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psychiatric genetics, psychiatric epidemiology, depression
Türkiye

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Employment (4)

Istanbul University: Istanbul, TR

2020-12-14 to present | Assoc. Prof. Dr. (Psychiatry)
Employment
Source: Self-asserted source
Nese Direk, MD, PhD

Dokuz Eylül University School of Medicine: Izmir, TR

2018-11-01 to 2020-11-02 | Assoc. Prof. Dr. (Psychiatry)
Employment
Source: Self-asserted source
Nese Direk, MD, PhD

Dokuz Eylul University School Of Medicine: Izmir, TR

2016-05-25 to 2018-08-18 | Assistant Professor (Psychiatry)
Employment
Source: Self-asserted source
Nese Direk, MD, PhD

Erasmus MC: Rotterdam, South-Holland, NL

2009-10-01 to 2014-10-01 (Epidemiology)
Employment
Source: Self-asserted source
Nese Direk, MD, PhD

Education and qualifications (4)

Erasmus MC: Rotterdam, Zuid-Holland, NL

2009 to 2013 | PhD (Epidemiology)
Education
Source: Self-asserted source
Nese Direk, MD, PhD

Nihes - Netherlands Institute for Health Sciences: Rotterdam, Zuid-Holland, NL

2009 to 2012 | Master of Science (Epidemiology)
Education
Source: Self-asserted source
Nese Direk, MD, PhD

School of Medicine, Istanbul University: Istanbul, TR

2003-05-24 to 2008-07-01 | Specialist (Psychiatry)
Education
Source: Self-asserted source
Nese Direk, MD, PhD

School of Medicine, Istanbul University: Istanbul, TR

1996-08-23 to 2002-10-01 | MD
Education
Source: Self-asserted source
Nese Direk, MD, PhD

Works (50 of 57)

Items per page:
Page 1 of 2

Facing the Pandemic: Burnout in Physicians in Turkey.

Turkish thoracic journal
2021-11-01 | Journal article
Source: Self-asserted source
Nese Direk, MD, PhD

The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.

JAMA psychiatry
2021-11-01 | Journal article
Source: Self-asserted source
Nese Direk, MD, PhD

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.

Biological psychiatry
2021-09-09 | Journal article
Source: Self-asserted source
Nese Direk, MD, PhD

Relationship of negative symptom severity with cognitive symptoms and functioning in subjects at ultra‐high risk for psychosis

Early Intervention in Psychiatry
2021-08 | Journal article
Contributors: Alp Üçok; Nese Direk; Hatice Kaya; Nuran Çağlar; Uğur Çıkrıkçılı; Handan Noyan; Çağdaş Yokuşoğlu; Müge Devrim‐Üçok
Source: check_circle
Crossref

Primary headaches among gender dysphoric female-to-male individuals: A cross-sectional survey on gender transition experience.

Headache
2021-08-31 | Journal article
Source: Self-asserted source
Nese Direk, MD, PhD

Evaluation of socio-demographic factors and attempted suicides in the elderly

Family Practice and Palliative Care
2021-04-03 | Journal article
Contributors: Sinan YENAL; Ahu PAKDEMİRLİ; Başak BAYRAM; Neşe DİREK
Source: check_circle
Crossref

İzolasyon, Karantina, Sosyal Mesafe ve Ruh Sağlığı

The Bulletin of Legal Medicine
2020-05-30 | Journal article
Contributors: Neşe Direk Tecirli; Gizem Ucuz; Fatih Ozel
Source: check_circle
Crossref

Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
2019 | Journal article
EID:

2-s2.0-85052912914

Contributors: Barbu, M.C.; Zeng, Y.; Shen, X.; Cox, S.R.; Clarke, T.-K.; Gibson, J.; Adams, M.J.; Johnstone, M.; Haley, C.S.; Lawrie, S.M. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression

Molecular Psychiatry
2019 | Journal article
EID:

2-s2.0-85059860496

Contributors: Amare, A.T.; Vaez, A.; Hsu, Y.-H.; Direk, N.; Kamali, Z.; Howard, D.M.; McIntosh, A.M.; Tiemeier, H.; Bültmann, U.; Snieder, H. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives

NeuroImage: Clinical
2019 | Journal article
EID:

2-s2.0-85061030589

Contributors: Yalin, N.; Saricicek, A.; Hidiroglu, C.; Zugman, A.; Direk, N.; Ada, E.; Cavusoglu, B.; Er, A.; Isik, G.; Ceylan, D. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Identification of common genetic risk variants for autism spectrum disorder

Nature Genetics
2019 | Journal article
EID:

