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Transmembrane transporter, Neurotransmitter, Molecular Dynamics Simulation, Electrophysiology, Structural Biology, Genetically Encoded Sensor, GABA Receptor, Radiotracer
Switzerland, Austria

Activities

Employment (5)

University of Zurich: Zurich, CH

2024-01-01 to present | Postdoc (Institute of Pharmacology and Toxicology, Department of Chemical Neuropharmacology)
Employment
Source: Self-asserted source
Ralph Gradisch

Medical University of Vienna: Vienna, AT

2023-10 to 2023-12-31 | Postdoctoral Researcher (Centre for Physiology and Pharmacology)
Employment
Source: Self-asserted source
Ralph Gradisch

Medical University of Vienna: Vienna, AT

2019-07 to 2023-10-03 | PhD student (Centre for Physiology and Pharmacology)
Employment
Source: Self-asserted source
Ralph Gradisch

University of Vienna: Vienna, AT

2020-10 to 2023-09 | Lecturer (Department of Pharmaceutical Chemistry)
Employment
Source: Self-asserted source
Ralph Gradisch

University of Vienna: Vienna, AT

2015-10 to 2019-06 | Tutor (Department of Pharmacology)
Employment
Source: Self-asserted source
Ralph Gradisch

Education and qualifications (2)

Medical University of Vienna: Vienna, AT

2019-07 to 2023-10 | Ph.D. (Centre for Physiology and Pharmacology)
Education
Source: Self-asserted source
Ralph Gradisch

University of Vienna: Vienna, AT

2012 to 2019 | Mag.pharm.
Education
Source: Self-asserted source
Ralph Gradisch

Professional activities (4)

International Transmembrane Transporter Society (ITTS): *, AT

2022 to present
Membership
Source: Self-asserted source
Ralph Gradisch

International Society of Serotonin Research (ISSR): *, US

2022 to present
Membership
Source: Self-asserted source
Ralph Gradisch

European Biophysical Societies' Association (EBSA): *, AT

2021 to present
Membership
Source: Self-asserted source
Ralph Gradisch

Austrian Pharmacological Society (APHAR): Vienna, AT

2019-07 to present (Institute of Pharmacology)
Membership
Source: Self-asserted source
Ralph Gradisch

Works (15)

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

2024-10-02 | Preprint
Contributors: Erika Lazzarin; Ralph Gradisch; Sophie MC Skopec; Leticia Alves da Silva; Chiara Sebastianelli-Schoditsch; Dániel Szöllősi; Julian Maier; Sonja Sucic; Marko Roblek; Baruch I Kanner et al.
Source: check_circle
Crossref

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

2024-10-02 | Preprint
Contributors: Erika Lazzarin; Ralph Gradisch; Sophie MC Skopec; Leticia Alves da Silva; Chiara Sebastianelli-Schoditsch; Dániel Szöllősi; Julian Maier; Sonja Sucic; Marko Roblek; Baruch I Kanner et al.
Source: check_circle
Crossref

De novo variants in GABRA4 are associated with a neurological phenotype including developmental delay, behavioral abnormalities and epilepsy

European Journal of Human Genetics
2024-08 | Journal article
Contributors: Samin A. Sajan; Ralph Gradisch; Florian D. Vogel; Alison J. Coffey; Daria Salyakina; Diana Soler; Parul Jayakar; Anuj Jayakar; Simona E. Bianconi; Annina H. Cooper et al.
Source: check_circle
Crossref

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

2024-06-05 | Preprint
Contributors: Erika Lazzarin; Ralph Gradisch; Sophie M.C. Skopec; Leticia Alves da Silva; Chiara Sebastianelli-Schoditsch; Dániel Szöllősi; Julian Maier; Sonja Sucic; Marko Roblek; Baruch I. Kanner et al.
Source: check_circle
Crossref

Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1)

2024-05-01 | Preprint
Contributors: Manan Bhatt; Erika Lazzarin; Ana Sofia Alberto-Silva; Guido Domingo; Rocco Zerlotti; Ralph Gradisch; Andre Bazzone; Harald H. Sitte; Thomas Stockner; Elena Bossi
Source: check_circle
Crossref

Free energy profile of the substrate‐induced occlusion of the human serotonin transporter

Journal of Neurochemistry
2024-02-05 | Journal article
Part of ISSN: 0022-3042
Part of ISSN: 1471-4159
Contributors: Leticia Alves da Silva; Erika Lazzarin; Ralph Gradisch; Amy Clarke; Thomas Stockner
Source: Self-asserted source
Ralph Gradisch

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

Nature Communications
2024-01-10 | Journal article
Contributors: Ralph Gradisch; Katharina Schlögl; Erika Lazzarin; Marco Niello; Julian Maier; Felix P. Mayer; Leticia Alves da Silva; Sophie M. C. Skopec; Randy D. Blakely; Harald H. Sitte et al.
Source: check_circle
Crossref

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

2024-01-08 | Preprint
Contributors: Erika Lazzarin; Ralph Gradisch; Sophie M.C. Skopec; Leticia Alves da Silva; Dániel Szöllősi; Julian Maier; Sonja Sucic; Baruch I. Kanner; Harald H. Sitte; Thomas Stockner
Source: Self-asserted source
Ralph Gradisch

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

2023-10-13 | Preprint
Contributors: Erika Lazzarin; Ralph Gradisch; Sophie M.C. Skopec; Leticia Alves da Silva; Dániel Szöllősi; Julian Maier; Sonja Sucic; Baruch I. Kanner; Harald H. Sitte; Thomas Stockner
Source: Self-asserted source
Ralph Gradisch
grade
Preferred source (of 2)‎

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

2023-08-16 | Preprint | Author
Contributors: Ralph Gradisch; Thomas Stockner; Katharina Schlögl; Erika Lazzarin; Marco Niello; Julian Maier; Felix Mayer; Leticia Alves da Silva; Sophie Skopec; Randy Blakely et al.
Source: Self-asserted source
Ralph Gradisch
grade
Preferred source (of 2)‎

Persistent binding at dopamine transporters determines sustained psychostimulant effects

Proceedings of the National Academy of Sciences
2023-02-07 | Journal article
Contributors: Marco Niello; Spyridon Sideromenos; Ralph Gradisch; Ronan O´Shea; Jakob Schwazer; Julian Maier; Nina Kastner; Walter Sandtner; Kathrin Jäntsch; Carl R. Lupica et al.
Source: check_circle
Crossref

Structural basis of organic cation transporter-3 inhibition

Nature Communications
2022-11-07 | Journal article
Contributors: Basavraj Khanppnavar; Julian Maier; Freja Herborg; Ralph Gradisch; Erika Lazzarin; Dino Luethi; Jae-Won Yang; Chao Qi; Marion Holy; Kathrin Jäntsch et al.
Source: check_circle
Crossref

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain

Journal of Biological Chemistry
2022-03 | Journal article
Part of ISSN: 0021-9258
Source: Self-asserted source
Ralph Gradisch

The role of the degenerate nucleotide binding site in type I ABC exporters

FEBS Letters
2020-12 | Journal article
Part of ISSN: 0014-5793
Part of ISSN: 1873-3468
Source: Self-asserted source
Ralph Gradisch

Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy

Trends in Pharmacological Sciences
2020-07 | Journal article
Part of ISSN: 0165-6147
Source: Self-asserted source
Ralph Gradisch