.; Ouboussad, L.; Lefevre, P.F.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Epigenetic control of a VDR-governed feed-forward loop that regulates p21 <sup>(waf1/cip1)</sup> expression and function in non-malignant prostate cells

Nucleic Acids Research
2011 | Journal article
EID:

2-s2.0-79953684295

Contributors: Thorne, J.L.; Maguire, O.; Doig, C.L.; Battaglia, S.; Fehr, L.; Sucheston, L.E.; Heinaniemi, M.; O'Neill, L.P.; McCabe, C.J.; Turner, B.M. et al.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

The molecular cancer biology of the VDR

Vitamin D and Cancer
2011 | Book
EID:

2-s2.0-84874057303

Contributors: Thorne, J.; Campbell, M.J.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Elevated NCOR1 disrupts PPARα/γ signaling in prostate cancer and forms a targetable epigenetic lesion

Carcinogenesis
2010 | Journal article
EID:

2-s2.0-77956296891

Contributors: Battaglia, S.; Maguire, O.; Thorne, J.L.; Hornung, L.B.; Doig, C.L.; Liu, S.; Sucheston, L.E.; Bianchi, A.; Khanim, F.L.; Gommersall, L.M. et al.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells

Carcinogenesis
2009 | Journal article
EID:

2-s2.0-62349138999

Contributors: Abedin, S.A.; Thorne, J.L.; Battaglia, S.; Maguire, O.; Hornung, L.B.; Doherty, A.P.; Mills, I.G.; Campbell, M.J.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Transcription factors, chromatin and cancer

International Journal of Biochemistry and Cell Biology
2009 | Journal article
EID:

2-s2.0-55949116070

Contributors: Thorne, J.L.; Campbell, M.J.; Turner, B.M.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

The vitamin D receptor in cancer

Proceedings of the Nutrition Society
2008 | Journal article
EID:

2-s2.0-42149112201

Contributors: Thorne, J.; Campbell, M.J.
Source: Self-asserted source
James L Thorne via Scopus - Elsevier

Peer review (4 reviews for 4 publications/grants)

Review activity for British journal of cancer. (1)
Review activity for Cellular and molecular life sciences (1)
Review activity for npj science of food. (1)
Review activity for Oncogene. (1)