Personal information

Verified email addresses

Verified email domains

XFELs, Serial Crystallography, Potein dynamics, Structural Biology, Microcrystals, Time-resolved SFX, Synchrotron radiation sources
Spain

Biography

Dr. José M. Martín García is a Associate Scientist in the Department of Crystallography and Structural Biology at the Institute of Physical Chemistry Blas Cabrera (IQF-CSIC) hired through the prestigious grant “Atracción de Talento” of the Comunidad de Madrid. He received his Diploma in Chemistry in 2004 and his PhD in 2010 from the University of Granada in Granada, Spain. Since his PhD, Dr. Martín García was focused on studying protein structures, their interactions, and dynamics, with the goal of structure-based drug discovery using X-ray crystallography at synchrotron radiation sources and X-ray Free Electron Lasers (XFELs). Dr. Martín García worked at Arizona State University from 2011 to 2020, where he laid the groundwork for: 1) advancing nano-crystallography as a routine method for growing, diagnosing, and assessing nano- and micro-crystals; 2) developing novel media for sample delivery with viscous jets; 3) developing novel sample delivery methods using microfluidic technology to reduce sample consumption in serial femtosecond crystallography (SFX) experiments at XFELs; 4) developing novel software and algorithms to improve existing SFX data processing; 5) Advancing and developing new methodologies to grow protein nano-crystals inside living cells for crystallography at XFELs; and 6) Developing and implementing the serial crystallography technique using the high-viscosity injector at a number of synchrotron beamlines worldwide. Dr. Martín García’s current research interests include: 1) structure and dynamics of macromolecules to study function and mechanisms of proteins, 2) drug discovery science, 3) serial crystallography at synchrotrons sources and X-ray free electron lasers (XFELs), and 4) development of crystallization and sample delivery methods for serial crystallography.

Activities

Funding (5)

New approaches in time-resoled crystallography at the millisecond scale for 3D structural and dynamic studies of enzymes of therapeutic interest. (TREX-3D)

2024-09 to 2027-12 | Grant
Agencia Estatal de Investigación (Madrid, ES)
GRANT_NUMBER:

PID2023-151100NB-I00

Source: Self-asserted source
JOSE MANUEL MARTIN GARCIA

Development and application of time-resolved crystallography for 3D structural and dynamic studies of allosteric regulation in bacteria

2024-09 to 2025-08 | Grant
Comunidad de Madrid (Madrid, ES)
GRANT_NUMBER:

2023-5ABMD-28921

Source: Self-asserted source
JOSE MANUEL MARTIN GARCIA

Linking time-resolved crystallography to dynamics and allosteric processes in proteins

2023-09 to 2025-08 | Grant
Agencia Estatal de Investigación (Madrid, ES)
GRANT_NUMBER:

CNS2022-135713

Source: Self-asserted source
JOSE MANUEL MARTIN GARCIA

Unraveling the resistance mechanism of the enzyme penicillin binding protein of Staphylococcus aureus by serial femtosecond crystallography at X-ray free electron lasers

2020-09 to 2024-08 | Grant
Comunidad de Madrid (Madrid, Madrid, ES)
GRANT_NUMBER:

2019-T1/BMD-15552

Source: Self-asserted source
JOSE MANUEL MARTIN GARCIA

Improving the quality of Taspase1 crystals by microgravity

2019 to 2019 | Grant
Center for the Advancement of Science in Space (FL, FL, US)
GRANT_NUMBER:

PCG-18

Source: Self-asserted source
JOSE MANUEL MARTIN GARCIA