Personal information

Websites & social links

https://www.umassmed.edu/sontheimerlab/lab-members/bin-liu/
https://www.umassmed.edu/xuelab/lab-members/bin-liu/

Keywords

Genome Editing, Gene Therapy, CRISPR, Cancer

Countries

United States, Netherlands, China

Activities

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Employment (2)

UMass Chan Medical School : WORCESTER, MA, US

2020-02-03 to present | Post-Doctoral Associate (RNA Therapeutics Institute)
Employment
Source: Self-asserted source
Bin Liu

University of Groningen: Groningen, NL

2015-10-01 to 2019-10-29 | PhD (Groningen Research Institute of Pharmacy)
Employment
Source: Self-asserted source
Bin Liu

Works (20)

Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates

Nature Biotechnology
2024-07 | Journal article
DOI: 10.1038/s41587-023-01947-w
Contributors: Bin Liu; Xiaolong Dong; Chunwei Zheng; David Keener; Zexiang Chen; Haoyang Cheng; Jonathan K. Watts; Wen Xue; Erik J. Sontheimer
Source: check_circle
Crossref

Template-jumping prime editing enables large insertion and exon rewriting in vivo

Nature Communications
2023-06-08 | Journal article
DOI: 10.1038/s41467-023-39137-6
Contributors: Chunwei Zheng; Bin Liu; Xiaolong Dong; Nicholas Gaston; Erik J. Sontheimer; Wen Xue
Source: check_circle
Crossref

Modulating CRISPR/Cas9 genome-editing activity by small molecules

Drug Discovery Today
2022 | Journal article
DOI: 10.1016/J.DRUDIS.2021.11.018THIS
WOSUID: WOS:000783311100004
Contributors: Chen, Siwei; Chen, Deng; Liu, Bin; Haisma, Hidde J.
Source: check_circle
Web of Science Researcher Profile Sync

A split prime editor with untethered reverse transcriptase and circular RNA template

Nature Biotechnology
2022-09 | Journal article
DOI: 10.1038/s41587-022-01255-9
Contributors: Bin Liu; Xiaolong Dong; Haoyang Cheng; Chunwei Zheng; Zexiang Chen; Tomás C. Rodríguez; Shun-Qing Liang; Wen Xue; Erik J. Sontheimer
Source: check_circle
Crossref

Modulating CRISPR/Cas9 genome-editing activity by small molecules

Drug Discovery Today
2022-04 | Journal article
DOI: 10.1016/j.drudis.2021.11.018
Part of ISSN: 1359-6446
Contributors: Bin Liu; Siwei Chen; Deng Chen; Bin Liu; Hidde J. Haisma
Source: Self-asserted source
Bin Liu

A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver

Molecular Therapy
2022-03 | Journal article
DOI: 10.1016/j.ymthe.2022.01.005
Contributors: Chunwei Zheng; Shun-Qing Liang; Bin Liu; Pengpeng Liu; Suet-Yan Kwan; Scot A. Wolfe; Wen Xue
Source: check_circle
Crossref

D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling

EBioMedicine
2021-06 | Journal article
DOI: 10.1016/j.ebiom.2021.103412
Contributors: Shanshan Song; Bin Liu; Habibie Habibie; Jelle van den Bor; Martine J. Smit; Reinoud Gosens; Xinhui Wu; Corry-Anke Brandsma; Robbert H. Cool; Hidde J. Haisma et al.
Source: check_circle
Crossref

Transcriptional activation of cyclin D1 via HER2/HER3 contributes to EGFR-TKI resistance in lung cancer

Biochemical Pharmacology
2020-08 | Journal article
DOI: 10.1016/j.bcp.2020.114095
Part of ISSN: 0006-2952
Contributors: Bin Liu; Bin Liu; Deng Chen; Shipeng Chen; Ali Saber; Hidde Haisma
Source: Self-asserted source
Bin Liu
grade
Preferred source (of 2)‎

CRISPR-mediated ablation of overexpressed EGFR in combination with sunitinib significantly suppresses renal cell carcinoma proliferation