2-s2.0-85062110842

Contributors: Grove, J.; Ripke, S.; Als, T.D.; Mattheisen, M.; Walters, R.K.; Won, H.; Pallesen, J.; Agerbo, E.; Andreassen, O.A.; Anney, R. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Nature Communications
2019 | Journal article
EID:

2-s2.0-85067229888

Contributors: Czamara, D.; Eraslan, G.; Page, C.M.; Lahti, J.; Lahti-Pulkkinen, M.; Hämäläinen, E.; Kajantie, E.; Laivuori, H.; Villa, P.M.; Reynolds, R.M. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

No interaction between childhood maltreatment and serotonin transporter gene in recurrent major depressive disorder: A clinical sample

Noropsikiyatri Arsivi
2019 | Journal article
EID:

2-s2.0-85068741200

Contributors: Özçürümez, G.; Yurdakul, H.T.; Terzi, Y.; Direk, N.; Eşsizoğlu, A.; Şahin, F.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Schizophrenia in microcephalic osteodysplastic primordial dwarfism type II syndrome: Supporting evidence for an association between the PCNT gene and schizophrenia

Psychiatric Genetics
2019 | Journal article
EID:

2-s2.0-85062106025

Contributors: Ozel, F.; Direk, N.; Ataseven Kulali, M.; Giray Bozkaya, O.; Ada, E.; Alptekin, K.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Corrigendum: Happiness, rather than depression, is associated with sexual behaviour in partnered older adults [Age and Ageing (2016) 101-107,] doi: 10.1093/ageing/afw168

Age and Ageing
2018 | Journal article
EID:

2-s2.0-85043454454

Contributors: Freak-Poli, R.; De Castro Lima, G.; Direk, N.; Jaspers, L.; Pitts, M.; Hofman, A.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Biological Psychiatry
2018 | Journal article
EID:

2-s2.0-85033387316

Contributors: Peyrot, W.J.; Van der Auwera, S.; Milaneschi, Y.; Dolan, C.V.; Madden, P.A.F.; Sullivan, P.F.; Strohmaier, J.; Ripke, S.; Rietschel, M.; Nivard, M.G. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Nature Genetics
2018 | Journal article
EID:

2-s2.0-85046022254

Contributors: Wray, N.R.; Ripke, S.; Mattheisen, M.; Trzaskowski, M.; Byrne, E.M.; Abdellaoui, A.; Adams, M.J.; Agerbo, E.; Air, T.M.; Andlauer, T.M.F. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

PLoS ONE
2018 | Journal article
EID:

2-s2.0-85058923883

Contributors: Arnau-Soler, A.; Adams, M.J.; Hayward, C.; Thomson, P.A.; Porteous, D.; Campbell, A.; Smith, B.H.; Black, C.; Padmanabhan, S.; McIntosh, A.M. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Prolonged Grief and Cognitive Decline: A Prospective Population-Based Study in Middle-Aged and Older Persons

American Journal of Geriatric Psychiatry
2018 | Journal article
EID:

2-s2.0-85040120789

Contributors: Pérez, H.C.S.; Ikram, M.A.; Direk, N.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Relationship between subjective memory complaints and objective memory impairment in a community-dwelling elderly population,Bir yaşli genel toplum örnekleminde öznel bellek yakinmasi ve nesnel bilişsel bozulmanin ilişkisi

Klinik Psikiyatri Dergisi
2018 | Journal article
EID:

2-s2.0-85055795213

Contributors: Aysevener, E.O.; Direk, N.; Özsoydan, E.O.; Diriöz, M.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

Biological Psychiatry
2017 | Journal article
EID:

2-s2.0-85009252485

Contributors: Direk, N.; Williams, S.; Smith, J.A.; Ripke, S.; Air, T.; Amare, A.T.; Amin, N.; Baune, B.T.; Bennett, D.A.; Blackwood, D.H.R. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulations

JAMA Psychiatry
2017 | Journal article
EID:

2-s2.0-85038239250

Contributors: Milaneschi, Y.; Lamers, F.; Peyrot, W.J.; Baune, B.T.; Breen, G.; Dehghan, A.; Forstner, A.J.; Grabe, H.J.; Homuth, G.; Kan, C. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Nature Communications
2017 | Journal article
EID:

2-s2.0-85019322396

Contributors: Justice, A.E.; Winkler, T.W.; Feitosa, M.F.; Graff, M.; Fisher, V.A.; Young, K.; Barata, L.; Deng, X.; Czajkowski, J.; Hadley, D. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Scientific Reports
2017 | Journal article
EID:

2-s2.0-85033567547

Contributors: Rietschel, L.; Streit, F.; Zhu, G.; McAloney, K.; Frank, J.; Couvy-Duchesne, B.; Witt, S.H.; Binz, T.M.; Bolton, J.L.; Hayward, C. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Happiness, rather than depression, is associated with sexual behaviour in partnered older adults

