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Works (37)

Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae.

Nature communications
2022-11 | Journal article
DOI: 10.1038/s41467-022-34538-5
PMID: 36443293
PMC: PMC9705543
Contributors: Rother C; Uhlmann RE; Müller SA; Schelle J; Skodras A; Obermüller U; Häsler LM; Lambert M; Baumann F; Xu Y et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Signatures of glial activity can be detected in the CSF proteome.

Proceedings of the National Academy of Sciences of the United States of America
2022-06 | Journal article
DOI: 10.1073/pnas.2119804119
PMID: 35666874
PMC: PMC9214531
Contributors: Eninger T; Müller SA; Bacioglu M; Schweighauser M; Lambert M; Maia LF; Neher JJ; Hornfeck SM; Obermüller U; Kleinberger G et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles.

Acta neuropathologica
2021-12 | Journal article
DOI: 10.1007/s00401-021-02400-5
PMID: 34961894
PMC: PMC8742811
Contributors: Kaeser SA; Häsler LM; Lambert M; Bergmann C; Bottelbergs A; Theunis C; Mercken M; Jucker M
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients.

BMC cancer
2021-10 | Journal article
DOI: 10.1186/s12885-021-08825-1
PMID: 34654395
PMC: PMC8520299
Contributors: Kemmerer CL; Schittenhelm J; Dubois E; Neumann L; Häsler LM; Lambert M; Renovanz M; Kaeser SA; Tabatabai G; Ziemann U et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

A neuronal blood marker is associated with mortality in old age

Nature Aging
2021-02-11 | Journal article
DOI: 10.1038/s43587-021-00028-4
Part of ISSN: 2662-8465
Contributors: Stephan A. Kaeser; Benoit Lehallier; Mikael Thinggaard; Lisa M. Häsler; Anja Apel; Carina Bergmann; Daniela Berdnik; Bernard Jeune; Kaare Christensen; Sebastian Grönke et al.
Source: Self-asserted source
Stephan A. Kaeser

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life.

Nature neuroscience
2020-11 | Journal article
DOI: 10.1038/s41593-020-00737-w
PMID: 33199898
PMC: PMC7783656
Contributors: Uhlmann RE; Rother C; Rasmussen J; Schelle J; Bergmann C; Ullrich Gavilanes EM; Fritschi SK; Buehler A; Baumann F; Skodras A et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.

Molecular psychiatry
2020-07 | Journal article
DOI: 10.1038/s41380-020-0807-4
PMID: 32632204
PMC: PMC8758476
Contributors: Pérez MJ; Ivanyuk D; Panagiotakopoulou V; Di Napoli G; Kalb S; Brunetti D; Al-Shaana R; Kaeser SA; Fraschka SA; Jucker M et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice.

EMBO molecular medicine
2020-06 | Journal article
DOI: 10.15252/emmm.201911803
PMID: 32510847
PMC: PMC7338806
Contributors: Wilke C; Haas E; Reetz K; Faber J; Garcia-Moreno H; Santana MM; van de Warrenburg B; Hengel H; Lima M; Filla A et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

2020-01 | Preprint
DOI: 10.1101/2020.01.27.919522
PPR: PPR110545
Contributors: Ivanyuk D; Pérez MJ; Panagiotakopoulou V; Di Napoli G; Brunetti D; Al-Shaana R; Kaeser SA; Jucker M; Zeviani M; Viscomi C et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Neurofilaments as blood biomarkers at the preataxic and ataxic stage of spinocerebellar ataxia type 3: a cross-species analysis in humans and mice

2019-11 | Preprint
DOI: 10.1101/19011882
PPR: PPR103549
Contributors: Wilke C; Haas E; Reetz K; Faber J; Garcia-Moreno H; Santana MM; van de Warrenburg B; Hengel H; Lima M; Filla A et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Early Aβ reduction prevents progression of cerebral amyloid angiopathy.

Annals of neurology
2019-08 | Journal article
DOI: 10.1002/ana.25562
PMID: 31359452
Contributors: Schelle J; Wegenast-Braun BM; Fritschi SK; Kaeser SA; Jährling N; Eicke D; Skodras A; Beschorner N; Obermueller U; Häsler LM et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.

