Personal information

Yersinia pestis pathogenesis, Oral Microbiology and Biofilms, Vibrio cholerae virulence gene regulation

Activities

Employment (1)

University of Detroit Mercy School of Dentistry: Detroit, MI, US

2013-07 to present | Associate Professor/Assistant Director of Research (Division of Integrated Biomedical Sciences)
Employment
Source: Self-asserted source
Eric Krukonis

Education and qualifications (2)

Tufts University School of Medicine: Boston, MA, US

1998 | PhD (Molecular and Microbiology)
Education
Source: Self-asserted source
Eric Krukonis

Rice University: Houston, TX, US

1990 | BA (Biology)
Education
Source: Self-asserted source
Eric Krukonis

Professional activities (10)

International Association for Dental Research: Alexandria, VA, US

2023 to present | Secretary/Treasurer of Microbiology and Immunology Division
Service
Source: Self-asserted source
Eric Krukonis

International Association for Dental Research: Alexandria, VA, US

2015 to present
Membership
Source: Self-asserted source
Eric Krukonis

American Association for Dental Research: Alexandria, Virginia, US

2015 to present
Membership
Source: Self-asserted source
Eric Krukonis

American Society for Microbiology: Washington D.C., District of Columbia, US

1995 to present
Membership
Source: Self-asserted source
Eric Krukonis

University of Detroit Mercy School of Dentistry: Detroit, MI, US

2022 | Outstanding Dental Didactic Faculty Member, Dental Class of 2025
Distinction
Source: Self-asserted source
Eric Krukonis

University of Detroit Mercy School of Dentistry: Detroit, Michigan, US

2019 | Outstanding Dental Didactic Faculty Member, Dental Class of 2022
Distinction
Source: Self-asserted source
Eric Krukonis

University of Detroit Mercy School of Dentistry: Detroit, Michigan, US

2014 | Outstanding Dental Hygiene Didactic Faculty Member, Dental Hygiene Class of 2015
Distinction
Source: Self-asserted source
Eric Krukonis

American Society for Microbiology: Washington D.C., District of Columbia, US

1999 | Student Travel Award
Distinction
Source: Self-asserted source
Eric Krukonis

American Society for Microbiology: Washington D.C., District of Columbia, US

1998 | Student Travel Award
Distinction
Source: Self-asserted source
Eric Krukonis

American Society for Microbiology: Washington D.C., District of Columbia, US

1996 | Student Travel Award
Distinction
Source: Self-asserted source
Eric Krukonis

Funding (7)

U-RISE at the University of Detroit Mercy

2023-04 to 2028-03 | Grant
National Institute of General Medical Sciences (Bethesda, Maryland, US)
GRANT_NUMBER:

GM-149474

Source: Self-asserted source
Eric Krukonis

Ail-mediated serum resistance in Yersinia pestis and its contribution to plague virulence

2018-05-07 to 2023-04-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI133570
Source: Self-asserted source
Eric Krukonis via DimensionsWizard

2011 Midwest Microbial Pathogenesis Conference

2011-09-01 to 2012-08-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R13AI096750
Source: Self-asserted source
Eric Krukonis via DimensionsWizard

Evaluation of Ail as a protective immunogen for plague

2011-03-01 to 2013-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R03AI092318
Source: Self-asserted source
Eric Krukonis via DimensionsWizard

Role of Yersinia pestis Ail in Yop delivery and plague

2011-03-01 to 2013-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI090194
Source: Self-asserted source
Eric Krukonis via DimensionsWizard

Regulation of Vibrio cholerae virulence by ToxR and TcpP

2007-08-15 to 2011-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI075087
Source: Self-asserted source
Eric Krukonis via DimensionsWizard

TOXS AND ACTIVATION OF THE TOXR REGULON

1998-03-31 to 2000-01-01 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: F32AI009942
Source: Self-asserted source
Eric Krukonis via DimensionsWizard

Works (33)

A Potential Intracanal Medicament, 2-Hydroxyisocaproic Acid (HICA): Cytotoxicity, Genotoxicity, and Its Effect on SCAP Differentiation

Dentistry Journal
2023-11 | Journal article | Author
Contributors: Cristine Smoczer; Yun K. Park; James B. Herrington; Mazin A. Askar; Sarah Plecha; Eric Krukonis; Susan Paurazas
Source: check_circle
Multidisciplinary Digital Publishing Institute

ToxR activates the Vibrio cholerae virulence genes by tethering DNA to the membrane through versatile binding to multiple sites

Proceedings of the National Academy of Sciences
2023-07-18 | Journal article
Contributors: Albert Canals; Simone Pieretti; Mireia Muriel-Masanes; Nour El Yaman; Sarah C. Plecha; Joshua J. Thomson; Montserrat Fàbrega-Ferrer; Rosa Pérez-Luque; Eric S. Krukonis; Miquel Coll
Source: check_circle
Crossref

A Co-Association of Streptococcus mutans and Veillonella parvula/dispar in Root Caries Patients and In Vitro Biofilms

Infection and Immunity
2022-10-20 | Journal article | Author
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Amber M. Abram; Michelle M. Szewczyk; Seon G. Park; Sumita S. Sam; Haya B. Eldana; Fadi J. Koria; Joseph M. Ferracciolo; Laura A. Young; Hina Qadir; Aaron J. Bonham et al.
Source: Self-asserted source
Eric Krukonis

Complement evasion mechanisms of the systemic pathogens Yersiniae and Salmonellae

FEBS Letters
2020-08 | Journal article
Contributors: Eric S. Krukonis; Joshua J. Thomson
Source: check_circle
Crossref

The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU

PLOS ONE
2019-09-09 | Journal article | Author
Part of ISSN: 1932-6203
Contributors: Sarah J. Morgan; Emily L. French; Sarah C. Plecha; Eric Krukonis
Source: Self-asserted source
Eric Krukonis
grade
Preferred source (of 2)‎

Ail provides multiple mechanisms of serum resistance to Yersinia pestis

Molecular Microbiology
2019-01 | Journal article
Contributors: Joshua J. Thomson; Sarah C. Plecha; Eric S. Krukonis
Source: check_circle
Crossref

Defining the Ail Ligand-Binding Surface: Hydrophobic Residues in Two Extracellular Loops Mediate Cell and Extracellular Matrix Binding To Facilitate Yop Delivery

Infection and Immunity
2017-04 | Journal article
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Tiffany M. Tsang; Jeffrey S. Wiese; Jamal A. Alhabeil; Lisa D. Usselman; Joshua J. Thomson; Rafla Matti; Malte Kronshage; Natalie Maricic; Shanedah Williams; Naama H. Sleiman et al.
Source: Self-asserted source
Eric Krukonis

Formation of an Intramolecular Periplasmic Disulfide Bond in TcpP Protects TcpP and TcpH from Degradation in Vibrio cholerae

Journal of Bacteriology
2016-02 | Journal article
Part of ISSN: 0021-9193
Part of ISSN: 1098-5530
Contributors: Sarah J. Morgan; Emily L. French; Joshua J. Thomson; Craig P. Seaborn; Christian A. Shively; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Yersinia pestis targets neutrophils via complement receptor 3

Cellular Microbiology
2015-05 | Journal article
Part of ISSN: 1462-5814
Contributors: Peter M. Merritt; Thomas Nero; Lesley Bohman; Suleyman Felek; Eric S. Krukonis; Melanie M. Marketon
Source: Self-asserted source
Eric Krukonis

Ail Proteins of Yersinia pestis and Y. pseudotuberculosis Have Different Cell Binding and Invasion Activities

PLoS ONE
2013-12-27 | Journal article
Part of ISSN: 1932-6203
Contributors: Tiffany M. Tsang; Jeffrey S. Wiese; Suleyman Felek; Malte Kronshage; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

