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University of Iowa Immunology Webpage

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Scopus Author ID: 57195952935

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Education and qualifications (3)

Columbia University: New York, NY, US

2021-08-16 to present | Post Doc (Microbiology and Immunology)
Qualification
Source: Self-asserted source
Isaac Jensen

University of Iowa: Iowa City, IA, US

2015-08-15 to 2021-07-31 | Ph.D. in Immunology
Education
Source: Self-asserted source
Isaac Jensen

University of North Dakota: Grand Forks, ND, US

2011-08 to 2015-05 | B.S. in Biology
Education
Source: Self-asserted source
Isaac Jensen

Works (28)

Sublethal whole-body irradiation induces permanent loss and dysfunction in pathogen-specific circulating memory CD8 T cell populations

Proceedings of the National Academy of Sciences
2023-07-04 | Journal article
DOI: 10.1073/pnas.2302785120
Contributors: Mohammad Heidarian; Isaac J. Jensen; Shravan Kumar Kannan; Lecia L. Pewe; Mariah Hassert; SungRye Park; Hai-Hui Xue; John T. Harty; Vladimir P. Badovinac
Source: check_circle
Crossref

Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition

The Journal of Immunology
2023-01-15 | Journal article
DOI: 10.4049/jimmunol.2200676
Contributors: Steven J Moioffer; Roger R Berton; Patrick W McGonagill; Isaac J Jensen; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

Gutsy memory T cells stand their ground against pathogens

Science Immunology
2022-11-25 | Journal article
DOI: 10.1126/sciimmunol.ade7168
Contributors: Isaac J. Jensen; Donna L. Farber
Source: check_circle
Crossref

Inflammation Controls Susceptibility of Immune-Experienced Mice to Sepsis

ImmunoHorizons
2022-07-01 | Journal article
DOI: 10.4049/immunohorizons.2200050
Contributors: Roger R Berton; Isaac J Jensen; John T Harty; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

Novel Mouse Model of Murine Cytomegalovirus–Induced Adaptive NK Cells

ImmunoHorizons
2022-01-01 | Journal article
DOI: 10.4049/immunohorizons.2100113
Contributors: Isaac J Jensen; Matthew D Martin; Sandeep K Tripathy; Vladimir P Badovinac
Source: check_circle
Crossref

Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

Cell Reports
2021-11 | Journal article
DOI: 10.1016/j.celrep.2021.109956
Contributors: Mitchell N. Lefebvre; Fionna A. Surette; Scott M. Anthony; Rahul Vijay; Isaac J. Jensen; Lecia L. Pewe; Lisa S. Hancox; Natalija Van Braeckel-Budimir; Stephanie van de Wall; Stina L. Urban et al.
Source: check_circle
Crossref

Sepsis and multiple sclerosis: Causative links and outcomes

Immunology Letters
2021-10 | Journal article
DOI: 10.1016/j.imlet.2021.07.008
Contributors: Đorđe Miljković; Suzana Stanisavljević; Isaac J Jensen; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

eLife
2021-10-15 | Journal article
DOI: 10.7554/eLife.70989
Contributors: Isaac J jensen; Xiang Li; Patrick W McGonagill; Qiang Shan; Micaela G Fosdick; Mikaela M Tremblay; Jon CD Houtman; Hai-Hui Xue; Thomas S Griffith; Weiqun Peng et al.
Source: check_circle
Crossref

Autoimmunity Increases Susceptibility to and Mortality from Sepsis

ImmunoHorizons
2021-10-01 | Journal article
DOI: 10.4049/immunohorizons.2100070
Contributors: Isaac J Jensen; Samantha N Jensen; Patrick W McGonagill; Thomas S Griffith; Ashutosh K Mangalam; Vladimir P Badovinac
Source: check_circle
Crossref

Severity of Sepsis Determines the Degree of Impairment Observed in Circulatory and Tissue-Resident Memory CD8 T Cell Populations

The Journal of Immunology
2021-10-01 | Journal article
DOI: 10.4049/jimmunol.2001142
Contributors: Steven J Moioffer; Derek B Danahy; Stephanie van de Wall; Isaac J Jensen; Frances V Sjaastad; Scott M Anthony; John T Harty; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

Autoimmunity increases susceptibility to and mortality from sepsis

2021-07-08 | Other
DOI: 10.1101/2021.07.06.451335
Contributors: Isaac J. Jensen; Samantha N. Jensen; Patrick W. McGonagill; Thomas S. Griffith; Ashutosh K. Mangalam; Vladimir P. Badovinac
Source: check_circle
Crossref

Protective function and durability of mouse lymph node-resident memory CD8+ T cells

eLife
2021-06-18 | Journal article
DOI: 10.7554/eLife.68662
Contributors: Scott M Anthony; Natalija Van Braeckel-Budimir; Steven J Moioffer; Stephanie van de Wall; Qiang Shan; Rahul Vijay; Ramakrishna Sompallae; Stacey M Hartwig; Isaac J Jensen; Steven M Varga et al.
Source: check_circle
Crossref

