Victor-Manuel Barbera (0000-0002-4012-6973)

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Biography

Víctor Manuel Barberá Juan, graduated in Biological Sciences from the University of Alicante between 1990-1994. He then carried out a research stay between August 1995 and June 1996 in the Cellular Biology Unit of the Municipal Institute of Medical Research of Barcelona, under the direction of Dr. Francisco X. Real. He carried out his Doctoral Thesis in the area of Molecular Oncology, between 1997-2002, studying the genetic alterations in human exocrine pancreatic adenocarcinoma, under the direction of Drs. Alfredo Carrato and Francisco X. Real. During this stage, he carried out a one-month predoctoral stay (01/2000) at the Molecular Oncology Unit of the Hammersmith Hospital in London. The defense of his doctoral thesis was in July 2002 at the University Miguel Hernández, with an outstanding qualification Cum Laude and Extraordinary Doctoral Award that year. During this stage, Dr. Barberá also collaborated in other research works in Molecular Biology of human tumors.
Later, he continued his training at the Department of Molecular Biology of the University of Texas, UTSouthwestern Medical Center at Dallas (USA), as a postdoctoral researcher in the research group led by Prof. Raymond J. MacDonald, during the period 2002-2004, collaborating in the research line Transcriptional factors and regulation of gene expression in the pancreatic organogenesis process.
On his return to Spain, he joined the Torres Quevedo Program of the Ministry of Economy, Industry and Competitiveness, obtained in a public competitive call to the Research and Development Department of the private company LABAQUA S.A., where he participated in the technological development of molecular diagnostic systems based on gene expression, participating in two patents.
In July 2006, he joined the Molecular Genetics Unit of the Hospital General Universitario de Elche, which is part of the Hereditary Cancer Program of the Oncological Plan of the Consellería de Sanidad Universal i Salut Publica. Since 2007 he has been a member of the Hereditary Cancer Advisory Group of the Valencian Community. In 2010 he joined the Department of Physiology, Genetics and Microbiology, area of knowledge of genetics, at the University of Alicante as an Associate Professor.

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Universidad de Alicante: Alicante, Comunidad Valenciana, ES

2010 to present | Profesor Asociado - Associate Professor (Fisiología, Genética y Microbiología)

Employment

Victor-Manuel Barbera

https://orcid.org/0000-0002-4012-6973

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Biography

Activities

Employment (5)

Universidad de Alicante: Alicante, Comunidad Valenciana, ES

Hospital General Universitario de Elche: Elche, Comunidad Valenciana, ES

LABAQUA S.A.: Alicante, Comunidad Valenciana, ES

University of Texas Southwestern Medical Center: Dallas, TX, US

Hospital General Universitario de Elche: Elche, Comunidad Valenciana, ES

Education and qualifications (3)

Universidad Miguel Hernández de Elche: Elche, Valenciana, ES

Institut Municipal d'Investigacions Mèdiques: Barcelona, Catalunya, ES

Universidad de Alicante: Alicante, Comunidad Valenciana, ES

Works (50 of 51)

Identification of new targets for glioblastoma therapy based on a DNA expression microarray

Presenilin 1 Modulates Acetylcholinesterase Trafficking and Maturation.

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study.

CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?

Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose–Response Relationships

Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses

CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, Induces Cell Death in Human Cancer Cells

Implementation of massive sequencing in the genetic diagnosis of hereditary cancer syndromes: diagnostic performance in the Hereditary Cancer Programme of the Valencia Community (FamCan-NGS)

Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case–control approaches

DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors

Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3

A phylogenetic approach to the Philippines endemic centipedes of the genus Scolopendra Linnaeus, 1758 (Scolopendromorpha, Scolopendridae), with the description of a new species

Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives.

A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk

Characterization of a novel POLD1 missense founder mutation in a Spanish population

Lack of cytomegalovirus detection in human glioma

Reduced risk of pancreatic cancer associated with asthma and nasal allergies

Streptococcus gallolyticus infection in colorectal cancer and association with biological and clinical factors

HGUE-C-1 is an atypical and novel colon carcinoma cell line

Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Prevalence of germline MUTYH mutations among Lynch-like syndrome patients

EU pancreas: An integrated european platform for pancreas cancer research - From basic science to clinical and public health interventions for a rare disease

Prevalence of Lynch syndrome among patients with newly diagnosed endometrial cancers

Risk of cancer in cases of suspected lynch syndrome without germline mutation

Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancer

Recurrent testicular germ cell tumors in a family with MYH-Associated polyposis

TGFBR1 intralocus epistatic interaction as a risk factor for colorectal cancer

Clinically important molecular features of Peruvian colorectal tumours: High prevalence of DNA mismatch repair deficiency and low incidence of KRAS mutations

Evidence for classification of c.1852_1853AA&gt;GC in MLH1 as a neutral variant for Lynch syndrome

Biallelic MYH germline mutations as cause of Muir-Torre syndrome

EPCAM germ line deletions as causes of lynch syndrome in Spanish patients

Methylation analysis of MLH1 improves the selection of patients for genetic testing in Lynch syndrome

Quantitative detection of Helicobacter pylori in water samples by real-time PCR amplification of the cag pathogenicity island gene, cagE

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study

The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: A case-control study

Utility of p16 immunohistochemistry for the identification of Lynch syndrome

p53 genetic abnormalities and P-glycoprotein expression in stump and primary gastric carcinomas

Validation of a new seminested PCR-based detection method for Legionella pneumophila

A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs

Molecular biology of exocrine pancreatic cancer

Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines

Molecular biology of exocrine pancreatic cancer | Biología molecular del cáncer de páncreas exocrino

Quantitative detection of Legionella pneumophila in water samples by immunomagnetic purification and real-time PCR amplification of the dotA gene

Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors

Incomplete overlapping of biological, clinical, and environmental information in molecular epidemiological studies: A variety of causes and a cascade of consequences

Detection of HuD transcripts by means of reverse transcriptase and polymerase chain reaction: Implications for the detection of minimal residual disease in patients with small cell lung cancer

Occupation and pancreatic cancer in Spain: A case-control study based on job titles

The 18q21 region in colorectal and pancreatic cancer: Independent loss of DCC and DPC4 expression

Peer review (1 review for 1 publication/grant)

Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome