Personal information

Activities

Employment (2)

Genentech: South San Francisco, CA, US

2015-06-01 to present | Scientist (Translational Oncology)
Employment
Source: Self-asserted source
Rafael Cubas

Vaccine & Gene Therapy Institute of Florida: Port Saint Lucie, Florida, US

2010-06-01 to 2015-04-10 | Postdoc
Employment
Source: Self-asserted source
Rafael Cubas

Education and qualifications (2)

Baylor College of Medicine: Houston, TX, US

2005-08-08 to 2010-04-08 | PhD (Microbiology and Molecular Virology)
Education
Source: Self-asserted source
Rafael Cubas

Washington University in St. Louis: St. Louis, MO, US

2001-08-18 to 2005-05-18 | BA Biochemistry and Molecular Biology
Education
Source: Self-asserted source
Rafael Cubas

Works (25)

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses

Immunity
2022-03 | Journal article
Contributors: Karl L. Banta; Xiaozheng Xu; Avantika S. Chitre; Amelia Au-Yeung; Chikara Takahashi; William E. O’Gorman; Thomas D. Wu; Stephanie Mittman; Rafael Cubas; Laetitia Comps-Agrar et al.
Source: check_circle
Crossref

Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling

PLOS Pathogens
2021-07-19 | Journal article
Contributors: Marita Chakhtoura; Guido Silvestri; Mike Fang; Rafael Cubas; Margaret H. O’Connor; Carmen N. Nichols; Brian Richardson; Aarthi Talla; Susan Moir; Mark J. Cameron et al.
Source: check_circle
Crossref

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Nature
2018 | Journal article
EID:

2-s2.0-85042495633

Contributors: Mariathasan, S.; Turley, S.J.; Nickles, D.; Castiglioni, A.; Yuen, K.; Wang, Y.; Kadel, E.E.; Koeppen, H.; Astarita, J.L.; Cubas, R. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1

Proceedings of the National Academy of Sciences
2018-11 | Journal article
Part of ISSN: 0027-8424
Contributors: Xiangnan Du; Patricia de Almeida; Nick Manieri; Denise de Almeida Nagata; Thomas D. Wu; Kristin Harden Bowles; Vidhyalakshmi Arumugam; Jill Schartner; Rafael Cubas; Stephanie Mittman et al.
Source: Self-asserted source
Rafael Cubas via Crossref Metadata Search

Chemotherapy Combines Effectively with Anti–PD-L1 Treatment and Can Augment Antitumor Responses

The Journal of Immunology
2018-10-15 | Journal article
Contributors: Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Jeong Kim; Stephen Gould
Source: check_circle
Crossref

Enhancement of microbiota in healthy macaques results in beneficial modulation of mucosal and systemic immune function

Journal of Immunology
2016 | Journal article
EID:

2-s2.0-84962026552

Contributors: Manuzak, J.A.; Hensley-McBain, T.; Zevin, A.S.; Miller, C.; Cubas, R.; Agricola, B.; Gile, J.; Richert-Spuhler, L.; Patilea, G.; Estes, J.D. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

Aging Cell
2015 | Journal article
EID:

2-s2.0-84927711067

Contributors: Metcalf, T.U.; Cubas, R.A.; Ghneim, K.; Cartwright, M.J.; Grevenynghe, J.V.; Richner, J.M.; Olagnier, D.P.; Wilkinson, P.A.; Cameron, M.J.; Park, B.S. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection

Journal of Immunology
2015 | Journal article
EID:

2-s2.0-84958259928

Contributors: Cubas, R.; Van Grevenynghe, .; Wills, S.; Kardava, L.; Santich, B.H.; Buckner, C.M.; Muir, R.; Tardif, V.; Nichols, C.; Procopio, F. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Erratum: Immune activation alters cellular and humoral responses to yellow fever 17D vaccine (The Journal of Clinical Investigation (2014) 124:10 (4669))

Journal of Clinical Investigation
2014 | Journal article
EID:

2-s2.0-84907528075

Contributors: Muyanja, E.; Ssemaganda, A.; Ngauv, P.; Cubas, R.; Perrin, H.; Srinivasan, D.; Canderan, G.; Lawson, B.; Kopycinski, J.; Graham, A.S. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

The dysfunction of T follicular helper cells

Current Opinion in HIV and AIDS
2014 | Journal article
EID:

2-s2.0-84906043406

Contributors: Cubas, R.; Perreau, M.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

Journal of Experimental Medicine
2013 | Journal article
EID:

