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Employment (1)

Yale University: New Haven, US

Employment
Source: Self-asserted source
Sarah Slavoff

Education and qualifications (3)

Harvard University: Cambridge, MA, US

2010-09 to 2014-06 | Postdoctoral Fellowship (Chemistry)
Education
Source: Self-asserted source
Sarah Slavoff

Massachusetts Institute of Technology: Cambridge, MA, US

2005-08 to 2010-09 | Ph.D. (Chemistry)
Education
Source: Self-asserted source
Sarah Slavoff

University of Maryland: College Park, Maryland, US

2001 to 2005 | B.S. (Chemistry and Biochemistry)
Education
Source: Self-asserted source
Sarah Slavoff

Funding (3)

Translation of overprinted non-canonical open reading frames from alternative transcript variants

2024-08-15 to 2028-06-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.14100470
GRANT_NUMBER: R01GM155404
Source: Self-asserted source
Sarah Slavoff via DimensionsWizard

Structural and functional roles of the microprotein NoBody in mRNA decapping and decay

2017-09-06 to 2022-08-31 | Grant
National Institute of General Medical Sciences (n/a, US)
URL: https://grants.uberresearch.com/100000057/R01GM122984/Structural-and-functional-roles-of-the-microprotein-NoBody-in-mRNA-decapping-and-decay
GRANT_NUMBER: grant.R01GM122984
Source: Self-asserted source
Sarah Slavoff via DimensionsWizard

Scope and mechanism of eptide translation from short open reading frames in the h

2011-08-01 to 2014-05-31 | Grant
National Institute of General Medical Sciences (n/a, US)
URL: https://grants.uberresearch.com/100000057/F32GM099408/Scope-and-mechanism-of-eptide-translation-from-short-open-reading-frames-in-the-h
GRANT_NUMBER: grant.F32GM099408
Source: Self-asserted source
Sarah Slavoff via DimensionsWizard

Works (34)

Microproteins—Discovery, structure, and function

PROTEOMICS
2023-12 | Journal article
DOI: 10.1002/pmic.202100211
Contributors: Jessica J. Mohsen; Alina A. Martel; Sarah A. Slavoff
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Crossref
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ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m<sup>6</sup>A modification-mediated RNA stability control.

Cell reports
2023-09 | Journal article
DOI: 10.1016/j.celrep.2023.113163
PMID: 37742191
PMC: PMC10636609
Contributors: Gao Y; Zimmer JT; Vasic R; Liu C; Gbyli R; Zheng SJ; Patel A; Liu W; Qi Z; Li Y et al.
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5.

Cell reports
2023-09 | Journal article
DOI: 10.1016/j.celrep.2023.113145
PMID: 37725512
PMC: PMC10629662
Contributors: Chen Y; Su H; Zhao J; Na Z; Jiang K; Bacchiocchi A; Loh KH; Halaban R; Wang Z; Cao X et al.
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Noncoding translation: Quality control in the BAG.

Molecular cell
2023-06 | Journal article
DOI: 10.1016/j.molcel.2023.05.033
PMID: 37327774
Contributors: Mohsen JJ; Slavoff SA
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides

Biochemical Society Transactions
2023-06-28 | Journal article
DOI: 10.1042/BST20221074
Contributors: Yanran Chen; Xiongwen Cao; Ken H. Loh; Sarah A. Slavoff
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BONCAT-based Profiling of Nascent Small and Alternative Open Reading Frame-encoded Proteins.

Bio-protocol
2023-01 | Journal article
DOI: 10.21769/bioprotoc.4585
PMID: 36789088
PMC: PMC9901453
Contributors: Cao X; Chen Y; Khitun A; Slavoff SA
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Massively parallel knock-in engineering of human T cells.

Nature biotechnology
2023-01 | Journal article
DOI: 10.1038/s41587-022-01639-x
PMID: 36702900
Contributors: Dai X; Park JJ; Du Y; Na Z; Lam SZ; Chow RD; Renauer PA; Gu J; Xin S; Chu Z et al.
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID.