Prolonged Reactive Oxygen Species Production following Septic Insult

ImmunoHorizons
2021-06-01 | Journal article
DOI: 10.4049/immunohorizons.2100027
Contributors: Isaac J Jensen; Patrick W McGonagill; Roger R Berton; Brett A Wagner; Elvia E Silva; Garry R Buettner; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

A Functionally Distinct CXCR3+/IFN-γ+/IL-10+ Subset Defines Disease-Suppressive Myelin-Specific CD8 T Cells

The Journal of Immunology
2021-03-15 | Journal article
DOI: 10.4049/jimmunol.2001143
Contributors: Ashley A Brate; Alexander W Boyden; Isaac J Jensen; Vladimir P Badovinac; Nitin J Karandikar
Source: check_circle
Crossref

NK Cell–Derived IL-10 Supports Host Survival during Sepsis

The Journal of Immunology
2021-03-15 | Journal article
DOI: 10.4049/jimmunol.2001131
Contributors: Isaac J Jensen; Patrick W McGonagill; Noah S Butler; John T Harty; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

Inducing Experimental Polymicrobial Sepsis by Cecal Ligation and Puncture.

Current protocols in immunology
2020-12-01 | Journal article
DOI: 10.1002/cpim.110
PMID: 33027848
Source: Self-asserted source
Isaac Jensen

Sepsis impedes EAE disease development and diminishes autoantigen-specific naïve CD4 T cells.

eLife
2020-11-16 | Journal article
DOI: 10.7554/elife.55800
PMID: 33191915
Source: Self-asserted source
Isaac Jensen
grade
Preferred source (of 2)‎

Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection

Nature Immunology
2020-08 | Journal article
DOI: 10.1038/s41590-020-0711-8
Contributors: Stina L. Urban; Isaac J. Jensen; Qiang Shan; Lecia L. Pewe; Hai-Hui Xue; Vladimir P. Badovinac; John T. Harty
Source: check_circle
Crossref

Worry and FRET: ROS Production Leads to Fluorochrome Tandem Degradation and impairs Interpretation of Flow Cytometric Results.

Immunity
2020-03-01 | Journal article
DOI: 10.1016/j.immuni.2020.02.003
PMID: 32187510
Source: Self-asserted source
Isaac Jensen

Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma

Journal for ImmunoTherapy of Cancer
2019 | Journal article
DOI: 10.1186/s40425-019-0550-z
Source: Self-asserted source
Isaac Jensen

Bystander responses impact accurate detection of murine and human antigen-specific CD8+ T cells

Journal of Clinical Investigation
2019-08-19 | Journal article
DOI: 10.1172/JCI124443
Contributors: Matthew D. Martin; Isaac J. Jensen; Andrew S. Ishizuka; Mitchell Lefebvre; Qiang Shan; Hai-Hui Xue; John T. Harty; Robert A. Seder; Vladimir P. Badovinac
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Crossref

Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.

Cell reports
2019-08-01 | Journal article
DOI: 10.1016/j.celrep.2019.07.028
PMID: 31412243
PMC: PMC6703181
Source: Self-asserted source
Isaac Jensen

Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell–Mediated Antitumor Immunity

The Journal of Immunology
2019-08-01 | Journal article
DOI: 10.4049/jimmunol.1900435
Contributors: Derek B Danahy; Samarchith P Kurup; Christina S Winborn; Isaac J Jensen; John T Harty; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

A preliminary analysis of interleukin-1 ligands as potential predictive biomarkers of response to cetuximab.

Biomarker research
2019-07-16 | Journal article
DOI: 10.1186/s40364-019-0164-0
PMID: 31346466
PMC: PMC6636109
Source: Self-asserted source
Isaac Jensen

Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival

The Journal of Immunology
2019-05-15 | Journal article
DOI: 10.4049/jimmunol.1900076
Contributors: Derek B Danahy; Isaac J Jensen; Thomas S Griffith; Vladimir P Badovinac
Source: check_circle
Crossref

Sepsis-induced t cell immunoparalysis: The ins and outs of impaired T cell immunity

Journal of Immunology
2018 | Journal article
DOI: 10.4049/jimmunol.1701618
EID:

2-s2.0-85044778972
Contributors: Jensen, I.J.; Sjaastad, F.V.; Griffith, T.S.; Badovinac, V.P.
Source: Self-asserted source
Isaac Jensen via Scopus - Elsevier
grade
Preferred source (of 2)‎

Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections

PLOS Pathogens
2018-10-31 | Journal article
DOI: 10.1371/journal.ppat.1007405
Contributors: Isaac J. Jensen; Christian Munz; Christina S. Winborn; Micaela G. Fosdick; Peng Shao; Mikaela M. Tremblay; Qiang Shan; Sandeep Kumar Tripathy; Christopher M. Snyder; Hai-Hui Xue et al.
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Crossref
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Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells

PLOS Pathogens
2017-09-14 | Journal article
DOI: 10.1371/journal.ppat.1006569
Contributors: Derek B. Danahy; David A Hildeman; Scott M. Anthony; Isaac J. Jensen; Stacey M. Hartwig; Qiang Shan; Hai-Hui Xue; John T. Harty; Thomas S. Griffith; Vladimir P. Badovinac
Source: check_circle
Crossref
grade
Preferred source (of 2)‎
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