Personal information

Other IDs

SciProfiles: 1590812
Loop profile: 1198028
ResearcherID: J-1261-2016

Keywords

Leprosy, Schwann cell, Myelin metabolism, Host-pathogen interaction, Peripheral nerve, Axon regeneration, Axon degeneration, Wallerian degeneration, Neuroinflammation

Countries

Brazil

Biography

I am an early career Assistant Professor in Brazil and my laboratory focuses on understanding Schwann cell responses in peripheral nerve biology/pathobiology. We use a combination of biochemical, histological, animal behavior and molecular and cellular biology techniques to study (i) Schwann cell-axon interactions, (ii) peripheral nerve degeneration and regeneration and (iii) myelin abnormalities, with the goal of understanding leprosy disease and promoting nerve repair. We are studying how leprosy pathogen perturbs Schwann cell biology for its persistence intracellularly and how this host-pathogen interaction is linked to the induction of nerve degeneration.

Activities

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Employment (1)

Universidade Federal de Juiz de Fora: Juiz de Fora, MG, BR

2018-07-24 to present | Assistant Professor of Molecular and Cellular Biology (Biology Department)
Employment
Source: Self-asserted source
Bruno Mietto

Education and qualifications (4)

Fundação Oswaldo Cruz: Rio de Janeiro, RJ, BR

2015-03-01 to 2018-07-01 | Postdoctoral researcher (Leprosy Department)
Education
Source: Self-asserted source
Bruno Mietto

Universidade Federal do Rio de Janeiro: Rio de Janeiro, RJ, BR

2011-03-01 to 2015-03-01 | PhD (Neuroscience)
Education
Source: Self-asserted source
Bruno Mietto

McGill University Health Centre: Montreal, QC, CA

2013-01-05 to 2014-05-05 | PhD visiting fellow (Centre for Research in Neuroscience)
Education
Source: Self-asserted source
Bruno Mietto

Universidade Federal do Rio de Janeiro: Rio de Janeiro, RJ, BR

2009-03-01 to 2011-03-01 | MSc (Neuroscience)
Education
Source: Self-asserted source
Bruno Mietto

Professional activities (1)

Society for Neuroscience: Washington, DC, US

2019-10-13 | Member of the Professional Development Committee
Distinction
Source: Self-asserted source
Bruno Mietto

Funding (2)

Schwann cell metabolism in leprosy disease

2019-06 to present | Grant
Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasilia, BR)
Source: Self-asserted source
Bruno Mietto

Demyelination in leprosy neuropathy

2019-02 to present | Grant
Fundação Oswaldo Cruz (Rio de Janeiro, BR)
Source: Self-asserted source
Bruno Mietto

Works (15)

Genomic and Phenotypic Variations Among Thai-53 and Mycobacterium leprae Clinical Isolates: Implications for Leprosy Pathogenesis and Research

Pathogens
2024-11-12 | Journal article
DOI: 10.3390/pathogens13110986
Contributors: Tiago Araujo Gomes; Tatiana Pereira da Silva; Edson Machado; Sidra Ezidio Gonçalves Vasconcelos; Bruno Siqueira Mietto; Daniela Ferreira de Faria Bertoluci; Patricia Sammarco Rosa; Roberta Olmo Pinheiro; Philip Noel Suffys; Letícia Miranda Santos Lery et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

DHA-rich fish oil plays a protective role against experimental cerebral malaria by controlling inflammatory and mechanical events from infection

The Journal of Nutritional Biochemistry
2024-01 | Journal article
DOI: 10.1016/j.jnutbio.2023.109492
Contributors: Bárbara Albuquerque Carpinter; Daniela Chaves Renhe; Jéssica Correa Bezerra Bellei; Carolina David Vieira; Cinthia Magalhães Rodolphi; Marcos Vinicius Rangel–Ferreira; Camila Simões de Freitas; Adolfo Firmino da Silva Neto; Eduardo Antônio Ferraz Coelho; Bruno de Siqueira Mietto et al.
Source: check_circle
Crossref