ToxR Recognizes a Direct Repeat Element in the toxT, ompU, ompT, and ctxA Promoters of Vibrio cholerae To Regulate Transcription

Infection and Immunity
2013-03 | Journal article
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Thomas J. Goss; Sarah J. Morgan; Emily L. French; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Ail Protein Binds Ninth Type III Fibronectin Repeat (9FNIII) within Central 120-kDa Region of Fibronectin to Facilitate Cell Binding by Yersinia pestis

Journal of Biological Chemistry
2012-05 | Journal article
Part of ISSN: 0021-9258
Contributors: Tiffany M. Tsang; Douglas S. Annis; Malte Kronshage; Jesse T. Fenno; Lisa D. Usselman; Deane F. Mosher; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Structural Insights into Ail-Mediated Adhesion in Yersinia pestis

Structure
2011-11 | Journal article
Part of ISSN: 0969-2126
Contributors: Satoshi Yamashita; Petra Lukacik; Travis J. Barnard; Nicholas Noinaj; Suleyman Felek; Tiffany M. Tsang; Eric S. Krukonis; B. Joseph Hinnebusch; Susan K. Buchanan
Source: Self-asserted source
Eric Krukonis

The two faces of ToxR: activator of ompU , co‐regulator of toxT in Vibrio cholerae

Molecular Microbiology
2011-07 | Journal article
Part of ISSN: 0950-382X
Part of ISSN: 1365-2958
Contributors: Sarah J. Morgan; Suleyman Felek; Shilpa Gadwal; Nicole M. Koropatkin; Jeffrey W. Perry; Alyson B. Bryson; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Contributions of chaperone/usher systems to cell binding, biofilm formation and Yersinia pestis virulence

Microbiology
2011-03-01 | Journal article
Part of ISSN: 1350-0872
Part of ISSN: 1465-2080
Contributors: Suleyman Felek; Jenny J. Jeong; Lisa M. Runco; Susan Murray; David G. Thanassi; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Identification of the TcpP-Binding Site in the toxT Promoter of Vibrio cholerae and the Role of ToxR in TcpP-Mediated Activation

Infection and Immunity
2010-10 | Journal article
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Thomas J. Goss; Craig P. Seaborn; Miranda D. Gray; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Three Yersinia pestis Adhesins Facilitate Yop Delivery to Eukaryotic Cells and Contribute to Plague Virulence

Infection and Immunity
2010-10 | Journal article
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Suleyman Felek; Tiffany M. Tsang; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Ail Binding to Fibronectin Facilitates Yersinia pestis Binding to Host Cells and Yop Delivery

Infection and Immunity
2010-08 | Journal article
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Tiffany M. Tsang; Suleyman Felek; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Phosphoglucomutase of Yersinia pestis Is Required for Autoaggregation and Polymyxin B Resistance

Infection and Immunity
2010-03 | Journal article
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Suleyman Felek; Artur Muszyński; Russell W. Carlson; Tiffany M. Tsang; B. Joseph Hinnebusch; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

The Yersinia pestis Ail Protein Mediates Binding and Yop Delivery to Host Cells Required for Plague Virulence

Infection and Immunity
2009-02 | Journal article
Part of ISSN: 0019-9567
Part of ISSN: 1098-5522
Contributors: Suleyman Felek; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

The Yersinia pestis autotransporter YapC mediates host cell binding, autoaggregation and biofilm formation

Microbiology
2008-06-01 | Journal article
Part of ISSN: 1350-0872
Part of ISSN: 1465-2080
Contributors: Suleyman Felek; Matthew B. Lawrenz; Eric S. Krukonis
Source: Self-asserted source
Eric Krukonis

Characterization of Six Novel Chaperone/Usher Systems in Yersinia pestis

Advances In Experimental Medicine And Biology
2007 | Book chapter
Part of ISBN: 9780387721231
Part of ISBN: 9780387721248
Part of ISSN: 0065-2598
Part of ISSN: 2214-8019
Contributors: Suleyman Felek; Eric S. Krukonis; David G. Thanassi; Lisa M. Runco
Source: Self-asserted source
Eric Krukonis