Molecular cell
2022-07 | Journal article
DOI: 10.1016/j.molcel.2022.06.035
PMID: 35905735
Contributors: Na Z; Dai X; Zheng SJ; Bryant CJ; Loh KH; Su H; Luo Y; Buhagiar AF; Cao X; Baserga SJ et al.
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor

Nature Chemical Biology
2022-06 | Journal article
DOI: 10.1038/s41589-022-01003-9
Contributors: Xiongwen Cao; Alexandra Khitun; Cecelia M. Harold; Carson J. Bryant; Shu-Jian Zheng; Susan J. Baserga; Sarah A. Slavoff
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Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular Condensates

Journal of the American Chemical Society
2021-08-18 | Journal article
DOI: 10.1021/jacs.1c05386
Contributors: Zhenkun Na; Yang Luo; Danica S. Cui; Alexandra Khitun; Stephanie Smelyansky; J. Patrick Loria; Sarah A. Slavoff
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Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

Nature Communications
2021-01-21 | Journal article
DOI: 10.1038/s41467-020-20841-6
Contributors: Xiongwen Cao; Alexandra Khitun; Yang Luo; Zhenkun Na; Thitima Phoodokmai; Khomkrit Sappakhaw; Elizabeth Olatunji; Chayasith Uttamapinant; Sarah A. Slavoff
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Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor

Cell Chemical Biology
2020-12 | Journal article
DOI: 10.1016/j.chembiol.2020.12.003
Part of ISSN: 2451-9456
Source: Self-asserted source
Sarah Slavoff
grade
Preferred source (of 2)‎

Global Profiling of Cellular Substrates of Human Dcp2

Biochemistry
2020-11-03 | Journal article
DOI: 10.1021/acs.biochem.0c00069
Contributors: Yang Luo; Jeremy A. Schofield; Matthew D. Simon; Sarah A. Slavoff
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A genetic code expansion-derived molecular beacon for the detection of intracellular amyloid-β peptide generation.

Angewandte Chemie (International ed. in English)
2020-10 | Journal article
DOI: 10.1002/anie.202010703
PMID: 33063327
Contributors: Uttamapinant C; Suppakhaw K; Jantarug K; Slavoff S; Israsena N
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

The NBDY Microprotein Regulates Cellular RNA Decapping

Biochemistry
2020-10-27 | Journal article
DOI: 10.1021/acs.biochem.0c00672
Contributors: Zhenkun Na; Yang Luo; Jeremy A. Schofield; Stephanie Smelyansky; Alexandra Khitun; Sowndarya Muthukumar; Eugene Valkov; Matthew D. Simon; Sarah A. Slavoff
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Crossref
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Comparative proteomic profiling of unannotated microproteins and alternative proteins in human cell lines.

Journal of proteome research
2020-05-24 | Journal article
DOI: 10.1021/acs.jproteome.0c00254
PMID: 32449352
Source: Self-asserted source
Sarah Slavoff
grade
Preferred source (of 2)‎

Non-AUG start codons: Expanding and regulating the small and alternative ORFeome.

Experimental cell research
2020-03 | Journal article
DOI: 10.1016/j.yexcr.2020.111973
PMID: 32209305
Contributors: Cao X; Slavoff SA
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Nucleolar localization of RAG1 modulates V(D)J recombination activity.

Proceedings of the National Academy of Sciences of the United States of America
2020-02-11 | Journal article
DOI: 10.1073/pnas.1920021117
PMID: 32047031
Source: Self-asserted source
Sarah Slavoff

Small open reading frames and cellular stress responses

Molecular Omics
2019 | Journal article
DOI: 10.1039/C8MO00283E
Contributors: Alexandra Khitun; Travis J. Ness; Sarah A. Slavoff
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Crossref
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Proteomic Detection and Validation of Translated Small Open Reading Frames.

Current protocols in chemical biology
2019-12-01 | Journal article
DOI: 10.1002/cpch.77
PMID: 31750990
Source: Self-asserted source
Sarah Slavoff

The translation of non-canonical open reading frames controls mucosal immunity.

Nature
2018-12 | Journal article
DOI: 10.1038/s41586-018-0794-7
PMID: 30542152
Contributors: Jackson R; Kroehling L; Khitun A; Bailis W; Jarret A; York AG; Khan OM; Brewer JR; Skadow MH; Duizer C et al.
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

P-Bodies: Composition, Properties, and Functions

Biochemistry
2018-05-01 | Journal article
DOI: 10.1021/acs.biochem.7b01162
Contributors: Yang Luo; Zhenkun Na; Sarah A. Slavoff
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Crossref
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How many human proteoforms are there?

Nature chemical biology
2018-02 | Journal article
DOI: 10.1038/nchembio.2576
PMID: 29443976
Contributors: Aebersold R; Agar JN; Amster IJ; Baker MS; Bertozzi CR; Boja ES; Costello CE; Cravatt BF; Fenselau C; Garcia BA et al.
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Comparative Membrane Proteomics Reveals a Nonannotated E. coli Heat Shock Protein

Biochemistry
2018-01-09 | Journal article
DOI: 10.1021/acs.biochem.7b00864
Contributors: Peijia Yuan; Nadia G. D’Lima; Sarah A. Slavoff
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Comparative Proteomics Enables Identification of Nonannotated Cold Shock Proteins in E. coli

Journal of Proteome Research
2017-10-06 | Journal article
DOI: 10.1021/acs.jproteome.7b00419
Contributors: Nadia G. D’Lima; Alexandra Khitun; Aaron D. Rosenbloom; Peijia Yuan; Brandon M. Gassaway; Karl W. Barber; Jesse Rinehart; Sarah A. Slavoff
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A human microprotein that interacts with the mRNA decapping complex.

2017-02 | Journal article
DOI: 10.1038/nchembio.2249
PMID: 27918561
Contributors: D'Lima NG; Ma J; Winkler L; Chu Q; Loh KH; Corpuz EO; Budnik BA; Lykke-Andersen J; Saghatelian A; Slavoff SA
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.

2014-04 | Journal article
DOI: 10.1074/jbc.c113.533968
PMID: 24610814
PMC: PMC4036235
Contributors: Slavoff SA; Heo J; Budnik BA; Hanakahi LA; Saghatelian A
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue.

2014-03 | Journal article
DOI: 10.1021/pr401280w
PMID: 24490786
PMC: PMC3993966
Contributors: Ma J; Ward CC; Jungreis I; Slavoff SA; Schwaid AG; Neveu J; Budnik BA; Kellis M; Saghatelian A
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Chemoproteomic discovery of cysteine-containing human short open reading frames.

2013-11 | Journal article
DOI: 10.1021/ja406606j
PMID: 24152191
PMC: PMC3868496
Contributors: Schwaid AG; Shannon DA; Ma J; Slavoff SA; Levin JZ; Weerapana E; Saghatelian A
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Peptidomic discovery of short open reading frame-encoded peptides in human cells.

2013-01 | Journal article
DOI: 10.1038/nchembio.1120
PMID: 23160002
PMC: PMC3625679
Contributors: Slavoff SA; Mitchell AJ; Schwaid AG; Cabili MN; Ma J; Levin JZ; Karger AD; Budnik BA; Rinn JL; Saghatelian A
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Discovering ligand-receptor interactions.

2012-10 | Journal article
DOI: 10.1038/nbt.2373
PMID: 23051814
Contributors: Slavoff SA; Saghatelian A
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Imaging protein-protein interactions inside living cells via interaction-dependent fluorophore ligation.

2011-12 | Journal article
DOI: 10.1021/ja206435e
PMID: 22098454
PMC: PMC3547671
Contributors: Slavoff SA; Liu DS; Cohen JD; Ting AY
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Expanding the substrate tolerance of biotin ligase through exploration of enzymes from diverse species.

2008-01 | Journal article
DOI: 10.1021/ja076655i
PMID: 18171066
PMC: PMC3501195
Contributors: Slavoff SA; Chen I; Choi YA; Ting AY
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Isolation and characterisation of selected germander diterpenoids from authenticated Teucrium chamaedrys and T. canadense by HPLC, HPLC-mS and NMR.

2006 | Journal article
DOI: 10.1002/pca.912
PMID: 16910040
Contributors: Sundaresan PR; Slavoff SA; Grundel E; White KD; Mazzola E; Koblenz D; Rader JI
Source: Self-asserted source
Sarah Slavoff via Europe PubMed Central

Peer review (17 reviews for 7 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for ACS omega. (1)
Review activity for Analytical chemistry. (1)
Review activity for Biochemistry. (2)
Review activity for Journal of proteome research. (6)
Review activity for Journal of the American Chemical Society. (5)
Review activity for Nature cell biology (1)
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