Nature medicine
2019-01 | Journal article
DOI: 10.1038/s41591-018-0304-3
PMID: 30664784
PMC: PMC6367005
Contributors: Preische O; Schultz SA; Apel A; Kuhle J; Kaeser SA; Barro C; Gräber S; Kuder-Buletta E; LaFougere C; Laske C et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America
2017-11 | Journal article
DOI: 10.1073/pnas.1713215114
PMID: 29158413
PMC: PMC5724274
Contributors: Rasmussen J; Mahler J; Beschorner N; Kaeser SA; Häsler LM; Baumann F; Nyström S; Portelius E; Blennow K; Lashley T et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.

EMBO reports
2017-07 | Journal article
DOI: 10.15252/embr.201744067
PMID: 28701326
PMC: PMC5579388
Contributors: Ye L; Rasmussen J; Kaeser SA; Marzesco AM; Obermüller U; Mahler J; Schelle J; Odenthal J; Krüger C; Fritschi SK et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2016-10 | Journal article
DOI: 10.1016/j.jalz.2016.09.005
PMID: 27750032
Contributors: Schelle J; Häsler LM; Göpfert JC; Joos TO; Vanderstichele H; Stoops E; Mandelkow EM; Neumann U; Shimshek DR; Staufenbiel M et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuron
2016-07 | Journal article
DOI: 10.1016/j.neuron.2016.07.007
PMID: 27477021
Contributors: Bacioglu M; Maia LF; Preische O; Schelle J; Apel A; Kaeser SA; Schweighauser M; Eninger T; Lambert M; Pilotto A et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuron
2016-06 | Journal article
DOI: 10.1016/j.neuron.2016.05.018
PMID: 27292537
Contributors: Bacioglu M; Maia LF; Preische O; Schelle J; Apel A; Kaeser SA; Schweighauser M; Eninger T; Lambert M; Pilotto A et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2016-05 | Journal article
DOI: 10.1523/jneurosci.0258-16.2016
PMID: 27147660
PMC: PMC6601857
Contributors: Novotny R; Langer F; Mahler J; Skodras A; Vlachos A; Wegenast-Braun BM; Kaeser SA; Neher JJ; Eisele YS; Pietrowski MJ et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease.

Current Alzheimer research
2016-01 | Journal article
DOI: 10.2174/1567205013666160314151247
PMID: 26971930
Contributors: Wilke C; Gillardon F; Deuschle C; Dubois E; Hobert MA; Müller vom Hagen J; Krüger S; Biskup S; Blauwendraat C; Hruscha M et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Persistence of Aβ seeds in APP null mouse brain.

Nature neuroscience
2015-09 | Journal article
DOI: 10.1038/nn.4117
PMID: 26352792
Contributors: Ye L; Fritschi SK; Schelle J; Obermüller U; Degenhardt K; Kaeser SA; Eisele YS; Walker LC; Baumann F; Staufenbiel M et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models.

EMBO molecular medicine
2015-07 | Journal article
DOI: 10.15252/emmm.201505026
PMID: 25978969
PMC: PMC4520655
Contributors: Maia LF; Kaeser SA; Reichwald J; Lambert M; Obermüller U; Schelle J; Odenthal J; Martus P; Staufenbiel M; Jucker M
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Parenchymal cystatin C focal deposits and glial scar formation around brain arteries in Hereditary Cystatin C Amyloid Angiopathy.

Brain research
2015-06 | Journal article
DOI: 10.1016/j.brainres.2015.06.019
PMID: 26115583
Contributors: Osk Snorradottir A; Isaksson HJ; Kaeser SA; Skodras AA; Olafsson E; Palsdottir A; Thor Bragason B
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid.

Brain : a journal of neurology
2014-09 | Journal article
DOI: 10.1093/brain/awu255
PMID: 25212850
PMC: PMC5367518
Contributors: Fritschi SK; Langer F; Kaeser SA; Maia LF; Portelius E; Pinotsi D; Kaminski CF; Winkler DT; Maetzler W; Keyvani K et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.

EMBO reports
2013-09 | Journal article
DOI: 10.1038/embor.2013.137
PMID: 23999102
PMC: PMC3818077
Contributors: Heilbronner G; Eisele YS; Langer F; Kaeser SA; Novotny R; Nagarathinam A; Aslund A; Hammarström P; Nilsson KP; Jucker M
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Deposition of collagen IV and aggrecan in leptomeningeal arteries of hereditary brain haemorrhage with amyloidosis.

Brain research
2013-08 | Journal article
DOI: 10.1016/j.brainres.2013.08.029
PMID: 23973860
Contributors: Snorradottir AO; Isaksson HJ; Kaeser SA; Skodras AA; Olafsson E; Palsdottir A; Bragason BT
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.