TcpH Influences Virulence Gene Expression in Vibrio cholerae by Inhibiting Degradation of the Transcription Activator TcpP

Journal of Bacteriology
2004-12-15 | Journal article
Part of ISSN: 0021-9193
Part of ISSN: 1098-5530
Contributors: Nancy A. Beck; Eric S. Krukonis; Victor J. DiRita
Source: Self-asserted source
Eric Krukonis

DNA Binding and ToxR Responsiveness by the Wing Domain of TcpP, an Activator of Virulence Gene Expression in Vibrio cholerae

Molecular Cell
2003-07 | Journal article
Part of ISSN: 1097-2765
Contributors: Eric S. Krukonis; Victor J. DiRita
Source: Self-asserted source
Eric Krukonis

From motility to virulence: sensing and responding to environmental signals in Vibrio cholerae

Current Opinion in Microbiology
2003-04 | Journal article
Part of ISSN: 1369-5274
Contributors: Eric S Krukonis; Victor J DiRita
Source: Self-asserted source
Eric Krukonis

Membrane localization of the ToxR winged-helix domain is required for TcpP-mediated virulence gene activation in Vibrio cholerae

Molecular Microbiology
2003-02-19 | Journal article
Part of ISSN: 0950-382X
Part of ISSN: 1365-2958
Contributors: J. Adam Crawford; Eric S. Krukonis; Victor J. DiRita
Source: Self-asserted source
Eric Krukonis

The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoter

Molecular Microbiology
2000-10 | Journal article
Part of ISSN: 0950-382X
Part of ISSN: 1365-2958
Contributors: Eric S. Krukonis; Rosa R. Yu; Victor J. DiRita
Source: Self-asserted source
Eric Krukonis

Integrin β1-chain residues involved in substrate recognition and specificity of binding to invasin

Cellular Microbiology
2000-06 | Journal article
Part of ISSN: 1462-5814
Part of ISSN: 1462-5822
Contributors: Eric S. Krukonis; Ralph R. Isberg
Source: Self-asserted source
Eric Krukonis

Differential Effects of Integrin α Chain Mutations on Invasin and Natural Ligand Interaction

Journal of Biological Chemistry
1998-11 | Journal article
Part of ISSN: 0021-9258
Contributors: Eric S. Krukonis; Petra Dersch; Johannes A. Eble; Ralph R. Isberg
Source: Self-asserted source
Eric Krukonis

Recombinant Soluble Human α3β1ntegrin:  Purification, Processing, Regulation, and Specific Binding to Laminin-5 and Invasin in a Mutually Exclusive Manner

Biochemistry
1998-08-01 | Journal article
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Contributors: Johannes A. Eble; Kai W. Wucherpfennig; Laurent Gauthier; Petra Dersch; Eric Krukonis; Ralph R. Isberg; M. E. Hemler
Source: Self-asserted source
Eric Krukonis

SWIM analysis allows rapid identification of residues involved in invasin-mediated bacterial uptake

Gene
1998-04 | Journal article
Part of ISSN: 0378-1119
Contributors: Eric S Krukonis; Ralph R Isberg
Source: Self-asserted source
Eric Krukonis

Microbial Pathogens and Integrin Interactions

Integrin-Ligand Interaction
1997 | Book chapter
Part of ISBN: 9781475740660
Part of ISBN: 9781475740646
Contributors: Eric S. Krukonis; Ralph R. Isberg
Source: Self-asserted source
Eric Krukonis

Mutations in the Cytoplasmic Domain of the Integrin β1 Chain Indicate a Role for Endocytosis Factors in Bacterial Internalization

Journal of Biological Chemistry
1996-03 | Journal article
Part of ISSN: 0021-9258
Contributors: Guy Tran Van Nhieu; Eric S. Krukonis; Alfred A. Reszka; Alan F. Horwitz; Ralph R. Isberg
Source: Self-asserted source
Eric Krukonis