zeger debyser (0000-0002-3982-1565)

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Biography

DEBYSER Zeger, MD PhD

Current professional address

Laboratory for Molecular Virology and Gene Therapy
Division of Molecular Medicine
KULAK and K.U.Leuven – Faculty of Medicine
Kapucijnenvoer 33
B-3000 Leuven
Flanders Belgium
Tel. +32 16 33.21.83
Fax +32 16 33.33.36

Personalia

Name : DEBYSER Zeger Marie Jacques
Place of birth : Brugge
Date of birth : 18/06/1965
Address : Korbeeklose Straat 108
3001 Heverlee
tel. 016/35 30 77
Civil registration : Married
Children : Jakob, °26/06/95, Soetkin, °02/09/97, Linde, °07/09/2000, Lander, °22/08/2003

Activities

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KU Leuven: Leuven, Flanders, BE

2013-10-01 to present | Full Professor, Head of Division of Molecular Virology and Gene Therapy (Pharmaceutical and Pharmacological Sciences)

Employment

zeger debyser

https://orcid.org/0000-0002-3982-1565

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Biography

Activities

Employment (5)

KU Leuven: Leuven, Flanders, BE

Katholieke Universiteit Leuven - Campus Kortrijk: Kortrijk, BE

Katholieke Universiteit Leuven - Campus Kortrijk: Kortrijk, BE

Katholieke Universiteit Leuven - Campus Kortrijk: Kortrijk, BE

Katholieke Universiteit Leuven Rega Institute for Medical Research: Leuven, BE

Education and qualifications (4)

Universitaire Ziekenhuis Gasthuisberg: Leuven, BE

KU Leuven: Leuven, BE

Harvard Medical School: Boston, MA, US

KU Leuven: Leuven, BE

Works (50 of 209)

The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function

HDAC inhibitors rescue MeCP2T158Mspeckles in a high content screen

Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles

Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection

Expansion microscopy allows high resolution single cell analysis of epigenetic readers

Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators

Role of Transportin-SR2 in HIV-1 Nuclear Import

GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

The chromatin landscape at the HIV-1 provirus integration site determines viral expression

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

The free energy landscape of retroviral integration

Design of reverse transcriptase–specific nucleosides to visualize early steps of HIV-1 replication by click labeling

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

N-terminal half of transportin SR2 interacts with HIV integrase

Structure, mechanics, and binding mode heterogeneity of LEDGF/p75–DNA nucleoprotein complexes revealed by scanning force microscopy

Validation of host factors of HIV integration as novel drug targets for anti-HIV therapy

Bioluminescence imaging of stroke-induced endogenous neural stem cell response

Switching STRATEGIES in HIV treatment

The HIV-1 integrase mutant R263A/K264A is two-fold defective for TRN-SR2 binding and viral nuclear import

Immunological Ignorance Allows Long-Term Gene Expression After Perinatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer to Murine Airways

Investigation of a Novel Series of 2-Hydroxyisoquinoline-1,3(2 H ,4 H )-diones as Human Immunodeficiency Virus Type 1 Integrase Inhibitors

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 – 2014)

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process

A new potential approach to block HIV-1 replication via protein–protein interaction and strand-transfer inhibition

HIV Virions as Nanoscopic Test Tubes for Probing Oligomerization of the Integrase Enzyme

Optimization of Multimodal Imaging of Mesenchymal Stem Cells Using the Human Sodium Iodide Symporter for PET and Cerenkov Luminescence Imaging

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo

2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance

Bromodomain and extra-terminal (BET) proteins target Moloney murine leukemia virus integration to transcription start sites

Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors

HIV-1 Integrase Drug Discovery Comes of Age

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection

The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

New scaffolds of natural origin as Integrase–LEDGF/p75 interaction inhibitors: Virtual screening and activity assays

Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor

4-Substituted 2-Hydroxyisoquinoline-1,3(2 H ,4 H )-diones as a Novel Class of HIV-1 Integrase Inhibitors

2-Hydroxyisoquinoline-1,3(2 H ,4 H )-diones (HIDs), Novel Inhibitors of HIV Integrase with a High Barrier to Resistance

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

Corrigendum to “The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy”

Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase–Lens Epithelium-Derived Growth Factor/p75 (IN–LEDGF/p75) Interaction

Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

Discovery of novel inhibitors of LEDGF/p75-IN protein–protein interactions

Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy

Peer review (15 reviews for 11 publications/grants)