2-s2.0-84874519282

Contributors: Perreau, M.; Savoye, A.-L.; De Crignis, E.; Jean-Marc Corpataux; Cubas, R.; Haddad, E.K.; De Leval, L.; Graziosi, C.; Pantaleo, G.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Human circulating PD-1<sup>+</sup>CXCR3<sup>-</sup>CXCR5<sup>+</sup>memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

Immunity
2013 | Journal article
EID:

2-s2.0-84885743368

Contributors: Locci, M.; Havenar-Daughton, C.; Landais, E.; Wu, J.; Kroenke, M.A.; Arlehamn, C.L.; Su, L.F.; Cubas, R.; Davis, M.M.; Sette, A. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes

Blood
2013 | Journal article
EID:

2-s2.0-84879429159

Contributors: Mudd, J.C.; Murphy, P.; Manion, M.; Debernardo, R.; Hardacre, J.; Ammori, J.; Hardy, G.A.; Harding, C.V.; Mahabaleshwar, G.H.; Jain, M.K. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Inadequate T follicular cell help impairs B cell immunity during HIV infection

Nature Medicine
2013 | Journal article
EID:

2-s2.0-84878454838

Contributors: Cubas, R.A.; Mudd, J.C.; Savoye, A.-L.; Perreau, M.; Van Grevenynghe, J.; Metcalf, T.; Connick, E.; Meditz, A.; Freeman, G.J.; Abesada-Terk, G. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Mesothelin Virus-Like Particle Immunization Controls Pancreatic Cancer Growth through CD8<sup>+</sup> T Cell Induction and Reduction in the Frequency of CD4<sup>+</sup>foxp3<sup>+</sup>ICOS<sup>-</sup> Regulatory T Cells

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84879953494

Contributors: Zhang, S.; Yong, L.-K.; Li, D.; Cubas, R.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Erratum: Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis (Journal of Clinical Investigation (2011) 121, 10 (3877-3888) DOI: 10.1172/JCI59211)

Journal of Clinical Investigation
2012 | Journal article
EID:

2-s2.0-84863550138

Contributors: Van Grevenynghe, J.; Cubas, R.A.; Noto, A.; DaFonseca, S.; He, Z.; Peretz, Y.; Filali-Mouhim, A.; Dupuy, F.P.; Procopio, F.A.; Chomont, N. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Foxo3a: An integrator of immune dysfunction during HIV infection

Cytokine and Growth Factor Reviews
2012 | Journal article
EID:

2-s2.0-84864920849

Contributors: Van Grevenynghe, J.; Cubas, R.A.; DaFonseca, S.; Metcalf, T.; Tremblay, C.L.; Trautmann, L.; Sekaly, R.-P.; Schatzle, J.; Haddad, E.K.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Chimeric Trop2 virus-like particles: A potential immunotherapeutic approach against pancreatic cancer

Journal of Immunotherapy
2011 | Journal article
EID:

2-s2.0-79953056191

Contributors: Cubas, R.; Zhang, S.; Li, M.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis

Journal of Clinical Investigation
2011 | Journal article
EID:

2-s2.0-80053399756

Contributors: Van Grevenynghe, J.; Cubas, R.A.; Noto, A.; DaFonseca, S.; He, Z.; Peretz, Y.; Filali-Mouhim, A.; Dupuy, F.P.; Procopio, F.A.; Chomont, N. et al.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Response to: Letter to the Editor: R. Cubas, M. Li, C. Chen and Q. Yao, Biochim Biophys Acta 1796 (2009) 309-1

Biochimica et Biophysica Acta - Reviews on Cancer
2010 | Journal article
EID:

2-s2.0-77949263114

Contributors: Cubas, R.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.

Molecular cancer
2010 | Journal article
EID:

2-s2.0-77956671612

Contributors: Cubas, R.; Zhang, S.; Li, M.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Trop2: A possible therapeutic target for late stage epithelial carcinomas

Biochimica et Biophysica Acta - Reviews on Cancer
2009 | Journal article
EID:

2-s2.0-70349175559

Contributors: Cubas, R.; Li, M.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes

Journal of Immunotherapy
2009 | Journal article
EID:

2-s2.0-63649120342

Contributors: Cubas, R.; Zhang, S.; Kwon, S.; Sevick-Muraca, E.M.; Li, M.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells

Molecular Immunology
2009 | Journal article
EID:

2-s2.0-67349209319

Contributors: Zhang, S.; Cubas, R.; Li, M.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier

Colorectal cancer: New advances in immunotherapy

Cancer Biology and Therapy
2007 | Journal article
EID:

2-s2.0-33847125343

Contributors: Cubas, R.; Li, M.; Chen, C.; Yao, Q.
Source: Self-asserted source
Rafael Cubas via Scopus - Elsevier