Phenolic glycolipid‐1 of Mycobacterium leprae is involved in human Schwann cell line ST8814 neurotoxic phenotype

Journal of Neurochemistry
2023-01 | Journal article
DOI: 10.1111/jnc.15722
Contributors: Karina do Carmo de Vasconcelos Girardi; Bruno Siqueira Mietto; Karoline dos Anjos Lima; Geórgia Correa Atella; Débora Santos da Silva; Antonio Marcos Rodrigues Pereira; Patrícia Sammarco Rosa; Flavio Alves Lara
Source: check_circle
Crossref

Four Seasons for Schwann Cell Biology, Revisiting Key Periods: Development, Homeostasis, Repair, and Aging

Biomolecules
2021-12-15 | Journal article
DOI: 10.3390/biom11121887
Contributors: Gabriela Sardella-Silva; Bruno Siqueira Mietto; Victor Túlio Ribeiro-Resende
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Schwann cells provide iron to axonal mitochondria and its role in nerve regeneration

The Journal of Neuroscience
2021-07-16 | Journal article
DOI: 10.1523/jneurosci.0900-21.2021
Part of ISSN: 0270-6474
Part of ISSN: 1529-2401
Source: Self-asserted source
Bruno Mietto

Myelin breakdown favours Mycobacterium leprae survival in Schwann cells

Cellular Microbiology
2020-01-13 | Journal article
DOI: 10.1111/cmi.13128
Contributors: Bruno Siqueira Mietto; Beatriz Junqueira Souza; Patricia Sammarco Rosa; Maria Cristina Vidal Pessolani; Flavio Alves Lara; Euzenir Nunes Sarno
Source: check_circle
Crossref

Demyelination in Peripheral Nerves: Much to Learn from Leprosy Neuropathy

Journal of Multiple Sclerosis
2016 | Journal article
DOI: 10.4172/2376-0389.1000174
Part of ISSN: 2376-0389
Source: Self-asserted source
Bruno Mietto

Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae.

The Journal of biological chemistry
2016-08-23 | Journal article
DOI: 10.1074/jbc.M116.725283
PMID: 27555322
PMC: PMC5076808
Source: Self-asserted source
Bruno Mietto

Rescuing axons from degeneration does not affect retinal ganglion cell death.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
2016-03-18 | Journal article
DOI: 10.1590/1414-431X20155106
PMID: 27007653
PMC: PMC4819409
Source: Self-asserted source
Bruno Mietto

Role of IL-10 in Resolution of Inflammation and Functional Recovery after Peripheral Nerve Injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2015-12-01 | Journal article
DOI: 10.1523/jneurosci.2119-15.2015
PMID: 26674868
Source: Self-asserted source
Bruno Mietto

Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats.

Neuroscience letters
2015-09-25 | Journal article
DOI: 10.1016/j.neulet.2015.09.021
PMID: 26391746
Source: Self-asserted source
Bruno Mietto

Neurotrauma and inflammation: CNS and PNS responses.

Mediators of inflammation
2015-03-31 | Journal article
DOI: 10.1155/2015/251204
PMID: 25918475
PMC: PMC4397002
Source: Self-asserted source
Bruno Mietto

Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve.

The European journal of neuroscience
2013-02-14 | Journal article
DOI: 10.1111/ejn.12161
PMID: 23406314
Source: Self-asserted source
Bruno Mietto

Wallerian Degeneration in Injury and Diseases: Concepts and Prevention

Advanced Understanding of Neurodegenerative Diseases
2011-12-16 | Book chapter
DOI: 10.5772/31927
Part of ISBN: 9789533075297
Source: Self-asserted source
Bruno Mietto

Sciatic nerve regeneration is accelerated in galectin-3 knockout mice.

Experimental neurology
2009-01-22 | Journal article
DOI: 10.1016/j.expneurol.2009.01.008
PMID: 19416680
Source: Self-asserted source
Bruno Mietto

Peer review (3 reviews for 1 publication/grant)

Review activity for PLoS neglected tropical diseases (3)
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