Personal information

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Websites & social links

https://www.iit.it/web/synaptic-plasticity-of-inhibitory-networks

Other IDs

Scopus Author ID: 55674108100
Loop profile: 2245195

Keywords

Synapse, inhibitory, plasticity, epilepsy, pain

Biography

Sara Nencini graduated in Biotechnology at the University of Milano in 2011. From 2011 to 2014 she worked as research fellow at CNR (Milano) under the supervision of Gabriele Biella studying connectivity anomalies between thalamus and somatosensory cortex in chronic pain models. In 2018, she accomplished her PhD at the Department of Anatomy and Neuroscience - University of Melbourne - under the supervision of Jason Ivanusic and James Brock, investigating the functional properties of pain-sensing neurons that innervate the bone marrow cavity, and contributing with novel and significant addition to the field of bone pain. During her post-doc, in the Jan Siemens’s lab at Heidelberg University (DE, EMBO fellowship award, 2018-2021) she studied the role of LepR-positive cells located in the preoptic area of the hypothalamus in heat acclimation and feeding. Currently, she is post doc at the Italian Institute of Technology (IIT, Genova) where she focuses on the study of epilepsy mechanisms and novel RNA-based therapeutic approach (in collaboration with Stefano Gustincich's lab). Her research line aims to understand how a seizure is generated by exploring how synaptic plasticity and dendritic integration impacts on the functioning of neuronal circuits.

Activities

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Employment (4)

Istituto Italiano di Tecnologia: Genova, Italy, IT

2020-11-01 to present | Post doc researcher (Neuroscience)
Employment
Source: Self-asserted source
Sara Nencini

University of Melbourne: VIC, VIC, AU

2015 to 2018 | PhD (Anatomy and Neuroscience department)
Employment
Source: Self-asserted source
Sara Nencini

Universität Heidelberg: Heidelberg, DE

2015 to 2018 | post doc (Pharmakologisches Institut)
Employment
Source: Self-asserted source
Sara Nencini

Consiglio Nazionale delle Ricerche: Milano, IT

2011 to 2014 | Research Fellow (Institute of Molecular Bioimaging and Physiology)
Employment
Source: Self-asserted source
Sara Nencini

Education and qualifications (3)

The University of Melbourne: Melbourne, VIC, AU

2015 to 2018-10-17 | PhD (Anatomy and Neuroscience)
Education
Source: Self-asserted source
Sara Nencini

Universita degli Studi di Milano Scienze Matematiche: Milano, Lombardia, IT

2009 to 2011-10-05 | Master degree in Medical Biotechnology and Molecular Biology (curriculum: Neuroscience)
Education
Source: Self-asserted source
Sara Nencini

University of Siena: Siena, IT

2006 to 2009-07-29 | BSc in Biotechnology
Education
Source: Self-asserted source
Sara Nencini

Funding (2)

EVALUATION OF THE FUNCTIONAL INVOLVEMENT OF SPECIFIC SUBSETS OF POA NEURONS IN REGULATING TEMPERATURE-DEPENDENT METABOLIC ADAPTATIONS

Award
EMBO (Heidelberg, DE, DE)
Source: Self-asserted source
Sara Nencini

The physiology of bone marrow nociceptors

Award
Melbourne Neuroscience Institute, University of Melbourne (VIC, VIC, AU)
Source: Self-asserted source
Sara Nencini

Works (13)

Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance

Nature Neuroscience
2024-12-09 | Journal article
DOI: 10.1038/s41593-024-01830-0
Part of ISSN: 1097-6256
Part of ISSN: 1546-1726
Contributors: Wojciech Ambroziak; Sara Nencini; Jörg Pohle; Kristina Zuza; Gabriela Pino; Sofia Lundh; Carolina Araujo-Sousa; Larissa I. L. Goetz; Katrin Schrenk-Siemens; GOKUL MANOJ et al.
Source: Self-asserted source
Sara Nencini

A synaptic temperature sensor for body cooling

Neuron
2021-10 | Journal article
DOI: 10.1016/j.neuron.2021.10.001
Part of ISSN: 0896-6273
Contributors: Gretel B. Kamm; Juan C. Boffi; Kristina Zuza; Sara Nencini; Joaquin Campos; Katrin Schrenk-Siemens; Ivo Sonntag; Burçe Kabaoğlu; Muad Y. Abd El Hay; Yvonne Schwarz et al.
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons

Frontiers in Physiology
2021-07-15 | Journal article
DOI: 10.3389/fphys.2021.644929
Part of ISSN: 1664-042X
Contributors: Sara Nencini; Michael Morgan; Jenny Thai; Andrew I. Jobling; Stuart B. Mazzone; Jason J. Ivanusic
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

TRPV1 activation alters the function of Aδ and C fiber sensory neurons that innervate bone

Bone
2019-06 | Journal article
DOI: 10.1016/j.bone.2019.03.040
Part of ISSN: 8756-3282
Contributors: Michael Morgan; Sara Nencini; Jenny Thai; Jason Ivanusic
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

Sequestration of artemin reduces inflammation-induced activation and sensitization of bone marrow nociceptors in a rodent model of carrageenan-induced inflammatory bone pain

European Journal of Pain
2019-02 | Journal article
DOI: 10.1002/ejp.1315
Part of ISSN: 1090-3801
Contributors: Sara Nencini; Jenny Thai; Jason J. Ivanusic
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain

The Journal of Neuroscience
2018-05-23 | Journal article | Author
DOI: 10.1523/jneurosci.0421-18.2018
Part of ISSN: 0270-6474
Part of ISSN: 1529-2401
Contributors: Sara Nencini; Mitchell Ringuet; Dong-Hyun Kim; Claire Greenhill; Jason Ivanusic
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 3)‎

Mechanically sensitive Aδ nociceptors that innervate bone marrow respond to changes in intra-osseous pressure

The Journal of Physiology
2017-07-01 | Journal article
DOI: 10.1113/jp273877
Part of ISSN: 0022-3751
Contributors: Sara Nencini; Jason Ivanusic
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain

Molecular Pain
2017-01 | Journal article
DOI: 10.1177/1744806917697011
Part of ISSN: 1744-8069
Part of ISSN: 1744-8069
Contributors: Sara Nencini; Mitchell Ringuet; Dong-Hyun Kim; Yu-Jen Chen; Claire Greenhill; Jason J Ivanusic
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

The Physiology of Bone Pain. How Much Do We Really Know?

Frontiers in Physiology
2016-04-26 | Journal article
DOI: 10.3389/fphys.2016.00157
Part of ISSN: 1664-042X
Contributors: Sara Nencini; Jason J. Ivanusic
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Journal of Visualized Experiments
2014-03-25 | Journal article
DOI: 10.3791/50941
Part of ISSN: 1940-087X
Contributors: Antonio G. Zippo; Sara Nencini; Gian Carlo Caramenti; Maurizio Valente; Riccardo Storchi; Gabriele E.M. Biella
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

Handwritten Digits Recognition by Bio-inspired Hierarchical Networks

Neural Nets and Surroundings
2013 | Book chapter
DOI: 10.1007/978-3-642-35467-0_20
Part of ISBN: 9783642354663
Part of ISBN: 9783642354670
Part of ISSN: 2190-3018
Part of ISSN: 2190-3026
Contributors: Antonio G. Zippo; Giuliana Gelsomino; Sara Nencini; Gabriele E. M. Biella
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

Small-world networks in neuronal populations: A computational perspective

Neural Networks
2013-08 | Journal article
DOI: 10.1016/j.neunet.2013.04.003
Part of ISSN: 0893-6080
Contributors: Antonio G. Zippo; Giuliana Gelsomino; Pieter Van Duin; Sara Nencini; Gian Carlo Caramenti; Maurizio Valente; Gabriele E.M. Biella
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎

Neuronal Functional Connection Graphs among Multiple Areas of the Rat Somatosensory System during Spontaneous and Evoked Activities

PLoS Computational Biology
2013-06-13 | Journal article
DOI: 10.1371/journal.pcbi.1003104
Part of ISSN: 1553-7358
Contributors: Antonio G. Zippo; Riccardo Storchi; Sara Nencini; Gian Carlo Caramenti; Maurizio Valente; Gabriele Eliseo M. Biella
Source: Self-asserted source
Sara Nencini
grade
Preferred source (of 2)‎
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