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Works (5)

Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site

International Journal of Molecular Sciences
2022-10 | Journal article | Author
DOI: 10.3390/ijms232012591
Contributors: Irina Sevrioukova
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Multidisciplinary Digital Publishing Institute

Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment

International Journal of Molecular Sciences
2022-06 | Journal article | Author
DOI: 10.3390/ijms23137291
Contributors: Eric Samuels; Irina Sevrioukova
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Multidisciplinary Digital Publishing Institute

Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7

International Journal of Molecular Sciences
2021-05 | Journal article | Author
DOI: 10.3390/ijms22115831
Contributors: Irina Sevrioukova
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Multidisciplinary Digital Publishing Institute

Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength

International Journal of Molecular Sciences
2021-01 | Journal article | Author
DOI: 10.3390/ijms22020852
Contributors: Eric R. Samuels; Irina Sevrioukova
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Multidisciplinary Digital Publishing Institute

Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6′,7′-Dihydroxybergamottin

International Journal of Molecular Sciences
2019-08 | Journal article | Author
DOI: 10.3390/ijms20174245
Contributors: Irina Sevrioukova
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Multidisciplinary Digital Publishing Institute
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