Age and Ageing
2017 | Journal article
EID:

2-s2.0-85018278638

Contributors: Freak-Poli, R.; Lima, G.D.C.; Direk, N.; Jaspers, L.; Pitts, M.; Hofman, A.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Sexual Activity and Physical Tenderness in Older Adults: Cross-Sectional Prevalence and Associated Characteristics

Journal of Sexual Medicine
2017 | Journal article
EID:

2-s2.0-85021675006

Contributors: Freak-Poli, R.; Kirkman, M.; De Castro Lima, G.; Direk, N.; Franco, O.H.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

The impact of complicated grief on diurnal cortisol levels two years after loss: A population-based study

Psychosomatic Medicine
2017 | Journal article
EID:

2-s2.0-84996844729

Contributors: Pérez, H.C.S.; Direk, N.; Milic, J.; Ikram, M.A.; Hofman, A.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels

Psychoneuroendocrinology
2017 | Journal article
EID:

2-s2.0-85028014724

Contributors: Neumann, A.; Direk, N.; Crawford, A.A.; Mirza, S.; Adams, H.; Bolton, J.; Hayward, C.; Strachan, D.P.; Payne, E.K.; Smith, J.A. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Nature Genetics
2016 | Journal article
EID:

2-s2.0-84964388798

Contributors: Okbay, A.; Baselmans, B.M.L.; De Neve, J.-E.; Turley, P.; Nivard, M.G.; Fontana, M.A.; Meddens, S.F.W.; Linnér, R.K.; Rietveld, C.A.; Derringer, J. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Markers of cerebral small vessel disease and severity of depression in the general population

Psychiatry Research - Neuroimaging
2016 | Journal article
EID:

2-s2.0-84969791858

Contributors: Direk, N.; Perez, H.S.; Akoudad, S.; Verhaaren, B.F.J.; Niessen, W.J.; Hofman, A.; Vernooij, M.W.; Ikram, M.A.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Meta-analysis of genome-wide association studies of anxiety disorders

Molecular Psychiatry
2016 | Journal article
EID:

2-s2.0-84954550234

Contributors: Otowa, T.; Hek, K.; Lee, M.; Byrne, E.M.; Mirza, S.S.; Nivard, M.G.; Bigdeli, T.; Aggen, S.H.; Adkins, D.; Wolen, A. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: A meta-analysis of genome-wide association studies

Psychological Medicine
2016 | Journal article
EID:

2-s2.0-84961786478

Contributors: Demirkan, A.; Lahti, J.; Direk, N.; Viktorin, A.; Lunetta, K.L.; Terracciano, A.; Nalls, M.A.; Tanaka, T.; Hek, K.; Fornage, M. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

The very low-dose dexamethasone suppression test in the general population: A cross-sectional study

PLoS ONE
2016 | Journal article
EID:

2-s2.0-84992061382

Contributors: Direk, N.; Dekker, M.J.H.J.; Luik, A.I.; Kirschbaum, C.; De Rijke, Y.B.; Hofman, A.; Hoogendijk, W.J.G.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

24-hour activity rhythm and sleep disturbances in depression and anxiety: A population-based study of middle-aged and older persons

Depression and Anxiety
2015 | Journal article
EID:

2-s2.0-84940893536

Contributors: Luik, A.I.; Zuurbier, L.A.; Direk, N.; Hofman, A.; Van Someren, E.J.W.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Cognition, structural brain changes and complicated grief. A population-based study

Psychological Medicine
2015 | Journal article
EID:

2-s2.0-84925873133

Contributors: Saavedra Pérez, H.C.; Ikram, M.A.; Direk, N.; Prigerson, H.G.; Freak-Poli, R.; Verhaaren, B.F.J.; Hofman, A.; Vernooij, M.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

History of childhood physical trauma is related to cognitive decline in individuals with ultra-high risk for psychosis

Schizophrenia Research
2015 | Journal article
EID:

2-s2.0-84953839200

Contributors: Üçok, A.; Kaya, H.; Uğurpala, C.; Çikrikçili, U.; Ergül, C.; Yokuşoğlu, C.; Bülbül, O.; Direk, N.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Identifying genetic loci associated with antidepressant drug response with drug-gene interaction models in a population-based study

Journal of Psychiatric Research
2015 | Journal article
EID:

2-s2.0-84924324541

Contributors: Noordam, R.; Direk, N.; Sitlani, C.M.; Aarts, N.; Tiemeier, H.; Hofman, A.; Uitterlinden, A.G.; Psaty, B.M.; Stricker, B.H.; Visser, L.E.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Sleep and 24-h activity rhythms in relation to cortisol change after a very low-dose of dexamethasone

