Personal information

Emails & domains

Verified email addresses

Verified email domains

Other IDs

Scopus Author ID: 57195320842

Biography

Dr. Bernard's research centers on understanding the mechanisms that initiate carcinogenesis, particularly those influenced by external risk factors such as diet, obesity, and environmental exposures. Her laboratory has made significant discoveries, including dentifying that dysfunctional visceral adipose tissue releases fibroblast growth factor-2 (FGF2), which can stimulate the malignant transformation of non-tumorigenic cells and demonstrating that intra-abdominal (visceral) fat can promote carcinogenesis in both in vitro models and animal models of high-fat diet-induced obesity by releasing FGF2 and activating FGFR1. The Bernard Lab aims to identify specific mechanisms of obesity-promoted cancer, with a focus on visceral fat inflammation. They are exploring the translational relevance of FGF2 as a biomarker for adiposity-associated cancer risk. Additionally, the lab is interested in screening for new compounds, including natural products, that target these pathways for chemoprevention.

Activities

Collapse all

Works (32)

Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor

Biochemical Pharmacology
2023-10 | Journal article
DOI: 10.1016/j.bcp.2023.115763
Contributors: Jonathan D. Diedrich; Romina Gonzalez-Pons; Hyllana C.D. Medeiros; Elliot Ensink; Karen T. Liby; Elizabeth A. Wellberg; Sophia Y. Lunt; Jamie J. Bernard
Source: check_circle
Crossref

The Tumor Promotional Role of Adipocytes in the Breast Cancer Microenvironment and Macroenvironment

The American Journal of Pathology
2021-08 | Journal article
DOI: 10.1016/j.ajpath.2021.02.006
Contributors: Jamie J. Bernard; Elizabeth A. Wellberg
Source: check_circle
Crossref

Photoimmunology: how ultraviolet radiation affects the immune system

Nature Reviews Immunology
2019-11-18 | Journal article
DOI: 10.1038/s41577-019-0185-9
Contributors: Jamie J. Bernard; Richard L. Gallo; Jean Krutmann
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay.

Scientific reports
2019-07-16 | Journal article
DOI: 10.1038/s41598-019-46531-y
PMID: 31311976
PMC: PMC6635484
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 4)‎

Lipectomizing Mice for Applications in Metabolism.

Methods in molecular biology (Clifton, N.J.)
2019-01-01 | Journal article
DOI: 10.1007/978-1-4939-8769-6_17
PMID: 30315472
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

A role for FGF2 in visceral adiposity-associated mammary epithelial transformation.

Adipocyte
2018-03-21 | Journal article
DOI: 10.1080/21623945.2018.1445889
PMID: 29561195
PMC: PMC6152512
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Why does a high-fat diet increase cancer risk?

Future oncology (London, England)
2018-02-07 | Journal article
DOI: 10.2217/fon-2017-0610
PMID: 29411646
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

A BET Bromodomain Inhibitor Suppresses Adiposity-Associated Malignant Transformation.

Cancer prevention research (Philadelphia, Pa.)
2017-12-15 | Journal article
DOI: 10.1158/1940-6207.capr-17-0262
PMID: 29246955
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Elucidating the role of adipose tissue secreted factors in malignant transformation.

Adipocyte
2017-11-02 | Journal article
DOI: 10.1080/21623945.2017.1388971
PMID: 29095087
PMC: PMC5915015
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer.

Oncogene
2017-08-07 | Journal article
DOI: 10.1038/onc.2017.278
PMID: 28783178
PMC: PMC5709202
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Deciphering metabolic rewiring in breast cancer subtypes.

Translational research : the journal of laboratory and clinical medicine
2017-07-15 | Journal article
DOI: 10.1016/j.trsl.2017.07.004
PMID: 28774752
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis.

PloS one
2014-10-16 | Journal article
DOI: 10.1371/journal.pone.0109862
PMID: 25330380
PMC: PMC4199678
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage.

The Journal of investigative dermatology
2014-08-12 | Journal article
DOI: 10.1038/jid.2014.354
PMID: 25118157
PMC: PMC4289479
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Parametrial fat tissue from high fat diet-treated SKH-1 mice stimulates transformation of mouse epidermal JB6 cells.

Journal of carcinogenesis & mutagenesis
2014-07-01 | Journal article
DOI: 10.4172/2157-2518.1000183
PMID: 25821644
PMC: PMC4376014
Source: Self-asserted source
Jamie Bernard

Innate immune sensors stimulate inflammatory and immunosuppressive responses to UVB radiation.