PLOS ONE
2020-05-15 | Journal article
DOI: 10.1371/journal.pone.0232985
Contributors: Bin Liu; Hodaka Fujii; Olivia Adaly Diaz Arguello; Deng Chen; Siwei Chen; Ali Saber; Hidde J. Haisma
Source: check_circle
Crossref

A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL

Biochemical Pharmacology
2020-03 | Journal article
DOI: 10.1016/j.bcp.2020.113914
Part of ISSN: 0006-2952
Source: Self-asserted source
Bin Liu

Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

Nucleic Acids Research
2020-01-24 | Journal article
DOI: 10.1093/nar/gkz1136
Contributors: Bin Liu; Siwei Chen; Anouk La Rose; Deng Chen; Fangyuan Cao; Martijn Zwinderman; Dominik Kiemel; Manon Aïssi; Frank J Dekker; Hidde J Haisma
Source: check_circle
Crossref

Transcriptional activation of cyclin D1 via HER2/HER3 contributes to cell survival and EGFR tyrosine kinase inhibitor resistance in non-small cell lung carcinoma

2019-11-21 | Other
DOI: 10.1101/851279
Contributors: Bin Liu; Deng Chen; Shipeng Chen; Ali Saber; Hidde Haisma
Source: check_circle
Crossref

Inhibition of Histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

2019-06-13 | Other
DOI: 10.1101/670554
Contributors: Bin Liu; Siwei Chen; Anouk La Rose; Deng Chen; Fangyuan Cao; Dominik Kiemel; Manon Aïssi; FJ Dekker; HJ Haisma
Source: check_circle
Crossref

Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer Cells

Cancers
2019-05-10 | Journal article
DOI: 10.3390/cancers11050645
Contributors: Baojie Zhang; Bin Liu; Deng Chen; Rita Setroikromo; Hidde J. Haisma; Wim J. Quax
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

CRISPR/Cas9: a powerful tool for identification of new targets for cancer treatment

2019-03 | Journal article
DOI: 10.1016/j.drudis.2019.02.011
Part of ISSN: 1359-6446
Source: Self-asserted source
Bin Liu

CX Chemokine Receptor 7 Contributes to Survival of <i>KRAS</i>-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor

Cancers
2019-03 | Journal article | Author
DOI: 10.3390/cancers11040455
Contributors: Bin Liu; Shanshan Song; Rita Setroikromo; Siwei Chen; Wenteng Hu; Deng Chen; Anthonie J. van der Wekken; Barbro N. Melgert; Wim Timens; Anke van den Berg et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

CRISPR/Cas9 for overcoming drug resistance in solid tumors

2019-01-21 | Journal article
DOI: 10.1007/s40199-019-00240-z
Part of ISSN: 2008-2231
Source: Self-asserted source
Bin Liu
grade
Preferred source (of 2)‎

A Mutation-Sensitive Switch Assay to Detect Five Clinically Significant Epidermal Growth Factor Receptor Mutations

2015-06 | Journal article
DOI: 10.1089/gtmb.2014.0329
Part of ISSN: 1945-0265
Part of ISSN: 1945-0257
Source: Self-asserted source
Bin Liu

A Nanoscale Mutation-Sensitive On/Off Switch Based Assays for the Detection of Hepatitis B Virus Lamivudine-Resistant Mutations

2015-05-01 | Journal article
DOI: 10.1166/jnn.2015.9277
Part of ISSN: 1533-4880
Part of ISSN: 1533-4899
Source: Self-asserted source
Bin Liu

CRISPR/Cas: A Faster and More Efficient Gene Editing System

2015-03-01 | Journal article
DOI: 10.1166/jnn.2015.9832
Part of ISSN: 1533-4880
Part of ISSN: 1533-4899
Source: Self-asserted source
Bin Liu
grade
Preferred source (of 2)‎

Peer review (13 reviews for 5 publications/grants)

Review activity for Biochemical pharmacology. (2)
Review activity for Biochemical pharmacology. (3)
Review activity for Molecular therapy. (1)
Review activity for Nature. (1)
Review activity for Nucleic acids research. (6)
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