Science translational medicine
2013-07 | Journal article
DOI: 10.1126/scitranslmed.3006446
PMID: 23863834
Contributors: Maia LF; Kaeser SA; Reichwald J; Hruscha M; Martus P; Staufenbiel M; Jucker M
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

CSF biomarker variability in the Alzheimer's Association quality control program.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2013-05 | Journal article
DOI: 10.1016/j.jalz.2013.01.010
PMID: 23622690
PMC: PMC3707386
Contributors: Mattsson N; Andreasson U; Persson S; Carrillo MC; Collins S; Chalbot S; Cutler N; Dufour-Rainfray D; Fagan AM; Heegaard NH et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

The Journal of biological chemistry
2011-08 | Journal article
DOI: 10.1074/jbc.m111.288373
PMID: 21873424
PMC: PMC3199491
Contributors: Kilger E; Buehler A; Woelfing H; Kumar S; Kaeser SA; Nagarathinam A; Walter J; Jucker M; Coomaraswamy J
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2011-07 | Journal article
DOI: 10.1016/j.jalz.2011.05.2243
PMID: 21784349
PMC: PMC3710290
Contributors: Mattsson N; Andreasson U; Persson S; Arai H; Batish SD; Bernardini S; Bocchio-Chiavetto L; Blankenstein MA; Carrillo MC; Chalbot S et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

Science (New York, N.Y.)
2010-10 | Journal article
DOI: 10.1126/science.1194516
PMID: 20966215
PMC: PMC3233904
Contributors: Eisele YS; Obermüller U; Heilbronner G; Baumann F; Kaeser SA; Wolburg H; Walker LC; Staufenbiel M; Heikenwalder M; Jucker M
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America
2010-04 | Journal article
DOI: 10.1073/pnas.1001056107
PMID: 20385796
PMC: PMC2867864
Contributors: Coomaraswamy J; Kilger E; Wölfing H; Schäfer C; Kaeser SA; Wegenast-Braun BM; Hefendehl JK; Wolburg H; Mazzella M; Ghiso J et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.

Nature neuroscience
2009-10 | Journal article
DOI: 10.1038/nn.2432
PMID: 19838177
PMC: PMC4721582
Contributors: Grathwohl SA; Kälin RE; Bolmont T; Prokop S; Winkelmann G; Kaeser SA; Odenthal J; Radde R; Eldh T; Gandy S et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Cystatin C modulates cerebral beta-amyloidosis.

Nature genetics
2007-11 | Journal article
DOI: 10.1038/ng.2007.23
PMID: 18026102
Contributors: Kaeser SA; Herzig MC; Coomaraswamy J; Kilger E; Selenica ML; Winkler DT; Staufenbiel M; Levy E; Grubb A; Jucker M
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

Science (New York, N.Y.)
2006-09 | Journal article
DOI: 10.1126/science.1131864
PMID: 16990547
Contributors: Meyer-Luehmann M; Coomaraswamy J; Bolmont T; Kaeser S; Schaefer C; Kilger E; Neuenschwander A; Abramowski D; Frey P; Jaton AL et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.

EMBO reports
2006-08 | Journal article
DOI: 10.1038/sj.embor.7400784
PMID: 16906128
PMC: PMC1559665
Contributors: Radde R; Bolmont T; Kaeser SA; Coomaraswamy J; Lindau D; Stoltze L; Calhoun ME; Jäggi F; Wolburg H; Gengler S et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice.

Neurobiology of aging
2005-05 | Journal article
DOI: 10.1016/j.neurobiolaging.2004.06.010
PMID: 15708435
Contributors: Boncristiano S; Calhoun ME; Howard V; Bondolfi L; Kaeser SA; Wiederhold KH; Staufenbiel M; Jucker M
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Extracellular amyloid formation and associated pathology in neural grafts.

Nature neuroscience
2003-04 | Journal article
DOI: 10.1038/nn1022
PMID: 12598899
Contributors: Meyer-Luehmann M; Stalder M; Herzig MC; Kaeser SA; Kohler E; Pfeifer M; Boncristiano S; Mathews PM; Mercken M; Abramowski D et al.
Source: Self-asserted source
Stephan A. Kaeser via Europe PubMed Central

Peer review (2 reviews for 2 publications/grants)

Review activity for Molecular neurodegeneration (1)
Review activity for Nature aging. (1)
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