The Journal of investigative dermatology
2014-06-01 | Journal article
DOI: 10.1038/jid.2014.32
PMID: 24825061
PMC: PMC4271625
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Inhibition of UVB-induced nonmelanoma skin cancer: A path from tea to caffeine to exercise to decreased tissue fat

Topics in Current Chemistry
2013 | Book
DOI: 10.1007/128-2012-336
EID:

2-s2.0-84874490642

Part of ISBN:

03401022
Contributors: Conney, A.H.; Lou, Y.-R.; Nghiem, P.; Bernard, J.J.; Wagner, G.C.; Lu, Y.-P.
Source: Self-asserted source
Jamie Bernard via Scopus - Elsevier
grade
Preferred source (of 2)‎

Inverse relationship between p53 and phospho-Chk1 (Ser317) protein expression in UVB-induced skin tumors in SKH-1 mice.

Experimental and molecular pathology
2013-10-30 | Journal article
DOI: 10.1016/j.yexmp.2013.10.011
PMID: 24184701
PMC: PMC4365929
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases inflammatory cytokines in UVB-treated mice.

Nutrition and cancer
2013-09-26 | Journal article
DOI: 10.1080/01635581.2013.812224
PMID: 24070239
PMC: PMC3830615
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.

Topics in current chemistry
2013-01-01 | Journal article
DOI: 10.1007/128_2012_336
PMID: 22752580
PMC: PMC4049109
Source: Self-asserted source
Jamie Bernard

Ultraviolet radiation damages self noncoding RNA and is detected by TLR3.

Nature medicine
2012-07-08 | Journal article
DOI: 10.1038/nm.2861
PMID: 22772463
PMC: PMC3812946
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.

Proceedings of the National Academy of Sciences of the United States of America
2012-05-21 | Journal article
DOI: 10.1073/pnas.1205810109
PMID: 22615388
PMC: PMC3384184
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides.

Journal of immunology (Baltimore, Md. : 1950)
2011-12-02 | Journal article
DOI: 10.4049/jimmunol.1101703
PMID: 22140255
PMC: PMC3244574
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Protecting the boundary: the sentinel role of host defense peptides in the skin.

Cellular and molecular life sciences : CMLS
2011-05-15 | Journal article
DOI: 10.1007/s00018-011-0712-8
PMID: 21573782
PMC: PMC3125593
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition.

Thrombosis research
2011-01-26 | Journal article
DOI: 10.1016/j.thromres.2010.12.013
PMID: 21272923
PMC: PMC3081947
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Cyclooxygenase-2 enhances antimicrobial peptide expression and killing of Staphylococcus aureus.

Journal of immunology (Baltimore, Md. : 1950)
2010-10-22 | Journal article
DOI: 10.4049/jimmunol.1002009
PMID: 20971925
PMC: PMC3025174
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Foxp3 regulates megakaryopoiesis and platelet function.

Arteriosclerosis, thrombosis, and vascular biology
2009-08-06 | Journal article
DOI: 10.1161/ATVBAHA.109.193805
PMID: 19661482
PMC: PMC3017715
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis.

Journal of thrombosis and haemostasis : JTH
2008-10-10 | Journal article
DOI: 10.1111/j.1538-7836.2008.03191.x
PMID: 18983509
PMC: PMC2821682
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes.

Blood
2008-08-28 | Journal article
DOI: 10.1182/blood-2008-05-158535
PMID: 18755987
PMC: PMC2581982
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.

Thrombosis and haemostasis
2008-01-01 | Journal article
DOI: 10.1160/TH07-05-0328
PMID: 18217139
PMC: PMC2754860
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects.

PPAR research
2008-01-01 | Journal article
DOI: 10.1155/2008/328172
PMID: 18288284
PMC: PMC2233896
Source: Self-asserted source
Jamie Bernard

The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands.

Prostaglandins & other lipid mediators
2006-07-10 | Journal article
DOI: 10.1016/j.prostaglandins.2006.05.018
PMID: 17164134
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎

Platelets as a novel target for PPARgamma ligands : implications for inflammation, diabetes, and cardiovascular disease.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
2006-01-01 | Journal article
DOI: 10.2165/00063030-200620040-00004
PMID: 16831022
Source: Self-asserted source
Jamie Bernard
grade
Preferred source (of 3)‎
How many people are using ORCID?