Psychoneuroendocrinology
2015 | Journal article
EID:

2-s2.0-84922817661

Contributors: Luik, A.I.; Direk, N.; Zuurbier, L.A.; Hofman, A.; Van Someren, E.J.W.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Anxiety is not associated with the risk of dementia or cognitive decline: The rotterdam study

American Journal of Geriatric Psychiatry
2014 | Journal article
EID:

2-s2.0-84928214512

Contributors: De Bruijn, R.F.A.G.; Direk, N.; Mirza, S.S.; Hofman, A.; Koudstaal, P.J.; Tiemeier, H.; Ikram, M.A.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Depressive symptoms predict incident dementia during short- but not long-term follow-up period

Alzheimer's and Dementia
2014 | Journal article
EID:

2-s2.0-84908240660

Contributors: Mirza, S.S.; De Bruijn, R.F.A.G.; Direk, N.; Hofman, A.; Koudstaal, P.J.; Ikram, M.A.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Genetic diversity is a predictor of mortality in humans

BMC Genetics
2014 | Journal article
EID:

2-s2.0-84964315519

Contributors: Bihlmeyer, N.A.; Brody, J.A.; Smith, A.V.; Lunetta, K.L.; Nalls, M.; Smith, J.A.; Tanaka, T.; Davies, G.; Yu, L.; Mirza, S.S. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

PLoS Genetics
2014 | Journal article
EID:

2-s2.0-84905506146

Contributors: Bolton, J.L.; Hayward, C.; Direk, N.; Lewis, J.G.; Hammond, G.L.; Hill, L.A.; Anderson, A.; Huffman, J.; Wilson, J.F.; Campbell, H. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Psychiatric epidemiology in Turkey: Main advances in recent studies and future directions

Turk Psikiyatri Dergisi
2014 | Journal article
EID:

2-s2.0-84916925586

Contributors: Binbay, T.; Direk, N.; Aker, T.; Akvardar, Y.; Alptekin, K.; Cimilli, C.; Çam, B.; Deveci, A.; Gültekin, B.K.; Şar, V. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Thyroid function within the normal range and the risk of depression: A Population-based cohort study

Journal of Clinical Endocrinology and Metabolism
2014 | Journal article
EID:

2-s2.0-84898438115

Contributors: Medici, M.; Direk, N.; Visser, W.E.; Korevaar, T.I.M.; Hofman, A.; Visser, T.J.; Tiemeier, H.; Peeters, R.P.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Anxiety disorders and salivary cortisol levels in older adults: A population-based study

Psychoneuroendocrinology
2013 | Journal article
EID:

2-s2.0-84872845535

Contributors: Hek, K.; Direk, N.; Newson, R.S.; Hofman, A.; Hoogendijk, W.J.G.; Mulder, C.L.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Cognitive deficits in clinical and familial high risk groups for psychosis are common as in first episode schizophrenia

Schizophrenia Research
2013 | Journal article
EID:

2-s2.0-84889098139

Contributors: Üçok, A.; Direk, N.; Koyuncu, A.; Keskin-Ergen, Y.; Yüksel, T.; Güler, J.; Karadayi, G.; Akturan, E.; Devrim-Üçok, M.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Plasma amyloid β, depression, and dementia in community-dwelling elderly

Journal of Psychiatric Research
2013 | Journal article
EID:

2-s2.0-84874426681

Contributors: Direk, N.; Schrijvers, E.M.C.; de Bruijn, R.F.A.G.; Mirza, S.; Hofman, A.; Ikram, M.A.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Silent brain infarcts: A cause of depression in the elderly?

Psychiatry Research - Neuroimaging
2013 | Journal article
EID:

2-s2.0-84873477943

Contributors: Saavedra Perez, H.C.; Direk, N.; Hofman, A.; Vernooij, M.W.; Tiemeier, H.; Ikram, M.A.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

The impact of physical and psychological comorbid conditions on the quality of life of patients with acute myocardial infarction: A multi-center, cross-sectional observational study from Turkey

International Journal of Psychiatry in Medicine
2013 | Journal article
EID:

2-s2.0-84879665073

Contributors: Sertoz, O.; Aydemir, O.; Gulpek, D.; Elbi, H.; Ozenli, Y.; Yilmaz, A.; Ozan, E.; Atesci, F.; Abay, E.; Semiz, M. et al.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier

Cerebral hemodynamics and incident depression: The rotterdam study

Biological Psychiatry
2012 | Journal article
EID:

2-s2.0-84864281033

Contributors: Direk, N.; Koudstaal, P.J.; Hofman, A.; Ikram, M.A.; Hoogendijk, W.J.; Tiemeier, H.
Source: Self-asserted source
Nese Direk, MD, PhD via Scopus - Elsevier
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